keyword
https://read.qxmd.com/read/38402297/indoleamine-2-3-dioxygenase-1-mediated-iron-metabolism-in-macrophages-contributes-to-lipid-deposition-in-nonalcoholic-steatohepatitis
#1
JOURNAL ARTICLE
Chaofeng Wu, Junjie Li, Hui Jia, Jiamin Zhao, Mengchen Qin, Hao Shi, Chang Liu, Jiajie Lin, Min Cai, Yong Gu, Bin Liu, Lei Gao
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is a rapidly progressing chronic liver disease of global significance. However, the underlying mechanisms responsible for NASH remain unknown. Indoleamine 2,3-dioxygenase 1 (IDO1) has been recognized as essential factor in immune response and metabolic regulation. Here we aimed to investigate the functions and mechanisms of the IDO1 in macrophages on hepatic lipid deposition and iron metabolism in NASH. METHODS: The effect of IDO1 in NASH was evaluated by WT and IDO1-/- mice model fed with methionine/choline-deficient (MCD) diet in vivo...
February 24, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/37714372/depletion-of-igfbp7-alleviates-zebrafish-nafld-progression-through-inhibiting-hepatic-ferroptosis
#2
JOURNAL ARTICLE
Yanqin Wang, Jiaqi Bo, Zhonghua Zhao, Yuhang Han, Qianqian Zhang, Lixin Liu
AIMS: The global increased expression of Insulin-like growth factor binding protein 7 (IGFBP7) has been detected in non-alcoholic fatty liver disease (NAFLD) patients, however, its roles in NAFLD and the mechanism remain largely unclear. The goal of this study is to investigate the effect and mechanism of Igfbp7 using a zebrafish NAFLD model. MAIN METHODS: The igfbp7-/- null zebrafish mutant and the Igfbp7 liver overexpressed (LOE) transgenic zebrafish based on Gal4/UAS system were generated by CRISPR/Cas9 and Tol2 transgenic technique, respectively...
September 13, 2023: Life Sciences
https://read.qxmd.com/read/36185720/hereditary-hemochromatosis-temporal-trends-sociodemographic-characteristics-and-independent-risk-factor-of-hepatocellular-cancer-nationwide-population-based-study
#3
JOURNAL ARTICLE
Maryam Bilal Haider, Ali Al Sbihi, Ahmed Jamal Chaudhary, Syed M Haider, Ahmed Iqbal Edhi
BACKGROUND: Hereditary hemochromatosis (HH) has an increased risk of hepatocellular cancer (HCC) both due to genetic risks and iron overload as iron overload can be carcinogenic; HH impacts the increasing risk of HCC, not only through the development of cirrhosis but concerning hepatic iron deposition, which has been studied further recently. AIM: To evaluate HH yearly trends, patient demographics, symptoms, comorbidities, and hospital outcomes. The secondary aim sheds light on the risk of iron overload for developing HCC in HH patients, independent of liver cirrhosis complications...
September 27, 2022: World Journal of Hepatology
https://read.qxmd.com/read/35830923/increased-iron-uptake-in-the-bladder-wall-of-racemose-cysts-of-taenia-solium
#4
JOURNAL ARTICLE
Miguel A Orrego, Carlos M Vasquez, Kayla Togneri, Juan P Laclette, Hector H Garcia, Theodore E Nash
Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion and proliferation of the bladder wall of the Taenia solium cyst within the subarachnoid spaces of the human brain. The parasite develops and proliferates in a microenvironment with low concentrations of growth factors and micronutrients compared to serum. Iron is important for essential biological processes, but its requirement for racemose cyst viability and proliferation has not been studied. The presence of iron in the bladder wall of racemose and normal univesicular T...
