keyword
https://read.qxmd.com/read/38506130/the-revival-of-sorbents-in-chronic-dialysis-treatment
#1
REVIEW
Jeroen Peter Kooman
Interest in the use of sorbents in chronic dialysis treatment has undergone a revival in the last decades, for which two major factors are responsible. The first is the potential of sorbents as adjunct therapy for the removal of substances that are difficult to remove by conventional dialysis therapies. The second is their use in regeneration of dialysate, which is of pivotal importance in the design of portable or even wearable treatments, next to the potential for reducing water use during conventional dialysis treatment...
March 20, 2024: Seminars in Dialysis
https://read.qxmd.com/read/38504636/prevention-of-dialysis-disequilibrium-syndrome-in-children-with-advanced-uremia-with-a-structured-hemodialysis-protocol-a-quality-improvement-initiative-study
#2
JOURNAL ARTICLE
Sidharth Kumar Sethi, Valerie Luyckx, Timothy Bunchman, Aishwarya Nair, Shyam Bihari Bansal, Bryce Pember, Kritika Soni, Savita, Dinesh Kumar Yadav, Vivek Sharma, Khalid Alhasan, Rupesh Raina
BACKGROUND: Dialysis disequilibrium syndrome (DDS) is a rare but significant concern in adult and pediatric patients undergoing dialysis initiation with advanced uremia or if done after an interval. It is imperative to gain insights into the epidemiological patterns, pathophysiological mechanisms, and preventive strategies aimed at averting the onset of this ailment. DESIGN: Prospective observational quality improvement initiative cohort study. SETTING AND PARTICIPANTS: A prospective single-center study involving 50 pediatric patients under 18 years recently diagnosed with chronic kidney disease stage V with blood urea ≥200 mg/dL, admitted to our tertiary care center for dialysis initiation from January 2017 to October 2023...
March 20, 2024: Hemodialysis International
https://read.qxmd.com/read/38465136/metastatic-calcinosis-cutis-unusual-locations-in-end-stage-renal-disease
#3
Jc Charm C Asoy, Justin Luke D Yap
Metastatic calcinosis cutis is a rare consequence of end-stage renal disease (ESRD), which occurs due to elevated levels of serum phosphorus and abnormal phosphate and calcium metabolism, leading to the precipitation and deposition of calcium in the cutaneous and subcutaneous tissues. This paper reports the case of a 33-year-old male with ESRD and a six-year history of hemodialysis treatment who presented with multiple areas of gradually enlarging, lobulated calcified soft tissue masses observed bilaterally at the level of the acromioclavicular joint and superomedial aspect of the right thigh, extensively involving the perineal region and the right superior anterior chest wall...
February 2024: Curēus
https://read.qxmd.com/read/38443857/the-association-between-new-inflammation-markers-and-frequent-peritoneal-dialysis-associated-peritonitis
#4
JOURNAL ARTICLE
Jing Tang, Dongxue Wang, Yun Chen, Jinhong Feng
OBJECTIVE: To validate an association between new inflammation and frequent peritoneal dialysis-associated peritonitis (PDAP). MATERIALS AND METHODS: In China, retrospective clinical data were collected on 208 patients who received continuous ambulatory peritoneal dialysis (CAPD) between 2010 and 2021. The patients were divided into two groups: non-frequent PDAP (the interval between two peritonitis episodes of more than one year) and frequent PDAP (the interval between two peritonitis episodes of less than one year)...
March 5, 2024: BMC Nephrology
https://read.qxmd.com/read/38412204/haematological-indices-and-iron-status-in-pre-dialysis-chronic-kidney-disease-patients
#5
JOURNAL ARTICLE
I R Edeki, E I Unuigbe, E I Okaka
BACKGROUND: Chronic kidney disease (CKD) is associated with haematological changes, the commonest being anaemia. The number and function of white blood cells (WBC) and platelets are equally affected. Iron deficiency is a common cause of anaemia in the CKD population and anaemia has been associated with reduced cardiac function, increased rates of hospitalization, morbidity and mortality. This study aimed to determine the haematological indices and iron status among pre-dialysis CKD patients...
