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occult malignancy

Erika D Sears, Yu-Ting Lu, Ting-Ting Chung, Adeyiza O Momoh, Kevin C Chung
BACKGROUND: This study aimed to measure the use of pathology evaluation of breast specimens among patients undergoing reduction mammaplasty and assess rates of new diagnoses of breast disease and associated cost. METHODS: We analyzed the Truven MarketScan Databases from 2009 to 2015 to identify adult female patients undergoing reduction mammaplasty for macromastia. We recorded patient age, rates of obtaining pathology evaluation, new diagnoses of benign or malignant breast disease after pathology evaluation, and total cost for the surgery encounter...
February 4, 2019: World Journal of Surgery
Keiichiro Uehara, Fumi Kawakami, Takanori Hirose, Hiroki Morita, Eiji Kudo, Masanori Yasuda, Bruno Märkl, Yoh Zen, Tomoo Itoh, Yukihiro Imai
The clinicopathological and immunohistochemical characteristics of clinically occult extrapulmonary lymphangioleiomyomatosis in lymph nodes (LN-LAM) being dissected during surgical staging of pelvic malignancy have not been well investigated. We assessed samples from nine female patients (median age, 61). None had past or familial history of tuberous sclerosis and had LAM lesions other than LN such as lung. The primary malignancies included four endometrial endometrioid carcinomas, one endometrial carcinosarcoma, three ovarian serous carcinomas and one urothelial carcinoma...
January 2019: Pathology International
Quan D Nguyen, James W Randall, Taylor S Harmon, Angelica S Robinson, Claudia Cotes, Anne E Lee, Brian H Mahon, Sarfaraz Sadruddin
Screening mammography has helped to identify countless incidences of breast cancer since its adoption in the 1960s. Over time, the screening guidelines and techniques have been refined to better detect malignancies and to avoid false positive results. However, weaknesses remain in mammography and represent an opportunity for improvement. The interference of natural breast tissue and glands can obscure the presence of occult breast malignancies. Additionally, the inability to differentiate breast tissue on the basis of depth, and the compounding of breast densities that occurs as a consequence of two-dimensional imaging, are setbacks when it comes to relying on mammography...
November 14, 2018: Curēus
Samira Jeimy, Pari Basharat, Fiona Lovegrove
Background: Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized. Delayed anaphylactoid and serum sickness-like reactions have also been described; however, their relationship to the drug remains uncertain, and the frequency is unknown. Case presentation: We present a case of a 59-year old female who developed amyopathic dermatomyositis (DM) after receiving omalizumab infusions for steroid-refractory severe asthma...
2019: Allergy, Asthma, and Clinical Immunology
Nobuhiro Hanai, Takahiro Asakage, Naomi Kiyota, Akihiro Homma, Ryuichi Hayashi
The standard local treatment for early-stage tongue cancer with no clinical lymph node metastases is partial glossectomy. The frequency of occult lymph node metastasis is ~20-30%. Thus, whether prophylactic neck dissection with glossectomy or glossectomy alone should be performed has been a controversial issue since the 1980s. Both treatments have advantages and disadvantages; however, especially in cases involving prophylactic neck dissection, surgical invasion and complications including the cosmetic disadvantage caused by neck skin incision, accessory nerve paralysis or facial nerve (mandibular marginal branch) paralysis, stiffness of the shoulder or neck and a feeling of neck tightness have been considered issues that could be solved by providing less-invasive treatment to the 70-80% of patients without occult lymph node metastasis...
January 22, 2019: Japanese Journal of Clinical Oncology
Shen-Ju Gou, Lu-Jia Xue, Zhang-Xue Hu
BACKGROUND: Understanding the uncommon association of IgG4-related disease with other disorders is essential for the accurate diagnosis and effective treatment of patients. To the best of our knowledge, there have been only few reports of patients with IgG4-related kidney disease coexisting with metastasis of malignancy. Here, we report a rare case of simultaneous occurring IgG4-related tubulointerstitial nephritis and colon adenocarcinoma with hepatic metastasis. CASE PRESENTATION: A 71-year-old Chinese man presented with dysuria and was initially diagnosed as benign prostatic hyperplasia for one year...
January 16, 2019: BMC Nephrology
Johan F Arendt, Henrik Toft Sorensen, Laura J Horsfall, Irene Petersen
BACKGROUND: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. However, the implications for early cancer detection in primary care have not been assessed. METHODS: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, United Kingdom. Persons with low B12 levels were excluded together with persons with cancer or B12 treatment before date of B12 measurement. Incident cancer was the outcome of interest and was identified through Read codes...
