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Nutrition and Diabetics

Emmelien E M Schillern, Andreas Pasch, Martin Feelisch, Femke Waanders, Steven H Hendriks, Rik Mencke, Geert Harms, Klaas H Groenier, Henk J G Bilo, Jan-Luuk Hillebrands, Harry van Goor, Peter R van Dijk
Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status. Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6...
June 2019: Journal of Clinical & Translational Endocrinology
Akio Kodama, Noriko Takahashi, Masayuki Sugimoto, Kiyoaki Niimi, Hiroshi Banno, Kimihiro Komori
OBJECTIVE: Open surgical repair (OSR) for abdominal aortic aneurysms is a more invasive approach than endovascular aneurysm repair but has more enduring results and may lead to a lower reintervention rate. Therefore, strict selection of patients should be based on assessments of both early and late outcomes. The controlling nutritional status (CONUT) score and skeletal muscle mass index (SMI) have been reported as indicators of nutritional status and muscle size, respectively. The aim of this study was to identify prognostic factors, including sarcopenia and nutritional status, for early and late outcomes...
March 19, 2019: Journal of Vascular Surgery
Junichi Ishigami, William V Padula, Morgan E Grams, Alexander R Chang, Bernard Jaar, Ron T Gansevoort, John F P Bridges, Csaba P Kovesdy, Shinichi Uchida, Josef Coresh, Kunihiro Matsushita
RATIONALE & OBJECTIVE: Pneumococcal vaccine is recommended for adults 65 years and older and those younger than 65 years with clinical indications (eg, diabetes, lung/heart disease, kidney failure, and nephrotic syndrome). Its cost-effectiveness in less severe chronic kidney disease (CKD) is uncharacterized. STUDY DESIGN: Cost-effectiveness analysis. SETTING & POPULATION: US adults aged 50 to 64 and 65 to 79 years stratified by CKD risk status: no CKD (estimated glomerular filtration rate≥60mL/min/1...
March 19, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Catherine R Knight-Agarwal, Rebecca Cubbage, Roslyn Sesleja, Madeleine Hinder, Rebecca Mete
BACKGROUND: The prevalence of high body mass index is increasing amongst women of child bearing age. High maternal body mass index has ramifications for both mother and baby including increased health risks from gestational diabetes mellitus, caesarean section and stillbirth. Despite the increasing prevalence of high maternal body mass index little is known of the experiences of these women regarding nutrition information access and use during the antenatal period. METHODS: A qualitative study using individual interviews was undertaken at a tertiary hospital in south-eastern Australia...
March 18, 2019: Women and Birth: Journal of the Australian College of Midwives
Elena Barengolts, Emily Daviau Smith, Sirimon Reutrakul, Livia Tonucci, Thunyarat Anothaisintawee
Probiotic yogurt is suggested as a nutritional approach in type 2 diabetes (T2D) and obesity. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the effects of probiotic yogurt on glycemic outcomes in T2D or obesity. The databases used to search for RCTs included Medline and Scopus. The RCTs were eligible if outcomes included selected glycemic markers. In nine eligible trials, 237 and 235 subjects were in treatment (probiotic yogurt) and control (mostly conventional yogurt) groups, respectively...
March 20, 2019: Nutrients
Dong Wang, Mohamad Hatahet, Yanning Wang, Hong Liang, Yvette Bazikian, Christopher L Bray
PURPOSE: Since the publication of the 2017 ACC/AHA hypertension guideline, few studies have analyzed the epidemiology and management of hypertension across many heterogeneous subgroups in the US. MATERIALS AND METHODS: We analyzed the data collected by the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. Participants greater than 20 years of age, who had valid blood pressure measurements, were included in the study. A comprehensive analysis of 14 population subgroups was done to systematically examine how hypertension awareness, treatment, and control varied by subpopulations...
March 21, 2019: Blood Pressure
Lynette J Oost, Monika Kustermann, Andrea Armani, Bert Blaauw, Vanina Romanello
BACKGROUND: Skeletal muscle is a plastic tissue that adapts to changes in exercise, nutrition, and stress by secreting myokines and myometabolites. These muscle-secreted factors have autocrine, paracrine, and endocrine effects, contributing to whole body homeostasis. Muscle dysfunction in aging sarcopenia, cancer cachexia, and diabetes is tightly correlated with the disruption of the physiological homeostasis at the whole body level. The expression levels of the myokine fibroblast growth factor 21 (FGF21) are very low in normal healthy muscles...
