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isolation of phytochemicals

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https://read.qxmd.com/read/30897408/the-vitamin-e-derivative-garcinoic-acid-from-garcinia-kola-nut-seeds-attenuates-the-inflammatory-response
#1
Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmölz, Yung-Chih Chen, Melanie Ziegler, Amy K Searle, Alexander Maxones, Martin Schubert, Maria Thürmer, Helmut Pein, Andreas Koeberle, Oliver Werz, Marc Birringer, Karlheinz Peter, Stefan Lorkowski
The plant Garcinia kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bioactive compounds are not well characterized. Garcinoic acid (GA) is one of the few phytochemicals that have been isolated from Garcinia kola. We investigated the anti-inflammatory potential of the methanol extract of Garcinia kola seeds (NE) and purified GA, as a major phytochemical in these seeds, in lipopolysaccharide (LPS)-activated mouse RAW264.7 macrophages and its anti-atherosclerotic potential in high fat diet fed ApoE-/- mice...
March 12, 2019: Redox Biology
https://read.qxmd.com/read/30884752/isolation-of-a-novel-flavanonol-and-an-alkylresorcinol-with-highly-potent-anti-trypanosomal-activity-from-libyan-propolis
#2
Weam Siheri, Godwin U Ebiloma, John O Igoli, Alexander I Gray, Marco Biddau, Pilaslak Akrachalanont, Samya Alenezi, Mohammad A Alwashih, RuAngelie Edrada-Ebel, Sylke Muller, Catherine E Lawrence, James Fearnley, David G Watson, Harry P De Koning
Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two helminth species, Trichinella spiralis and Caenorhabditis elegans , showing various degrees of activity. Fourteen compounds were isolated from the propolis samples, including a novel compound Taxifolin-3-acetyl-4'-methyl ether ( 4 ), a flavanonol derivative. The crude extracts showed moderate activity against T...
March 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30878545/wound-healing-potential-of-oil-extracted-from-parrotiopsis-jacquemontiana-decne-rehder
#3
Saima Ali, Muhammad Rashid Khan, Riffat Batool, Sonia Maryam, Muhammad Majid
ETHNOPHARMACOLOGICAL RELEVANCE: Oil extracted from Parrotiopsis jacquemontiana stem traditionally used for wound healing, body aches and dermatitis. In this study we have evaluated oil for its phytoconstituents, antioxidant, antimicrobial and wound healing activities. METHODS: Phytochemical characterization of oil was determined by standard qualitative procedures, gas chromatography mass spectrometry technique (GC-MS) and Fourier transform infra-red spectroscopy (FT-IR)...
March 13, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30873863/phytochemical-investigation-of-the-needles-of-aabies-nebrodensis-lojac-mattei
#4
Rosario Schicchi, Anna Geraci, Sergio Rosselli, Alberto Spinella, Antonella Maggio, Maurizio Bruno
Abies nebrodensis (Lojac.) Mattei (Pinaceae) is a species living in a very small population only in a confined area of Sicily. In this study, the dichloromethane extract of the leaves was analyzed. Apart from three already known metabolites namely dehydroabietic acid; maltol; and rheosmin, previously detected in other species of Abies, a lanostane derivative was isolated. Its chemical structure was elucidated by means of extensive spectroscopic methods.
March 15, 2019: Natural Product Research
https://read.qxmd.com/read/30871325/nmr-and-ir-analysis-of-natural-substances-isolated-from-cordyceps-medicinal-mushrooms
#5
Jarmila Harvanová, Lucia Ungvarská Maľučká, Anna Uhrinová, Mária Vilková, Martin Vavra, Martin Pavlík, Martin Rajtar, Anna Furmaníková
There exist about 750 species of Cordyceps at present. A high price of natural Cordyceps and its lack in nature caused that the attention has been focused to its cultivation in laboratory conditions. The demand for this “fungus-parasite” is still quite high nowadays, as shown by the amount of commercial nutritional supplements. Phytochemical diversity has ensured that Cordyceps is used as an immunomodulatory and an antioxidant; it has anti-cancer, anti-inflammatory, anti-diabetic, antibacterial, anti-HIV effects...