January 14, 2019: Cancer Epidemiology, Biomarkers & Prevention
Rajesh Devassy, Cristina Cezar, Harald Krentel, Hugo Christian Verhoeven, Rohan Devassy, Maya Sophie de Wilde, Luz Angela Torres-de la Roche, Rudy Leon de Wilde
PURPOSE: To evaluate the feasibility of using contained endobags (Morsafe®) in the retrieval of the specimen during laparoscopic surgeries in presumably benign myomatous pathology. MATERIAL AND METHODS: We conducted a retrospective single center case - control study on 239 patients, between 01.05.2014 and 31.12.2017 for uterine myomata, presumed to be benign. The analyzed parameters were the method for contained specimen retrieval, the time of bag manipulation, practicability of action and the perioperative complications rate...
January 9, 2019: International Journal of Surgery
Radgonde Amer, Nadav Levinger
PURPOSE: Posterior scleritis is the least frequent form of scleritis accounting for around 2%-8% of all scleritis cases. We aim to present the 6-year clinical course of a 62-year-old female patient with bilateral progressive necrotizing posterior scleritis who suffered from concurrent active psoriasis and psoriatic arthritis. METHODS: Descriptive case report. RESULTS: A middle-aged female patient was referred to our clinic because of left eye peripheral progressively enlarging white retinochoroidal lesions...
January 14, 2019: European Journal of Ophthalmology
Aditi Sharma, Jin-Wook Kim, Jun-Young Paeng
Objectives: The purpose of this study was to evaluate the neck node metastasis pattern and related clinical factors in oral cavity cancer patients. Materials and Methods: In total, 76 patients (47 males, 29 females) with oral squamous cell carcinoma (OSCC) who had no previous malignancies and were not undergoing neoadjuvant concomitant chemoradiotherapy or radiotherapy were selected for analysis. Results: Occult metastases were found in 8 of 52 patients with clinically negative nodes (cN0, 15...
December 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Adesina O Adewale, Ladeji A Mofoluwake, Opaleye T Olamide, Salami A Yussuf
Metastatic tumours of the oral cavity are not common. The most common site for bone metastases in the head and neck region is the mandible. Metastatic lesion of the mandible most commonly originate from the lungs in men and breast in women, and these lesions (or tumours) usually are carcinomas rather than sarcomas. We report two cases of metastatic lesions in the mandible: (1) A 19year old male with right mandibular swelling and a nodular swelling in the distal two-third of the right tibia. Radiograghs revealed sclerotic lesion with a sunburst appearance in both the jaw and tibia...
September 2018: Ghana Medical Journal
Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tüting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hölzel, Laura K Mackay, Jason Waithman, Thomas Gebhardt
The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread of cancer cells that resist eradication1 . Clinical and experimental data suggest that the latter mode of control-termed cancer-immune equilibrium1 -can be maintained for prolonged periods of time, possibly up to several decades2-4 . Although cancers most frequently originate in epithelial layers, the nature and spatiotemporal dynamics of immune responses that maintain cancer-immune equilibrium in these tissue compartments remain unclear...
December 31, 2018: Nature
Marie-Hélène Errera, Anthony G Robson, Tracey Wong, Philip G Hykin, Bishwanath Pal, Mandeep S Sagoo, Carlos E Pavesio, Anthony T Moore, Andrew R Webster, Graham E Holder
PURPOSE: To review the clinical characteristics and address the aetiology in a group of patients presenting with unilateral retinal pigmentary changes, best described as unilateral pigmentary retinopathy (UPR). METHODS: The cohort of 42 patients was identified retrospectively from the Moorfields Eye Hospital electrophysiology database. All had undergone full-field [electroretinography (ERG)] and pattern electroretinography (PERG), with 13 additionally having multifocal ERG (mfERG)...
December 31, 2018: Acta Ophthalmologica
Guy Lifshitz, Maayan Gruber, Ohad Ronen
OBJECTIVE: To evaluate the incidence of tonsil and adenoid malignancy in pediatric patients in Israel compared to the known literature and to revisit the common practice of routine histopathologic examination of tonsils and adenoids. METHODS: Analysis of the Israel National Cancer Registry data on pediatric tonsil and adenoid malignancies between the years 2005 and 2015, and a systematic literature review of all relevant articles that reported on malignancies amongst pediatric patients who underwent tonsillectomy with or without adenoidectomy...
