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https://read.qxmd.com/read/30723707/tumor-tissue-explant-culture-of-patient-derived-xenograft-as-potential-prioritization-tool-for-targeted-therapy
#1
Susmita Ghosh, Manu Prasad, Kiran Kundu, Limor Cohen, Ksenia M Yegodayev, Jonathan Zorea, Ben-Zion Joshua, Batel Lasry, Orr Dimitstein, Anat Bahat-Dinur, Aviram Mizrachi, Vladimir Lazar, Moshe Elkabets, Angel Porgador
Despite of remarkable progress made in the head and neck cancer (HNC) therapy, the survival rate of this metastatic disease remain low. Tailoring the appropriate therapy to patients is a major challenge and highlights the unmet need to have a good preclinical model that will predict clinical response. Hence, we developed an accurate and time efficient drug screening method of tumor ex vivo analysis (TEVA) system, which can predict patient-specific drug responses. In this study, we generated six patient derived xenografts (PDXs) which were utilized for TEVA...
2019: Frontiers in Oncology
https://read.qxmd.com/read/30719545/the-value-of-four-stage-vestibular-hydrops-grading-and-asymmetric-perilymphatic-enhancement-in-the-diagnosis-of-meni%C3%A3-re-s-disease-on-mri
#2
Anja Bernaerts, Robby Vanspauwen, Cathérine Blaivie, Joost van Dinther, Andrzej Zarowski, Floris L Wuyts, Stephanie Vanden Bossche, Erwin Offeciers, Jan W Casselman, Bert De Foer
PURPOSE: There is still a clinical-radiologic discrepancy in patients with Menière's disease (MD). Therefore, the purpose of this study was to investigate the reliability of current MRI endolymphatic hydrops (EH) criteria according to Baráth in a larger study population and the clinical utility of new imaging signs such as a supplementary fourth low-grade vestibular EH and the degree of perilymphatic enhancement (PE) in patients with Menière's disease (MD). METHODS: This retrospective study included 148 patients with probable or definite MD according to the 2015 American Academy of Otolaryngology, Head and Neck Surgery criteria who underwent a 4-h delayed intravenous Gd-enhanced 3D-FLAIR MRI between January 2015 and December 2016...
February 5, 2019: Neuroradiology
https://read.qxmd.com/read/30710861/neck-posture-is-influenced-by-anticipation-of-stepping
#3
Jason L Baer, Anita Vasavada, Rajal G Cohen
BACKGROUND: Postural deviations such as forward head posture (FHP) are associated with adverse health effects. The causes of these deviations are poorly understood. We hypothesized that anticipating target-directed movement could cause the head to get "ahead of" the body, interfering with optimal head/neck posture, and that the effect may be exacerbated by task difficulty and/or poor inhibitory control. METHOD: We assessed posture in 45 healthy young adults standing quietly and when they anticipated walking to place a tray: in a simple condition and in conditions requiring that they bend low or balance an object on the tray...
January 30, 2019: Human Movement Science
https://read.qxmd.com/read/30694565/met-activation-confers-resistance-to-cetuximab-and-prevents-her2-and-her3-upregulation-in-head-and-neck-cancer
#4
Ofra Novoplansky, Matthew Fury, Manu Prasad, Ksenia Yegodayev, Jonathan Zorea, Limor Cohen, Raphael Pelossof, Liz Cohen, Nora Katabi, Fabiola Cecchi, Ben-Zion Joshua, Aron Popovtzer, Jose Baselga, Maurizio Scaltriti, Moshe Elkabets
An understanding of the mechanisms underlying acquired resistance to cetuximab is urgently needed to improve cetuximab efficacy in patients with head and neck squamous cell carcinoma (HNSCC). Here, we present a clinical observation that MET pathway activation constitutes the mechanism of acquired resistance to cetuximab in a patient with HNSCC. Specifically, RNA sequencing and mass spectrometry analysis of cetuximab-sensitive (CetuxSen ) and cetuximab-resistant (CetuxRes ) tumors indicated MET amplification and overexpression in the CetuxRes tumor compared to the CetuxSen lesion...