2019: Ceská a Slovenská Farmacie
https://read.qxmd.com/read/30870993/antiproliferative-activity-of-rabdosiin-isolated-from-ocimum-sanctum-l
#6
Alexandros Flegkas, Tanja Milosević Ifantis, Christina Barda, Pinelopi Samara, Ourania Tsitsilonis, Helen Skaltsa
Background: Ocimum sanctum L. (holy basil; Tulsi in Hindi) is an important medicinal plant, traditionally used in India. Methods: The phytochemical study of the nonpolar (dichloromethane 100%) and polar (methanol:water; 7:3) extracts yielded fourteen compounds. Compounds 6 , 7 , 9 , 11 , 12 , and 13 , along with the methanol:water extract were evaluated for their cytotoxicity against the human cancer cell lines MCF-7, SKBR3, and HCT-116, and normal peripheral blood mononuclear cells (PBMCs). Results: Five terpenoids, namely, ursolic acid ( 1 ), oleanolic acid ( 2 ), betulinic acid ( 3 ), stigmasterol ( 4 ), and β -caryophyllene oxide ( 5 ); two lignans, i...
March 12, 2019: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/30870986/chemical-profile-antibacterial-activity-and-antibiotic-modulating-effect-of-the-hexanic-zea-mays-l-silk-extract-poaceae
#7
Ana Beatriz Linard de Carvalho, Cleciana Alves Cruz, Cicero Lucas Almeida de Freitas, José Junior Dos Santos Aguiar, Paula Leticia Wendy de Souza Nunes, Valéria Maria da Silva Lima, Edinardo Fagner Ferreira Matias, Débora Feitosa Muniz, Henrique Douglas Melo Coutinho
The present study aimed to determine the chemical profile and to evaluate the antibacterial activity and antibiotic-modulating action of the hexanic Zea mays silk extract in association with aminoglycosides. Standard Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains, as well as multi-resistant Escherichia coli 27, Staphylococcus aureus 35, and Pseudomonas aeruginosa 31 strains, were used in this study. Phytochemical prospection revealed the presence of the following secondary metabolites: tannins, flavones, flavonoids, and xanthones, with the main chemical constituents being identified in plant extracts obtained with apolar organic solvents such as hexane...
March 12, 2019: Antibiotics
https://read.qxmd.com/read/30870007/chemical-constituents-from-glehnia-littoralis-and-their-chemotaxonomic-significance
#8
Shouwen Zhang, Fang Cheng, Li Yang, Jinxiang Zeng, Fengyu Han, Xiuling Yu, Yuye Zhu, Guoyue Zhong, Junwei He
Phytochemical investigation of the roots of Glehnia littoralis Fr. Schmidt. ex Miq. led to the isolation of 16 known compounds, including three β-carboline alkaloids (1-3), four phenylpropanoids (4-7), five phenolic acids (8-12), three polyacetylenes (13-15) and one fatty acid (16). The structures of these compounds were elucidated on the basis of spectral analysis and comparison with those reported in literatures. To the best of knowledge, the report of the first β-carboline alkaloid in the Umbelliferae family...
March 14, 2019: Natural Product Research
https://read.qxmd.com/read/30863444/antibacterial-activity-of-coumarins-and-carbazole-alkaloid-from-roots-of-clausena-anisata
#9
Dandena Tamene, Milkyas Endale
Clausena anisata is one of the medicinal plants used traditionally for treatment of parasitic infections, irritation (boils, ringworm, and eczema), flatworm infestations, influenza, abdominal cramps, and constipation. Phytochemical screening test of dichloromethane/methanol (1 : 1) roots extract revealed the presence of flavonoids, phytosterols, coumarins, phenols, alkaloids, tannins, terpenoids, and free reducing sugars and the absence of saponins. Silica gel column chromatographic separation of the dichloromethane/methanol (1 : 1) extract afforded a carbazole alkaloid derivative of heptazoline ( 1 ) and three coumarins ( 2 - 4 ), including the known coumarins imperatorin ( 3 ) and chalepin ( 4 )...
2019: Advances in Pharmacological Sciences
https://read.qxmd.com/read/30857362/hemi-synthesis-of-chiral-imine-benzimidazole-and-benzodiazepines-from-essential-oil-of-ammodaucus-leucotrichus-subsp-leucotrichus
#10
Farid Chebrouk, Khodir Madani, Brahim Cherfaoui, Leila Boukenna, Mónica Válega, Ricardo F Mendes, Filipe A A Paz, Khaldoun Bachari, Oualid Talhi, Artur M S Silva
The hemi-synthesis of chiral imine, benzimidazole and benzodiazepine structures is reported by the condensation of ( S )-(-)-perillaldehyde, the major phytochemical of Ammodaucus leucotrichus subsp. leucotrichus essential oil, with different amine derivatives of 2,3-diaminomaleonitrile, o -phenylenediamine and 3-[(2-aminoaryl)amino]dimedone. The reaction proceeds in situ at ambient temperature without prior isolation of the natural ( S )-(-)-perillaldehyde. Final products precipitate in the ethanolic reaction medium...
