keyword
Keywords "no evidence of disease activi...

"no evidence of disease activity" OR NEDA

https://read.qxmd.com/read/38533129/ursapgx-a-new-r-package-to-annotate-pharmacogenetic-star-alleles-using-phased-whole-genome-sequencing-data
#1
JOURNAL ARTICLE
Gennaro Calendo, Dara Kusic, Jozef Madzo, Neda Gharani, Laura Scheinfeldt
Long-read sequencing technologies offer new opportunities to generate high-confidence phased whole-genome sequencing data for robust pharmacogenetic annotation. Here, we describe a new user-friendly R package, ursaPGx, designed to accept multi-sample phased whole-genome sequencing data VCF input files and output star allele annotations for pharmacogenes annotated in PharmVar.
2024: Front Bioinform
https://read.qxmd.com/read/38532143/early-prediction-of-unfavorable-evolution-after-a-first-clinical-episode-suggestive-of-multiple-sclerosis-the-eumus-score
#2
JOURNAL ARTICLE
Giulia Mallucci, Ottavia Eleonora Ferraro, Maria Trojano, Maria Pia Amato, Antonio Scalfari, Mauro Zaffaroni, Elena Colombo, Eleonora Rigoni, Pietro Iaffaldano, Emilio Portaccio, Lorenzo Saraceno, Damiano Paolicelli, Lorenzo Razzolini, Cristina Montomoli, Roberto Bergamaschi
BACKGROUND: Predicting disease progression in patients with the first clinical episode suggestive of multiple sclerosis (MS) is crucial for personalized therapeutic approaches. This study aimed to develop the EUMUS score for accurately estimating the risk of early evidence of disease activity and progression (EDA). METHODS: Retrospective analysis was conducted on data from 221 patients with a first clinical MS episode collected from four Italian MS centers. Various variables including socio-demographics, clinical features, cerebrospinal fluid analysis, evoked potentials, and brain MRI were considered...
March 26, 2024: Journal of Neurology
https://read.qxmd.com/read/38530697/sensory-organization-and-postural-control-strategies-in-individuals-with-mild-and-moderate-to-severe-forward-head-posture-a-comparative-study
#3
JOURNAL ARTICLE
Nahid Pirayeh, Zahra Heidary, Mohammad Mehravar, Mohammad Jafar Shaterzadeh Yazdi, Neda Mostafaee
OBJECTIVE: This study aimed to compare sensory organization test and postural control strategies between individuals with mild and moderate-to-severe forward head posture (FHP). METHODS: A sensory organization test (SOT) was performed in 6 conditions using computerized dynamic posturography, to assess postural control. Equilibrium scores representing overall balance, strategy analysis to assess ankle vs hip strategy dominance, and sensory analysis (Somatosensory, visual, vestibular, visual preference ratio) as an indicator of the use of sensory systems were obtained...
