Samuel Speaks, Matthew I McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E Roettger, Adam D Kenney, Hannah Bone, Lizhi Zhang, Parker J Denz, Adrian C Eddy, Amal O Amer, Richard T Robinson, Chuanxi Cai, Jianjie Ma, Emily A Hemann, Adriana Forero, Jacob S Yount
Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice (Gsdmd-/- ) significantly attenuates influenza virus-induced weight loss, lung dysfunction, lung histopathology, and mortality compared with wild type (WT) mice, despite similar viral loads. Infected Gsdmd-/- mice exhibit decreased inflammatory gene signatures shown by lung transcriptomics...
March 29, 2024: Nature Communications