January 29, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30677426/the-ability-of-magnetic-resonance-black-blood-vessel-wall-imaging-to-evaluate-blunt-cerebrovascular-injury-following-acute-trauma
#5
Justin E Vranic, Thien J Huynh, Peter Fata, Jason Barber, Robert H Bonow, Michael R Levitt, Nancy Temkin, Ryan Morton, Cory Kelly, Dean K Shibata, Mahmud Mossa-Basha
BACKGROUND AND PURPOSE: Blunt cerebrovascular injury (BCVI) is associated with a significant risk of ischemic stroke when left untreated. Cross-sectional imaging is vital to early BCVI diagnosis and treatment; however, conventional luminal vessel imaging is limited in its ability to evaluate for vessel wall pathology. The purpose of this study is to evaluate the ability of vessel wall MRI (VWI) to detect and evaluate BCVI in acutely injured trauma patients relative to neck CTA. MATERIALS AND METHODS: Trauma patients with suspected BCVI on initial neck CTA were prospectively recruited for VWI evaluation...
January 21, 2019: Journal of Neuroradiology. Journal de Neuroradiologie
https://read.qxmd.com/read/30653508/use-and-timing-of-referral-to-specialized-palliative-care-services-for-people-with-cancer-a-mortality-follow-back-study-among-treating-physicians-in-belgium
#6
Gaëlle Vanbutsele, Luc Deliens, Veronique Cocquyt, Joachim Cohen, Koen Pardon, Kenneth Chambaere
BACKGROUND: Referral to specialized palliative care services (SPCS) occurs often late in the illness trajectory but may differ across cancer types. We examined differences between cancer types in the use and timing of referral to specialized palliative care services (SPCS) and in the reasons for non-referral. METHODS: We conducted a population-based mortality follow-back survey among physicians who certified a representative sample of deaths in Flanders, Belgium...
2019: PloS One
https://read.qxmd.com/read/30639032/the-reliability-of-a-garden-ao-and-simple-ii-stage-classifications-for-intracapsular-hip-fractures
#7
Povilas Masionis, Valentinas Uvarovas, Giedrius Mazarevičius, Kiril Popov, Šarūnas Venckus, Karolis Baužys, Narūnas Porvaneckas
INTRODUCTION: Successful treatment starts by accurate classification of pathology, but there is no conclusive, reliable and universally accepted method for classification of intracapsular femoral neck fractures. As a perfect classification should have high intra- and interobserver agreement, this study aims to access reliability of three classification systems: Garden, AO and simple II stage classification. MATERIALS AND METHODS: Four orthopaedic trauma surgeons (two of them professors) and two senior orthopaedic trauma residents were invited to evaluated 136 blinded anterior-posterior and lateral X-rays of patients with femoral neck fractures...
January 9, 2019: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/30632130/immunotherapeutic-approaches-to-the-management-of-head-and-neck-cancer
#8
Xinyu Nan, Kathryn A Gold, Ezra Cohen
The two programmed death 1 checkpoint inhibitors nivolumab and pembrolizumab are approved by the US Food and Drug Administration as second-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Based on the existing data, the effectiveness of these two drugs is similar in this setting. When choosing between them, the decision should be individualized and can be determined by patient and provider preferences, as well as scheduling. Testing for tumor programmed death ligand 1 (PD-L1) and human papillomavirus status is not required for use of these checkpoint inhibitors in the second-line setting, but the level of tumor PD-L1 expression can be useful for decision making in special situations...
December 17, 2018: Oncology (Williston Park, NY)
https://read.qxmd.com/read/30617729/feasibility-of-hyperfunctioning-parathyroid-gland-localization-using-18-f-fluciclovine-pet-ct
#9
Akinyemi A Akintayo, O A Abiodun-Ojo, C Weber, J Sharma, C Cohen, G Sica, R Halkar, M M Goodman, D M Schuster
PURPOSE: To evaluate the ability of anti-1-amino-3-anti-1-amino-3-[18 F]fluorocyclobutane-1-carboxylic acid ([18 F]fluciclovine) positron emission tomography/X-ray computed tomography (PET/CT) in comparison to Technetium-99m 2-methoxy isobutyl isonitrile ([99m Tc]sestamibi) single-photon emission computed tomography/CT (SPECT/CT) for the localization of hyperfunctioning parathyroid glands in patients with hyperparathyroidism. PROCEDURES: Four patients with hyperparathyroidism underwent 60-minutes sequential neck and thorax PET/CT after [18 F]fluciclovine (352 ± 28 MBq) injection...
January 7, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30588636/the-medial-sural-artery-perforator-flap-a-better-option-in-complex-head-and-neck-reconstruction
#10
Zahrah M Taufique, David A Daar, Leslie E Cohen, Vishal D Thanik, Jamie P Levine, Adam S Jacobson
OBJECTIVES: The medial sural artery perforator (MSAP) free flap is an uncommonly utilized soft tissue flap in head and neck reconstruction. It is a thin, pliable, fasciocutaneous flap that provides significant pedicle length. The donor site can be closed primarily, and its location is more aesthetically pleasing to patients. We aim to describe the MSAP flap and compare it to other commonly used free flaps in the head and neck. STUDY DESIGN: Retrospective case series...
