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Mustafa R Bashir, Tanya Wolfson, Anthony C Gamst, Kathryn J Fowler, Michael Ohliger, Shetal N Shah, Adina Alazraki, Andrew T Trout, Cynthia Behling, Daniela S Allende, Rohit Loomba, Arun Sanyal, Jeffrey Schwimmer, Joel E Lavine, Wei Shen, James Tonascia, Mark L Van Natta, Adrija Mamidipalli, Jonathan Hooker, Kris V Kowdley, Michael S Middleton, Claude B Sirlin
BACKGROUND: The liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates. PURPOSE: To identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD). STUDY TYPE: Retrospective analysis of prospectively acquired data. POPULATION: Baseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
David A Brenner
No abstract text is available yet for this article.
December 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Shima Kumei, Koh-Ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Yoshitaka Imamichi, Toshikatsu Okumura, Shuh Narumiya, Fumitaka Ushikubi
Nonalcoholic steatohepatitis (NASH) is a hepatic manifestation of metabolic syndrome. Although the prostaglandin (PG)I2 receptor IP is expressed broadly in the liver, the role of PGI2 -IP signaling in the development of NASH remains to be determined. Here, we investigated the role of the PGI2 -IP system in the development of steatohepatitis using mice lacking the PGI2 receptor IP [IP-knockout (IP-KO) mice] and beraprost (BPS), a specific IP agonist. IP-KO and wild-type (WT) mice were fed a methionine- and choline-deficient diet (MCDD) for 2, 5, or 10 wk...
May 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Priya Handa, Akhila L Vemulakonda, Bryan D Maliken, Vicki Morgan-Stevenson, James E Nelson, Barjinder K Dhillon, Kelly A Hennessey, Rohit Gupta, Matthew M Yeh, Kris V Kowdley
 Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic reticuloendothelial system (RES) iron deposition is associated with an advanced degree of nonalcoholic steatohepatitis (NASH) in humans. In this study, we aimed to determine differentially expressed genes related to iron overload, inflammation and oxidative stress pathways, with the goal of identifying factors associated with NASH progression. Seventy five patients with NAFLD were evaluated for their biochemical parameters and their liver tissue analyzed for NASH histological characteristics...
January 2017: Annals of Hepatology
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
Shu-lin Yang, Ji-han Xia, Yuan-yuan Zhang, Jian-gao Fan, Hua Wang, Jing Yuan, Zhan-zhao Zhao, Qin Pan, Yu-lian Mu, Lei-lei Xin, Yao-xing Chen, Kui Li
The minipig can serve as a good pharmacological model for human subjects. However, the long-term pathogenesis of high-calorie diet-induced metabolic syndromes, including NASH, has not been well described in minipigs. We examined the development of metabolic syndromes in Bama minipigs that were fed a high-fat, high-sucrose diet (HFHSD) for 23 months, by using histology and serum biochemistry and by profiling the gene expression patterns in the livers of HFHSD pigs compared to controls. The pathology findings revealed microvesicular steatosis, iron overload, arachidonic acid synthesis, lipid peroxidation, reduced antioxidant capacity, increased cellular damage, and inflammation in the liver...
2015: Scientific Reports
Toshifumi Hoki, Koji Miyanishi, Shingo Tanaka, Kohichi Takada, Yutaka Kawano, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
UNLABELLED: Increased hepatic iron accumulation is thought to be involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). Hepatic iron accumulation, as well as oxidative DNA damage, is significantly increased in NASH livers. However, the precise mechanism of iron accumulation in the NASH liver remains unclear. In this study, 40 cases with a diagnosis of NASH (n = 25) or simple steatosis (SS; n = 15) by liver biopsy were enrolled. An oral iron absorption test (OIAT) was used, in which 100 mg of sodium ferrous citrate was administered to each individual...
September 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Yoshio Sumida, Kazuyuki Kanemasa, Shunsuke Imai, Kojiro Mori, Saiyu Tanaka, Hideto Shimokobe, Yoko Kitamura, Kohei Fukumoto, Akira Kakutani, Tomoyuki Ohno, Hiroyoshi Taketani, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Akira Okajima, Kanji Yamaguchi, Michihisa Moriguchi, Hironori Mitsuyoshi, Kohichiroh Yasui, Masahito Minami, Yoshito Itoh
BACKGROUND: Clinical data regarding Helicobacter pylori (H. pylori) infection in nonalcoholic fatty liver disease (NAFLD) are limited. The aim was to evaluate H. pylori infection in patients with NAFLD and its association with disease severity. METHODS: One hundred and thirty patients with biopsy-proven NAFLD [43 with nonalcoholic fatty liver (NAFL) and 87 with nonalcoholic steatohepatitis (NASH)] were recruited for blood samples for anti-H. pylori immunoglobulin G (IgG) and standard biochemical tests were obtained after overnight fasting...