July 10, 2022: Molecular and Biochemical Parasitology
https://read.qxmd.com/read/35795637/a-novel-non-invasive-approach-based-on-serum-ceruloplasmin-for-identifying-non-alcoholic-steatohepatitis-patients-in-the-non-diabetic-population
#5
JOURNAL ARTICLE
Qingling Wang, Da Zhou, Mingjie Wang, Mingyu Zhu, Peizhan Chen, Hu Li, Meng Lu, Xinxin Zhang, Xizhong Shen, Taotao Liu, Li Chen
Background and Aim: Few non-invasive models were established to identify patients with non-alcoholic steatohepatitis (NASH). Liver biopsy remains the gold standard in the clinic. Decreased serum ceruloplasmin (CP) is reported in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to develop a non-invasive model incorporating CP for identifying NASH from NAFLD without type 2 diabetes mellitus (T2DM). Methods: A total of 138 biopsy-proven patients with NAFLD without T2DM were enrolled...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35726536/ferroptosis-resistance-cooperates-with-cellular-senescence-in-the-overt-stage-of-nonalcoholic-fatty-liver-disease-nonalcoholic-steatohepatitis
#6
JOURNAL ARTICLE
Antonella Vetuschi, Alfredo Cappariello, Paolo Onori, Eugenio Gaudio, Giovanni Latella, Simona Pompili, Roberta Sferra
Cellular senescence and ferroptosis are the two main, fine-tuned processes in tissue damage restraint; however, they can be overactivated in pathologies such as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH), becoming dangerous stimuli. Senescence is characterized by a decline in cell division and an abnormal release of reactive oxygen species (ROS), and ferroptosis is represented by iron deposition associated with an excessive accumulation of ROS. ROS and cellular stress pathways are also drivers of NAFLD/NASH development...
June 21, 2022: European Journal of Histochemistry: EJH
https://read.qxmd.com/read/35563591/genetic-deficiency-of-indoleamine-2-3-dioxygenase-aggravates-vascular-but-not-liver-disease-in-a-nonalcoholic-steatohepatitis-and-atherosclerosis-comorbidity-model
#7
JOURNAL ARTICLE
Aastha Arora, Gustavo Luis Tripodi, Ilona Kareinen, Martin Berg, Maria Josefa Forteza, Anton Gisterå, Silke Griepke, Felipe Beccaria Casagrande, Joilson O Martins, Dulcineia Saes Parra Abdalla, Jennifer Cole, Claudia Monaco, Daniel F J Ketelhuth
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that increases cardiovascular disease risk. Indoleamine 2,3-dioxygenase-1 (IDO1)-mediated tryptophan (Trp) metabolism has been proposed to play an immunomodulatory role in several diseases. The potential of IDO1 to be a link between NASH and cardiovascular disease has never been investigated. Using Apoe-/- and Apoe-/- Ido1-/- mice that were fed a high-fat, high-cholesterol diet (HFCD) to simultaneously induce NASH and atherosclerosis, we found that Ido1 deficiency significantly accelerated atherosclerosis after 7 weeks...
May 6, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35317186/glycogen-hepatopathy-in-type-1-diabetes-mellitus-a-case-report
#8
Yuvaraj Singh, Susant Gurung, Maya Gogtay
BACKGROUND: It has been studied that fluctuating glucose levels may superimpose glycated hemoglobin in determining the risk for diabetes mellitus (DM) complications. While non-alcoholic steatohepatitis (NASH) remains a predominant cause of elevated transaminases in Type 2 DM due to a strong underplay of metabolic syndrome, Type 1 DM can contrastingly affect the liver in a direct, benign, and reversible manner, causing Glycogen hepatopathy (GH) - with a good prognosis. CASE SUMMARY: A 50-year-old female with history of poorly controlled type 1 DM, status post cholecystectomy several years ago, and obesity presented with nausea, vomiting, and abdominal pain...
February 27, 2022: World Journal of Hepatology
https://read.qxmd.com/read/32981113/digital-pathology-accurate-technique-for-quantitative-assessment-of-histological-features-in-metabolic-associated-fatty-liver-disease
#9
JOURNAL ARTICLE
David Marti-Aguado, Alejandro Rodríguez-Ortega, Claudia Mestre-Alagarda, Mónica Bauza, Elena Valero-Pérez, Clara Alfaro-Cervello, Salvador Benlloch, Judith Pérez-Rojas, Antonio Ferrández, Pilar Alemany-Monraval, Desamparados Escudero-García, Cristina Monton, Victoria Aguilera, Ángel Alberich-Bayarri, Miguel Ángel Serra, Luis Marti-Bonmati
BACKGROUND: Histological evaluation of metabolic-associated fatty liver disease (MAFLD) biopsies is subjective, descriptive and with interobserver variability. AIMS: To examine the relationship between different histological features (fibrosis, steatosis, inflammation and iron) measured with automated whole-slide quantitative digital pathology and corresponding semiquantitative scoring systems, and the distribution of digital pathology measurements across Fatty Liver Inhibition of Progression (FLIP) algorithm and Steatosis, Activity and Fibrosis (SAF) scoring system METHODS: We prospectively included 136 consecutive patients who underwent liver biopsy for MAFLD at three Spanish centres (January 2017-January 2020)...
