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"Anaphylaxis" OR "Anaphylactic Shock" OR "Severe Allergic Reaction"

Allan R Escher, Jonathan B Cohen
In this case report, we present a patient who developed anaphylaxis immediately after sugammadex administration. A 67-year-old female with the diagnosis of papillary serous carcinoma was scheduled for an exploratory laparotomy exam under anesthesia and total abdominal hysterectomy. At the end of the operation, sugammadex was administered; it was rapidly accompanied with marked hypotension and bradycardia. Multiple boluses of phenylephrine were administered with minimal effect. Boluses of epinephrine and vasopressin were given and the patient's hemodynamic instability rapidly abated...
January 12, 2019: Curēus
Athanasia Tourlaki, Francesca Germiniasi, Luisa Rossi, Stefano Veraldi, Lucia Brambilla
BACKGROUND: Paclitaxel has recently been approved for AIDS-related Kaposi's sarcoma (KS) and there is much interest also in HIV-negative KS. OBJECTIVE: To assess the safety and effectiveness of intravenous paclitaxel in the treatment of non-HIV associated KS. METHOD: A retrospective database analysis of our departmental database in histologically proven, HIV-negative KS. RESULTS: 58 patients treated with intravenous paclitaxel 100 mg weekly were identified...
March 21, 2019: Journal of Dermatological Treatment
Ana Teresa Fróis, Teresa Cardoso
INTRODUCTION: Anaphylaxis is significantly underdiagnosed, and the medical community's knowledge about it is precarious. The aim of this study is to characterize the patient population and the Emergency Department approach of anaphylaxis. MATERIAL AND METHODS: Retrospective study of adult patients attending the Emergency Department of a tertiary care Portuguese hospital, over a year, with anaphylaxis. Data were obtained from each patient's clinical records and anonymized...
February 28, 2019: Acta Médica Portuguesa
Aziza Saidova, Merima Bublin, Klara Schmidthaler, Veronika Fajgelj, Florian Klinglmueller, Andreas Spittler, Christine Hafner, Zsolt Szépfalusi, Heimo Breiteneder, Thomas Eiwegger
Peanut allergy is considered to be the most common cause for food-induced anaphylaxis. Currently, no approved treatment is available. Avoidance is the only measure to prevent anaphylactic reactions to peanuts. T-helper cells are of special importance for the sensitization process and the maintenance of allergic inflammation. Identifying markers of allergen-specific T-cell responses may help to develop novel treatment approaches. Therefore, we aimed to define new T-cell target genes in Ara h 2-specific T cells and to investigate the possibility of using them as biomarkers of peanut allergy in peripheral blood mononuclear cells (PBMCs)...
March 20, 2019: International Archives of Allergy and Immunology
Vinicius Aniceto, Marina M Dias, Janaina M L Melo, Orlando Trevisan-Neto, Davi C Aragon, Luana S M Maia, Adriana S Moreno, Luisa Karla Arruda
BACKGROUND: Anaphylaxis is a severe and potentially fatal allergic disease or hypersensitivity reaction with variable clinical presentation. Biomarkers in anaphylaxis could be useful to improve diagnosis, to allow endotyping of patients, and to predict risk. OBJECTIVE: To investigate the role of serum basal tryptase (sBT) levels in the management of patients with anaphylaxis. METHODS: Patients with at least 1 episode of anaphylaxis were selected among those who attended the Allergy Clinics of the Clinical Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, upon evaluation by allergy/immunology specialists of our medical staff...
March 20, 2019: International Archives of Allergy and Immunology
Julia Upton, Montserrat Alvaro, Kari Nadeau
The current edition of Allergy contains a report of 18 food allergy deaths from the French Anaphylaxis Vigilance Network (AVN) from 2002-20181 . The AVN maintains a database of food allergy related severe anaphylaxis formed of voluntary, structured reports of anonymous patients submitted by allergists. Therefore, no population estimates can be made, but important cases can be revealed. This article is protected by copyright. All rights reserved.
March 20, 2019: Allergy
Lydia Wong, Elizabeth Huiwen Tham, Bee Wah Lee
PURPOSE OF REVIEW: Shellfish is an important cause of food allergy worldwide, and a major cause of food-triggered anaphylaxis. Despite the wide variety of shellfish, there is considerable serological and clinical cross-reactivity of major shellfish allergens, and accurate diagnosis remains a challenge in the management of shellfish allergy. RECENT FINDINGS: Novel minor allergens have been discovered and characterized, and advances in component resolved diagnostics have provided insights into the prevalence of sensitization and their clinical importance in shellfish allergy...
