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Factors And Neonatal Outcomes Associated With Histologic

N Johal, C Arthurs, P Cuckow, K Cao, D N Wood, A Ahmed, C H Fry
INTRODUCTION: Bladder exstrophy is a congenital anomaly involving foetal exposure and protrusion of the open bladder through an incomplete lower abdominal wall. Techniques to surgically correct exstrophy after birth have greatly improved, but it still presents a major challenge to achieve continence and a good quality of life for patients and their families as the pathophysiology of bladder dysfunction is unknown. OBJECTIVES: A multimodal approach was used to characterise the histological and biomechanical properties of exstrophy detrusor...
December 27, 2018: Journal of Pediatric Urology
Carlo Pietrasanta, Lorenza Pugni, Daniela Merlo, Barbara Acaia, Dario Consonni, Andrea Ronchi, Manuela Wally Ossola, Beatrice Ghirardi, Ilaria Bottino, Fulvia Milena Cribiù, Silvano Bosari, Fabio Mosca
OBJECTIVE: To investigate the impact of different stages of intrauterine inflammation (IUI) on neonatal outcomes, before and after adjusting for gestational age (GA) and other perinatal confounders. METHODS: This was an observational, prospective, single-center cohort study including all eligible neonates with GA < 35 weeks and/or birth weight ≤ 1500 g born at a 3rd level Neonatal Intensive Care Unit between 2011 and 2014. Pathological patterns of placenta, membranes and cord were classified according to Redline's criteria...
2019: PloS One
Hadas Ganer Herman, Letizia Schreiber, Hadas Miremberg, Masha Ben Zvi, Jacob Bar, Michal Kovo
OBJECTIVE: To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset. STUDY DESIGN: During 2013-6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries. RESULTS: A total of 260 placentas were obtained, 65 from each group. Rates of HCA for the spontaneous labor, PROM, induction and CD groups were: 49, 32, 24 and 4%, respectively (p < 0...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
Charis Bourgioti, Konstantina Zafeiropoulou, Stavros Fotopoulos, Maria Evangelia Nikolaidou, Marianna Theodora, George Daskalakis, Chara Tzavara, Konstantinos Chatoupis, Evangelia Panourgias, Aristeidis Antoniou, Anastasia Konstantinidou, Lia Angela Moulopoulos
BACKGROUND: Placenta accreta spectrum (PAS) disorders may be associated with significant mortality and morbidity for both mother and fetus. PURPOSE/HYPOTHESIS: To identify MRI risk factors for poor peripartum outcome in gravid patients at risk for PAS. STUDY TYPE: Prospective. POPULATION: One hundred gravid women (mean age: 34.9 years) at third trimester, with placenta previa. FIELD STRENGTH/SEQUENCE: T2 -SSTSE (single-shot turbo spin echo), T2 -TSE, T1 -TSEFS (TSE images with fat-suppression) at 1...
December 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jiyoung Chun, Sang Hoon Chun, Yea Seul Han, Tae-Jung Sung
BACKGROUND: Ureaplasma spp. is a known risk factor for bronchopulmonary dysplasia (BPD). However, little is known about the effect of different degrees of maternal Ureaplasma colonization and their adverse outcomes. Hence, the aim of this study was to determine the effects of different degrees of maternal Ureaplasma colonization on BPD. METHODS: A retrospective cohort study of preterm infants delivered at <32 weeks' gestational age (GA) was performed. The infants were divided according to maternal Ureaplasma status as follows: high-colonization (≥104  CCU/ml, UUH), low-colonization (<104  CCU/ml, UUL), and noncolonization (controls)...
November 27, 2018: Pediatrics and Neonatology
Sara Pinto, Maria Filipa Malheiro, Ana Vaz, Teresa Rodrigues, Nuno Montenegro, Hercília Guimarães
PURPOSE: To evaluate neonatal outcomes in preterm infants with less than 34 weeks after spontaneous labor, preterm premature rupture of membranes (PPROM) or iatrogenic delivery and to clarify whether the mechanism of labor onset is a risk factor for adverse short-term neonatal outcome. METHODS: We performed a retrospective case-control study, which included 266 preterm newborns with less than 34-week gestation, between 2011 and 2015. Neonatal outcomes were compared according to the mechanism of labor onset...
June 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
Daniel Bierstone, Nienke Wagenaar, Dawn L Gano, Ting Guo, Gregory Georgio, Floris Groenendaal, Linda S de Vries, Jojy Varghese, Hannah C Glass, Catherine Chung, Jefferson Terry, Maarten Rijpert, Ruth E Grunau, Anne Synnes, A James Barkovich, Donna M Ferriero, Manon Benders, Vann Chau, Steven P Miller
Importance: Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. Objective: To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood...
