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Keywords Factors And Neonatal Outcomes ...

Factors And Neonatal Outcomes Associated With Histologic

https://read.qxmd.com/read/35644247/acute-histologic-chorioamnionitis-independently-and-directly-increases-the-risk-for-brain-abnormalities-seen-on-magnetic-resonance-imaging-in-very-preterm-infants
#21
MULTICENTER STUDY
Viral G Jain, Julia E Kline, Lili He, Beth M Kline-Fath, Mekibib Altaye, Louis J Muglia, Emily A DeFranco, Namasivayam Ambalavanan, Nehal A Parikh
BACKGROUND: The independent risk for neurodevelopmental impairments attributed to chorioamnionitis in premature infants remains controversial. Delayed brain maturation or injury identified on magnetic resonance imaging at term-equivalent age can be used as a surrogate measure of neurodevelopmental impairments that is less confounded by postdelivery neonatal intensive care unit environmental factors to investigate this relationship more clearly. OBJECTIVE: This study aimed to determine whether preterm infants born with moderate to severe acute histologic chorioamnionitis would have a higher magnetic resonance imaging-determined global brain abnormality score, independent of early premature birth, when compared with preterm infants with no or mild chorioamnionitis...
October 2022: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/35307779/placental-histology-and-pregnancy-complications-following-intracytoplasmic-sperm-injection-for-non-male-factor-infertility
#22
JOURNAL ARTICLE
Hadas Ganer Herman, Alexander Volodarsky-Perel, Tuyet Nhung Ton Nu, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H Dahan
PURPOSE: To assess obstetric outcomes and placental histology following intracytoplasmic sperm injection (ICSI), for non-male infertility. METHODS: This was a retrospective cohort of live born singleton deliveries after in vitro fertilization (IVF) at a single university affiliated medical center between 2009 and 2017. Excluded were IVF cycles with male infertility and oocyte recipients. We compared obstetric outcomes and placental histology in cases ICSI was performed (ICSI group) and cases with no ICSI (IVF group)...
May 2022: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/34794371/efficacy-of-distal-haemostasis-during-caesarean-delivery-in-women-with-placenta-accreta-spectrum-disorders
#23
JOURNAL ARTICLE
S V Barinov, R G Shmakov, I V Medyannikova, Yu I Tirskaya, T V Kadtsyna, O V Lazareva, I N Razdobedina, T N Neustroyeva, S S Stepanov
 : Pregnancies complicated by the placenta praevia are associated with an increased risk of massive obstetric bleeding and high rates of hysterectomy which are often caused by the placenta accreta. The aim of our study was to identify the risk factors for placenta praevia associated with PAS disorders and the efficacy of distal haemostasis during Cesarean delivery. METHODS: This was a cohort study carried out between 2014 and 2020 in 532 women with abnormal placental localization and attachment...
November 18, 2021: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/34368025/adverse-maternal-and-neonatal-outcomes-in-women-with-elevated-intrapartum-temperature-complicated-by-histological-chorioamnionitis-at-term-a-propensity-score-matched-study
#24
JOURNAL ARTICLE
Yingzhou Ge, Chen Zhang, Yanqing Cai, Hefeng Huang
Background: Elevated intrapartum temperature has been widely proven to be associated with adverse clinical outcomes in both mothers and neonates. Histological chorioamnionitis (HCA), the inflammation of chorion and amniotic membranes, is commonly observed in those with elevated intrapartum temperature. Thus, we aimed to explore whether the combination of HCA would further affect the pregnancy outcomes in those with intrapartum temperature ≥ 37.5°C. Methods: This retrospective cohort study was conducted at the International Peace Maternity and Child Health Hospital (IPMCH), including all full-term women with intrapartum temperature ≥ 37...