December 26, 2018: Laryngoscope
https://read.qxmd.com/read/30566535/the-correlation-between-upper-extremity-musculoskeletal-symptoms-and-joint-kinematics-playing-habits-and-hand-span-during-playing-among-piano-students
#11
Yael Kaufman-Cohen, Sigal Portnoy, Ran Sopher, Lital Mashiach, Lilach Baruch-Halaf, Navah Z Ratzon
OBJECTIVE: We aimed to investigate the correlations between Upper Extremity Musculoskeletal Symptoms (MSD) and joint kinematics while playing the piano, as well as correlations between MSD and psychosocial, professional and personal habits, and bio-demographic risk factors of piano students. METHOD: This cross-sectional study included 15 piano students. The research tools included 3D motion capture, anthropometric measurements, and questionnaires for obtaining data about MSD, psychological, and personal factors...
2018: PloS One
https://read.qxmd.com/read/30534483/patient-satisfaction-after-aesthetic-chondrolaryngoplasty
#12
Michael B Cohen, Louis F Insalaco, Christopher R Tonn, Jeffrey H Spiegel
Background: Patient's pursuing aesthetic surgery often inquire about the success of the procedure. Having objective data for these patients improves preoperative counseling. To assess patient satisfaction after aesthetic chondrolaryngoplasty using specifically developed outcomes assessment instrument and to evaluate the anatomy of the vocalis insertion on the thyroid cartilage and its effect on the extent of surgical resection. Methods: Retrospective survey of patients who underwent chondrolaryngoplasty from 2006 to 2012...
October 2018: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/30531631/is-the-medial-sural-artery-perforator-flap-a-new-workhorse-flap-a-systematic-review-and-meta-analysis
#13
David A Daar, Salma A Abdou, Joshua M Cohen, Stelios C Wilson, Jamie P Levine
BACKGROUND: The medial sural artery perforator (MSAP) flap offers thin, pliable tissue with a relatively long pedicle and low donor site morbidity. This study explores the characteristics and uses of the MSAP flap as well as postoperative outcomes and complications. METHODS: A systematic literature review was performed using PubMed, Embase, and Cochrane CENTRAL to identify all cases of MSAP flap reconstruction. Descriptive and meta-analyses were performed on pooled outcomes...
November 26, 2018: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30530818/novel-prognostic-histopathological-grading-system-in-oral-squamous-cell-carcinoma-based-on-tumour-budding-and-cell-nest-size-shows-high-interobserver-and-intraobserver-concordance
#14
Melanie Boxberg, Christine Bollwein, Korinna Jöhrens, Peer-Hendrik Kuhn, Bernhard Haller, Katja Steiger, Klaus-Dietrich Wolff, Andreas Kolk, Moritz Jesinghaus, Wilko Weichert
AIMS: Squamous cell carcinoma of the oral cavity (OSCC) is a common tumour entity with a variable, partially highly aggressive clinical course. Recently, we proposed a novel (three-tiered) clinically useful grading scheme strongly associated with patient outcome in OSCC, consisting of a sum score of the histomorphological patterns tumour budding and cell nest size which outperforms WHO based grading algorithms currently in use. The aim of our study was to probe for interobserver and intraobserver reliability of this novel grading system...
December 8, 2018: Journal of Clinical Pathology
https://read.qxmd.com/read/30509740/pembrolizumab-versus-methotrexate-docetaxel-or-cetuximab-for-recurrent-or-metastatic-head-and-neck-squamous-cell-carcinoma-keynote-040-a-randomised-open-label-phase-3-study
#15
Ezra E W Cohen, Denis Soulières, Christophe Le Tourneau, José Dinis, Lisa Licitra, Myung-Ju Ahn, Ainara Soria, Jean-Pascal Machiels, Nicolas Mach, Ranee Mehra, Barbara Burtness, Pingye Zhang, Jonathan Cheng, Ramona F Swaby, Kevin J Harrington
BACKGROUND: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. METHODS: We did a randomised, open-label, phase 3 study at 97 medical centres in 20 countries...