March 20, 2019: Journal of Cachexia, Sarcopenia and Muscle
Diego Haro, Pedro F Marrero, Joana Relat
The ability to detect changes in nutrient levels and generate an adequate response to these changes is essential for the proper functioning of living organisms. Adaptation to the high degree of variability in nutrient intake requires precise control of metabolic pathways. Mammals have developed different mechanisms to detect the abundance of nutrients such as sugars, lipids and amino acids and provide an integrated response. These mechanisms include the control of gene expression (from transcription to translation)...
March 19, 2019: International Journal of Molecular Sciences
Anna Shin, Seunghwan Shin, Ji Hyoun Kim, You-Jung Ha, Yun Jong Lee, Yeong Wook Song, Eun Ha Kang
OBJECTIVES: We examined the association between socioeconomic status (SES) and comorbidity distribution among patients with RA. METHODS: Information on comprehensive health status of 1088 RA patients (weighted n = 612 303) was obtained from the 2007-2015 Korea National Health and Nutrition Examination Survey database. SES components were household equivalence income, education and area of residence. To minimize confounding by age, patients were stratified by median age (63 years)...
March 19, 2019: Rheumatology
Eduardo Montero, David Herrera, Mariano Sanz, Sangeeta Dhir, Thomas Van Dyke, Corneliu Sima
AIM: To develop and validate a predictive model for moderate-to-severe periodontitis in the adult USA population, with data from the 2011-2012 National Health and Nutrition Examination Survey (NHANES) cycle. MATERIAL AND METHODS: A subset of 3017 subjects aged >30 years, with >14 teeth present and having received a periodontal examination in addition to data collected on cardio-metabolic risk measures (smoking habit, body mass index [BMI], blood pressure, total cholesterol and glycated haemoglobin [HbA1c]) were used for model development by multivariable logistic regression...
March 19, 2019: Journal of Clinical Periodontology
Koichi Morisaki, Tadashi Furuyama, Yutaka Matsubara, Kentaro Inoue, Shun Kurose, Shinichiro Yoshino, Ken Nakayama, Sho Yamashita, Keiji Yoshiya, Ryosuke Yoshiga, Yoshihiko Maehara
OBJECTIVES: CLI Frailty is a useful diagnostic criterion of frailty in patients with critical limb ischemia (CLI). It is important to evaluate not only comorbidities but also frailty in decision making to select the type of treatment for CLI patients. The purposes of our study were to externally validate the CLI Frailty Index and to evaluate the modified CLI Frailty Index by measurement of skeletal muscle mass using computed tomography. METHODS: Patients who underwent preoperative computed tomography examination and infrainguinal revascularization between 2002 and 2015 were retrospectively analyzed...
March 19, 2019: Vascular
Yujin Lee, Dariush Mozaffarian, Stephen Sy, Yue Huang, Junxiu Liu, Parke E Wilde, Shafika Abrahams-Gessel, Thiago de Souza Veiga Jardim, Thomas A Gaziano, Renata Micha
BACKGROUND: Economic incentives through health insurance may promote healthier behaviors. Little is known about health and economic impacts of incentivizing diet, a leading risk factor for diabetes and cardiovascular disease (CVD), through Medicare and Medicaid. METHODS AND FINDINGS: A validated microsimulation model (CVD-PREDICT) estimated CVD and diabetes cases prevented, quality-adjusted life years (QALYs), health-related costs (formal healthcare, informal healthcare, and lost-productivity costs), and incremental cost-effectiveness ratios (ICERs) of two policy scenarios for adults within Medicare and Medicaid, compared to a base case of no new intervention: (1) 30% subsidy on fruits and vegetables ("F&V incentive") and (2) 30% subsidy on broader healthful foods including F&V, whole grains, nuts/seeds, seafood, and plant oils ("healthy food incentive")...
March 2019: PLoS Medicine
Frédéric Bonté, Dorothée Girard, Jean-Christophe Archambault, Alexis Desmoulière
The skin provides the primary protection for the body against external injuries and is essential in the maintenance of general homeostasis. During ageing, resident cells become senescent and the extracellular matrix, mainly in the dermis, is progressively damaged affecting the normal organization of the skin and its capacity for repair. In parallel, extrinsic factors such as ultraviolet irradiation, pollution, and intrinsic factors such as diabetes or vascular disease can further accelerate this phenomenon...
2019: Sub-cellular Biochemistry
Masahiro Tsujiura, Naoki Hiki, Manabu Ohashi, Souya Nunobe, Koshi Kumagai, Satoshi Ida, Takuma Ohashi, Takeshi Sano, Toshiharu Yamaguchi
BACKGROUND: Pylorus-preserving gastrectomy is an alternative to distal gastrectomy for early gastric cancer, and is expected to have postoperative advantages including maintenance of body weight. Overweight/obesity is a risk factor for chronic disorders, including hypertension and diabetes mellitus; in these conditions, body weight control is frequently required as part of treatment. It remains unknown whether pylorus-preserving gastrectomy should be performed in overweight/obese patients because excess body weight may be maintained postoperatively...
