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Heart *Ischemia Heart Disease

Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia is damaging to several organs including eyes, kidneys, nerve, and/or heart. The damages are associated with a high risk of morbidity and mortality. Diabetes has been implicated in ischemia in the microvasculature of the target tissues, which occurs due to the insufficient perfusion of tissues. The resulting occlusion and pain affect the quality of life...
February 15, 2019: Archives of Pharmacal Research
Anna Lisowska, Przemysław Święcki, Małgorzata Knapp, Monika Gil, Włodzimierz J Musiał, Karol Kamiński, Tomasz Hirnle, Agnieszka Tycińska
PURPOSE: The role of insulin-like growth factor-binding protein-7 (IGFBP-7) in atherosclerosis is still not well-known. The objective of this study was to find out the following: 1) whether IGFBP-7 may act as a biomarker of coronary artery disease (CAD) occurrence and extent; 2) whether IGFBP-7 is potentially related to the classical and new markers of cardiovascular risk (carotid intima-media thickness - cIMT); 3) whether IGFBP-7 may be a marker of mortality in the group of patients with myocardial infarction (MI)...
February 12, 2019: Advances in Medical Sciences
Ahmed AlBadri, C Noel Bairey Merz, B Delia Johnson, Janet Wei, Puja K Mehta, Galen Cook-Wiens, Steven E Reis, Sheryl F Kelsey, Vera Bittner, George Sopko, Leslee J Shaw, Carl J Pepine, Bina Ahmed
BACKGROUND: Currently as many as one-half of women with suspected myocardial ischemia have no obstructive coronary artery disease (CAD), and abnormal coronary reactivity (CR) is commonly found. OBJECTIVES: The authors prospectively investigated CR and longer-term adverse cardiovascular outcomes in women with and with no obstructive CAD in the National Heart, Lung, and Blood Institute-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. METHODS: Women (n = 224) with signs and symptoms of ischemia underwent CR testing...
February 19, 2019: Journal of the American College of Cardiology
Marcus Ståhlberg, Ryo Nakagawa, Djahida Bedja, Guangshuo Zhu, Brian L Lin, Amir Saberi, Dong I Lee, David A Kass
BACKGROUND: The mouse is the most widely used mammal in experimental biology. Although many clinically relevant in vivo cardiac stressors are used, one that has eluded translation is long-term cardiac pacing. Here, we present the first method to chronically simulate and simultaneously record cardiac electrical activity in conscious mobile mice. We then apply it to study right ventricular pacing induced electromechanical dyssynchrony and its reversal (resynchronization). METHODS AND RESULTS: The method includes a custom implantable bipolar stimulation and recording lead and flexible external conduit and electrical micro-commutator linked to a pulse generator/recorder...
February 2019: Circulation. Heart Failure
Puja K Mehta, Aneesha Thobani, Viola Vaccarino
Symptomatic individuals suspected of having myocardial ischemia often have no obstructive atherosclerotic narrowing of epicardial coronary arteries. Abnormal coronary vascular reactivity, and in particular, coronary artery vasospasm (CAS), may be an explanation in a subset of these patients. Psychological factors play an important role in ischemic heart disease, but their role in CAS is not clear; autonomic dysfunction and increased inflammation are two prevailing pathophysiological mechanisms implicated in abnormal coronary reactivity resulting from mental health conditions...
February 8, 2019: Psychosomatic Medicine
Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler, Cristobal G Dos Remedios, Jiayu Yu, Chen Gao, Stephan Lange
The protein kinase C (PKC) and closely related protein kinase N (PKN) families of serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC subfamily of protein kinases that also include the cAMP dependent protein kinase (PKA), protein kinase B (PKB/AKT), protein kinase G (PKG) and the ribosomal protein S6 kinase (S6K). Involvement of PKC family members in heart disease has been well documented over the years, as their activity and levels are mis-regulated in several pathological heart conditions, such as ischemia, diabetic cardiomyopathy, as well as hypertrophic or dilated cardiomyopathy...
February 8, 2019: Journal of Molecular and Cellular Cardiology
Ye Tian, Jason Mendes, Apoorva Pedgaonkar, Mark Ibrahim, Leif Jensen, Joyce D Schroeder, Brent Wilson, Edward V R DiBella, Ganesh Adluru
PURPOSE: Dynamic contrast enhanced MRI of the heart typically acquires 2-4 short-axis (SA) slices to detect and characterize coronary artery disease. This acquisition scheme is limited by incomplete coverage of the left ventricle. We studied the feasibility of using radial simultaneous multi-slice (SMS) technique to achieve SA, 2-chamber and/or 4-chamber long-axis (2CH LA and/or 4CH LA) coverage with and without electrocardiography (ECG) gating using a motion-robust reconstruction framework...
