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Ellen E Fitzsimmons-Craft, Katherine N Balantekin, Andrea K Graham, Lauren Smolar, Dan Park, Claire Mysko, Burkhardt Funk, C Barr Taylor, Denise E Wilfley
OBJECTIVE: The treatment gap between those who need and those who receive care for eating disorders is wide. Scaling a validated, online screener that makes individuals aware of the significance of their symptoms/behaviors is a crucial first step for increasing access to care. The objective of the current study was to determine the reach of disseminating an online eating disorder screener in partnership with the National Eating Disorders Association (NEDA), as well to examine the probable eating disorder diagnostic and risk breakdown of adult respondents...
February 13, 2019: International Journal of Eating Disorders
Qamar Salamat, Yadollah Yamini, Morteza Moradi, Abolfazl Farahani, Neda Feizi
In the present study, a supramolecular solvent was formed from reverse micelle aggregates of octanol. The proposed supramolecular solvent was used for rapid extraction of some antidepressants drugs including amitriptyline, imipramine, desipramine, maprotiline, sertraline, and doxepin from biological samples. Alkanol-based supramolecular solvent have a unique array of physicochemical properties, making them a very attractive alternative to replace organic solvents in analytical extractions. The parameters affecting the extraction of target analytes (i...
February 13, 2019: Journal of Separation Science
Neda Mokhberian, Seyed Mahmoud Hashemi, Vahid Jajarmi, Mohamad Eftekhary, Ameneh Koochaki, Hossein Ghanbarian
Natural antisense transcripts (NATs) have recently been associated with the development of human cancers. Recent studies have shown that a natural antisense transcript (NAT) is present in Sirt1 gene which encodes a NAD-dependent deacetylase. Interestingly, expression of Sirt1 mRNA changes during development and progression of human cancers. However, it remains unclear to what extent Sirt1 antisense transcript (AS) may contribute to changes in the expression of Sirt1 mRNA. To determine this, we used quantitative measurement of RNA to reveal relationship between Sirt1 mRNA and Sirt1-AS across human cancer tissues, cell lines and stem cells...
February 12, 2019: Molecular Biology Reports
Neda Valizadeh, Kunal Suradkar, Ravi P Kiran
The aim of this study was to identify preoperative characteristics that may determine the need for emergency surgery for diverticulitis and assess postoperative outcomes for these patients when compared with elective surgery. All patients included in the ACS-NSQIP-targeted colectomy database from 2012 to 2013 who underwent colectomy with an underlying diagnosis of diverticulitis were included. Preoperative characteristics and 30-day postoperative outcomes were evaluated for patients who underwent elective versus emergent/urgent surgery using univariable and multivariable analyses...
November 1, 2018: American Surgeon
Laura A Leaton, Jonathan Shortt, Katherine M Kichula, Sudan Tao, Neda Nemat-Gorgani, Alexander J Mentzer, Stephen J Oppenheimer, Zhihui Deng, Jill A Hollenbach, Christopher R Gignoux, Lisbeth A Guethlein, Peter Parham, Mary Carrington, Paul J Norman
Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy number, KIR3DL3 is ubiquitously present in every individual across diverse populations. No ligand or function is known for KIR3DL3, but limited knowledge of expression suggests involvement in reproduction, likely during placentation. With 157 human alleles, KIR3DL3 is also highly polymorphic and we show heterozygosity exceeds that of HLA-B in many populations...
2019: Frontiers in Immunology
Neda M Bassir Kazeruni, Stanislav Tsitkov, Henry Hess
This protocol describes how to create kinesin-powered molecular shuttles with a weak and reversible attachment of the kinesins to the surface. In contrast to previous protocols, in this system, microtubules recruit kinesin motor proteins from solution and place them on a surface. The kinesins will, in turn, facilitate the gliding of the microtubules along the surface before desorbing back into the bulk solution, thus being available to be recruited again. This continuous assembly and disassembly leads to striking dynamic behavior in the system, such as the formation of temporary kinesin trails by gliding microtubules...
January 26, 2019: Journal of Visualized Experiments: JoVE
Bagher Farhood, Keywan Mortezaee, Hamed Haghi-Aminjan, Neda Khanlarkhani, Ensieh Salehi, Maryam Shabani Nashtaei, Masoud Najafi, Amirhossein Sahebkar
BACKGROUND: Prostate cancer is the second most common malignancy in men in the world, and radiotherapy is used as a standard treatment modality for this cancer. Although this treatment modality effectively kills prostate cancerous cells, it unavoidably irradiates the organs/tissues that are away from the treatment site. In this regard, radiation-induced testicular toxicities following prostate radiotherapy can affect sexual function, reproduction, and quality of life in cancer survivors...