November 30, 2018: Lancet
https://read.qxmd.com/read/30503213/anti-nkg2a-mab-is-a-checkpoint-inhibitor-that-promotes-anti-tumor-immunity-by-unleashing-both-t-and-nk-cells
#16
Pascale André, Caroline Denis, Caroline Soulas, Clarisse Bourbon-Caillet, Julie Lopez, Thomas Arnoux, Mathieu Bléry, Cécile Bonnafous, Laurent Gauthier, Ariane Morel, Benjamin Rossi, Romain Remark, Violette Breso, Elodie Bonnet, Guillaume Habif, Sophie Guia, Ana Ines Lalanne, Caroline Hoffmann, Olivier Lantz, Jérôme Fayette, Agnès Boyer-Chammard, Robert Zerbib, Pierre Dodion, Hormas Ghadially, Maria Jure-Kunkel, Yannis Morel, Ronald Herbst, Emilie Narni-Mancinelli, Roger B Cohen, Eric Vivier
Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor enhances tumor immunity by promoting both natural killer (NK) and CD8+ T cell effector functions in mice and humans. Monalizumab, a humanized anti-NKG2A antibody, enhanced NK cell activity against various tumor cells and rescued CD8+ T cell function in combination with PD-x axis blockade. Monalizumab also stimulated NK cell activity against antibody-coated target cells...
November 13, 2018: Cell
https://read.qxmd.com/read/30426267/exploratory-study-of-low-resolution-electromagnetic-tomography-loreta-real-time-z-score-feedback-in-the-treatment-of-pain-in-patients-with-head-and-neck-cancer
#17
S Prinsloo, D I Rosenthal, R Lyle, S M Garcia, S Gabel-Zepeda, R Cannon, E Bruera, L Cohen
Acute pain from mucositis in patients with head and neck cancer (HNC) undergoing radiation therapy (RT) is common, and may not respond well to narcotics. We used low resolution electromagnetic tomography z-score neurofeedback (LFBz) to investigate whether patients could modify brain wave activity associated with acute pain and whether this would reduce the experience of pain. HNC patients scheduled for RT had baseline pre-pain onset measures (EEG and numeric rating scale) collected before RT and then at pain onset before using analgesics, after each LFBz session and at the end of RT...
November 13, 2018: Brain Topography
https://read.qxmd.com/read/30397815/does-including-neck-cta-in-work-up-of-suspected-intracranial-hemorrhage-add-value
#18
William A Mehan, Christopher J Stapleton, Scott B Raymond
PURPOSE: Neck CT angiography (CTA) is frequently performed in conjunction with head CTA in patients presenting with clinical signs and symptoms concerning for acute intracranial hemorrhage, despite relatively low appropriateness (ACR Appropriateness Criteria 2-6). This decision is sometimes justified by suggesting that CTA neck findings are useful in planning subsequent catheter angiography. METHODS: We investigated the value of neck CTA in patients with suspected acute intracranial hemorrhage by reviewing 220 head and neck CTAs performed in our emergency room over a 24-month period for the indication of hemorrhage or headache...
November 5, 2018: Emergency Radiology
https://read.qxmd.com/read/30390197/discrimination-of-normal-oral-mucosa-from-oral-cancer-by-mass-spectrometry-imaging-of-proteins-and-lipids
#19
Katarzyna Bednarczyk, Marta Gawin, Mykola Chekan, Agata Kurczyk, Grzegorz Mrukwa, Monika Pietrowska, Joanna Polanska, Piotr Widlak
Identification of biomarkers for molecular classification of cancer and for differentiation between cancerous and normal epithelium remains a vital issue in the field of head and neck cancer. Here we aimed to compare the ability of proteome and lipidome components to discriminate oral cancer from normal mucosa. Tissue specimens including squamous cell cancer and normal epithelium were analyzed by MALDI mass spectrometry imaging. Two molecular domains of tissue components were imaged in serial sections-peptides (resulting from trypsin-processed proteins) and lipids (primarily zwitterionic phospholipids), then regions of interest corresponding to cancer and normal epithelium were compared...
November 3, 2018: Journal of Molecular Histology
https://read.qxmd.com/read/30389348/the-interrater-reliability-of-a-pain-mechanisms-based-classification-for-patients-with-nonspecific-neck-pain
#20
Vincent Dewitte, Robby De Pauw, Lieven Danneels, Katie Bouche, Arne Roets, Barbara Cagnie
OBJECTIVE: To examine the interrater reliability and agreement of a pain mechanisms-based classification for patients with nonspecific neck pain (NSNP). METHODS: Design - Observational, cross-sectional reliability study with a simultaneous examiner design. SETTING: University hospital-based outpatient physical therapy clinic. PARTICIPANTS: A random sample of 48 patients, aged between 18 and 75 years old, with a primary complaint of neck pain was included...
October 29, 2018: Brazilian Journal of Physical Therapy
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