2019: PloS One
Inna Rabinovich-Nikitin, Brooke Lieberman, Tami A Martino, Lorrie A Kirshenbaum
BACKGROUND: Over the past several years, a variety of human and animal studies have shown that circadian clocks regulate biological cardiovascular rhythms in both health and disease. For example, heart rate and blood pressure fluctuate over 24-hour daily periods, such that levels are higher in the morning and progressively decline in the evening. METHODS AND RESULTS: It is interesting to note that the timing of the administration of various cardiac treatments can also benefit some cardiovascular outcomes...
February 12, 2019: Circulation
Fabio V Lima, Dhaval Kolte, David W Louis, Kevin F Kennedy, J Dawn Abbott, Peter A Soukas, Omar N Hyder, Shafiq T Mamdani, Herbert D Aronow
There are limited contemporary data on readmission after revascularization for chronic mesenteric ischemia (CMI). This study aimed to determine the rates, reasons, predictors, and costs of 30-day readmission after endovascular or surgical revascularization for CMI. Patients with CMI discharged after endovascular or surgical revascularization during 2013 to 2014 were identified from the Nationwide Readmissions Database. The rates, reasons, length of stay, and costs of 30-day all-cause, non-elective, readmission were determined using weighted national estimates...
February 10, 2019: Vascular Medicine
Bailin Liu, Xiangqun Hu, Yong Li, Jun Ke, Chiranjib Dasgupta, Xiaohui Huang, Andrew Walayat, Lubo Zhang, Daliao Xiao
BACKGROUND: Fetal origin of adult cardiovascular disease is one of the most pressing public concerns and economic problem in modern life. Maternal cigarette smoking/nicotine abuse increases the risk of cardiovascular disease in offspring. However, the underlying mechanisms and theranostics remain unclear. We hypothesized that fetal and neonatal nicotine exposure enhances microRNA-181a (miR-181a) which targets large-conductance Ca2+ -activated K+ (BKCa ) channels, resulting in increased coronary vascular tone in adult offspring...
January 31, 2019: International Journal of Cardiology
Guanyi Liao, Siyang Chen, Haoyang Cao, Wuwan Wang, Qing Gao
BACKGROUND: Acute mesenteric ischemia (AMI) is a life-threatening medical condition that occurs when a sudden decreased perfusion to the intestines which leads to bowel infarction, and acute superior mesenteric artery embolism (ASMAE) is the main cause of AMI. Unfortunately, with the improvement of diagnosis and treatment technology, the mortality remains high due to less frequent clinical suspicion resulted from the unclear clinical manifestation and non-specific laboratory findings...
February 2019: Medicine (Baltimore)
Hao Wu, William Ferguson, Eumenia Castro, Debra Kearney, Milton Finegold, Kalyani Patel
Autopsy reports of 78 stillbirths and early infant deaths (up to age 8 weeks) were reviewed to investigate the prevalence of extrahepatic nonreticuloendothelial siderosis (EHNRS) in the context of neonatal liver failure. Of these, 10 liveborns (12.8%), M:F 3:2, with mean gestational age 37.6 weeks (range: 35-39) and mean age at the time of demise 19.1 days (range: 7-42), showed significant liver injury: infection (n = 7, viral > fungal), congenital malformations (n = 2), and ischemia (n = 1)...
February 5, 2019: Pediatric and Developmental Pathology
Mustafa Kilic, Betul Kilic, Mehmet Dumlu Aydin, Ayhan Kanat, Ilhan Yilmaz, Metehan Eseoglu, Betul Gundogdu
ACKGROUND: The relationship between superior cervical ganglia (SCG) ischemia due to bilateral common carotid artery ligation (BCCAL) and basilar artery (BA) reconfiguration was investigated. METHOD: Twenty-three rabbits were randomly divided into three groups: GIII rabbits underwent BCCAL (n = 13), GII rabbits were sham-operated controls (n = 5), and GI rabbits did not undergo surgery (n = 5). Degenerated neuron densities (DND) within SCG were correlated with the BA vasodilatation index (VDI)...
February 1, 2019: World Neurosurgery
Qingguo Lu, Xuan Li, Jia Liu, Xiaodong Sun, Thomas Rousselle, Di Ren, Nanwei Tong, Ji Li
Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of anti-diabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injury, improving heart failure (HF) and ventricular remodeling, ameliorating vascular endothelial dysfunction, anti-chronic inflammation, anti-apoptosis and regulating autophagy...