March 26, 2024: Journal of Manipulative and Physiological Therapeutics
https://read.qxmd.com/read/38525390/investigating-the-effect-of-aspirin-on-apoai-induced-atp-binding-cassette-transporter-1-protein-expression-and-cholesterol-efflux-in-human-astrocytes
#4
JOURNAL ARTICLE
Zahra Nazeri, Neda Abdeveiszadeh, Vahid Zarezade, Shirin Azizidoost, Maryam Cheraghzadeh, Mohammad Aberumand, Alireza Kheirollah
BACKGROUND: Neurons need a high amount of cholesterol to maintain the stability of their membrane-rich structures. Astrocytes synthesize and distribute cholesterol to neurons, and ABCA1 is a key mediator of cholesterol efflux to generate HDL for cholesterol transport in the brain. Several studies imply the effect of aspirin on ABCA1 expression in peripheral cells such as macrophages. Here, we compared the effect of aspirin with apoA-I on ABCA1 protein expression and cholesterol efflux in human astrocytes...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38523882/do-serological-tests-eliminate-the-need-for-endoscopic-biopsy-for-the-diagnosis-of-symptomatic-patients-with-celiac-disease-a-retrospective-study-with-review-of-literature
#5
JOURNAL ARTICLE
Mohammad Hossein Anbardar, Neda Soleimani, Ehsan Torabi Dashtaki, Naser Honar, Mozhgan Zahmatkeshan, Sahand Mohammadzadeh
Background: Celiac disease is one of the most common genetic allergies worldwide. The prevalence of celiac disease in Iran is similar to or even higher than the global prevalence. Celiac disease is a chronic inflammatory disease that affects the small intestine. Affected patients are allergic to gluten protein that exists in some grains, such as wheat and barley. Methods: Serological endomysial IgA antibody (EMA-AB) and tissue transglutaminase IgA antibody (TTG-IgA) tests were performed on 114 patients aged the ages of 0-18 years with histopathological findings of celiac disease...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523775/erratum-neurofilament-light-chain-and-vaccination-status-associate-with-clinical-outcomes-in-severe-covid-19
#6
Young Erben, Mercedes Prudencio, Christopher P Marquez, Karen R Jansen-West, Michael G Heckman, Launia J White, Judith A Dunmore, Casey N Cook, Meredith T Lilley, Neda Qosja, Yuping Song, Rana Hanna Al Shaikh, Lillian M Daughrity, Jordan L Bartfield, Gregory S Day, Björn Oskarsson, Katharine A Nicholson, Zbigniew K Wszolek, Jonathan B Hoyne, Tania F Gendron, James F Meschia, Leonard Petrucelli
[This corrects the article DOI: 10.1016/j.isci.2022.105272.].
April 19, 2024: IScience
https://read.qxmd.com/read/38522663/protective-effects-of-different-lyoprotectants-on-survival-of-clinical-bacterial-isolates-in-a-hospital-biobank
#7
JOURNAL ARTICLE
Masoud Alebouyeh, Nasim Almasian Tehrani, Fatemeh Fallah, Leila Azimi, Mehrzad Sadredinamin, Neda Yousefi, Ghazale Ghandchi, Mostafa Haji Molla Hoseini
Nowadays the significant role of biobanks in medical, diagnostic, industrial, and environmental research is well known. Bacterial biobanks could be used as a good resource for designing new treatments, biomedical and industrial researches, and laboratory diagnostics. To have a collection of bacteria from clinical samples and maintain their long-term viability, their preservation needs appropriate protective agents, like cryoprotectants and lyoprotectants. In this study, we collected and characterized Gram-negative and Gram-positive bacteria carrying important antibiotic resistance markers from different clinical samples of hospitalized children...
March 22, 2024: Cryobiology
https://read.qxmd.com/read/38521522/prepregnancy-body-mass-index-and-other-risk-factors-for-early-onset-and-late-onset-haemolysis-elevated-liver-enzymes-and-low-platelets-hellp-syndrome-a-population-based-retrospective-cohort-study-in-british-columbia-canada
#8
JOURNAL ARTICLE
Li Qing Wang, Jeffrey N Bone, Giulia M Muraca, Neda Razaz, K S Joseph, Sarka Lisonkova
BACKGROUND: Obesity increases risk of pre-eclampsia, but the association with haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is understudied. OBJECTIVE: To examine the association between prepregnancy body mass index (BMI) and HELLP syndrome, including early-onset versus late-onset disease. STUDY DESIGN: A retrospective cohort study using population-based data. SETTING: British Columbia, Canada, 2008/2009-2019/2020...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38513830/increased-incidence-of-thyroid-renal-lung-melanoma-bladder-and-prostate-cancers-after-diagnosis-of-primary-cutaneous-b-cell-lymphoma-a-seer-database-analysis
#9
JOURNAL ARTICLE
Lauren Banner, Thomas Z Rohan, Rachel Zachian, Tyler Gross, Henry Y Yang, Daniel Joffe, Pierluigi Porcu, Neda Nikbakht
No abstract text is available yet for this article.