September 2015: Journal of Gastroenterology
Yvette Simon, Sonja M Kessler, Katja Gemperlein, Rainer M Bohle, Rolf Müller, Johannes Haybaeck, Alexandra K Kiemer
AIM: To characterize how insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IMP2-2 promotes steatohepatitis in the absence of dietary cholesterol. METHODS: Non-alcoholic steatohepatitis (NASH) was induced in wild-type mice and in mice overexpressing p62 specifically in the liver by feeding the mice a methionine and choline deficient (MCD) diet for either two or four weeks. As a control, animals were fed a methionine and choline supplemented diet. Serum triglycerides, cholesterol, glucose, aspartate aminotransferase and alanine transaminase were determined by standard analytical techniques...
December 21, 2014: World Journal of Gastroenterology: WJG
Sherie C Harding, Barbara P Nash, Erich U Petersen, A A Ekdale, Christopher D Bradbury, M Darby Dyar
The Main Glauconite Bed (MGB) is a pelleted greensand located at Stone City Bluff on the south bank of the Brazos River in Burleson County, Texas. It was deposited during the Middle Eocene regional transgression on the Texas Gulf Coastal Plain. Stratigraphically it lies in the upper Stone City Member, Crockett Formation, Claiborne Group. Its mineralogy and geochemistry were examined in detail, and verdine facies minerals, predominantly odinite, were identified. Few glauconitic minerals were found in the green pelleted sediments of the MGB...
2014: PloS One
Albert Tran, Philippe Gual
The hepatic complications of morbid obesity range from steatosis to steatohepatitis (Non-alcoholic steatohepatitis [NASH]), fibrosis, cirrhosis and finally hepatocellular carcinoma. The pathophysiological mechanisms of the progression of a normal liver to a liver showing steatosis and then steatohepatitis are complex, including, per se, insulin-resistance, iron accumulation, oxidative stress and hepatocyte death. An imbalance in anti- and pro-inflammatory factors may be the trigger. These factors can originate from intra- or extrahepatic sites, particularly the adipose tissue and the gut...
February 2013: Clinics and Research in Hepatology and Gastroenterology
Bryan D Maliken, James E Nelson, Heather M Klintworth, Mary Beauchamp, Matthew M Yeh, Kris V Kowdley
UNLABELLED: The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of oxidative stress (OS) and cell death in nonalcoholic fatty liver disease (NAFLD). Clinical, biochemical, metabolic, and independent histopathologic assessment was conducted in 83 unselected patients with biopsy-proven NAFLD from a single center. Apoptosis and necrosis in serum was quantified using serum cytokeratin 18 (CK18) M30 and M65 enzyme-linked immunosorbent assays and in liver by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining in situ...
May 2013: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Takahisa Kawaguchi, Yoshio Sumida, Atsushi Umemura, Keitaro Matsuo, Meiko Takahashi, Toshinari Takamura, Kohichiroh Yasui, Toshiji Saibara, Etsuko Hashimoto, Miwa Kawanaka, Sumio Watanabe, Sumio Kawata, Yasuharu Imai, Miki Kokubo, Toshihide Shima, Hyohun Park, Hideo Tanaka, Kazuo Tajima, Ryo Yamada, Fumihiko Matsuda, Takeshi Okanoue
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately 10-30% of NAFLD and causes a higher frequency of liver-related death, and its progression of NASH has been considered to be complex involving multiple genetic factors interacting with the environment and lifestyle...
2012: PloS One
James E Nelson, Elizabeth M Brunt, Kris V Kowdley
UNLABELLED: Hepcidin regulation is linked to both iron and inflammatory signals and may influence iron loading in nonalcoholic steatohepatitis (NASH). The aim of this study was to examine the relationships among HFE genotype, serum hepcidin level, hepatic iron deposition, and histology in nonalcoholic fatty liver disease (NAFLD). Single-nucleotide polymorphism genotyping for C282Y (rs1800562) and H63D (rs1799945) HFE mutations was performed in 786 adult subjects in the NASH Clinical Research Network (CRN)...