January 31, 2024: West African Journal of Medicine
https://read.qxmd.com/read/38404240/most-recently-developed-polyester-polymer-alloy-dialyzer-a-new-medium-cut-off-membrane
#6
JOURNAL ARTICLE
Francisco Maduell, Diana Rodríguez-Espinosa, Lida María Rodas, Miquel Gómez, Marta Arias-Guillén, Néstor Fontseré, Manel Vera, Maria Del Carmen Salgado, Nayra Rico, José Jesús Broseta
BACKGROUND: New versions of the polyester polymer alloy (PEPA) membrane have appeared over the years, with increases in both the pore size and the amount of polyvinylpyrrolidone (PVP) to optimize hydrophilicity performance. This study aimed to assess the efficacy of the most recently developed PEPA dialyzer, the FDY series, in hemodialysis (HD) modality in terms of uremic toxin removal and albumin loss and to compare it with that of several high-flux dialyzers currently used in HD and post-dilution hemodiafiltration (HDF) treatments...
February 26, 2024: Artificial Organs
https://read.qxmd.com/read/37993752/effect-of-membrane-permeance-and-system-parameters-on-the-removal-of-protein-bound-uremic-toxins-in-hemodialysis
#7
JOURNAL ARTICLE
Chun Man Chow, Aaron H Persad, Rohit Karnik
Inadequate clearance of protein-bound uremic toxins (PBUTs) during dialysis is associated with morbidities in chronic kidney disease patients. The development of high-permeance membranes made from materials such as graphene raises the question whether they could enable the design of dialyzers with improved PBUT clearance. Here, we develop device-level and multi-compartment (body) system-level models that account for PBUT-albumin binding (specifically indoxyl sulfate and p-cresyl sulfate) and diffusive and convective transport of toxins to investigate how the overall membrane permeance (or area) and system parameters including flow rates and ultrafiltration affect PBUT clearance in hemodialysis...
November 22, 2023: Annals of Biomedical Engineering
https://read.qxmd.com/read/37971865/association-of-bioimpedance-parameters-with-increases-in-blood-pressure-during-hemodialysis
#8
JOURNAL ARTICLE
Enass Elsayed, Youssef M K Farag, Katherine Scovner Ravi, Glenn M Chertow, Finnian R Mc Causland
BACKGROUND: Intradialytic hypertension, defined as an increase in BP from pre- to post-hemodialysis (HD), affects 5%-15% of patients receiving maintenance HD and is associated with cardiovascular and all-cause mortality. Hypervolemia is believed to be a major etiological factor, yet the association of more objective biomarkers of volume status with intradialytic hypertension is not well described. METHODS: In a post hoc analysis of the Frequent Hemodialysis Network Daily Trial ( n =234), using data from baseline, 1-, 4-, and 12-month visits ( n =800), we used random-effects regression to assess the association of bioimpedance estimates of volume (vector length) with post-HD systolic BP (continuous) and any increase in systolic BP (categorical) from pre- to post-HD...
November 16, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/37757455/prescribing-the-dialysis-dose-and-treatment-frequency-in-home-haemodialysis
#9
JOURNAL ARTICLE
Francesco Gaetano Casino, Maria Fernanda Slon Roblero, Silvia González-Sanchidrian, Sandra Gallego Dominguez, Ignacio Lorenzo Ferris, Valerie A Luyckx, Vassilios Liakopoulos, Sandip Mitra, Javier Deira Lorenzo, Carlo Basile
BACKGROUND: There is growing interest in home haemodialysis (HHD) performed with low-flow dialysate devices and variable treatment schedules. The target standard Kt/V (stdKt/V) should be 2.3 volumes/week, according to KDOQI guidelines (2015). The current formula for stdKt/V does not help prescribe the dialysis dose (eKt/V) and treatment frequency (TF). The aim of this study was to obtain a formula for stdKt/V that is able to define the minimum required values of eKt/V and TF to achieve the targeted stdKtV...
February 28, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37755973/renal-embolization-induced-uremic-swine-model-for-assessment-of-next-generation-implantable-hemodialyzers
#10
JOURNAL ARTICLE
Jarrett Moyer, Mark W Wilson, Thomas A Sorrentino, Ana Santandreu, Caressa Chen, Dean Hu, Amy Kerdok, Edward Porock, Nathan Wright, Jimmy Ly, Charles Blaha, Lynda A Frassetto, William H Fissell, Shant M Vartanian, Shuvo Roy
Reliable models of renal failure in large animals are critical to the successful translation of the next generation of renal replacement therapies (RRT) into humans. While models exist for the induction of renal failure, none are optimized for the implantation of devices to the retroperitoneal vasculature. We successfully piloted an embolization-to-implantation protocol enabling the first implant of a silicon nanopore membrane hemodialyzer (SNMHD) in a swine renal failure model. Renal arterial embolization is a non-invasive approach to near-total nephrectomy that preserves retroperitoneal anatomy for device implants...
