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https://read.qxmd.com/read/30868962/suppression-of-tgf-%C3%AE-and-erk-signaling-pathways-as-a-new-strategy-to-provide-rodent-and-non-rodent-pluripotent-stem-cells
#1
Maryam Farzaneh, Zahra Derakhshan, Jamal Hallajzadeh, Neda Hosseini Sarani, Armin Nejabatdoust, Seyed Esmaeil Khoshnam
Stem cells are unspecialized cells and excellent model in developmental biology and a promising approach to the treatment of disease and injury. In the last 30 years, pluripotent embryonic stem (ES) cells were established from murine and primate sources, and display indefinite replicative potential and the ability to differentiate to all three embryonic germ layers. Despite large efforts in many aspects of rodent and non-rodent pluripotent stem cell culture, a number of diverse challenges remain. Natural and synthetic small molecules (SMs) strategy has the potential to overcome these hurdles...
March 13, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30867861/an-artificial-placenta-type-microfluidic-blood-oxygenator-with-double-sided-gas-transfer-microchannels-and-its-integration-as-a-neonatal-lung-assist-device
#2
Mohammadhossein Dabaghi, Gerhard Fusch, Neda Saraei, Niels Rochow, John L Brash, Christoph Fusch, P Ravi Selvaganapathy
Preterm neonates suffering from respiratory distress syndrome require assistive support in the form of mechanical ventilation or extracorporeal membrane oxygenation, which may lead to long-term complications or even death. Here, we describe a high performance artificial placenta type microfluidic oxygenator, termed as a double-sided single oxygenator unit (dsSOU), which combines microwire stainless-steel mesh reinforced gas permeable membranes on both sides of a microchannel network, thereby significantly reducing the diffusional resistance to oxygen uptake as compared to the previous single-sided oxygenator designs...
July 2018: Biomicrofluidics
https://read.qxmd.com/read/30865427/manifestation-of-kinetic-inductance-in-terahertz-plasmon-resonances-in-thin-film-cd-3-as-2
#3
Ashish Chanana, Neda Loftizadeh, Hugo O Condori Quispe, Prashanth Gopalan, Joshua R Winger, Steve Blair, Ajay Nahata, Vikram V Deshpande, Michael A Scarpulla, Berardi Sensale-Rodriguez
Three-dimensional (3D) semimetals have been predicted and demonstrated to have a wide variety of interesting properties associated with their linear energy dispersion. In analogy to two-dimensional (2D) Dirac semimetals, such as graphene, Cd3 As2 has shown ultrahigh mobility and large Fermi velocity and has been hypothesized to support plasmons at terahertz frequencies. In this work, we experimentally demonstrate synthesis of high-quality large-area Cd3 As2 thin films through thermal evaporation as well as the experimental realization of plasmonic structures consisting of periodic arrays of Cd3 As2 stripes...
March 14, 2019: ACS Nano
https://read.qxmd.com/read/30863891/efficacy-and-safety-of-alemtuzumab-in-a-real-life-cohort-of-patients-with-multiple-sclerosis
#4
Jessica Frau, Giancarlo Coghe, Lorena Lorefice, Giuseppe Fenu, Luigina Musu, Eleonora Cocco
BACKGROUND: No postmarketing randomised clinical trials are available about alemtuzumab, and real-world data are limited. We aimed to analyse the efficacy and safety of alemtuzumab in a single-centre cohort of patients with relapsing-remitting MS. METHODS: Patients who took alemtuzumab were enrolled. We collected the following data: age, sex, MS history, expanded disability status scale (EDSS), relapses, magnetic resonance imaging (MRI) parameters after alemtuzumab, and adverse events...
March 12, 2019: Journal of Neurology
https://read.qxmd.com/read/30862232/sex-specific-clinical-outcomes-of-impaired-glucose-status-a-long-follow-up-from-the-tehran-lipid-and-glucose-study
#5
Donna Parizadeh, Neda Rahimian, Samaneh Akbarpour, Fereidoun Azizi, Farzad Hadaegh
AIMS: To investigate the sex-specific associations of prediabetes with major clinical outcomes including incident type 2 diabetes, chronic kidney disease, hypertension, coronary heart disease, stroke and all-cause mortality. METHODS: Among 8498 Iranian adults from the Tehran Lipid and Glucose Study, aged ≥30 years and without diagnosed type 2 diabetes, gender-interactions were assessed for each outcome, followed by sex-separated multivariate-adjusted Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs) of different prediabetes categories, including impaired fasting glucose (IFG), defined by the American Diabetes Association (ADA) and World Health Organization (WHO), as fasting plasma glucose of 5...