January 2021: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/31193082/development-of-a-mouse-iron-overload-induced-liver-injury-model-and-evaluation-of-the-beneficial-effects-of-placenta-extract-on-iron-metabolism
#10
JOURNAL ARTICLE
Akihiro Yamauchi, Akiko Kamiyoshi, Takayuki Sakurai, Hiroyuki Miyazaki, Eiichi Hirano, Hong-Seok Lim, Taiichi Kaku, Takayuki Shindo
Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a mouse model of NASH with hepatic iron deposition by combining a methione- and choline-deficient (MCD) diet with an iron-overload diet. Using this model, we evaluated the effects of human placenta extract (HPE), which has been shown to ameliorate the pathology of NASH. Four-week-old male C57BL/6 mice were fed the MCD diet with 2% iron for 12 weeks...
May 2019: Heliyon
https://read.qxmd.com/read/30851216/evaluating-the-association-of-serum-ferritin-and-hepatic-iron-with-disease-severity-in-non-alcoholic-fatty-liver-disease
#11
MULTICENTER STUDY
Elena Buzzetti, Salvatore Petta, Roberta Manuguerra, Tu Vinh Luong, Daniela Cabibi, Elena Corradini, Antonio Craxì, Massimo Pinzani, Emmanuel Tsochatzis, Antonello Pietrangelo
BACKGROUND & AIMS: Hyperferritinemia, with or without increased hepatic iron, represents a common finding in non-alcoholic fatty liver disease (NAFLD). However, it is unclear whether it reflects hepatic inflammation or true iron-overload and, in case the latter is confirmed, whether this influences disease progression. We therefore explored the association between serum ferritin, degree and pattern of hepatic iron deposition and liver disease severity in patients with NAFLD. METHODS: We selected 468 patients with biopsy-proven NAFLD from 2 European centres...
July 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30835899/iron-alters-macrophage-polarization-status-and-leads-to-steatohepatitis-and-fibrogenesis
#12
JOURNAL ARTICLE
Priya Handa, Sunil Thomas, Vicki Morgan-Stevenson, Bryan D Maliken, Eric Gochanour, Sarag Boukhar, Matthew M Yeh, Kris V Kowdley
We have previously demonstrated that iron overload in hepatic reticuloendothelial system cells (RES) is associated with severe nonalcoholic steatohepatitis (NASH) and advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Recruited myeloid-derived macrophages have gained a pivotal position as drivers of NASH progression and fibrosis. In this study, we used bone marrow-derived macrophages (BMDM) from C57Bl6 mice as surrogates for recruited macrophages and examined the effect of iron on macrophage polarization...
May 2019: Journal of Leukocyte Biology
https://read.qxmd.com/read/30318834/hepatic-r2-is-more-strongly-associated-with-proton-density-fat-fraction-than-histologic-liver-iron-scores-in-patients-with-nonalcoholic-fatty-liver-disease
#13
JOURNAL ARTICLE
Mustafa R Bashir, Tanya Wolfson, Anthony C Gamst, Kathryn J Fowler, Michael Ohliger, Shetal N Shah, Adina Alazraki, Andrew T Trout, Cynthia Behling, Daniela S Allende, Rohit Loomba, Arun Sanyal, Jeffrey Schwimmer, Joel E Lavine, Wei Shen, James Tonascia, Mark L Van Natta, Adrija Mamidipalli, Jonathan Hooker, Kris V Kowdley, Michael S Middleton, Claude B Sirlin
BACKGROUND: The liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates. PURPOSE: To identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD). STUDY TYPE: Retrospective analysis of prospectively acquired data. POPULATION: Baseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/30033687/of-mice-and-men-and-nonalcoholic-steatohepatitis
#14
EDITORIAL
David A Brenner
No abstract text is available yet for this article.
December 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/29247122/prostaglandin-i-2-suppresses-the-development-of-diet-induced-nonalcoholic-steatohepatitis-in-mice
#15
JOURNAL ARTICLE
Shima Kumei, Koh-Ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Yoshitaka Imamichi, Toshikatsu Okumura, Shuh Narumiya, Fumitaka Ushikubi
Nonalcoholic steatohepatitis (NASH) is a hepatic manifestation of metabolic syndrome. Although the prostaglandin (PG)I2 receptor IP is expressed broadly in the liver, the role of PGI2 -IP signaling in the development of NASH remains to be determined. Here, we investigated the role of the PGI2 -IP system in the development of steatohepatitis using mice lacking the PGI2 receptor IP [IP-knockout (IP-KO) mice] and beraprost (BPS), a specific IP agonist. IP-KO and wild-type (WT) mice were fed a methionine- and choline-deficient diet (MCDD) for 2, 5, or 10 wk...
