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Hydroxyapatite Hyaluronic Acid

Takanori Kumai, Naoko Yui, Kanaka Yatabe, Chizuko Sasaki, Ryoji Fujii, Mitsuko Takenaga, Hiroto Fujiya, Hisateru Niki, Kazuo Yudoh
Purpose: We previously created a self-assembled cartilage-like complex in vitro from only three cartilage components, hyaluronic acid (HA), aggrecan (AG) and type II collagen, without other materials such as cross-linking agents. Based on this self-organized AG/HA/collagen complex, we have created three novel types of biphasic cartilage and bone-like scaffolds combined with hydroxyapatite (HAP) for osteochondral tissue engineering. These scaffolds have been developed from self-assembled cartilage component molecules and HAP at the nanometer scale by manipulating the intermolecular relations...
2019: International Journal of Nanomedicine
Nima Khosravani, Lee Weber, Rina Patel, Anup Patel
Many patients are pursuing simultaneous facial and hand rejuvenation with the latter receiving increased interest in recent years. Various materials have been purported to rejuvenate the hands including fat, calcium hydroxyapatite, and hyaluronic fillers. Despite the seemingly ubiquitous use of fillers, the Food and Drug Administration has approved only a select number for hand rejuvenation. This year, Restylane Lyft (Galderma, Texas) became the first hyaluronic acid filler to garner Food and Drug Administration approval for hand rejuvenation...
January 2019: Plastic and Reconstructive Surgery. Global Open
Shoghik Hakobyan, Nima Roohpour, Julien E Gautrot
Stoichiometric hydroxyapatite is a particularly important type of bioceramic sharing crystallographic similarities to the dominant mineral phases found in hard tissues such as bone and enamel, and routinely applied in the field of bone engineering. Adsorption of polymer coatings, often polyelectrolytes, is typically used to alter hydroxyapatite biointerfaces and alter their bioactivity, for example to promote cell adhesion or prevent biofilm formation. The morphology of the resulting coatings is typically expected to play an important role in determining its bioactivity, yet a full picture of such structures at the surface of hydroxyapatite remains incomplete...
February 20, 2019: Journal of Colloid and Interface Science
Miles H Graivier
No abstract text is available yet for this article.
January 4, 2019: Aesthetic Surgery Journal
Jorge Solana Muñoz, Ulrike Kettenberger, Philip Procter, Dominique P Pioletti
BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks such as induced toxicity and/or impaired bone neo-formation. A new approach to enhance bone screw primary stability without affecting bone formation is the use of non-setting, calcium phosphate loaded soft materials as the augmentation material...
September 23, 2018: Clinical Biomechanics
Jong Seo Kim
Background: Volume restoration using filler in the dorsum of the hand is a simple and effective procedure to improve wrinkles and to hide veins and tendons. Currently, Calcium-Hydroxyapatite (CaHA)-filler is the only FDA-accepted material to use in the hand dorsum. However, it is not easy to inject due to swelling and redness. In addition, hand anatomy through sonography is wrongly described in PRS. Through incorrect anatomy, physicians will make erroneous surgeries. Objectives: CaHA-filler and HA-filler were both injected into the hand to compare intra-individually the effect of each filler...
September 5, 2018: Aesthetic Surgery Journal
Daniel P Ballard, Jason Abramowitz, Daniel C Sukato, Boris Bentsianov, Richard M Rosenfeld
Objective To assist otolaryngologists in counseling patients with hoarseness who would benefit from injection laryngoplasty on whether or not to perform the procedure in the office vs the operating room. Data Sources Cochrane library, CINAHL, PubMed, and EMBASE. Review Methods Systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting standards of English-language articles that compared voice outcomes for in-office and in the operating room injection laryngoplasty...
October 2018: Otolaryngology—Head and Neck Surgery
Annika Wenz, Iva Tjoeng, Isabelle Schneider, Petra J Kluger, Kirsten Borchers
The coculture of osteogenic and angiogenic cells and the resulting paracrine signaling via soluble factors are supposed to be crucial for successfully engineering vascularized bone tissue equivalents. In this study, a coculture system combining primary human adipose-derived stem cells (hASCs) and primary human dermal microvascular endothelial cells (HDMECs) within two types of hydrogels based on methacryloyl-modified gelatin (GM) as three-dimensional scaffolds was examined for its support of tissue specific cell functions...