February 1, 2019: Bioscience Reports
Abdonas Tamosiunas, Janina Petkeviciene, Ricardas Radisauskas, Gailute Bernotiene, Dalia Luksiene, Mindaugas Kavaliauskas, Irena Milvidaitė, Dalia Virviciute
BACKGROUND: This study aimed to assess the trends in the prevalence of electrocardiographic (ECG) abnormalities from 1986 to 2015 and impact of ECG abnormalities on risk of death from cardiovascular diseases (CVD) in the Lithuanian population aged 40-64 years. METHODS: Data from four surveys carried out in Kaunas city and five randomly selected municipalities of Lithuania were analysed. A resting ECG was recorded and CVD risk factors were measured in each survey...
January 30, 2019: BMC Cardiovascular Disorders
Xiaoxia Li, Hong Xiao, Chaowen Lin, Weitong Sun, Teng Wu, Jin Wang, Bin Chen, Xia Chen, Du Cheng
Background: Atherosclerosis is a major cardiovascular disease that causes ischemia of the heart, brain, or extremities, and can lead to infarction. The hypolipidemic agent atorvastatin calcium (Ato) alleviates atherosclerosis by reducing plasma lipid and inflammatory factors. However, the low bioavailability of Ato limits its widespread use and clinical effectiveness. Curcumin (Cur), a natural polyphenol with antioxidation and anti-inflammation bioactivities, has potential anti-atherosclerosis activity and may reduce Ato-induced cytotoxicity...
2019: International Journal of Nanomedicine
Sami Viskin, Ehud Chorin, Dana Viskin, Aviram Hochstadt, Amir Halkin, Oholi Tovia-Brodie, John K Lee, Elad Asher, Avishag Laish-Farkash, Guy Amit, Ofer Havakuk, Bernard Belhassen, Raphael Rosso
BACKGROUND: Polymorphic ventricular tachycardia (VT) without QT prolongation is well described in patients without structural heart disease [mainly idiopathic ventricular fibrillation (VF) and Brugada syndrome] and in patients with acute ST-elevation myocardial infarction. METHODS: Retrospective study of patients with polymorphic VT related to coronary artery disease but without evidence of acute myocardial ischemia. RESULTS: We identified 43 patients who developed polymorphic VT within days of an otherwise uncomplicated myocardial infarction or coronary revascularization procedure...
January 30, 2019: Circulation
Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu, Feng Gao, Nali Zhu, Xiangju Yin, Qi Cheng, Pan Zhang, Wei Dai, Jinghai Chen, Fuquan Yang, Huang-Tian Yang, Andreas Linkermann, Wei Gu, Junxia Min, Fudi Wang
Heart disease is the leading cause of death worldwide. A key pathogenic factor in the development of lethal heart failure is loss of terminally differentiated cardiomyocytes. However, mechanisms of cardiomyocyte death remain unclear. Here, we discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubicin (DOX)- and ischemia/reperfusion (I/R)-induced cardiomyopathy. In canonical apoptosis and/or necroptosis-defective Ripk3 -/- , Mlkl -/- , or Fadd -/- Mlkl -/- mice, DOX-treated cardiomyocytes showed features of typical ferroptotic cell death...
January 28, 2019: Proceedings of the National Academy of Sciences of the United States of America
Elena Salmoirago-Blotcher, Kathleen M Hovey, Cristopher A Andrews, Matthew Allison, Robert L Brunner, Nathalie L Denburg, Charles Eaton, Lorena Garcia, Shawnita M Sealy-Jefferson, Oleg Zaslavsky, Joseph Kang, Lenny López, Stephen G Post, Hilary Tindle, Sylvia Wassertheil-Smoller
OBJECTIVE: Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS: We conducted a longitudinal analysis using data from the Women's Health Initiative Myocardial Ischemia and Migraine Study. Participants underwent 24-hour ambulatory ECG monitoring 3 years after enrollment...
January 24, 2019: Psychosomatic Medicine
Kohei Suzuki, Junkoh Yamamoto, Shingo Kakeda, Seishiro Takamatsu, Ryo Miyaoka, Takehiro Kitagawa, Takeshi Saito, Yoshiteru Nakano, Shigeru Nishizawa
Nilotinib, a second-generation tyrosine kinase inhibitor, is considered as one of the most effective drugs for the treatment of chronic myeloid leukemia (CML); however, the use of nilotinib has been reported to be associated with vascular adverse events, such as peripheral arterial occlusive disease and ischemic heart disease. Moreover, there are few reports on cerebral vascular disease associated with nilotinib use. We herein describe the case of a 55-year-old male patient with CML, who presented with cerebral infarction and severe cerebrovascular stenosis that developed during nilotinib treatment...
February 2019: Molecular and Clinical Oncology
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