February 10, 2019: Journal of Cellular Physiology
Behafarid Ghalandari, Kazem Asadollahi, Ali Shakerizadeh, Ali Komeili, Gholamhossein Riazi, Seyed Kamran Kamrava, Neda Attaran
Photothermal therapy is achieving ever-increasing attention as a promising method for killing cancer cells. Although, gold nanoparticles are regarded as one of the most effective photothermal therapy agents, the mechanisms underlying their action have to be addressed. Moreover, studies have showed that gold nanoparticles induce apoptosis in treated cultures. Hence, in this study, we investigated the interaction of folic acid functionalized gold nanoparticles and gold-shelled Fe3 O4 nanoparticles with microtubule and microtubule associated protein tau in order to introduce intracellular targets of these nanoparticles and provide a holistic view about the mechanism of action of gold nanoparticles used in photothermal therapy...
January 31, 2019: Journal of Photochemistry and Photobiology. B, Biology
Ivana Beara, Tatjana Majkić, Stefania Fioravanti, Laura Trulli, Neda Mimica-Dukić, Lucio Pellacani, Luciano Saso
BACKGROUND: Convenient approach to modulation of the inflammation is influence on production of inflammatory mediators - eicosanoids, generated in arachidonic acid (AA) metabolism. Common therapeutic activity of non-steroidal anti-inflammatory drugs (NSAID), such as aspirin, includes inhibition of two crucial enzymes of AA metabolism - cyclooxygenase-1 and -2 (COX-1/2), with certain risk for gastrointestinal and renal intolerance. Ever since enrolment of COX-2, particularly overabundance of its main products prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) in numerous pathological processes was recognized, it became significant therapeutic target...
February 8, 2019: Medicinal Chemistry
Mehdi Ansari, Parvane Sadeghi, Hamid Mahdavi, Mohsen Fattahi-Dolatabadi, Neda Mohamadi, Amir Asadi, Fariba Sharififar
Background Fenugreek seeds have shown antinociceptive effect in animal studies. This double-blind placebo controlled trial was designed to study the effect of fenugreek transdermal patch 10% (FDP) for management of inguinal hernia (IH) post-operative pain. Methods Standardized extract of fenugreek seeds was used for FDP formulation. Ninety patients treated with 10% FDP, diclofenac dermal patch 1% (DP) and placebo twice daily after IH surgery. The pain intensity score was evaluated using a visual analogue score (VAS) up to 48 h after operation...
February 5, 2019: Journal of Complementary & Integrative Medicine
Negin Navaei, Shirin Pourafshar, Neda S Akhavan, Nicole S Litwin, Elizabeth M Foley, Kelli S George, Shannon C Hartley, Marcus L Elam, Sangeeta Rao, Bahram H Arjmandi, Sarah A Johnson
Previous research suggests potential for fresh pears as a functional food for promoting cardiometabolic health. The purpose of this randomized, open-label, placebo-controlled, crossover clinical trial was to evaluate the influence of daily fresh pear consumption on blood pressure (primary outcome) and other biomarkers of cardiometabolic health in middle-aged/older adults with metabolic syndrome (MetS). Forty men and women aged 45-65 years with MetS were included and randomly assigned to receive either two medium-sized fresh pears (Pear) or a calorie-matched control drink (Control) per day for each 12-week treatment period, each separated by a 4-week washout period...
February 5, 2019: Food & Function
H N Beadnall, C Wang, W Van Hecke, A Ribbens, T Billiet, M H Barnett
Background: Whole brain atrophy (WBA) estimates in multiple sclerosis (MS) correlate more robustly with clinical disability than traditional, lesion-based metrics. We compare Structural Image Evaluation using Normalisation of Atrophy (SIENA) with the icobrain longitudinal pipeline (icobrain long), for assessment of longitudinal WBA in MS patients. Methods: Magnetic resonance imaging (MRI) scan pairs [1.05 (±0.15) year separation] from 102 MS patients were acquired on the same 3T scanner...
2019: Therapeutic Advances in Neurological Disorders
Neda Barghi, Raymond Tobler, Viola Nolte, Ana Marija Jakšić, François Mallard, Kathrin Anna Otte, Marlies Dolezal, Thomas Taus, Robert Kofler, Christian Schlötterer
The genetic architecture of adaptive traits is of key importance to predict evolutionary responses. Most adaptive traits are polygenic-i.e., result from selection on a large number of genetic loci-but most molecularly characterized traits have a simple genetic basis. This discrepancy is best explained by the difficulty in detecting small allele frequency changes (AFCs) across many contributing loci. To resolve this, we use laboratory natural selection to detect signatures for selective sweeps and polygenic adaptation...