November 2012: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Julia O'Brien, Lawrie W Powell
Non-alcoholic fatty liver disease (NAFLD) is a common and ubiquitous disorder (Bedogni et al. in Hepatology 42:44-52, 2005; Bellentani et al. in Ann Intern Med 132:112-117, 2000) which in a proportion of subjects leads to non-alcoholic steatohepatitis (NASH), advanced liver disease and hepatocellular carcinoma. Although the factors responsible for progression of disease are still uncertain, there is evidence that insulin resistance (IR) is a key operative mechanism (Angulo et al. in Hepatology 30:1356-1362, 1999) and that two stages are involved...
January 2012: Hepatology International
Kris V Kowdley, Patricia Belt, Laura A Wilson, Matthew M Yeh, Brent A Neuschwander-Tetri, Naga Chalasani, Arun J Sanyal, James E Nelson
UNLABELLED: Serum ferritin (SF) levels are commonly elevated in patients with nonalcoholic fatty liver disease (NAFLD) because of systemic inflammation, increased iron stores, or both. The aim of this study was to examine the relationship between elevated SF and NAFLD severity. Demographic, clinical, histologic, laboratory, and anthropometric data were analyzed in 628 adult patients with NAFLD (age, ≥ 18 years) with biopsy-proven NAFLD and an SF measurement within 6 months of their liver biopsy...
January 2012: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Masahiro Okada, Takashi Katsube, Seishi Kumano, Yuki Kagawa, Tetsuro Araki, Natsuko Tsuda, Tomoyuki Okuaki, Izumi Imaoka, Noboru Tanigawa, Kazunari Ishii, Takamichi Murakami
BACKGROUND: Non-invasive MR imaging is expected to be used for accurate diagnosis and quantification of non-alcoholic steatohepatitis (NASH), because NASH is a progressive fatty liver disease. New MR techniques, such as fat fraction ratio (FFR) and T2* value measurement, have attracted an increasing attention, because those techniques can measure quantitative parameters of fibrosis, fat and iron deposition in the liver. PURPOSE: To investigate the potential of FFR and T2* value in NASH with pre-enhancement, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) or super-paramagnetic iron oxide (SPIO)-enhanced MRI...
July 1, 2011: Acta Radiologica
Brad Q Starley, Christopher J Calcagno, Stephen A Harrison
Hepatocellular carcinoma (HCC) is a common and deadly malignancy that is increasing in incidence in developed countries. The emergence of hepatitis C virus (HCV) accounts for about half of this increase in HCC, although the etiology of HCC in 15%-50% of new HCC cases remains unclear. The most common form of chronic liver disease in developed countries is nonalcoholic fatty liver disease (NAFLD), which encompasses a broad spectrum of histopathology. The prevalence of NAFLD, including the more aggressive nonalcoholic steatohepatitis (NASH), is increasing with the growing epidemics of diabetes and obesity...
May 2010: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
D G Tiniakos
Alcoholic liver disease and non-alcoholic liver disease share a similar histological spectrum that starts with 'simple' steatosis, and may be accompanied by inflammation. Alcoholic steatohepatitis and non-alcoholic steatohepatitis (NASH) are progressive forms of alcoholic liver disease and non-alcoholic liver disease, respectively, and can evolve into cirrhosis. The currently accepted minimum diagnostic criteria for steatohepatitis include steatosis, lobular inflammation and hepatocellular injury, but not fibrosis...
October 2009: Gastroentérologie Clinique et Biologique
Naoki Fujita, Hirohide Miyachi, Hideaki Tanaka, Masaki Takeo, Naoki Nakagawa, Yoshinao Kobayashi, Motoh Iwasa, Shozo Watanabe, Yoshiyuki Takei
Several lines of evidence have suggested that oxidative stress plays an important role for the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, by using immunohistochemical staining of liver biopsy samples, we measured hepatic 7,8-dihydro-8-oxo-2' deoxyguanosine (8-oxodG), a DNA base-modified product generated by hydroxyl radicals, of 38 NASH patients and compared with 24 simple steatosis and 10 healthy subjects. Relation of hepatic 8-oxodG with clinical, biochemical, and histologic variables and changes after iron reduction therapy (phlebotomy plus iron-restricted diet) were also examined...
February 2009: Cancer Epidemiology, Biomarkers & Prevention
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