July 7, 2018: Biotechnology and Bioengineering
B Kaczmarek, A Sionkowska, M Gołyńska, I Polkowska, T Szponder, D Nehrbass, A M Osyczka
Scaffolds based on chitosan, collagen, and hyaluronic acid supplemented with nano-hydroxyapatite were obtained with the use of the freeze-drying method. Composites swelling behavior was assessed by the liquid uptake test. The adhesion and proliferation of human osteosarcoma SaOS-2 cells on the scaffolds were examined in 4-day culture. The biocompatibility of the chosen scaffolds was further studied by in vivo implantation into subcutaneous tissue of rabbits. The results showed low stability of the scaffolds based on chitosan, collagen, and hyaluronic acid supplemented with hydroxyapatite...
October 15, 2018: International Journal of Biological Macromolecules
Isabel Oliveira, Ana L Carvalho, Hajer Radhouani, Cristiana Gonçalves, J Miguel Oliveira, Rui L Reis
The osteochondral defect (OD) comprises the articular cartilage and its subchondral bone. The treatment of these lesions remains as one of the most problematic clinical issues, since these defects include different tissues, requiring distinct healing approaches. Among the growing applications of regenerative medicine, clinical articular cartilage repair has been used for two decades, and it is an effective example of translational medicine; one of the most used cell-based repair strategies includes implantation of autologous cells in degradable scaffolds such as alginate, agarose, collagen, chitosan, chondroitin sulfate, cellulose, silk fibroin, hyaluronic acid, and gelatin, among others...
2018: Advances in Experimental Medicine and Biology
Yi-Ho Hsieh, Bo-Yuan Shen, Yao-Horng Wang, Bojain Lin, Hung-Maan Lee, Ming-Fa Hsieh
Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) and hydroxyapatite at a weight ratio of 2:1 were mixed via fused deposition modeling (FDM) layer by layer to form a solid scaffold. The scaffolds were further infiltrated with glycidyl methacrylate hyaluronic acid loading with 10 ng/mL of Transforming Growth Factor-β1 and photo cross-linked on top of the scaffolds...
April 9, 2018: International Journal of Molecular Sciences
Nicola Zerbinati, Torello Lotti, Damiano Monticelli, Raffaele Rauso, Pablo González-Isaza, Edoardo D'Este, Alberto Calligaro, Sabrina Sommatis, Cristina Maccario, Roberto Mocchi, Jacopo Lotti, Uwe Wollina, Georgi Tchernev, Katlein França
OBJECTIVE: Neauvia Stimulate is biocompatible, injectable hyaluronic acid (HA) filler (26 mg/ml) PEG cross-linked with 1% of calcium hydroxyapatite (CaHA) for facial soft-tissue augmentation that provides volume to tissues, followed by process of neocollagenesis for improving skin quality. AIM: The aim of the present study is to evaluate the biosafety of the product (Lot. 160517-26-1/2 PEG) on human keratinocytes cultured in vitro. MATERIAL AND METHODS: The experimental model proposed, despite being an in vitro system, allows the derivation of useful information to predict the possible activity of the product in further in vivo application...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Jihoon Kim, Ji-Youn Chang, Yoon-Young Kim, Moon-Jong Kim, Hong-Seop Kho
OBJECTIVES: To investigate the effects of the molecular weight of hyaluronic acid on its viscosity and enzymatic activities of lysozyme and peroxidase in solution and on the hydroxyapatite surface. DESIGN: Hyaluronic acids of four different molecular weights (10 kDa, 100 kDa, 1 MDa, and 2 MDa), hen egg-white lysozyme, bovine lactoperoxidase, and human whole saliva were used. Viscosity values of hyaluronic acids were measured using a cone-and-plate viscometer at six different concentrations (0...
May 2018: Archives of Oral Biology
Nurettin Diker, Serap Gulsever, Taner Koroglu, Eda Yilmaz Akcay, Yener Oguz
Hyaluronic acid (HyA) is an outstanding new product in the field of oral and maxillofacial surgery. The aim of this study was to evaluate the effects of HyA on bone regeneration in critical-size calvarial defects. Twenty-four female Sprague-Dawley rats were used in the present study. In each rat, 4 critical-size defects received different treatments: no treatment (control); HyA; Graft; and HyA + Graft combination. New bone formation, defect closure, inflammation, vascular proliferation, immature bone formation, mature bone formation, and bone marrow existence were investigated based on histological findings...