March 19, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38513425/substantial-and-comparable-suppression-of-disease-activity-following-early-initiation-of-cladribine-tablets-ocrelizumab-or-alemtuzumab-as-first-pharmacologic-treatment-for-relapsing-multiple-sclerosis-a-real-world-study
#10
JOURNAL ARTICLE
Raed Alroughani, Jasem Al-Hashel, Samar Farouk Ahmed
BACKGROUND: We describe the efficacy and safety of recent high efficacy disease DMTs in DMT-naive patients with highly active RMS. METHODS: This was a retrospective, cross sectional study from the Kuwait national MS registry. Patients with RMS who received alemtuzumab, cladribine tablets or ocrelizumab as their first DMT for RMS, with ≥2 year of follow up were included. The primary endpoint was the change in relapse rate from treatment initiation to 1 year; changes in disability (Expanded Disability Status Scale [EDSS]), radiologic activity, the proportion with no evidence of disease activity-3 (NEDA-3), and the frequency of adverse events were secondary endpoints...
March 19, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38510343/a-roadmap-for-developing-and-engineering-in-vitro-pulmonary-fibrosis-models
#11
REVIEW
Mohammadhossein Dabaghi, Mabel Barreiro Carpio, Neda Saraei, Jose Manuel Moran-Mirabal, Martin R Kolb, Jeremy A Hirota
Idiopathic pulmonary fibrosis (IPF) is a severe form of pulmonary fibrosis. IPF is a fatal disease with no cure and is challenging to diagnose. Unfortunately, due to the elusive etiology of IPF and a late diagnosis, there are no cures for IPF. Two FDA-approved drugs for IPF, nintedanib and pirfenidone, slow the progression of the disease, yet fail to cure or reverse it. Furthermore, most animal models have been unable to completely recapitulate the physiology of human IPF, resulting in the failure of many drug candidates in preclinical studies...
June 2023: Biophysics reviews
https://read.qxmd.com/read/38509001/in-hydrogel-cell-free-protein-expression-system-as-biocompatible-and-implantable-biomaterial
#12
JOURNAL ARTICLE
Mercedes Sánchez-Costa, Ane Urigoitia, Natalia Comino, Blanca Arnaiz, Neda Khatami, Raquel Ruiz-Hernandez, Eleftheria Diamanti, Ander Abarrategi, Fernando López-Gallego
Biomaterials capable of delivering therapeutic proteins are relevant in biomedicine, yet their manufacturing relies on centralized manufacturing chains that pose challenges to their remote implementation at the point of care. This study explores the viability of confined cell-free protein synthesis within porous hydrogels as biomaterials that dynamically produce and deliver proteins to in vitro and in vivo biological microenvironments. These functional biomaterials have the potential to be assembled as implants at the point of care...
March 20, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38508497/brain-inflammation-in-experimental-autoimmune-encephalomyelitis-induced-in-dark-agouti-rats-with-spinal-cord-homogenate
#13
JOURNAL ARTICLE
Goran Stegnjaić, Bojan Jevtić, Milica Lazarević, Đurđica Ignjatović, Mirko Tomić, Neda Nikolovski, Ivana Bjelobaba, Miljana Momčilović, Mirjana Dimitrijević, Đorđe Miljković, Suzana Stanisavljević
We have recently characterized experimental autoimmune encephalomyelitis (EAE) induced in DA rats with spinal cord homogenate without complete Freund's adjuvant (CFA). The main advantage of this multiple sclerosis model is the lack of CFA-related confounding effects which represent the major obstacles in translating findings from EAE to multiple sclerosis. Here, antigen specificity of the cellular and humoral immune response directed against the central nervous system was explored. The reactivity of T and B cells to myelin basic protein, myelin oligodendrocyte glycoprotein, and β-synuclein was detected...