March 10, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30856530/biologically-active-compounds-and-pharmacological-activities-of-species-of-the-genus-crocus-a-review
#11
REVIEW
Olga Mykhailenko, Volodymyr Kovalyov, Olga Goryacha, Liudas Ivanauskas, Victoriya Georgiyants
The present article is the first comprehensive review on the chemical composition and pharmacological activities of the raw materials of Crocus species. In the present review, data on chemical constituents and pharmacological profile of Crocus sativus stigmas, as well as of other plant parts (perianth, stamens, leaves, corms) of different Crocus spp. are given. This review discusses all the classes of compounds (carotenoids, flavonoids, anthocyanins, terpenoids, phenol carboxylic acids, etc.) detected in raw materials of Crocus plants providing information on the current state of knowledge on phytochemicals of Crocus species...
March 8, 2019: Phytochemistry
https://read.qxmd.com/read/30856010/two-new-diprenylated-flavanones-from-derris-laxiflora-benth
#12
Hui-Chi Huang, Shih-Chang Chien, Ching-Chuan Kuo, Ming-Der Wu, Ming-Jen Cheng, Jih-Jung Chen, Hsi-Lin Chiu, Yueh-Hsiung Kuo
Phytochemical reinvestigation on the whole plants of Derris laxiflora Benth. afforded two new diprenylated flavanones, derriflavanones B and C (1-2), together with thirty-two known compounds, including sixteen flavonoids (3-18), eleven aromatic compounds (19-29), and five chlorophylls (30-34). All known compounds were first isolated from this plant. The structures of these compounds were determined by analysis of the NMR spectroscopy, mass data, IR spectra, UV spectra, optical rotation and by comparison with literature data...
March 11, 2019: Natural Product Research
https://read.qxmd.com/read/30855191/evaluation-of-pistia-stratiotes-fractions-as-effective-larvicide-against-anopheles-mosquitoes
#13
Jincai Ma, Yunusa Adamu Ugya, Asma'u Isiyaku, Xiuyi Hua, Tijjani Sabiu Imam
Mosquito are well-known vectors that cause diseases particularly malaria and filariasis which are detrimental to human health. These vectors occur mainly in tropical countries where more than 2 billion people live in endemic regions with about one million deaths been claimed yearly from malaria and filariasis. The study is aimed at evaluating the larvicidal activity of Pistia stratiotes fractions on Anopheles mosquitoes (Diptera: Culicidae). The ethyl acetate extract of P. stratiotes was obtained through percolation process and was chromatographed to yield nine fractions...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
https://read.qxmd.com/read/30852764/medicinal-plants-and-their-isolated-phytochemicals-for-the-management-of-chemotherapy-induced-neuropathy-therapeutic-targets-and-clinical-perspective
#14
Vahideh Oveissi, Mahboobe Ram, Roodabeh Bahramsoltani, Farnaz Ebrahimi, Roja Rahimi, Rozita Naseri, Tarun Belwal, Hari Prasad Devkota, Zahra Abbasabadi, Mohammad Hosein Farzaei
BACKGROUND: Chemotherapy, as one of the main approaches of cancer treatment, is accompanied with several adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Since current methods to control the condition are not completely effective, new treatment options should be introduced. Medicinal plants can be suitable candidates to be assessed regarding their effects in CIPN. Current paper reviews the available preclinical and clinical studies on the efficacy of herbal medicines in CIPN...
March 9, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30843651/structural-characterization-and-biological-evaluation-of-18-nor-ent-labdane-diterpenoids-from-grazielia-gaudichaudeana-dc-r-m-king-h-rob-asteraceae
#15
Rodolfo B Balbinot, Josiane A M de Oliveira, Darlon I Bernardi, Ulisses Z Melo, Érica B Zanqueta, Eliana H Endo, Fabianne M Ribeiro, Hélito Volpato, Mariana C Figueiredo, Davi F Back, Ernani A Basso, Ana L T G Ruiz, João E de Carvalho, Mary Ann Foglio, Benedito D Prado Filho, Tania U Nakamura, Celso V Nakamura, Marta R B do Carmo, Maria H Sarragiotto, Debora Cristina Baldoqui
The phytochemical investigation of Grazielia gaudichaudeana aerial parts yielded fifteen compounds, including diterpenes, triterpenes, sterols and flavonoids. With exception to ent-kaurenic acid diterpenes, the compounds isolated are being described for the first time in this species. Some unusual ¹H-NMR chemical shifts of 18-nor-ent-labdane (7-9) led us to carry on a conformational analysis by theoretical calculations in order to support the experimental data. Moreover, due the limitation of studies focused on pharmacological potential of Grazielia gaudichaudeana, the present study was carried out to investigate the antioxidant, antiproliferative, antiviral, anti-leishmanial and antimicrobial activities from the extract, fractions and isolated compounds obtained from this species...