June 2018: Journal of Craniofacial Surgery
Drew Clearfield, Andrew Nguyen, Mei Wei
The zonal organization of osteochondral tissue underlies its long term function. Despite this, tissue engineering strategies targeted for osteochondral repair commonly rely on the use of isotropic biomaterials for tissue reconstruction. There exists a need for a new class of highly biomimetic, anisotropic scaffolds that may allow for the engineering of new tissue with zonal properties. To address this need, we report the facile production of monolithic multidirectional collagen-based scaffolds that recapitulate the zonal structure and composition of osteochondral tissue...
April 2018: Journal of Biomedical Materials Research. Part A
Eun Jin Doh, Jiwon Kim, Dong Hun Lee, Je-Young Park
BACKGROUND: A multimodal approach is essential for neck rejuvenation because many factors contribute to the aging of the neck. OBJECTIVES: We evaluated the effect of combined therapy using microfocused ultrasound with visualization (MFU-V), neuromodulator injection, and filler injection for neck rejuvenation. METHODS: Subjects were sequentially treated with three kinds of interventions in a single session, as follows: (A) MFU-V or calcium hydroxyapatite injection for restoring skin laxity; (B) hyaluronic acid filler injection for horizontal neck lines; and (C) neuromodulator injection for platysmal bands...
June 2018: Journal of Dermatological Treatment
Annika Wenz, Kirsten Borchers, Günter E M Tovar, Petra J Kluger
Though bioprinting is a forward-looking approach in bone tissue engineering, the development of bioinks which are on the one hand processable with the chosen printing technique, and on the other hand possess the relevant mechanical as well as osteoconductive features remains a challenge. In the present study, polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite (HAp) particles (5 wt%) were prepared. Encapsulation of primary human adipose-derived stem cells in the HAp-containing gels and culture for 28 d resulted in a storage moduli significantly increased to 126% ± 9...
November 14, 2017: Biofabrication
Pravin Mundada, Romain Kohler, Sana Boudabbous, Laurence Toutous Trellu, Alexandra Platon, Minerva Becker
Injectable fillers are widely used for facial rejuvenation, correction of disabling volumetric fat loss in HIV-associated facial lipoatrophy, Romberg disease, and post-traumatic facial disfiguring. The purpose of this article is to acquaint the reader with the anatomy of facial fat compartments, as well as with the properties and key imaging features of commonly used facial fillers, filler-related complications, interpretation pitfalls, and dermatologic conditions mimicking filler-related complications. The distribution of facial fillers is characteristic and depends on the anatomy of the superficial fat compartments...
December 2017: Insights Into Imaging
P Bui, A Pons Guiraud, C Lepage
Injectable substances known as fillers are used to palliate age-related atrophy and ptosis, and for their so-called "pseudo-lifting" action. They do not replace face and neck lift, but allow it to be postponed or, when injected after surgical lifting, make the result durable. Hyaluronic acid has a predominant and unchallenged place among fillers, well ahead of poly-L-lactic acid or calcium hydroxyapatite. Approaches and injection methods are the same for all fillers, corresponding to those for autologous fat injection, the reference substance, with a few particularities...
October 2017: Annales de Chirurgie Plastique et Esthétique
D P Walsh, A Heise, F J O'Brien, S-A Cryan
Recent developments within the field of tissue engineering (TE) have shown that biomaterial scaffold systems can be augmented via the incorporation of gene therapeutics. The objective of this study was to assess the potential of the activated polyamidoamine dendrimer (dPAMAM) transfection reagent (SuperfectTM ) as a gene delivery system to mesenchymal stem cells (MSCs) in both monolayer and 3D culture on collagen based scaffolds. dPAMAM-pDNA polyplexes at a mass ratio (M:R) 10:1 (dPAMAM : pDNA) (1 ug pDNA) were capable of facilitating prolonged reporter gene expression in monolayer MSCs which was superior to that facilitated using polyethylenimine (PEI)-pDNA polyplexes (2 ug pDNA)...
November 2017: Gene Therapy
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