May 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/28051796/%C3%A2-differences-in-hepatic-expression-of-iron-inflammation-and-stress-related-genes-in-patients-with-nonalcoholic-steatohepatitis
#16
JOURNAL ARTICLE
Priya Handa, Akhila L Vemulakonda, Bryan D Maliken, Vicki Morgan-Stevenson, James E Nelson, Barjinder K Dhillon, Kelly A Hennessey, Rohit Gupta, Matthew M Yeh, Kris V Kowdley
 Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic reticuloendothelial system (RES) iron deposition is associated with an advanced degree of nonalcoholic steatohepatitis (NASH) in humans. In this study, we aimed to determine differentially expressed genes related to iron overload, inflammation and oxidative stress pathways, with the goal of identifying factors associated with NASH progression. Seventy five patients with NAFLD were evaluated for their biochemical parameters and their liver tissue analyzed for NASH histological characteristics...
January 2017: Annals of Hepatology
https://read.qxmd.com/read/27937040/multiparametric-or-practical-quantitative-liver-mri-towards-millisecond-fat-fraction-kilopascal-and-function-era
#17
REVIEW
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
https://read.qxmd.com/read/26358367/hyperinsulinemia-shifted-energy-supply-from-glucose-to-ketone-bodies-in-early-nonalcoholic-steatohepatitis-from-high-fat-high-sucrose-diet-induced-bama-minipigs
#18
JOURNAL ARTICLE
Shu-lin Yang, Ji-han Xia, Yuan-yuan Zhang, Jian-gao Fan, Hua Wang, Jing Yuan, Zhan-zhao Zhao, Qin Pan, Yu-lian Mu, Lei-lei Xin, Yao-xing Chen, Kui Li
The minipig can serve as a good pharmacological model for human subjects. However, the long-term pathogenesis of high-calorie diet-induced metabolic syndromes, including NASH, has not been well described in minipigs. We examined the development of metabolic syndromes in Bama minipigs that were fed a high-fat, high-sucrose diet (HFHSD) for 23 months, by using histology and serum biochemistry and by profiling the gene expression patterns in the livers of HFHSD pigs compared to controls. The pathology findings revealed microvesicular steatosis, iron overload, arachidonic acid synthesis, lipid peroxidation, reduced antioxidant capacity, increased cellular damage, and inflammation in the liver...
2015: Scientific Reports
https://read.qxmd.com/read/25753988/increased-duodenal-iron-absorption-through-up-regulation-of-divalent-metal-transporter-1-from-enhancement-of-iron-regulatory-protein-1-activity-in-patients-with-nonalcoholic-steatohepatitis
#19
JOURNAL ARTICLE
Toshifumi Hoki, Koji Miyanishi, Shingo Tanaka, Kohichi Takada, Yutaka Kawano, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
UNLABELLED: Increased hepatic iron accumulation is thought to be involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). Hepatic iron accumulation, as well as oxidative DNA damage, is significantly increased in NASH livers. However, the precise mechanism of iron accumulation in the NASH liver remains unclear. In this study, 40 cases with a diagnosis of NASH (n = 25) or simple steatosis (SS; n = 15) by liver biopsy were enrolled. An oral iron absorption test (OIAT) was used, in which 100 mg of sodium ferrous citrate was administered to each individual...
September 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/25622927/helicobacter-pylori-infection-might-have-a-potential-role-in-hepatocyte-ballooning-in-nonalcoholic-fatty-liver-disease
#20
JOURNAL ARTICLE
Yoshio Sumida, Kazuyuki Kanemasa, Shunsuke Imai, Kojiro Mori, Saiyu Tanaka, Hideto Shimokobe, Yoko Kitamura, Kohei Fukumoto, Akira Kakutani, Tomoyuki Ohno, Hiroyoshi Taketani, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Akira Okajima, Kanji Yamaguchi, Michihisa Moriguchi, Hironori Mitsuyoshi, Kohichiroh Yasui, Masahito Minami, Yoshito Itoh
BACKGROUND: Clinical data regarding Helicobacter pylori (H. pylori) infection in nonalcoholic fatty liver disease (NAFLD) are limited. The aim was to evaluate H. pylori infection in patients with NAFLD and its association with disease severity. METHODS: One hundred and thirty patients with biopsy-proven NAFLD [43 with nonalcoholic fatty liver (NAFL) and 87 with nonalcoholic steatohepatitis (NASH)] were recruited for blood samples for anti-H. pylori immunoglobulin G (IgG) and standard biochemical tests were obtained after overnight fasting...
September 2015: Journal of Gastroenterology
keyword
keyword
158153
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.