September 4, 2023: Toxins
https://read.qxmd.com/read/37655458/-in-silico-screening-of-nanoporous-materials-for-urea-removal-in-hemodialysis-applications
#11
JOURNAL ARTICLE
Thomas Fabiani, Eleonora Ricci, Cristiana Boi, Simone Dimartino, Maria Grazia De Angelis
The design of miniaturized hemodialysis devices, such as wearable artificial kidneys, requires regeneration of the dialysate stream to remove uremic toxins from water. Adsorption has the potential to capture such molecules, but conventional adsorbents have low urea/water selectivity. In this work, we performed a comprehensive computational study of 560 porous crystalline adsorbents comprising mainly covalent organic frameworks (COFs), as well as some siliceous zeolites, metal organic frameworks (MOFs) and graphitic materials...
September 1, 2023: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/37559023/hyperkalaemia-prevalence-and-dialysis-patterns-in-chinese-patients-on-haemodialysis-an-interim-analysis-of-a-prospective-cohort-study-precede-k
#12
JOURNAL ARTICLE
Zhaohui Ni, Haijiao Jin, Renhua Lu, Lihong Zhang, Li Yao, Guojian Shao, Li Zuo, Shuguang Qin, Xinzhou Zhang, Qinghong Zhang, Weimin Yu, Qun Luo, Yuqing Ren, Hui Peng, Jie Xiao, Qiongqiong Yang, Qinkai Chen, Yifan Shi
BACKGROUND: Hyperkalaemia is a known risk factor for cardiac arrhythmia and mortality in patients on haemodialysis. Despite standard adequate haemodialysis, hyperkalaemia is common in patients with end-stage renal disease (ESRD) at interdialytic intervals. Data on hyperkalaemia burden and its effects on dialysis patterns and serum potassium (sK) fluctuations in patients on haemodialysis in China remain limited. The prospective, observational cohort study (PRECEDE-K; NCT04799067) investigated the prevalence, recurrence, and treatment patterns of hyperkalaemia in Chinese patients with ESRD on haemodialysis...
August 9, 2023: BMC Nephrology
https://read.qxmd.com/read/37481478/monitoring-of-minerals-level-in-dialysate-during-hemodialysis-treatment-of-kidney-patients-using-libs-technique
#13
JOURNAL ARTICLE
Pratima Mishra, Pradeep Kumar Rai, Rohit Kumar, Vidit Maniyar, Awadhesh Kumar Rai
Chronic kidney patients may have difficulties in blood filtration to eliminate the waste from the blood and to maintain the level of the minerals in the blood. Hemodialysis (HD) is an artificial way to remove the waste from the blood of a kidney patient and to maintain the proper mineral level in the blood. Reverse osmosis (RO) water having less total dissolved solids (TDS) < 50 ppm is used to prepare dialysis fluid/dialysate in dialysis with two chemicals (electrolytes and salts such as sodium bicarbonate)...
July 22, 2023: Lasers in Medical Science
https://read.qxmd.com/read/37474512/high-flux-novel-polymeric-membrane-for-renal-applications
#14
JOURNAL ARTICLE
Christa N Hestekin, Efecan Pakkaner, Jamie A Hestekin, Leticia Santos De Souza, Partha Pratim Chowdhury, Juliana Louzada Marçal, John Moore, Sarah A Hesse, Christopher J Takacs, Christopher J Tassone, Soma Shekar Dachavaram, Peter A Crooks, Kate Williams, Ira Kurtz
Biocompatibility and the ability to mediate the appropriate flux of ions, urea, and uremic toxins between blood and dialysate components are key parameters for membranes used in dialysis. Oxone-mediated TEMPO-oxidized cellulose nanomaterials have been demonstrated to be excellent additives in the production and tunability of ultrafiltration and dialysis membranes. In the present study, nanocellulose ionic liquid membranes (NC-ILMs) were tested in vitro and ex vivo. An increase in flux of up to two orders of magnitude was observed with increased rejection (about 99...