March 18, 2024: Immunology Letters
https://read.qxmd.com/read/38506074/treatment-of-sleep-apnea-and-reduction-in-blood-pressure-the-role-of-heart-rate-response-and-hypoxic-burden
#14
JOURNAL ARTICLE
Ludovico Messineo, Scott Sands, Christopher Schmickl, Gonzalo Labarca, Wen-Hsin Hu, Neda Esmaeili, Daniel Vena, Laura Gell, Nicole Calianese, Atul Malhotra, Daniel J Gottlieb, Andrew Wellman, Susan Redline, Ali Azarbarzin
BACKGROUND: Obstructive sleep apnea is associated with increased blood pressure (BP). Obstructive sleep apnea treatment reduces BP with substantial variability, not explained by the apnea-hypopnea index, partly due to inadequate characterization of obstructive sleep apnea's physiological consequences, such as oxygen desaturation, cardiac autonomic response, and suboptimal treatment efficacy. We sought to examine whether a high baseline heart rate response (ΔHR), a marker of high cardiovascular risk in obstructive sleep apnea, predicts a larger reduction in posttreatment systolic BP (SBP)...
March 20, 2024: Hypertension
https://read.qxmd.com/read/38505563/transcriptome-analysis-reveals-distinct-patterns-between-the-invasive-and-noninvasive-pituitary-neuroendocrine-tumors
#15
JOURNAL ARTICLE
Jelena Jotanovic, Abdellah Tebani, Neda Hekmati, Åsa Sivertsson, Cecilia Lindskog, Mathias Uhlèn, Olafur Gudjonsson, Erika Tsatsaris, Britt Edén Engström, Johan Wikström, Fredrik Pontén, Olivera Casar-Borota
Although most pituitary neuroendocrine tumors (PitNETs)/pituitary adenomas remain intrasellar, a significant proportion of tumors show parasellar invasive growth and 6% to 8% infiltrate the bone structures, thus affecting the prognosis. There is an unmet need to identify novel markers that can predict the parasellar growth of PitNETs. Furthermore, mechanisms that regulate bone invasiveness of PitNETs and factors related to tumor vascularization are largely unknown. We used genome-wide mRNA analysis in a cohort of 77 patients with PitNETs of different types to explore the differences in gene expression patterns between invasive and noninvasive tumors with respect to the parasellar growth and regarding the rare phenomenon of bone invasiveness...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38504380/a-gender-specific-geodatabase-of-five-cancer-types-with-the-highest-frequency-of-occurrence-in-iran
#16
JOURNAL ARTICLE
Sharareh Faramarzi, Behzad Kiani, Mohammedreza Hoseinkhani, Neda Firouraghi
OBJECTIVES: Cancer is a global health challenge with complex characteristics. Despite progress in research and treatment, a universally effective prevention strategy is lacking. Access to reliable information, especially on occurrence rates, is vital for cancer management. This study aims to create a database containing individual and spatially integrated data on commonly diagnosed cancers in Iran from 2014 to 2017, serving as a valuable resource for spatial-epidemiological approaches...
March 19, 2024: BMC Research Notes
https://read.qxmd.com/read/38503058/psychometric-properties-of-the-persian-version-of-the-stuttering-generalization-self-measure-tool-in-adults-who-stutter
#17
JOURNAL ARTICLE
Ebtesam Hozeili, Tabassom Azimi, Akram Ahmadi, Hassan Khoramshahi, Neda Tahmasebi, Maryam Dastoorpoor
PURPOSE: Our study aimed to translate the Stuttering Generalization Self-Measure (SGSM) into Persian and investigate its validity, reliability, and internal responsiveness in the Iranian population. METHOD: This study was conducted on 30 adults who stutter (AWS) and 30 adults who do not stutter (AWNS). The International Quality of Life Assessment protocol (IQOLA) was applied to translate SGSM into Persian. The face and content validity were determined. Also, the discriminant validity was evaluated by comparing the scores of two groups...