March 12, 2019: European Journal of Preventive Cardiology
https://read.qxmd.com/read/30862060/gastroprotective-effect-of-zingerone-on-ethanol-induced-gastric-ulcers-in-rats
#6
Neda Sistani Karampour, Ardeshir Arzi, Anahita Rezaie, Marzieh Pashmforoosh, Fatemeh Kordi
Background and objectives: Zingerone is an ingredient of ginger ( Zingiber officinale ) with different pharmacological activities. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea. This study is aimed to evaluate the effect of zingerone on ethanol-induced gastric ulcers in rats. Materials and Methods: Gastric ulcers were induced by ethanol (96%, 5 mL/kg, po) in male wistar rats and zingerone (50, 100, and 200 mg/kg) was administrated orally...
March 11, 2019: Medicina
https://read.qxmd.com/read/30858948/the-effect-of-oral-intake-of-honey-syrup-on-the-pain-intensity-of-active-phase-of-parturition-of-nulliparous-women-a-randomized-clinical-trial
#7
Simin Taavoni, Leila Fathi, Neda Nazem-Ekbatani, Hamid Haghani
Background: Labor is a natural pain despite the fact that the severity of the pain and response to it differ in various people, but most women refer to labor as an unpleasant experience of their lives. The present study was carried out to determine the effect of honey on the severity of labor in primigravida women. Methods: In this study, 80 healthy volunteer primigravida women were entered to the research as randomized clinical trial (40 subjects in each group) after studying and signing consent form and they were randomly divided into two intervention honey group and control group...
2019: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/30857305/bovine-herpesvirus-type-4-bohv-4-vector-delivering-nucleocapsid-protein-of-crimean-congo-hemorrhagic-fever-virus-induces-comparable-protective-immunity-against-lethal-challenge-in-ifn%C3%AE-%C3%AE-%C3%AE-r-mice-models
#8
Touraj Aligholipour Farzani, Katalin Földes, Alireza Hanifehnezhad, Burcu Yener Ilce, Seval Bilge Dagalp, Neda Amirzadeh Khiabani, Koray Ergünay, Feray Alkan, Taner Karaoglu, Hurrem Bodur, Aykut Ozkul
Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a tick-borne infection with a significant mortality rate of up to 40% in endemic areas, with evidence of geographical expansion. Due to a lack of effective therapeutics and control measures, the development of a protective CCHFV vaccine remains a crucial public health task. This paper describes, for the first time, a Bovine herpesvirus type 4 (BoHV-4)-based viral vector (BoHV4-∆TK-CCHFV-N) and its immunogenicity in BALB/c and protection potential in IFNα/β/γR-/- mice models in comparison with two routinely used vaccine platforms, namely, Adenovirus type 5 and a DNA vector (pCDNA3...
March 9, 2019: Viruses
https://read.qxmd.com/read/30855555/platelet-serotonin-signaling-in-patients-with-cardiovascular-disease-and-comorbid-depression
#9
Marlene S Williams, Roy C Ziegelstein, Una D McCann, Neda F Gould, Tamara Ashvetiya, Dhananjay Vaidya
OBJECTIVE: Depression in patients with cardiovascular disease is associated with increased risk of adverse clinical outcomes. Investigators have searched for potential biobehavioral explanations for this increased risk. Platelet activation and response to serotonin is an attractive potential mechanism. Our objective was to examine platelet serotonin signaling in a group of patients with coronary artery disease and comorbid depression to define the relationship between platelet serotonin signaling and cardiovascular complications...
March 7, 2019: Psychosomatic Medicine
https://read.qxmd.com/read/30854446/early-prediction-of-breast-cancer-therapy-response-using-multiresolution-fractal-analysis-of-dce-mri-parametric-maps
#10
Archana Machireddy, Guillaume Thibault, Alina Tudorica, Aneela Afzal, May Mishal, Kathleen Kemmer, Arpana Naik, Megan Troxell, Eric Goranson, Karen Oh, Nicole Roy, Neda Jafarian, Megan Holtorf, Wei Huang, Xubo Song
We aimed to determine whether multiresolution fractal analysis of voxel-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parametric maps can provide early prediction of breast cancer response to neoadjuvant chemotherapy (NACT). In total, 55 patients underwent 4 DCE-MRI examinations before, during, and after NACT. The shutter-speed model was used to analyze the DCE-MRI data and generate parametric maps within the tumor region of interest. The proposed multiresolution fractal method and the more conventional methods of single-resolution fractal, gray-level co-occurrence matrix, and run-length matrix were used to extract features from the parametric maps...