March 18, 2019: Current Opinion in Allergy and Clinical Immunology
Ru-Xin Foong, Mattia Giovannini, George du Toit
PURPOSE OF REVIEW: The following article provides an overview of food-dependent exercise-induced anaphylaxis (FD-EIAn). The review focuses on the epidemiology, pathophysiology, and clinical findings of FD-EIAn and details current practice in terms of the investigation, management, and treatment options available. RECENT FINDINGS: The management of FD-EIAn has not changed significantly over the last few years and still requires careful investigation by an experienced clinician to ensure that the correct diagnosis is made and appropriate treatment is given...
March 18, 2019: Current Opinion in Allergy and Clinical Immunology
J Garland, W Philcox, S McCarthy, S Hensby-Bennet, B Ondruschka, L Woydt, U Da Broi, C Palmiere, L Lam, Y Ahn, K Kesha, S Stables, R Tse
Different sampling techniques can impact on post mortem tryptase levels. A previous study demonstrated significantly lower femoral post mortem total tryptase levels in samples collected via transcutaneous aspiration compared with directly sampling during internal examination. However, an outlier with high tryptase level was noted in one transcutaneous aspiration sample. This 6-month prospective study compared total post mortem tryptase levels between 21 paired aspirated venous and arterial femoral blood samples, and 19 paired aspirated and cutdown femoral venous blood samples in non-anaphylactic deaths only...
March 16, 2019: International Journal of Legal Medicine
Morten Schjørring Opstrup, Gregor Borut Ernst Jemec, Lene Heise Garvey
PURPOSE OF REVIEW: In recent years, the risk of allergy to chlorhexidine is increasingly recognised. In this review, we discuss why the allergy is so easily overlooked and point out several preventative initiatives that can minimise the risk of both chlorhexidine sensitisation and allergy development and accidental re-exposure in patients with chlorhexidine allergy. Testing for chlorhexidine allergy is also discussed. RECENT FINDINGS: Numerous reports have been published from many different specialties...
March 14, 2019: Current Allergy and Asthma Reports
Agnès Esiéné, Paul Owono Etoundi, Joel Noutakdie Tochie, Arlette Junette Mbengono Metogo, Jacqueline Ze Minkande
BACKGROUND: Snake envenomation is an underestimated pathology in sub-Saharan Africa associated with severe emergencies, and even death in case of late presentation. We herein present a case of severe envenomation managed at the surgical emergency department of the Yaoundé Central Hospital. CASE PRESENTATION: We report a case of a 47-year-old female farmer with no relevant past history who sustained a snakebite by an Echis occellatus viper during an agricultural activity...
March 12, 2019: BMC Emergency Medicine
Suhail Al-Salam, Elhadi H Aburawi, Suleiman Al-Hammadi, Sekhar Dhanasekaran, Mohamed Shafiuallah, Javed Yasin, Manjusha Sudhadevi, Aktham Awwad, Seth L Alper, Elsadig E Kazzam, Abdelouahab Bellou
Anaphylactic shock (AS) is a life-threatening, multisystem disorder arising from sudden release of mast cell- and basophil-derived mediators into the circulation. In this study, we have used a Wistar rat model to investigate AS-associated histopathologic changes in various organs. Rats were sensitized with ovalbumin (1 mg s.c), and AS was induced by intravenous injection of ovalbumin (1 mg). Experimental groups included nonallergic rats (n = 6) and allergic rats (n = 6). Heart rate and blood pressure were monitored during one hour...
March 13, 2019: Biomolecules
Paul H Sadleir, Peter R Platt
No abstract text is available yet for this article.
January 2019: Anaesthesia and Intensive Care
Brigid T Doolan, Helen M Crilly
We report three precautionary cases of perioperative anaphylaxis to chlorhexidine isopropyl alcohol antiseptic wipes (CAW). In two cases, the patients were inadvertently re-exposed to CAW despite known chlorhexidine hypersensitivity. Chlorhexidine has been described as 'the hidden allergen'. As a result, patients may suffer multiple reactions before chlorhexidine is confirmed as the cause. Healthcare workers may not recognize that products they use for common clinical steps contain chlorhexidine. These cases highlight the need for constant vigilance to facilitate the safe management of patients with a history of chlorhexidine anaphylaxis...
January 2019: Anaesthesia and Intensive Care
Peter A Baird, Chris J Cokis
We report a case series of anaphylaxis to chlorhexidine-coated central venous catheters (CVCs) when used in cardiac surgical patients in our institution. Our experience, together with increasing reports of anaphylaxis to chlorhexidine-coated CVCs from other sources indicates that chlorhexidine-coated CVCs are not without additional risk. Attempts to lower rates of catheter-related bloodstream infection has led to the widespread adoption of chlorhexidine-coated CVCs in the perioperative and critical care setting, including for routine cardiac surgery...
January 2019: Anaesthesia and Intensive Care
Marija Toleska, Biljana Kuzmanovska, Andrijan Kartalov, Mirjana Shosholcheva, Jasminka Nancheva, Aleksandar Dimitrovski, Natasha Toleska
Opioid free anesthesia (OFA) is deffined as anaesthesiological technique where opioids are not used in the intraoperative period (systemic, neuroaxial or intracavitary). Anaphylaxis caused by opioids (fentanyl) is very rare, and the reaction is presented with hypotension and urticaria. When we have proven allergy to fentanyl, patients' refusal of placing epidural catheter and refusal of receiving bilateral ultrasound guided transversus abdominis plane block (USG TAPB), we must think of using multimodal nonopioide analgesia...
December 1, 2018: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Francesca Losa, Margherita Deidda, Davide Firinu, Maria Luisa Di Martino, Maria Pina Barca, Stefano Del Giacco
BACKGROUND: The practice of Indian Ayurvedic medicine is spreading in Western countries and Shilajit is one of the most used drugs, for its antioxidant activities and immunomodulatory effects. Albeit Shilajit has showed a high degree of safety, it can act as cofactor of anaphylaxis, especially in condition at high risk, such as mast cell activation syndrome (MCAS). We reported this case to sensitize practitioners to investigate to the use of complementary and alternative medicine, in case of exercise-induced anaphylaxis (EIAn)...
March 6, 2019: World Journal of Clinical Cases
Douglas B Aidoo, David D Obiri, Newman Osafo, Aaron O Antwi, Leslie B Essel, Babatunde M Duduyemi, Martins Ekor
Bergapten (5-methoxypsoralen, 5-MOP) is a plant-derived furocoumarin with demonstrated anti-inflammatory action. The present study investigated its effects on allergic inflammation in two related pathways of mast cell degranulation. Compound 48/80 and lipopolysaccharide (LPS) were used to activate the IgE-independent pathway while bovine serum albumin (BSA) was used as allergen for the IgE-dependent pathway. The modulatory effect of bergapten on mast cell degranulation, neutrophil extravasation, protein concentration, lung histopathology, and oxidative stress was assessed...
2019: Advances in Pharmacological Sciences
Shuilian Fu, Saihong Ni, Danni Wang, Meng Fu, Tie Hong
The anti-allergic effect of berberine was evaluated in cellular and animal models of allergic responses. In this study, the results of the in vitro model of immunoglobulin (Ig) E-mediated mast cell degranulation showed that berberine significantly inhibited the release of β-hexosaminidase (β-HEX), histamine, IL-4 and TNF-α in rat basophilic leukemia cells (RBL-2H3 cells). Pretreatment with berberine prevented morphological changes in IgE-stimulated RBL-2H3 cells such as the recovery of an elongated shape...
March 9, 2019: International Immunopharmacology
Fizah S Chaudhary, Jasir T Nayati, Ather M Ali, Alan R Hirsch
Study ObjectiveDelusional parasitosis, or Ekbom syndrome, is a fixed false belief of being infested by parasites [Bellanger 2009]. With easy accessibility of the internet, serving as a vital tool in acquiring myriad information, these delusions typically arise and can be fueled by external sources as self-research [Bell2005]. For instance, garlic (allium sativum) has been reported to exhibit anthelmintic activity against cestodes (tapeworms), proving to be a natural treatmentoption [Abdel-Ghaffar 2010]. Without proper instructions, guidelines, or control of such information, psychopathological manifestations may be derived...
February 2019: CNS Spectrums
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