Atsushi Uchiyama, Kaoru Okazaki, Masatoshi Kondo, Shuntaro Oka, Yukiko Motojima, Fumihiko Namba, Nobuhiko Nagano, Kayo Yoshikawa, Kazunori Kayama, Akira Kobayashi, Yoshiki Soeno, Osamu Numata, Hideyo Suenaga, Ken Imai, Hidehiko Maruyama, Hideshi Fujinaga, Hiroyuki Furuya, Yushi Ito
OBJECTIVES: Our aim is to compare the efficacy and safety of high-flow nasal cannula (HFNC) against those of nasal continuous positive airway pressure (NCPAP) or nasal intermittent positive-pressure ventilation (NIPPV) after extubation in preterm infants. METHODS: This prospective, randomized, noninferiority trial was conducted in 6 tertiary NICUs. Infants born at <34 weeks who needed noninvasive ventilation after extubation were enrolled. We randomly assigned infants to an HFNC group when HFNC was used or to an NCPAP/NIPPV group when NCPAP or NIPPV was used...
December 2020: Pediatrics