2021: Frontiers in Pediatrics
https://read.qxmd.com/read/34212381/the-association-between-placenta-associated-circulating-biomarkers-and-composite-adverse-delivery-outcome-of-a-likely-placental-cause-in-healthy-post-date-pregnancies
#25
JOURNAL ARTICLE
Sophie Bowe, Birgitte Mitlid-Mork, Antoniya Georgieva, Jon M Gran, Christopher W G Redman, Anne Cathrine Staff, Meryam Sugulle
INTRODUCTION: Post-date pregnancies have an increased risk of adverse delivery outcome. Our aim was to explore the association between placenta-associated circulating biomarkers and composite adverse delivery outcome of a likely placental cause in clinically healthy post-date pregnancies. MATERIAL AND METHODS: Women with healthy singleton post-date pregnancies between 40+2 and 42+2  weeks of gestation were recruited to this prospective, observational study conducted at Oslo University Hospital, Norway (NCT03100084)...
October 2021: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/34112053/complicated-placenta-accreta-spectrum-identifying-a-high-risk-cohort
#26
JOURNAL ARTICLE
Brian A Crosland, Alice M Sherman-Brown, Megan C Oakes, Laura R Cuevas, Andreea I Dinicu, Emma J Altieri, Dana M Hutchison, Jenny Chang, Argyrios Ziogas, Michael P Nageotte, Vineet K Shrivastava
OBJECTIVE: To assess differences in the perioperative complication rate between patients with placenta accreta spectrum (PAS) with and without complicating factors. METHODS: This retrospective cohort study included subjects who underwent cesarean hysterectomy with histology-proven PAS between 23 0/7 and 42 0/7 weeks gestational age (GA) from 1 July 2008 to 11 April 2017. Perioperative outcomes were compared between those with uncomplicated PAS and "complicated PAS," defined as PAS subjects who experienced ≥2 bleeding episodes, preterm premature rupture of membranes (PPROM), or premature contractions requiring tocolysis...
June 10, 2021: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/34022751/placental-histological-features-and-neurodevelopmental-outcomes-at-two-years-in-very-low-birth-weight-infants
#27
JOURNAL ARTICLE
Arsenio Spinillo, Mattia Dominoni, Camilla Caporali, Ivana Olivieri, Roberta La Piana, Stefania Longo, Stefania Cesari, Giacomo Fiandrino, Simona Orcesi, Barbara Gardella
BACKGROUND: We evaluated the rates of placental pathologic lesions and their relationship with two-year neurodevelopmental outcomes in very-low-birth-weight (VLBW) infants. METHODS: This is a cohort observational study comprising 595 VLBW infants during 2007 to 2015. Neurodevelopmental assessment was carried out at 24 months corrected age. RESULTS: In univariate analysis the rates of survival with normal neurodevelopmental outcomes were lower in pregnancies with severe histologic chorioamnionitis (38 of 43, 88...
April 16, 2021: Pediatric Neurology
https://read.qxmd.com/read/33970907/associations-of-treated-and-untreated-human-papillomavirus-infection-with-preterm-delivery-and-neonatal-mortality-a-swedish-population-based-study
#28
JOURNAL ARTICLE
Johanna Wiik, Staffan Nilsson, Cecilia Kärrberg, Björn Strander, Bo Jacobsson, Verena Sengpiel
BACKGROUND: Treatment of cervical intraepithelial neoplasia (CIN) is associated with an increased risk of preterm delivery (PTD) although the exact pathomechanism is not yet understood. Women with untreated CIN also seem to have an increased risk of PTD. It is unclear whether this is attributable to human papillomavirus (HPV) infection or other factors. We aimed to investigate whether HPV infection shortly before or during pregnancy, as well as previous treatment for CIN, is associated with an increased risk of PTD and other adverse obstetric and neonatal outcomes...