March 2019: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/30851128/silent-progression-in-disease-activity-free-relapsing-multiple-sclerosis
#11
Bruce A C Cree, Jill A Hollenbach, Riley Bove, Gina Kirkish, Simone Sacco, Eduardo Caverzasi, Antje Bischof, Tristan Gundel, Alyssa H Zhu, Nico Papinutto, William A Stern, Carolyn Bevan, Andrew Romeo, Douglas S Goodin, Jeffrey M Gelfand, Jennifer Graves, Ari J Green, Michael R Wilson, Scott S Zamvil, Chao Zhao, Refujia Gomez, Nicholas R Ragan, Gillian Q Rush, Patrick Barba, Adam Santaniello, Sergio E Baranzini, Jorge R Oksenberg, Roland G Henry, Stephen L Hauser
OBJECTIVE: Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared to natural history studies from the pre-treatment era. Nonetheless, in our recently reported prospective cohort more than half of patients with relapsing MS accumulated significant new disability by the 10th year of follow-up. Notably, "no evidence of disease activity" at 2-years did not predict long-term stability. Here, we determined to what extent clinical relapses and radiographic evidence of disease activity contribute to long-term disability accumulation...
March 9, 2019: Annals of Neurology
https://read.qxmd.com/read/30850461/a-randomized-trial-to-train-vulnerable-primary-care-patients-to-use-a-patient-portal
#12
Courtney R Lyles, Lina Tieu, Urmimala Sarkar, Stephen Kiyoi, Shobha Sadasivaiah, Mekhala Hoskote, Neda Ratanawongsa, Dean Schillinger
BACKGROUND: Patient portals are becoming ubiquitous. Previous research has documented substantial barriers, especially among vulnerable patient subgroups such as those with lower socioeconomic status or limited health literacy (LHL). We tested the effectiveness of delivering online, video-based portal training to patients in a safety net setting. METHODS: We created an online video curriculum about accessing the San Francisco Health Network portal, and then randomized 93 English-speaking patients with 1+ chronic diseases to receive 1) an in-person tutorial with a research assistant, or 2) a link to view the videos on their own...
March 2019: Journal of the American Board of Family Medicine: JABFM
https://read.qxmd.com/read/30849681/efficacy-and-safety-of-alemtuzumab-in-korean-multiple-sclerosis-patients
#13
Hyunjin Kim, Eun-Jae Lee, Sung Keun Kim, Kwang-Kuk Kim, Young-Min Lim
BACKGROUND: Efficacy and safety profiles of alemtuzumab for relapsing-remitting multiple sclerosis (RRMS) mainly come from Western countries and have not been reported in Asian populations. The aim of this study was to report the efficacy and safety of alemtuzumab for RRMS patients in a Korean population. METHODS: We retrospectively reviewed RRMS patients treated with alemtuzumab. Study outcomes included annualized relapse rate (ARR), expanded disability status scale (EDSS) score, 6-month confirmed disability worsening (CDW), confirmed disability improvement (CDI), MRI lesion activity (new/enlarging T2 hyperintense and gadolinium-enhancing T1 lesions), no evidence of disease activity (NEDA), and adverse events...
March 2, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30849534/the-relation-between-pi3k-akt-signalling-pathway-and-cancer
#14
REVIEW
Saeed Noorolyai, Neda Shajari, Elham Baghbani, Sanam Sadreddini, Behzad Baradaran
Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling cascades is one among the most ordinary events in human cancers. Focusing on the PI3K pathway remains both a chance and a challenge for cancer therapy. The high recurrence of phosphoinositide 3-kinase (PI3K) pathway adjustments in cancer has led to a surge in the progression of PI3K inhibitors. Recent developments incorporate a re-assessment of the oncogenic mechanisms behind PI3K pathway modifications...
March 5, 2019: Gene
https://read.qxmd.com/read/30849341/effect-of-graft-attachment-status-and-intraocular-pressure-on-dsaek-outcomes-in-the-cornea-preservation-time-study
#15
Anthony J Aldave, Mark A Terry, Loretta B Szczotka-Flynn, Wendi Liang, Allison R Ayala, Maureen G Maguire, Robert C O'Brien, Beth Ann Benetz, John E Bokosky, Steven P Dunn, Thomas E Gillette, Kristin M Hammersmith, David R Hardten, Bennie H Jeng, Marc F Jones, Richard L Lindstrom, Kenneth J Maverick, Verinder S Nirankari, Matthew S Oliva, Irving M Raber, Christopher J Rapuano, George O D Rosenwasser, Kevin W Ross, John W Seedor, Neda Shamie, Christopher G Stoeger, Shachar Tauber, Woodford S Van Meter, David D Verdier, Jonathan H Lass
PURPOSE: To examine the association of donor, recipient, and operative factors on graft dislocation after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS) as well as the effects of graft dislocation and elevated IOP on graft success and endothelial cell density (ECD) 3 years postoperatively. DESIGN: Cohort study within a multi-center, double-masked, randomized clinical trial. METHODS: 1,090 individuals (1,330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (6% of eyes)...