June 1, 2018: JAMA Pediatrics
Michelle E Schober, Daniela F Requena, Christopher K Rodesch
In adult rats, erythropoietin improved outcomes early and late after traumatic brain injury, associated with increased levels of Brain Derived Neurotrophic Factor. Using our model of pediatric traumatic brain injury, controlled cortical impact in 17-day old rats, we previously showed that erythropoietin increased hippocampal neuronal fraction in the first two days after injury. Erythropoietin also decreased activation of caspase3, an apoptotic enzyme modulated by Brain Derived Neurotrophic Factor, and improved Novel Object Recognition testing 14 days after injury...
May 2018: Brain & Development
Vasantha H S Kumar, Huamei Wang, Sergei Kishkurno, Babu S Paturi, Lori Nielsen, Rita M Ryan
The outcomes of premature infants have improved greatly; however, the health risks in adulthood are still relatively unclear. Bronchopulmonary dysplasia (BPD) in premature infants is a major risk factor for alteration in lung function and predisposition to respiratory morbidity, and is associated with hyperoxia. The study explores the effect of neonatal hyperoxia on organ systems in adult mice. Newborn mouse litters were randomized to 85%O2 or room air (RA) on P3 for 12 days; mice were sacrificed at P3, P7, P15, 3 months and 9 months...
April 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
T J Bradnock, M Knight, S Kenny, M Nair, G M Walker
OBJECTIVES: To describe clinical characteristics and preoperative management of a national cohort of infants with Hirschsprung's disease (HD). DESIGN: Population-based cohort study of all live-born infants with HD born in the UK and Ireland from October 2010 to September 2012. SETTING: All 28 paediatric surgical centres in the UK and Ireland. PARTICIPANTS: 305 infants presenting before 6 months of age with histologically proven HD...
August 2017: Archives of Disease in Childhood
Akiko Ito, Yoshiaki Maseki, Sayako Ikeda, Atsuko Tezuka, Momoko Kuribayashi, Madoka Furuhashi
OBJECTIVE: To elucidate the factors that contribute to prolonged pregnancy and promote neonate survival in women with bulging fetal membranes. METHODS: A database was reviewed to identify women with singleton pregnancies who underwent amniocentesis on admission to determine amniotic fluid neutrophil elastase levels before 26 + 0 weeks gestation between July 2001 and January 2015. Following delivery, the placentas of these patients were examined for histologic chorioamnionitis...
September 2017: Journal of Maternal-fetal & Neonatal Medicine
Ju-Young Lee, Kyo-Hoon Park, Ahra Kim, Hye-Ran Yang, Eun-Young Jung, Soo-Hyun Cho
BACKGROUND: Despite the clinical relevance of necrotizing enterocolitis (NEC), it remains difficult to predict which preterm infants are more likely to develop NEC. Contrary to the neonatal risk factors for the development of NEC, little information is available regarding maternal (prenatal) risk factors. We aimed to identify maternal risk factors associated with the subsequent development of NEC in very preterm infants and to determine whether the placental inflammatory lesions were related to the NEC...
February 2017: Pediatrics and Neonatology
Toshio Nakayama, Akihiko Kikuchi, Takashi Okuno, Reona Matsumoto, Kaori Ishikawa, Atsushi Komatsu, Kimiyo Takagi, Yoshifumi Ogiso
Amniotic fluid 'sludge' (AFS) is defined as the presence of dense aggregates of hyperechogenic material in close proximity to the internal cervical os. The presence of AFS is an independent risk factor for impending preterm delivery, histological chorioamnionitis, and microbial invasion of the amniotic cavity in patients with spontaneous preterm labor with intact membranes, and preterm prelabor rupture of membranes. We describe a case showing enlarging AFS on transvaginal ultrasound in a patient with impending preterm labor, followed by chorioamnionitis and emergency cesarean section at 28 weeks of gestation, resulting in a severe course of sepsis and recurrent tension pneumothorax in the infant...
July 2012: Journal of Medical Ultrasonics
Stefania Triunfo, Francesca Crovetto, Fatima Crispi, Victor Rodriguez-Sureda, Carmen Dominguez, Alfons Nadal, Anna Peguero, Eduard Gratacos, Francesc Figueras
OBJECTIVE: To explore in women with late-onset preeclampsia (PE) the association between maternal levels of angiogenic/antiangiogenic factors in the first trimester of pregnancy and histological findings attributable to placental underperfusion (PUP). METHODS: A nested case-control cohort study was conducted in 73 women with pregnancies complicated by late-onset PE (>34 weeks at delivery) matched with controls. First trimester uterine artery Doppler (UtA); maternal levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were retrieved...