May 2021: PLoS Medicine
https://read.qxmd.com/read/33914739/adverse-pregnancy-outcomes-are-associated-with-plasmodium-vivax-malaria-in-a-prospective-cohort-of-women-from-the-brazilian-amazon
#29
MULTICENTER STUDY
Jamille Gregório Dombrowski, André Barateiro, Erika Paula Machado Peixoto, André Boler Cláudio da Silva Barros, Rodrigo Medeiros de Souza, Taane Gregory Clark, Susana Campino, Carsten Wrenger, Gerhard Wunderlich, Giuseppe Palmisano, Sabrina Epiphanio, Lígia Antunes Gonçalves, Claudio Romero Farias Marinho
BACKGROUND: Malaria in Brazil represents one of the highest percentages of Latin America cases, where approximately 84% of infections are attributed to Plasmodium (P.) vivax. Despite the high incidence, many aspects of gestational malaria resulting from P. vivax infections remain poorly studied. As such, we aimed to evaluate the consequences of P. vivax infections during gestation on the health of mothers and their neonates in an endemic area of the Amazon. METHODS AND FINDINGS: We have conducted an observational cohort study in Brazilian Amazon between January 2013 and April 2015...
April 2021: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/33847083/neonatal-outcomes-according-to-the-latent-period-from-membrane-rupture-to-delivery-among-extremely-preterm-infants-exposed-to-preterm-premature-rupture-of-membrane-a-nationwide-cohort-study
#30
JOURNAL ARTICLE
Jae Hyun Park, Jin Gon Bae, Yun Sil Chang
BACKGROUND: In accordance with the guidelines for the expectant management of women exposed to previable preterm premature rupture of membrane, we compared neonatal outcomes according to the latent period from membrane rupture to delivery among extremely preterm infants exposed to maternal preterm premature rupture of membrane using the Korean Neonatal Network database. METHODS: Of the 3,305 extremely preterm infants born at 23-27 weeks' gestation between 2014 and 2017 who were registered in the Korean Neonatal Network, 1,464 infants were born to pregnant women who were exposed to preterm premature rupture of membrane...
April 12, 2021: Journal of Korean Medical Science
https://read.qxmd.com/read/33784970/labor-dystocia-and-risk-of-histological-chorioamnionitis-and-funisitis-a-study-from-a-single-tertiary-referral-center
#31
JOURNAL ARTICLE
Hyo Kyozuka, Tuyoshi Murata, Toma Fukuda, Erina Suzuki, Riho Yazawa, Shun Yasuda, Aya Kanno, Akiko Yamaguchi, Yuko Hashimoto, Keiya Fujimori
BACKGROUND: Intrauterine inflammation affects short- and long-term neonatal outcomes. Histological chorioamnionitis and funisitis are acute inflammatory responses in the fetal membranes and umbilical cord, respectively. Although labor dystocia includes a potential risk of intrauterine inflammation, the risk of histological chorioamnionitis and funisitis of labor dystocia has not been evaluated yet. This study aimed to examine the association between labor dystocia and risk of histological chorioamnionitis and funisitis...
March 30, 2021: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/33462302/mortality-and-neurological-outcomes-in-extremely-and-very-preterm-infants-born-to-mothers-with-hypertensive-disorders-of-pregnancy
#32
JOURNAL ARTICLE
Noriyuki Nakamura, Takafumi Ushida, Masahiro Nakatochi, Yumiko Kobayashi, Yoshinori Moriyama, Kenji Imai, Tomoko Nakano-Kobayashi, Masahiro Hayakawa, Hiroaki Kajiyama, Fumitaka Kikkawa, Tomomi Kotani
To evaluate the impact of maternal hypertensive disorders of pregnancy (HDP) on mortality and neurological outcomes in extremely and very preterm infants using a nationwide neonatal database in Japan. This population-based retrospective study was based on an analysis of data collected by the Neonatal Research Network of Japan from 2003 to 2015 of neonates weighing 1,500 g or less at birth, between 22 and 31 weeks' gestation. A total of 21,659 infants were randomly divided into two groups, HDP (n = 4,584) and non-HDP (n = 4,584), at a ratio of 1:1 after stratification by four factors including maternal age, parity, weeks of gestation, and year of delivery...
January 18, 2021: Scientific Reports
https://read.qxmd.com/read/33264704/factors-associated-with-poor-fetal-outcome-in-placental-abruption
#33
JOURNAL ARTICLE
Claire de Moreuil, Jacob Hannigsberg, Juliette Chauvet, Annabelle Remoue, Christophe Tremouilhac, Philippe Merviel, Charles Bellot, Brigitte Pan Petesch, Emmanuelle Le Moigne, Karine Lacut, Pascale Marcorelles
OBJECTIVES: We aimed at describing placental abruption in our county and at evaluating factors associated with poor fetal outcome. STUDY DESIGN: In this case-control study, women with placental abruption were identified from two databases of Brest University Hospital between January 2013 and December 2018. MAIN OUTCOME MEASURES: Placental histological findings, course of pregnancies, maternal and fetal characteristics were described and compared between cases (placental abruption with stillbirth or neonatal death) and controls...
November 25, 2020: Pregnancy Hypertension
https://read.qxmd.com/read/33253176/gross-appearance-of-the-fetal-membrane-on-the-placental-surface-is-associated-with-histological-chorioamnionitis-and-neonatal-respiratory-disorders
#34
JOURNAL ARTICLE
Yoshimasa Horikoshi, Chizuko Yaguchi, Naomi Furuta-Isomura, Toshiya Itoh, Kenta Kawai, Tomoaki Oda, Masako Matsumoto, Yukiko Kohmura-Kobayashi, Naoaki Tamura, Toshiyuki Uchida, Naohiro Kanayama, Hiroaki Itoh
An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to provide scientific insights into the traditional concept of an opaque fetal membrane based on gross appearance being an indicator of histological chorioamnionitis. We examined the placental pathology after screening of the placental gross appearance and perinatal complications and did not examine uncomplicated deliveries...
2020: PloS One
https://read.qxmd.com/read/33214331/randomized-controlled-trial-of-high-flow-nasal-cannula-in-preterm-infants-after-extubation
#35
RANDOMIZED CONTROLLED TRIAL
Atsushi Uchiyama, Kaoru Okazaki, Masatoshi Kondo, Shuntaro Oka, Yukiko Motojima, Fumihiko Namba, Nobuhiko Nagano, Kayo Yoshikawa, Kazunori Kayama, Akira Kobayashi, Yoshiki Soeno, Osamu Numata, Hideyo Suenaga, Ken Imai, Hidehiko Maruyama, Hideshi Fujinaga, Hiroyuki Furuya, Yushi Ito
OBJECTIVES: Our aim is to compare the efficacy and safety of high-flow nasal cannula (HFNC) against those of nasal continuous positive airway pressure (NCPAP) or nasal intermittent positive-pressure ventilation (NIPPV) after extubation in preterm infants. METHODS: This prospective, randomized, noninferiority trial was conducted in 6 tertiary NICUs. Infants born at <34 weeks who needed noninvasive ventilation after extubation were enrolled. We randomly assigned infants to an HFNC group when HFNC was used or to an NCPAP/NIPPV group when NCPAP or NIPPV was used...
December 2020: Pediatrics
https://read.qxmd.com/read/33158859/the-endothelial-protein-c-receptor-plays-an-essential-role-in-the-maintenance-of-pregnancy
#36
JOURNAL ARTICLE
Michelle M Castillo, Qiuhui Yang, Abril Solis Sigala, Dosia T McKinney, Min Zhan, Kristen L Chen, Jason A Jarzembowski, Rashmi Sood
Placenta-mediated pregnancy complications are a major challenge in the management of maternal-fetal health. Maternal thrombophilia is a suspected risk factor, but the role of thrombotic processes in these complications has remained unclear. Endothelial protein C receptor (EPCR) is an anticoagulant protein highly expressed in the placenta. EPCR autoantibodies and gene variants are associated with poor pregnancy outcomes. In mice, fetal EPCR deficiency results in placental failure and in utero death. We show that inhibition of molecules involved in thrombin generation or in the activation of maternal platelets allows placental development and embryonic survival...