March 7, 2019: Chemistry & Biodiversity
https://read.qxmd.com/read/30841418/inhibitory-effects-of-morus-nigra-l-moraceae-against-local-paw-edema-and-mechanical-hypernociception-induced-by-bothrops-jararacussu-snake-venom-in-mice
#16
Anita Eugênia Alencar Santos Ribeiro, Juliana Mikaely Dias Soares, Helder Anderson Lima Silva, Carlos Wagner de Souza Wanderley, Celuane Alves Moura, Raimundo Gonçalves de Oliveira-Junior, Ana Paula de Oliveira, Larissa Araújo Rolim, Emmanoel Vilaça Costa, Jackson Roberto Guedes da Silva Almeida, Helinando Pequeno de Oliveira, Raimundo Campos Palheta-Junior
BACKGROUND: Bothropic venoms cause intense local damage, pain, edema, and myonecrosis. Morus nigra L. (Moraceae) has several uses in folk medicine and can be a promising candidate for the treatment of several inflammatory disorders. HYPOTHESIS/PURPOSE: The present study aims to evaluate the anti-inflammatory and antinociceptive effects of the ethanolic extract of Morus nigra L. (Mn-EtOH) on paw lesions induced by Bothrops jararacussu snake venom (BjcuV) in mice...
March 2019: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/30840916/an-unprecedented-chlorine-containing-piperamide-from-piper-pseudoarboreum-as-potential-leishmanicidal-agent
#17
Ninoska Flores, Juan C Ticona, Pablo Bilbao-Ramos, M Auxiliadora Dea-Ayuela, Juan C Ruiz Macedo, Isabel L Bazzocchi, Francisco Bolás-Fernández, Ignacio A Jiménez
A phytochemical investigation of the ethanolic extract of leaves from Piper pseudoarboreum led to the isolation of 3-chlorosintenpyridone 1, an unprecedented chlorinated piperamide, together with the known compounds 2-12. Their structures were established based on 1D and 2D (COSY, ROESY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The proposed biosynthetic pathway of compound 1 is discussed. Compounds 1-12 were tested in vitro for their leishmanicidal potential against promastigote stages of Leishmania amazonensis, L braziliensis, L...
March 3, 2019: Fitoterapia
https://read.qxmd.com/read/30838743/molluscicidal-activity-of-cardiac-glycosides-isolated-from-adenium-obesum
#18
Ali A Alzabib, Yasser Abobakr, Ali S Al-Sarar, Hamdy I Hussein, Omer A Basudan, Ali A El-Gamal, Maged S Abdel-Kader, Mahmoud H El Komy
BACKGROUND: Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS: The benzene-soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstrcata among different solvent fractions with a median lethal dose (LD50 ) of 4...
March 5, 2019: Pest Management Science
https://read.qxmd.com/read/30838736/progress-and-prospects-in-the-management-of-psoriasis-and-developments-in-phyto-therapeutic-modalities
#19
REVIEW
Muhammad Daniyal, Muhammad Akram, Rida Zainab, Naveed Munir, Syed Muhammad Ali Shah, Bin Liu, Wei Wang, Muhammad Riaz, Farhat Jabeen
OBJECTIVES: The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. METHODS: The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. KEY FINDINGS: Psoriasis is a common skin disease affecting 2 - 3% of the world's population. It is cosmetically debilitating and chronic disease which occurs both in developing and developed countries...
March 5, 2019: Dermatologic Therapy
https://read.qxmd.com/read/30836643/medicinal-uses-phytochemistry-and-pharmacological-properties-of-elaeodendron-transvaalense
#20
REVIEW
Alfred Maroyi, Sebua Silas Semenya
Elaeodendron transvaalense is a plant species, which is in high demand as a herbal medicine in southern Africa. This study critically reviewed the medicinal applications, phytochemistry and pharmacological activities of E. transvaalense . The literature on medicinal applications, phytochemical, and pharmacological activities of E. transvaalense , was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct, and Scopus. Complementary information was gathered from pre-electronic sources, such as books, book chapters, theses, scientific reports, and journal articles obtained from the University library...
March 4, 2019: Nutrients
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