March 5, 2019: American Journal of Ophthalmology
https://read.qxmd.com/read/30847906/herbal-medicine-as-an-auspicious-therapeutic-approach-for-the-eradication-of-helicobacter-pylori-infection-a-concise-review
#16
REVIEW
Abdolmajid Ghasemian, Azam Fattahi, Seyyed Khalil Shokouhi Mostafavi, Ali Hussein Almarzoqi, Mojtaba Memariani, Olfa Ben Braiek, Alexander Jon Cresswell-Boyes, Hadi M Yassine, Neda Sadat Shokouhi Mostafavi, Mohanad Mohsin Ahmed, Seyede Amene Mirforughi
Helicobacter pylori (H. pylori) causes gastric mucosa inflammation and gastric cancer mostly via several virulence factors. Induction of proinflammatory pathways plays a crucial role in chronic inflammation, gastric carcinoma, and H. pylori pathogenesis. Herbal medicines (HMs) are nontoxic, inexpensive, and mostly anti-inflammatory reminding meticulous emphasis on the elimination of H. pylori and gastric cancer. Several HM has exerted paramount anti-H. pylori traits. In addition, they exert anti-inflammatory effects through several cellular circuits such as inhibition of 5'-adenosine monophosphate-activated protein kinase, nuclear factor-κB, and activator protein-1 pathway activation leading to the inhibition of proinflammatory cytokines (interleukin 1α [IL-1α], IL-1β, IL-6, IL-8, IL-12, interferon γ, and tumor necrosis factor-α) expression...
March 7, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30847551/iron-oxide-gold-core-shell-nano-theranostic-for-magnetically-targeted-photothermal-therapy-under-magnetic-resonance-imaging-guidance
#17
Ziaeddin Abed, Jaber Beik, Sophie Laurent, Neda Eslahi, Tahereh Khani, Elnaz S Davani, Habib Ghaznavi, Ali Shakeri-Zadeh
Recent efforts in the area of photothermal therapy (PTT) follow two important aims: (i) selective targeting of plasmonic nanoparticles to the tumor and (ii) real-time guidance of PTT operation through employing multimodal imaging modalities. In the present study, we utilized a multifunctional theranostic nanoplatform constructed from iron (III) oxide-gold (Fe2 O3 @Au) core-shell nanoparticles to fulfill these aims. The Au shell exhibits surface plasmon resonance, a property that is exploited to realize PTT...
March 7, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30842793/evaluation-of-the-prevalence-of-temporomandibular-joint-involvement-in-rheumatoid-arthritis-using-research-diagnostic-criteria-for-temporomandibular-disorders
#18
Nazanin Mortazavi, Mansour Babaei, Neda Babaee, Hamed Hossein Kazemi, Roozbeh Mortazavi, Amrollah Mostafazadeh
Objectives: Temporomandibular joint (TMJ) disorders, known as TMDs, are significant public health problems and may result in pain and disability. In order to determine the prevalence of clinical/subjective TMD in rheumatoid arthritis (RA), we used the research diagnostic criteria (RDC)/TMD axes. We assessed the anti-cyclic citrullinated protein (anti-CCP)-related TMD in RA for the first time. Materials and Methods: Fifty-two RA patients were compared to 47 healthy controls with regard to complete blood count (CBC), serology, acute phase reactants (APR), and TMJ dysfunction...
November 2018: Journal of Dentistry of Tehran University of Medical Sciences
https://read.qxmd.com/read/30838857/temperature-dependence-of-the-urbach-energy-in-lead-iodide-perovskites
#19
Martin Ledinsky, Tereza Schönfeldová, Jakub Holovsky, Erkan Aydin, Zdeňka Hájková, Lucie Landová, Neda Neykova, Antonin Fejfar, Stefaan De Wolf
To gain insight in the properties of photovoltaic and light-emitting materials, detailed information about their optical absorption spectra is essential. Here, we elucidate the temperature dependence of such spectra for methylammonium lead iodide (CH3 NH3 PbI3 ), with specific attention for its sub bandgap absorption edge (often referred to as Urbach energy). Based on these data, firstly, we find clear further evidence for the universality of the correlation between the Urbach energy and open-circuit voltage losses of solar cells...
March 6, 2019: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/30838493/the-impact-of-the-affordable-care-act-medicaid-expansion-on-type-2-diabetes-diagnosis-and-treatment-a-national-survey-of-physicians
#20
Matthew A Present, Aviva G Nathan, Sandra A Ham, Robert M Sargis, Michael T Quinn, Elbert S Huang, Neda Laiteerapong
In 2014, the Affordable Care Act (ACA) provided funding for states to expand Medicaid coverage to include citizens who earned up to 138% of the federal poverty line. We sought to ascertain whether physicians practicing in Medicaid expansion states reported an increase in Medicaid or newly insured patients with type 2 diabetes in their panels, compared to physicians practicing in non-expansion states. We conducted a 55-question cross-sectional survey of 356 physicians providing outpatient care for adults with type 2 diabetes...
March 5, 2019: Journal of Community Health
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