Michael J Keogh, Laura Bennet, Paul P Drury, Lindsea C Booth, Sam Mathai, Andrew S Naylor, Mhoyra Fraser, Alistair J Gunn
Exposure to chorioamnionitis is strongly associated with neurodevelopmental disability after premature birth; however, it remains unclear whether subclinical infection affects functional EEG maturation. Chronically instrumented 103-104-day-old (0.7 gestational age: term 147 days) fetal sheep in utero were randomized to receive either gram-negative LPS by continuous low-dose infusion (100 ng iv over 24 h, followed by 250 ng/24 h for 4 days; n = 6) or the same volume of normal saline (n = 9). Arterial plasma cortisol, ACTH, and IL-6 were measured...
August 1, 2012: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology