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"Acute Coronary Syndrome" OR "ACS"

Klaus Orion, Jochen Mack, Gerd A Kullak-Ublick, Stefan Weiler
OBJECTIVE: Kounis syndrome (KS) is an acute coronary syndrome with coronary spasm, acute myocardial infarction and stent thrombosis that can be associated with a variety of drugs as an adverse drug reaction (ADR). To characterize this rare phenomenon, we analyzed all cases of KS in the WHO database for pharmacovigilance. MATERIALS AND METHODS: All cases of KS worldwide until December 31, 2017, were included and analyzed in terms of age, sex, country, year of ADR, seriousness, clinical outcome, suspected drugs, administration, reported reaction, and -MedDRA terms...
March 22, 2019: International Journal of Clinical Pharmacology and Therapeutics
Mohammad Alomari, Hunter Bratton, Ahmad Musmar, Laith A Al Momani, Mark Young
The P2Y12 inhibitor, ticagrelor, has been shown to prevent thrombotic events and hence, improve morbidity and mortality in patients with acute coronary syndrome following coronary artery stent placement. Despite many clinical benefits, ticagrelor has been associated with several adverse effects, including dyspnea, easy bruising, and gastrointestinal bleeding. We report the case of a 67-year-old patient with an acute coronary artery syndrome requiring percutaneous coronary artery intervention with stenting who developed ticagrelor-induced diarrhea...
January 12, 2019: Curēus
Ewelina A Dziedzic, Jakub S Gąsior, Mariusz Pawłowski, Beata Wodejko-Kucharska, Tomasz Saniewski, Anna Marcisz, Marek J Dąbrowski
Introduction: Ischaemic heart disease is the main cause of death in developed countries. There are many modifiable risk factors associated with coronary heart disease (CAD). A growing number of studies point to vitamin D deficiency as a risk factor for heart attacks and the conditions associated with cardiovascular disease. This study aimed to analyse the relationship between the level of 25-hydroxyvitamin D (25(OH)D) and the severity of coronary artery atherosclerosis and to study 25(OH)D levels in non-diabetic patients hospitalised due to acute coronary syndrome and those diagnosed with stable CAD...
March 2019: Archives of Medical Science: AMS
Ke Liang, Ning Ma, Shiguo Luo, Wentang Niu, Yong Wang, Peili Bu
BACKGROUND Our research was designed to investigate the relationship of spleen tyrosine kinase (Syk) and inflammatory factors with coronary heart disease (CHD) and the risk factors of CHD. MATERIAL AND METHODS In our study, 226 patients were enrolled, from October 2017 to March 2018. Clinical and biochemical data were collected. We collected samples of peripheral blood monocytes (PBMs) from the enrolled patients. The patients were divided in 4 groups: patients without coronary artery disease (control group), patients with stable angina pectoris (SAP group), patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS group), and patients with ST-segment elevation acute myocardial infarction group (STEMI group)...
March 22, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
J Wouter Jukema, Michael Szarek, Laurien E Zijlstra, H Asita de Silva, Deepak L Bhatt, Vera A Bittner, Rafael Diaz, Jay M Edelberg, Shaun G Goodman, Corinne Hanotin, Robert A Harrington, Yuri Karpov, Angèle Moryusef, Robert Pordy, Juan C Prieto, Matthew T Roe, Harvey D White, Andreas M Zeiher, Gregory G Schwartz, Ph Gabriel Steg
BACKGROUND: Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACE) and death. The impact of lipid-lowering by proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition in such patients is undetermined. OBJECTIVES: This pre-specified analysis from ODYSSEY OUTCOMES determined whether polyvascular disease (polyVD) influenced risks of MACE and death and their modification by alirocumab in patients with recent ACS and dyslipidemia despite intensive statin therapy...
March 12, 2019: Journal of the American College of Cardiology
Naofumi Amioka, Toru Miyoshi, Hiroaki Otsuka, Daisuke Yamada, Atsushi Takaishi, Masayuki Ueeda, Satoshi Hirohata, Hiroshi Ito
BACKGROUND: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a predictive marker of cardiovascular events in patients with stable angina pectoris. However, little is known about this marker in patients with acute coronary syndrome (ACS). We investigated the prognostic relevance of MDA-LDL to cardiovascular outcomes in patients with ACS. METHODS: A total of 370 consecutive patients with ACS who underwent primary percutaneous coronary intervention (PCI) were enrolled from October 2009 to September 2014 at Mitoyo General Hospital...
March 18, 2019: Journal of Cardiology
Hironori Homma, Yukitoshi Niiyama, Hajime Sonoda, Nobuaki Himuro, Michiaki Yamakage
OBJECTIVE: For patients with acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) within 120 minutes from onset is recommended. A helicopter emergency medical service (HEMS) is useful for transporting ACS patients. The purposes of this study were to investigate whether patients with ACS in the eastern part of Hokkaido could be transported to a PCI hospital by HEMS and undergo PCI within 120 minutes and to clarify the factors most related to delayed access to PCI. METHODS: This was a retrospective cohort study that analyzed 513 patients diagnosed with ACS at our institution, an HEMS base/PCI hospital...
March 2019: Air Medical Journal
Andrew Stowell, Xavier Bobbia, Julien Cheret, Romain Genre Grandpierre, Alexandre Moreau, Stéphane Pommet, Jean-Yves Lefrant, Jean Emmanuel de La Coussaye, Thibaut Markarian, Pierre-Géraud Claret
OBJECTIVE: Minimizing out-of-hospital time reduces morbidity and mortality in patients with severe trauma, acute coronary syndrome, or acute stroke. Our objective was to compare out-of-hospital times by helicopter versus ground services when the estimated time of arrival on the scene was over 20 minutes. METHODS: We proposed a retrospective observational monocentric study following 2 cohorts. The helicopter group and the ground group included patients with severe trauma, acute coronary syndrome, or acute stroke transported by helicopter or ground services...
March 2019: Air Medical Journal
Lloyd W Klein, Tanveer Rab, H Vernon Anderson, Amir Lotfi, Alexander G Truesdell, Peter L Duffy, Frederick Welt, Roxana Mehran, Neal S Kleiman
The responsibilities of the interventional cardiologist (IC) have evolved in contemporary practice to include substantial acute care clinical duties outside of the cardiac catheterization laboratory. In particular, the IC has assumed a central role in the global management of myocardial infarction and other acute coronary syndromes in the intensive care unit and beyond. These duties have expanded to include many nonprocedural tasks. The Interventional Section Leadership Council (ISLC) of the American College of Cardiology (ACC) therefore recommends: 1) these implications should be directly considered in the ACC's future planning and policy statements concerning manpower, competence, education, and reimbursement; 2) the development of an acute care cardiology subspecialty should be undertaken; 3) steps should be taken to adjust the number of ICs primarily on the basis of optimizing procedural volume and quality; and 4) the annual number of coronary interventions performed should not solely define competence in the future, but should include the performance of acute cardiology responsibilities...
March 25, 2019: JACC. Cardiovascular Interventions
Fernando Alfonso, Fernando Rivero
No abstract text is available yet for this article.
March 25, 2019: JACC. Cardiovascular Interventions
Tomoyo Sugiyama, Erika Yamamoto, Francesco Fracassi, Hang Lee, Taishi Yonetsu, Tsunekazu Kakuta, Tsunenari Soeda, Yoshihiko Saito, Bryan P Yan, Osamu Kurihara, Masamichi Takano, Giampaolo Niccoli, Filippo Crea, Takumi Higuma, Shigeki Kimura, Yoshiyasu Minami, Junya Ako, Tom Adriaenssens, Niklas F Boeder, Holger M Nef, James G Fujimoto, Valentin Fuster, Aloke V Finn, Erling Falk, Ik-Kyung Jang
OBJECTIVES: This study conducted detailed analysis of calcified culprit plaques in patients with acute coronary syndromes (ACS). BACKGROUND: Calcified plaques as an underlying pathology in patients with ACS have not been systematically studied. METHODS: From 1,241 patients presenting with ACS who had undergone pre-intervention optical coherence tomography imaging, 157 (12.7%) patients were found to have a calcified plaque at the culprit lesion...
March 25, 2019: JACC. Cardiovascular Interventions
Marloe Prince, Jose D Tafur, Christopher J White
Atherosclerotic renal artery stenosis is the leading cause of secondary hypertension and may lead to resistant (refractory) hypertension, progressive decline in renal function, and cardiac destabilization syndromes (pulmonary edema, recurrent heart failure, or acute coronary syndromes) despite guideline-directed medical therapy. Although randomized controlled trials comparing medical therapy with medical therapy and renal artery stenting have failed to show a benefit for renal artery stenting, according to comparative effectiveness reviews by the Agency for Healthcare Research and Quality, the trials may not have enrolled patients with the most severe atherosclerotic renal artery stenosis, who would be more likely to benefit from renal stenting...
March 25, 2019: JACC. Cardiovascular Interventions
Karim Abdur Rehman, Oussama M Wazni, Amr F Barakat, Walid I Saliba, Shailee Shah, Khaldoun G Tarakji, John Rickard, Mohamed Bassiouny, Bryan Baranowski, Patrick J Tchou, Mandeep Bhargava, Thomas J Dresing, Thomas D Callahan, Daniel J Cantillon, Mina Chung, Mohamed Kanj, Samuel Irefin, Bruce Lindsay, Ayman A Hussein
OBJECTIVES: This study sought to assess the incidence and outcomes of life-threatening complications from atrial fibrillation ablations in a high volume center. BACKGROUND: With increasing rates of atrial fibrillation ablation procedures, an increase in life-threatening procedure-related complications has been reported despite improvements in technology and ablation strategies. METHODS: Between 2000 and 2015, 10,378 patients underwent atrial fibrillation ablation at our institution and were enrolled in a prospectively maintained data registry...
March 2019: JACC. Clinical Electrophysiology
Kun Xia, Le-Feng Wang, Xin-Chun Yang, Hong-Yan Jiang, Li-Jing Zhang, Dao-Kuo Yao, Da-Yi Hu, Rong-Jing Ding
BACKGROUND: Depression and anxiety have been correlated with elevated risks for quality-of-life (QOL), adverse outcomes and medical expenditure in patients with acute coronary syndrome (ACS). However, the relevant data are lacking for Chinese ACS populations, especially regarding different effects of major depression, anxiety and comorbidity. The objective of this study was to evaluate the dynamic changes of depression and/or anxiety over 12 months and examine the effects of depression, anxiety and comorbidity on QOL, adverse outcomes and medical expenditure in Chinese ACS patients...
March 19, 2019: Chinese Medical Journal
Riyaz Patel, Vinicius Tragante, Amand F Schmidt, Raymond O McCubrey, Michael V Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S Virani, Karol A Kaminski, Jochen D Muehlschlegel, Hooman Allayee, Peter Almgren, Maris Alver, Ekaterina V Baranova, Hassan Behlouli, Bram Boeckx, Peter S Braund, Lutz P Breitling, Graciela Delgado, Nubia E Duarte, Marie-Pierre Dubé, Line Dufresne, Niclas Eriksson, Luisa Foco, Markus Scholz, Crystel M Gijsberts, Charlotte Glinge, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Jaroslav A Hubacek, Marcus Kleber, Daniel Kofink, Salma Kotti, Pekka Kuukasjärvi, Vei-Vei Lee, Andreas Leiherer, Petra A Lenzini, Daniel Levin, Leo-Pekka Lyytikäinen, Nicola Martinelli, Ute Mons, Christopher P Nelson, Kjell Nikus, Anna P Pilbrow, Rafal Ploski, Yan V Sun, Michael W T Tanck, W H Wilson Tang, Stella Trompet, Sander W van der Laan, Jessica Van Setten, Ragnar O Vilmundarson, Chiara Viviani Anselmi, Efthymia Vlachopoulou, Lawien Al Ali, Eric Boerwinkle, Carlo Briguori, John F Carlquist, Kathryn F Carruthers, Gavino Casu, John Deanfield, Panos Deloukas, Frank Dudbridge, Thomas Engström, Natalie Fitzpatrick, Kim Fox, Bruna Gigante, Stefan James, Marja-Liisa Lokki, Paulo A Lotufo, Nicola Marziliano, Ify R Mordi, Joseph B Muhlestein, Christopher Newton-Cheh, Jan Pitha, Christoph H Saely, Ayman Samman-Tahhan, Pratik B Sandesara, Andrej Teren, Adam Timmis, Frans Van de Werf, Els Wauters, Arthur A M Wilde, Ian Ford, David J Stott, Ale Algra, Maria G Andreassi, Diego Ardissino, Benoit J Arsenault, Christie M Ballantyne, Thomas O Bergmeijer, Connie R Bezzina, Simon C Body, Eric H Boersma, Peter Bogaty, Michiel Bots, Hermann Brenner, Jasper J Brugts, Ralph Burkhardt, Clara Carpeggiani, Gianluigi Condorelli, Rhonda M Cooper-DeHoff, Sharon Cresci, Nicolas Danchin, Ulf de Faire, Robert N Doughty, Heinz Drexel, James C Engert, Keith A A Fox, Domenico Girelli, Diederick E Grobbee, Emil Hagström, Stanley L Hazen, Claes Held, Harry Hemingway, Imo E Hoefer, G Kees Hovingh, Reza Jabbari, Julie A Johnson, J Wouter Jukema, Marcin P Kaczor, Mika Kähönen, Jiri Kettner, Marek Kiliszek, Olaf H Klungel, Bo Lagerqvist, Diether Lambrechts, Jari O Laurikka, Terho Lehtimäki, Daniel Lindholm, B K Mahmoodi, Anke H Maitland-van der Zee, Ruth McPherson, Olle Melander, Andres Metspalu, Anna Niemcunowicz-Janica, Oliviero Olivieri, Grzegorz Opolski, Colin N Palmer, Gerard Pasterkamp, Carl J Pepine, Alexandre C Pereira, Louise Pilote, Arshed A Quyyumi, A Mark Richards, Marek Sanak, Agneta Siegbahn, Tabassome Simon, Juha Sinisalo, J Gustav Smith, John A Spertus, Steen Stender, Alexandre F R Stewart, Wojciech Szczeklik, Anna Szpakowicz, Jean-Claude Tardif, Jurriën M Ten Berg, Jacob Tfelt-Hansen, George Thanassoulis, Joachim Thiery, Christian Torp-Pedersen, Yolanda van der Graaf, Frank L J Visseren, Johannes Waltenberger, Peter E Weeke, Pim Van der Harst, Chim C Lang, Naveed Sattar, Vicky A Cameron, Jeffrey L Anderson, James M Brophy, Guillaume Paré, Benjamin D Horne, Winfried März, Lars Wallentin, Nilesh J Samani, Aroon D Hingorani, Folkert W Asselbergs
BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events...
March 21, 2019: Circulation. Genomic and Precision Medicine
Lorenzo Genuardi, Francesco Burzotta, Giulio Russo, Osama Shoeib, Diana Verdirosi, Cristina Aurigemma, Giampaolo Niccoli, Italo Porto, Antonio M Leone, Carlo Trani
BACKGROUND: Long drug-eluting stents may limit the need of stent overlaps in patients with diffusely diseased coronary arteries. We evaluated the clinical results of percutaneous-coronary- intervention (PCI) using a novel ultra-long (48 mm) everolimus-eluting stent (EES) in a real- word population. METHODS: Patients who underwent PCI with 48 mm EES between June 2015 and April 2017 in our centre were enrolled. The only exclusion criteria was cardiogenic shock established before PCI...
March 19, 2019: Minerva Cardioangiologica
Matteo Bianco, Carol Gravinese, Enrico Cerrato, Iván Nuñez-Gil, Paola Destefanis, Alessia Luciano, Simone Biscaglia, Giorgio Quadri, Emanuele Tizzani, Antonella Corleto, Sara Giolitto, Luca Lo Savio, Gianluca Campo, Ferdinando Varbella, Roberto Pozzi
BACKGROUND: The optimal management of patients with aspirin intolerance undergoing stent implantation represents a challenge for physicians. The aim of this study was to assess the overall number of patients discharged with mono anti-platelet therapy after PCI, the most frequent aspirin intolerance symptoms in this population and the overall incidence of patient oriented composite end-points (POCE). METHODS: From January 2006 to June 2016 all patients discharged with mono-antiplatelet therapy because of aspirin intolerance/hypersensitivity/allergy and treated by means of PCI were included...
March 18, 2019: Minerva Cardioangiologica
Walter J Janse van Rensburg
BACKGROUND: Von Willebrand factor (VWF) has a central role in primary haemostasis and is a popular pharmaceutical target in the prevention and treatment of disorders such as acute coronary syndrome and thrombotic thrombocytopenic purpura. We have evaluated numerous possible treatments targeting VWF in the chacma baboon. Unfortunately, no data exist regarding the molecular similarity of the chacma baboon and human VWF protein, resulting in limited translatability of results. METHODS: Sanger sequencing was performed of the functionally vital VWF exon 28...
March 20, 2019: Journal of Medical Primatology
Vincenzo Russo, Anna Rago, Riccardo Proietti, Emilio Attena, Carmen Rainone, Mario Crisci, Andrea Antonio Papa, Paolo Calabrò, Antonio D'Onofrio, Paolo Golino, Gerardo Nigro
Background: Combination of dual antiplatelet (DAPT) and oral anticoagulation therapy is required to decrease cardioembolic stroke and stent thrombosis risk in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS). We compared the safety and efficacy of dabigatran etexilate with vitamin K antagonist (VKA), in combination with DAPT (aspirin plus clopidogrel) treatment in AF patients who underwent percutaneous coronary intervention (PCI) with stenting for ACS. Methods: Consecutive nonvalvular AF patients who received twice-daily dabigatran 110 mg (n = 389) or VKA (n = 510) and DAPT were included...
2019: BioMed Research International
Nathan D Wong, Michael D Shapiro
The recent development of monoclonal antibodies targeted to proprotein convertase subtilisin/kexin type 9 (PCSK9), e.g., PCSK9 inhibitors has revolutionized the landscape of lipid management. Many clinical trials assessing this class have demonstrated remarkable and consistent reductions in low-density lipoprotein-cholesterol. Moreover, the GLAGOV trial demonstrated the efficacy of evolocumab, when added to statin therapy, in reducing the progression of atherosclerosis measured by serial intravascular ultrasound, with the first suggestion of continued benefit down to LDL-C levels of 0...
2019: Frontiers in Cardiovascular Medicine
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