March 19, 2019: Gastric Cancer
Miet Schetz, Audrey De Jong, Adam M Deane, Wilfried Druml, Pleun Hemelaar, Paolo Pelosi, Peter Pickkers, Annika Reintam-Blaser, Jason Roberts, Yasser Sakr, Samir Jaber
The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue has a deleterious adipocyte secretory profile resulting in insulin resistance and a chronic low-grade inflammatory and procoagulant state. Obesity is strongly linked with chronic diseases such as type 2 diabetes, hypertension, cardiovascular diseases, dyslipidemia, non-alcoholic fatty liver disease, chronic kidney disease, obstructive sleep apnea and hypoventilation syndrome, mood disorders and physical disabilities...
March 19, 2019: Intensive Care Medicine
Edna S Costa, Carolina N França, Francisco A H Fonseca, Juliana T Kato, Henrique T Bianco, Thiago T Freitas, Henrique A R Fonseca, Antonio Martins Figueiredo Neto, Maria Cristina Izar
Diabetes mellitus is a global epidemic, characterized as a heterogeneous group of metabolic disorders associated with high risk of cardiovascular disease. Green banana biomass, which is composed of resistant starches (RS) and cannot be hydrolysed by amylases, delays gastric emptying and modulates insulin sensitivity thus contributing to improve metabolic disorders. The aim of this study was to investigate the effects of consumption of RS from green banana biomass on body composition, fasting plasma glucose, HbA1c, and HOMA-IR in subjects with pre-diabetes or type 2 diabetes on top of treatment...
March 19, 2019: British Journal of Nutrition
Moshe Ashkenazi, N Nathan, I Sarouk, B E Bar Aluma, A Dagan, Y Bezalel, S Keler, D Vilozni, O Efrati
INTRODUCTION: There is a strong association between cystic fibrosis and malnutrition, mainly because of the higher energy needs combined with lower intake. There is also a well-established correlation between good nutritional status and better lung function. To date, however, there are no studies examining nutritional status in childhood and adult lung function. To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population...
March 18, 2019: Lung
Iryna Liauchonak, Bessi Qorri, Fady Dawoud, Yatin Riat, Myron R Szewczuk
Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily caloric intake, lose weight, and sustain a healthy diet. There are insufficient scientific data that support the safety of consuming NNS. However, recent studies have suggested that NNS consumption can induce gut microbiota dysbiosis and promote glucose intolerance in healthy individuals that may result in the development of type 2 diabetes mellitus (T2DM). This sequence of events may result in changes in the gut microbiota composition through microRNA (miRNA)-mediated changes...
March 16, 2019: Nutrients
Clara G Zundel, Maxine H Krengel, Timothy Heeren, Megan K Yee, Claudia M Grasso, Patricia A Janulewicz Lloyd, Steven S Coughlin, Kimberly Sullivan
Prevalence of nine chronic medical conditions in the population-based Ft. Devens Cohort (FDC) of GW veterans were compared with the population-based 2013⁻2014 National Health and Nutrition Examination Survey (NHANES) cohort. Excess prevalence was calculated as the difference in prevalence estimates from the Ft. Devens and NHANES cohorts; and confidence intervals and p -values are based on the standard errors for the two prevalence estimates. FDC males were at increased risk for reporting seven chronic medical conditions compared with NHANES males...
March 16, 2019: International Journal of Environmental Research and Public Health
Karaponi A M Okesene-Gafa, Minglan Li, Christopher J D Mckinlay, Rennae S Taylor, Elaine C Rush, Clare R Wall, Jess Wilson, Rinki Murphy, Rachael Taylor, John M D Thompson, Caroline A Crowther, Lesley M E Mccowan
BACKGROUND: Pregnancy interventions that improve maternal and infant outcomes are urgently needed in populations with high rates of obesity. We undertook the Healthy Mums and Babies (HUMBA) randomized controlled trial to assess the effect of dietary interventions and or probiotics in a multiethnic population of pregnant women with obesity, living in an area of high deprivation. OBJECTIVES: To determine whether a culturally-tailored dietary intervention and or daily probiotic capsules in pregnant women with obesity reduces the co-primary outcomes of a) excessive gestational weight-gain (mean >0...
March 13, 2019: American Journal of Obstetrics and Gynecology
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