February 4, 2019: PLoS Biology
Lauren E Salminen, Rajendra A Morey, Brandalyn C Riedel, Neda Jahanshad, Emily L Dennis, Paul M Thompson
BACKGROUND AND PURPOSE: Posttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS influences traditionally defined brain signatures of PTSD. Here, we used a novel machine learning method - evolving partitions to improve classification (EPIC) - to identify shared and unique structural neuroimaging markers of ELS and PTSD in 97 combat-exposed military veterans...
February 3, 2019: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Zahra Rahimimoghadam, Zahra Rahemi, Zohre Sadat, Neda Mirbagher Ajorpaz
BACKGROUND AND PURPOSE: There is a need to investigate the effects of pilates exercises on the quality of life (QOL) of patients with chronic kidney diseases (CKD). The purpose of this study was to determine the effect of pilates exercises on the QOL of CKD patients. MATERIALS AND METHODS: For this randomized controlled clinical trial, we enrolled 50 CKD patients. The participants were randomly assigned to experimental (n = 25) and control (n = 25) groups...
February 2019: Complementary Therapies in Clinical Practice
Zaynab Sadeghi Ghadi, Rassoul Dinarvand, Neda Asemi, Fereshteh Talebpour Amiri, Pedram Ebrahimnejad
Designing novel drug delivery systems to improve drug efficiencies have gained great interests in recent years. In this study, a new vesicular system has been prepared using thin film hydration method with slight modifications, hydrophobic drugs have been used in both lipophilic and hydrophilic phases and dry film was hydrated by hyaluronan polymeric solution, to overcome curcumin and quercetin formulation drawbacks. Briefly, different formulations were prepared according to Box-Behnken design to assess the effect of HLB value, cholesterol and hyaluronan contents on the properties of niosomes...
January 31, 2019: European Journal of Pharmaceutical Sciences
Anne L Walsh, Susan Lehmann, Jeffrey Zabinski, Maria Truskey, Taylor Purvis, Neda F Gould, Susan Stagno, Margaret S Chisolm
OBJECTIVE: The authors conducted a systematic review of the published literature to identify interventions to prevent and/or reduce burnout among medical students and residents. METHODS: The authors searched 10 databases (from the start of each through September 21, 2016) using keywords related to burnout, medical education, and prevention. Teams of two authors independently reviewed the search results to select peer-reviewed, English language articles describing educational interventions to prevent and/or reduce burnout among medical students and/or residents that were evaluated using validated burnout measures...
February 1, 2019: Academic Psychiatry
Yechiam Ostchega, Rie Seu, Neda Sarafrazi, Guangyu Zhang, Jeffery P Hughes, Ivey Miller
Objective This report compares five methods of waist circumference (WC) measurements: 1) the National Heart, Lung, and Blood Institute (NHLBI-WC); 2) the World Health Organization (WHO-WC); 3) the Multi-Ethnic Study of Atherosclerosis (MESA-WC) using Gulick II Plus tape; 4) the Multi-Ethnic Study of Atherosclerosis (MESA-WC) using Lufkin tape; and 5) assisted self-measurement over clothes (MESA-assisted). Method During 2016, measurements were obtained from 2,297 participants aged 20 and over, who participated in the National Health and Nutrition Examination Survey (NHANES)...
January 2019: Vital and Health Statistics. Series 2, Data Evaluation and Methods Research
Ghanbar Mahmoodi Chalbatani, Hassan Dana, Feridon Memari, Elahe Gharagozlou, Shirin Ashjaei, Peyman Kheirandish, Vahid Marmari, Habibollah Mahmoudzadeh, Farnaz Mozayani, Ali Reza Maleki, Ehsan Sadeghian, Elham Zainali Nia, Seyed Rohollah Miri, Neda Zainali Nia, Omid Rezaeian, Anahita Eskandary, Narges Razavi, Mohammad Shirkhoda, Fatemeh Nouri Rouzbahani
Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer...
January 2019: Practical Laboratory Medicine
Neda Nozari, Maryam Shafiei, Soheila Sarmadi
Background: Bowel endometriosis affects about 3.8-37% of women with endometriosis diagnosis. Most of the time endometriosis involves the recto-sigmoid. Right colon involvement is not common in endometriosis and also a few studies have reported obstructive endometriosis of bowel. Here, a case of endometriosis was reported with the ileocolic intussusception and cecal mass. Case Presentation: A 32y old woman was referred to Yas hospital due to severe low abdominal pain and vomiting...
October 2018: Journal of Reproduction & Infertility
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