March 14, 2024: Journal of Fluency Disorders
https://read.qxmd.com/read/38500594/empty-sella-in-somatotropic-pituitary-adenomas-a-series-of-23-cases
#18
JOURNAL ARTICLE
Guive Sharifi, Esmaeil Mohammadi, Elham Paraandavaji, Seyed Mohammad Tavangar, Mohammad Amin Dabbagh Ohadi, Ali Jafari, Amin Jahanbakhshi, Nader Akbari Dilmaghani, Zahra Davoudi, Timothy R Smith, Gelareh Banihashemi, Masoumeh Azadi, Neda Hatami, Georgios A Zenonos, Mohammadreza Mohajeri Tehrani
PURPOSE: We aimed to investigate empty sella syndrome in somatotrophic pituitary adenoma for possible etiology, complications, and treatment options. METHOD: Among over 2,000 skull base masses that have been managed in our center since 2013, we searched for growth hormone-producing adenomas. Clinical, surgical, and imaging data were retrospectively collected from hospital records to check for sella that lacked pituitary tissue on routine imaging. RESULT: In 220 somatotrophic adenomas, 23 patients had an empty sella with surgical and follow-up data...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38500263/neurological-recovery-and-neurogenesis-by-curcumin-sustained-release-system-cross-linked-with-an-acellular-spinal-cord-scaffold-in-rat-spinal-cord-injury-targeting-nlrp3-inflammasome-pathway
#19
JOURNAL ARTICLE
Neda Ghaffari, Tahmineh Mokhtari, Mahdi Adabi, Babak Ebrahimi, Morteza Kamali, Morteza Gholaminejhad, Gholamreza Hassanzadeh
In the context of treating spinal cord injury (SCI), the modulation of inflammatory responses, and the creation of a suitable region for tissue regeneration may present a promising approach. This study aimed to evaluate the effects of curcumin (Cur)-loaded bovine serum albumin nanoparticles (Cur-BSA NPs) cross-linked with an acellular spinal cord scaffold (ASCS) on the functional recovery in a rat model of SCI. We developed an ASCS using chemical and physical methods. Cur-BSA, and blank (B-BSA) NPs were fabricated and cross-linked with ASCS via EDC-NHS, resulting in the production of Cur-ASCS and B-ASCS...
March 18, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38499871/mammal-responses-to-global-changes-in-human-activity-vary-by-trophic-group-and-landscape
#20
JOURNAL ARTICLE
A Cole Burton, Christopher Beirne, Kaitlyn M Gaynor, Catherine Sun, Alys Granados, Maximilian L Allen, Jesse M Alston, Guilherme C Alvarenga, Francisco Samuel Álvarez Calderón, Zachary Amir, Christine Anhalt-Depies, Cara Appel, Stephanny Arroyo-Arce, Guy Balme, Avi Bar-Massada, Daniele Barcelos, Evan Barr, Erika L Barthelmess, Carolina Baruzzi, Sayantani M Basak, Natalie Beenaerts, Jonathan Belmaker, Olgirda Belova, Branko Bezarević, Tori Bird, Daniel A Bogan, Neda Bogdanović, Andy Boyce, Mark Boyce, LaRoy Brandt, Jedediah F Brodie, Jarred Brooke, Jakub W Bubnicki, Francesca Cagnacci, Benjamin Scott Carr, João Carvalho, Jim Casaer, Rok Černe, Ron Chen, Emily Chow, Marcin Churski, Connor Cincotta, Duško Ćirović, T D Coates, Justin Compton, Courtney Coon, Michael V Cove, Anthony P Crupi, Simone Dal Farra, Andrea K