Carmine Dario Vizza, Claudio Letizia, Roberto Badagliacca, Susanna Sciomer, Roberto Poscia, Giorgio Della Rocca, Carlo Iacoboni, De Luca Leonardo, Serena Quattrucci, Cotesta Dario, Petramala Luigi, Francesco Fedele
AIM: To study the role of endothelin (ET-1) and adrenomedullin (AM) on pulmonary vascular pressure/flow characteristic (pulmonary arterial pressure/cardiac output (Pap/CO)) during low-dose dobutamine infusion. METHODS: Case control study of 14 patients (12 men, 2 women) with severe lung disease (chronic obstructive pulmonary disease, COPD n=5; cystic fibrosis, CF n=9) and 5 control subjects (CTRL, 4 men, 1 woman). ET-1 and AM plasma levels in pulmonary artery (mixed venous blood, ven) and aorta or femoral artery (arterial, art), were measured at baseline and during dobutamine infusion (5-10-15 mcg kg(-1) min(-1))...
September 11, 2006: Regulatory Peptides