Amit Mukerji, Brooke Read, Junmin Yang, Michelle Baczynski, Eugene Ng, Michael Dunn, Guillaume Ethier, Ayman Abou Mehrem, Marc Beltempo, Christine Drolet, Orlando da Silva, Deepak Louis, Brigitte Lemyre, Jehier Afifi, Balpreet Singh, Rebecca Sherlock, Miroslav Stavel, Edith Masse, Jaideep Kanungo, Jonathan Wong, Jaya Bodani, Faiza Khurshid, Kyong-Soon Lee, Sajit Augustine, Caio Barbosa de Oliveira, Hala Makary, Alana Newman, Cecil Ojah, Prakesh S Shah
BACKGROUND AND OBJECTIVES: Nasal intermittent positive pressure ventilation (NIPPV) has been shown to be superior to nasal continuous positive airway pressure (CPAP) postextubation in preterm neonates. However, studies have not permitted high CPAP pressures or rescue with other modes. We hypothesized that if CPAP pressures >8 cmH2O and rescue with other modes were permitted, CPAP would be noninferior to NIPPV. METHODS: We conducted a pragmatic, comparative-effectiveness, noninferiority study utilizing network-based real-world data from 22 Canadian NICUs...
March 21, 2024: Pediatrics