February 2019: International Journal of Pediatric Otorhinolaryngology
Pasquale Di Maio, Oreste Iocca, Armando De Virgilio, Fabio Ferreli, Giovanni Cristalli, Raul Pellini, Pawel Golusinski, Giampietro Ricci, Giuseppe Spriano
BACKGROUND: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin. METHODS: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy. RESULTS: Fourteen studies were included, comprising 673 patients who underwent 416 palatine tonsillectomies, 338 preformed during examination under anesthesia (EUA) and 78 managed with transoral robotic surgery (TORS)...
December 21, 2018: Head & Neck
Deandrea Ellis, Srikant Rangaraju, Alexander Duncan, Michael Hoskins, Syed Ali Raza, Haseeb Rahman, Melanie Winningham, Samir Belagaje, Nicolas Bianchi, Ghada A Mohamed, Mahmoud Obideen, Vera Sharashidze, Trina Belair, Laura Henriquez, Fadi Nahab
We evaluated the utility of left atrial volume index (LAVI) and markers of coagulation and hemostatic activation (MOCHA) in cryptogenic stroke (CS) patients to identify those more likely to have subsequent diagnosis of atrial fibrillation (AF), malignancy or recurrent stroke during follow-up.Consecutive CS patients who met embolic stroke of undetermined source (ESUS) who underwent transthoracic echocardiography and outpatient cardiac monitoring following stroke were identified from the Emory cardiac registry...
December 2018: Medicine (Baltimore)
Kamilla Bredlund Caspersen, Nikoletta Giannoutsou, Oke Gerke, Abass Alavi, Poul Flemming Høilund-Carlsen, Søren Hess
PURPOSE: Suspected serious disease (SSD) is a disease designation often given to patients with one or more non-specific symptoms of severe disease that could be due to cancer; the optimal diagnostic strategy is largely left to the clinician's discretion. Being a sensitive non-invasive whole-body imaging modality 18 F-FDG-PET/CT may have a potential role in this cancer-prevalent group of patients to confirm or refute suspected malignancy. We aimed to investigate the diagnostic value of 18 F-FDG-PET/CT in SSD using long-term follow-up as reference...
December 19, 2018: Annals of Nuclear Medicine
Apostolos Koffas, Faidon-Marios Laskaratos, Owen Epstein
Small bowel capsule endoscopy is a minimally-invasive endoscopic investigation that is often used in clinical practice to investigate overt or occult gastrointestinal (GI) bleeding among other clinical indications. International guidance recommends small bowel capsule endoscopy as a first-line investigation to detect abnormalities in the small bowel, when gastroscopy and colonoscopy fail to identify a cause of GI bleeding. It can diagnose with accuracy abnormalities in the small bowel. However, there has been increasing evidence indicating that small bowel capsule endoscopy may also detect lesions outside the small intestine that are within the reach of conventional endoscopy and have been probably missed during prior endoscopic investigations...
December 6, 2018: World Journal of Clinical Cases
Li-Jun Wang, Ping Wu, Xiao-Xiao Li, Ran Luo, Deng-Bin Wang, Wen-Bin Guan
BACKGROUND: Benign breast papilloma is currently managed with conservative management with close observation. In contrast, papilloma with high-risk or malignant lesions warrants surgical excision. The purpose of our study was to investigate magnetic resonance imaging (MRI) features of breast papilloma and to identify imaging diagnostic indicators for papilloma with high-risk or malignant lesions. METHODS: MRI features of 175 surgically confirmed papillomas on 158 patients were retrospectively reviewed...
December 17, 2018: World Journal of Surgical Oncology
Anna M Rose, Rong Luo, Utsav K Radia, Helen Kalirai, Sophie Thornton, Philip J Luthert, Channa N Jayasena, David H Verity, Sarah E Coupland, Geoffrey E Rose
BACKGROUND: Ocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest primary site), conjunctiva or the orbit. Primary orbital melanoma (POM) is exceedingly rare, with approximately 60 cases reported to date. Despite recent advances in our understanding of the genetics of primary uveal and conjunctival melanomas, this information is lacking for POM. METHODS: DNA was extracted from 12 POM tissues, with matched germline DNA (where available)...
December 17, 2018: BMC Cancer
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