Darracq, Miranda Davis, Kimberly Dawe, Valerie De Waele, Esther Descalzo, Tom A Diserens, Jakub Drimaj, Martin Duľa, Susan Ellis-Felege, Caroline Ellison, Alper Ertürk, Jean Fantle-Lepczyk, Jorie Favreau, Mitch Fennell, Pablo Ferreras, Francesco Ferretti, Christian Fiderer, Laura Finnegan, Jason T Fisher, M Caitlin Fisher-Reid, Elizabeth A Flaherty, Urša Fležar, Jiří Flousek, Jennifer M Foca, Adam Ford, Barbara Franzetti, Sandra Frey, Sarah Fritts, Šárka Frýbová, Brett Furnas, Brian Gerber, Hayley M Geyle, Diego G Giménez, Anthony J Giordano, Tomislav Gomercic, Matthew E Gompper, Diogo Maia Gräbin, Morgan Gray, Austin Green, Robert Hagen, Robert Bob Hagen, Steven Hammerich, Catharine Hanekom, Christopher Hansen, Steven Hasstedt, Mark Hebblewhite, Marco Heurich, Tim R Hofmeester, Tru Hubbard, David Jachowski, Patrick A Jansen, Kodi Jo Jaspers, Alex Jensen, Mark Jordan, Mariane C Kaizer, Marcella J Kelly, Michel T Kohl, Stephanie Kramer-Schadt, Miha Krofel, Andrea Krug, Kellie M Kuhn, Dries P J Kuijper, Erin K Kuprewicz, Josip Kusak, Miroslav Kutal, Diana J R Lafferty, Summer LaRose, Marcus Lashley, Richard Lathrop, Thomas E Lee, Christopher Lepczyk, Damon B Lesmeister, Alain Licoppe, Marco Linnell, Jan Loch, Robert Long, Robert C Lonsinger, Julie Louvrier, Matthew Scott Luskin, Paula MacKay, Sean Maher, Benoît Manet, Gareth K H Mann, Andrew J Marshall, David Mason, Zara McDonald, Tracy McKay, William J McShea, Matt Mechler, Claude Miaud, Joshua J Millspaugh, Claudio M Monteza-Moreno, Dario Moreira-Arce, Kayleigh Mullen, Christopher Nagy, Robin Naidoo, Itai Namir, Carrie Nelson, Brian O'Neill, M Teague O'Mara, Valentina Oberosler, Christian Osorio, Federico Ossi, Pablo Palencia, Kimberly Pearson, Luca Pedrotti, Charles E Pekins, Mary Pendergast, Fernando F Pinho, Radim Plhal, Xochilt Pocasangre-Orellana, Melissa Price, Michael Procko, Mike D Proctor, Emiliano Esterci Ramalho, Nathan Ranc, Slaven Reljic, Katie Remine, Michael Rentz, Ronald Revord, Rafael Reyna-Hurtado, Derek Risch, Euan G Ritchie, Andrea Romero, Christopher Rota, Francesco Rovero, Helen Rowe, Christian Rutz, Marco Salvatori, Derek Sandow, Christopher M Schalk, Jenna Scherger, Jan Schipper, Daniel G Scognamillo, Çağan H Şekercioğlu, Paola Semenzato, Jennifer Sevin, Hila Shamon, Catherine Shier, Eduardo A Silva-Rodríguez, Magda Sindicic, Lucy K Smyth, Anil Soyumert, Tiffany Sprague, Colleen Cassady St Clair, Jennifer Stenglein, Philip A Stephens, Kinga Magdalena Stępniak, Michael Stevens, Cassondra Stevenson, Bálint Ternyik, Ian Thomson, Rita T Torres, Joan Tremblay, Tomas Urrutia, Jean-Pierre Vacher, Darcy Visscher, Stephen L Webb, Julian Weber, Katherine C B Weiss, Laura S Whipple, Christopher A Whittier, Jesse Whittington, Izabela Wierzbowska, Martin Wikelski, Jacque Williamson, Christopher C Wilmers, Todd Windle, Heiko U Wittmer, Yuri Zharikov, Adam Zorn, Roland Kays
Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality...
March 18, 2024: Nature Ecology & Evolution
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