June 2016: Placenta
Tate Gisslen, Manuel Alvarez, Casey Wells, Man-Ting Soo, Donna S Lambers, Christine L Knox, Jareen K Meinzen-Derr, Claire A Chougnet, Alan H Jobe, Suhas G Kallapur
OBJECTIVE: To determine whether exposure to acute chorioamnionitis and fetal inflammation caused short-term adverse outcomes. DESIGN: This is a prospective observational study: subjects were mothers delivering at 32-36 weeks gestation and their preterm infants at a large urban tertiary level III perinatal unit (N=477 infants). Placentae and fetal membranes were scored for acute histological chorioamnionitis based on the Redline criteria. Fetal inflammation was characterised by histological diagnosis of funisitis (umbilical cord inflammation), increased cord blood cytokines measured by ELISA, and activation of the inflammatory cells infiltrating the placenta and fetal membranes measured by immunohistology...
March 23, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
Mirjam Kunze, Maximilian Klar, Christine A Morfeld, Beena Thorns, Ralf L Schild, Filiz Markfeld-Erol, Regina Rasenack, Heinrich Proempeler, Roland Hentschel, Wolfgang R Schaefer
BACKGROUND: In patients with preterm premature rupture of membranes, intrauterine inflammation and/or infection is frequently present, can lead to fetal inflammatory response syndrome, and is associated with adverse neonatal outcome. Clinical decision making requires balancing the potential benefits of pregnancy prolongation against the risk of intrauterine infection. Diagnostic tests in maternal serum are of moderate prediction value and amniocentesis is an invasive procedure. Therefore, markers obtained noninvasively would be helpful in patients with expectant management...
July 2016: American Journal of Obstetrics and Gynecology
Swathi Eluri, Thomas M Runge, Cary C Cotton, Caitlin M Burk, W Asher Wolf, John T Woosley, Nicholas J Shaheen, Evan S Dellon
BACKGROUND AND AIMS: Some patients with eosinophilic esophagitis (EoE) have an extremely narrow esophagus, but the characteristics of this group have not been extensively described. We aimed to characterize the narrow-caliber phenotype of EoE, determine associated risk factors, and identify differences in treatment response in this subgroup of patients. METHODS: This retrospective cohort study from 2001 to 2014 included subjects with a new diagnosis of EoE per consensus guidelines...
June 2016: Gastrointestinal Endoscopy
Hosung Kim, Dawn Gano, Mai-Lan Ho, Xiaoyue M Guo, Alisa Unzueta, Christopher Hess, Donna M Ferriero, Duan Xu, A James Barkovich
Premature birth globally affects about 11.1% of all newborns and is a risk factor for neurodevelopmental disability in surviving infants. Histology has suggested that hindbrain subdivisions grow differentially, especially in the third trimester. Prematurity-related brain injuries occurring in this period may selectively affect more rapidly developing areas of hindbrain, thus accompanying region-specific impairments in growth and ultimately neurodevelopmental deficits. The current study aimed to quantify regional growth of the cerebellum and the brainstem in preterm neonates (n = 65 with individually multiple scans)...
February 2016: Human Brain Mapping
Joo-Yeon Kim, Yeon Mee Kim
Acute atherosis is unique vascular changes of the placenta associated with poor placentation. It is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis of the arterial wall, perivascular lymphocytic infiltration, and it is histologically similar to early-stage atherosclerosis. Acute atherosis is rare in normal pregnancies, but is frequently observed in non- transformed spiral arteries in abnormal pregnancies, such as preeclampsia, small for gestational age (SGA), fetal death, spontaneous preterm labor and preterm premature rupture of membranes...
November 2015: Journal of Pathology and Translational Medicine
Katherine M Eichinger, Loreto Egaña, Jacob G Orend, Erin Resetar, Kacey B Anderson, Ravi Patel, Kerry M Empey
BACKGROUND: Poor interferon gamma (IFNγ) production during respiratory syncytial virus (RSV) is associated with prolonged viral clearance and increased disease severity in neonatal mice and humans. We previously showed that intra-nasal delivery of IFNγ significantly enhances RSV clearance from neonatal lungs prior to observed T-lymphocyte recruitment or activation, suggesting an innate immune mechanism of viral clearance. We further showed that alveolar macrophages dominate the RSV-infected neonatal airways relative to adults, consistent with human neonatal autopsy data...
October 5, 2015: Respiratory Research
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