November 2020: Science Advances
https://read.qxmd.com/read/32990839/long-term-functional-outcome-of-sacrococcygeal-teratoma-after-resection-in-neonates-and-infants-a-single-center-experience
#37
JOURNAL ARTICLE
Kazunori Masahata, Chihiro Ichikawa, Katsutoshi Makino, Takatoshi Abe, Kiyokazu Kim, Taku Yamamichi, Ai Tayama, Hideki Soh, Noriaki Usui
PURPOSE: This study aimed to evaluate the incidence and factors associated with long-term functional outcomes of sacrococcygeal teratoma (SCT) after resection in neonates and infants. METHODS: Twenty-nine patients with a minimum of 3 years of follow-up who underwent resection and were histologically diagnosed with SCTs between 1982 and 2017 at our institution were included. RESULTS: The median age at the time of the study was 10.0 years...
November 2020: Pediatric Surgery International
https://read.qxmd.com/read/32903026/intratracheal-budesonide-surfactant-attenuates-hyperoxia-induced-lung-injury-in-preterm-rabbits
#38
JOURNAL ARTICLE
Andre G Gie, Yannick Regin, Thomas Salaets, Costanza Casiraghi, Fabrizio Salomone, Jan Deprest, Jeroen Vanoirbeek, Jaan Toelen
Recent clinical trials have shown improvements in neonatal outcomes after intratracheal administration of a combination of budesonide/surfactant (ITBS) in infants at risk of bronchopulmonary dysplasia. However, the effect of ITBS on lung function and alveolar structure is not known. We aimed to determine the effect of ITBS on lung function, parenchymal structure, and inflammatory cytokine expression in a relevant preterm animal model for bronchopulmonary dysplasia. Premature neonatal rabbits were administered a single dose of ITBS on the day of delivery and exposed to 95% oxygen...
December 1, 2020: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/32898888/early-and-late-respiratory-outcome-in-very-low-birth-weight-with-or-without-intrauterine-inflammation
#39
JOURNAL ARTICLE
Simona Perniciaro, Jvan Casarin, Luana Nosetti, Chiara Binda, Silvia Salvatore, Fabio Ghezzi, Massimo Agosti
• IUI is a risk factor for spontaneous preterm birth and contributes to prematurity-associated mortality and morbidity.• HCA greatly affected Apgar's score and lung management of VLBWI at birth and later on with increased incidence of BPD.• HCA + FUN did not significantly impact on respiratory outcome. OBJECTIVE:  Intrauterine inflammation or infection (IUI) is a risk factor for spontaneous preterm birth and contributes to prematurity-associated mortality and morbidity. IUI can include inflammation, as well as infections of varying degrees of severity and duration...
September 2020: American Journal of Perinatology
https://read.qxmd.com/read/32861447/predicting-native-liver-injury-and-survival-in-biliary-atresia
#40
JOURNAL ARTICLE
Maria Hukkinen, Marjut Pihlajoki, Mikko P Pakarinen
Several patient and treatment related factors significantly modify outcomes of biliary atresia. The extremely variable prognosis mandates intensive postoperative monitoring following portoenterostomy. Accurate prediction of outcome and progression of liver injury would enable individualized treatment and follow-up protocols, patient counseling and meaningful stratification of patients into clinical trials. While results on most biomarkers of cholestasis, hepatocyte function, fibrosis and inflammation studied so far are inconsistent or have not been validated in independent patient cohorts, postoperative serum bilirubin level 3 months after portoenterostomy remains the most accurate clinically feasible predictor of native liver survival...
August 2020: Seminars in Pediatric Surgery
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