July 20, 2023: Scientific Reports
https://read.qxmd.com/read/37448903/impact-of-water-treatment-on-anemia-in-hemodialysis-patients
#15
JOURNAL ARTICLE
Mohamed S Hassan, Hayam A Hebah, Tarek A H Mourad, Reem M El-Sharabasy
INTRODUCTION: The microbiological quality of water in the dialysate used in hemodialysis has been suggested as a contributor to inflammation, and a link between dialysate purity, inflammation, and responsiveness to erythropoietin therapy has been suggested in many studies. The level of endotoxin might induce inflammation and resistance to erythropoietin therapy in dialysis patients. We aimed to compare the effect of using the central dialysis fluid delivery system (CDDS) versus the single-patient dialysis fluid delivery system (SPDDS) on anemia in prevalent hemodialysis patients...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37369284/improving-the-adsorption-performance-of-urea-by-using-polyhydroxy-groups-to-modify-two-dimensional-ti3c2tx
#16
JOURNAL ARTICLE
Hong Wei, Xiao Li, Cong Li, Kaidi Wang, Zhiping Liu, Jiarui Lu, Baixiong Liu, Xingyu He
Wearable artificial kidney can provide continuous dynamic dialysis for uremia patients. For the sake of practical application, the critical step is to find an adsorbent that can effectively remove urea and have excellent biological compatibility. The layered Ti3C2Tx (DL-Ti3C2Tx) with high specific surface area and good dispersion was prepared by a two-step etching method. From the first principles calculation, urea can be adsorbed by different groups (-F, -O, -OH) on the surface of Ti3C2Tx, among which -OH has the greatest binding energy to urea...
June 25, 2023: Chemosphere
https://read.qxmd.com/read/37179476/efficacy-of-sustained-low-efficiency-dialysis-in-the-management-of-topiramate-intoxication-case-report
#17
Silvia Barbarini, Vilma Martella, Emiliana Ferramosca, Paolo Ria, Anna Zito, M Luisa Lefons, Maria Caterina Carbonara, Giulia Fontò, Paolo Protopapa, Antonio De Pascalis, Marcello Napoli
Guidelines on the use of dialysis treatment in patients with chronic kidney disease (CKD) and TPM (Topiramate) intoxication are controversial. A 51-year-old man with epilepsy and CKD was carried to our emergency department for dysuria and sickness. He chronically assumed TPM 100 mg 3/day. Creatinine level was 2.1 mg/dL, blood urea nitrogen 70 mg/dL, and inflammation indexes were increased. We started empirical antibiotic therapy and rehydration. The day two he had diarrhea and an acute insurgence of dizziness, confusion, and bicarbonate levels reduction...
April 27, 2023: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/37085652/modelling-of-icodextrin-hydrolysis-and-kinetics-during-peritoneal-dialysis
#18
JOURNAL ARTICLE
Joanna Stachowska-Pietka, Jacek Waniewski, Anna Olszowska, Elvia Garcia-Lopez, Zofia Wankowicz, Bengt Lindholm
In peritoneal dialysis, ultrafiltration is achieved by adding an osmotic agent into the dialysis fluid. During an exchange with icodextrin-based solution, polysaccharide chains are degraded by α-amylase activity in dialysate, influencing its osmotic properties. We modelled water and solute removal taking into account degradation by α-amylase and absorption of icodextrin from the peritoneal cavity. Data from 16 h dwells with icodextrin-based solution in 11 patients (3 icodextrin-exposed, 8 icodextrin-naïve at the start of the study) on dialysate volume, dialysate concentrations of glucose, urea, creatinine and α-amylase, and dialysate and blood concentrations of seven molecular weight fractions of icodextrin were analysed...
April 21, 2023: Scientific Reports
https://read.qxmd.com/read/37071749/adsorption-and-clearance-of-the-novel-fluorescent-tracer-agent-mb-102-during-continuous-renal-replacement-therapy-in-vitro-results
#19
JOURNAL ARTICLE
Soo M Jang, Jeng-Jong Shieh, Ivan R Riley, Richard B Dorshow, Bruce A Mueller
MB-102 is a novel fluorescent tracer agent that is exclusively removed from the body by glomerular filtration. This agent can be detected transdermally to provide a real-time measurement of glomerular filtration rate at the point-of-care and is currently in clinical studies for such. MB-102 clearance during continuous renal replacement therapy (CRRT) is unknown. Its plasma protein binding (~0%), molecular weight (~372 Da) and volume of distribution (15-20 L) suggest that it may be removed by renal replacement therapies...
April 19, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/37037222/minimized-hemodiafiltration-for-extracorporeal-membrane-oxygenation-in-infants
#20
JOURNAL ARTICLE
Nicola Kwapil, Andreas Teske, Sven Dittrich, Robert Blumauer, Michela Cuomo, Ariawan Purbojo, Frank Münch
BACKGROUND:  Fluid overload is a serious complication in the treatment of infants with extracorporeal membrane oxygenation (ECMO). Volume overload leads to prolonged ECMO therapy if left untreated. The renal replacement therapy of choice in pediatric patients is peritoneal dialysis or conventional dialysis using a "large" hemofiltration machine via a Shaldon catheter or directly connected to the ECMO system. This study describes the implementation of a novel minimized hemodiafiltration (HDF) system in pediatric patients on ECMO...
January 2023: Thoracic and Cardiovascular Surgeon
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