Qingtian Zhu, Lu Hao, Qinhao Shen, Jiajia Pan, Weili Liu, Weijuan Gong, Lianghao Hu, Weiming Xiao, Mei Wang, Xinnong Liu, Yanbing Ding, Guotao Lu
As a calcium-regulated protein, CaMK II is closely related to cell death, and it participates in the development of pathological processes such as reperfusion injury, myocardial infarction, and oligodendrocyte death. The function of CaMK II activation in acute pancreatitis (AP) remains unclear. In our study, we confirmed that the expression of p-CaMK II was increased significantly and consistently in injured pancreatic tissues after caerulein-induced AP. Then, we found that KN93, an inhibitor of CaMK II, could mitigate the histopathological manifestations in pancreatic tissues, reduce serum levels of enzymology, and decrease oxidative stress products...
2021: Oxidative Medicine and Cellular Longevity