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"Acute Pulmoary Oedema" OR "APO" OR "Acute Pulmonary Edema" OR "APE" OR "Acute Heart Failure Syndrome" OR "AHFS"

Kenji Kuriya, Masahiro Nishio, Shohei Wada, Hirotaka Katsuzaki, Masayuki Nishise, Hiroyuki Okamoto, Hayato Umekawa
Osteoporosis is a systemic skeletal disease that causes bone weakness and fragility. Consuming bone-beneficial nutrients through diet can prevent and treat osteoporosis. Acer palmatum (Japanese maple) leaves are used to make tea, but there have been few reports of their health benefits, especially regarding bone homeostasis. In this study, we evaluated the effects of A. palmatum hot water extract (APE) on osteoclastogenesis and osteoblastogenesis in cultured cells. APE suppressed the number of tartrate-resistant acid phosphatase-positive multinucleated osteoclasts in RANKL induced RAW264...
February 20, 2019: Journal of Medicinal Food
Tabbetha J Bohac, Luting Fang, Daryl E Giblin, Timothy A Wencewicz
Environmental and pathogenic microbes produce siderophores as small iron-binding molecules to scavenge iron from natural environments. It is common for microbes to produce multiple siderophores to gain a competitive edge in mixed microbial environments. Strains of human pathogenic Acinetobacter baumannii produce up to three siderophores: acinetobactin, baumannoferrin, and fimsbactin. Production of acinetobactin and baumannoferrin is highly conserved amongst clinical isolates while fimsbactin production appears to be less common...
February 20, 2019: ACS Chemical Biology
Man Ye, Jun Zhou, Yixin Zhong, Jie Xu, Jingxin Hou, Xingyue Wang, Zhi-Gang Wang, Dajing Guo
Atherosclerosis is a major cause of sudden death and myocardial infarction, instigated by unstable plaques. Thus, the early detection of unstable plaques and corresponding treatment can improve the prognosis and reduce mortality. In this study, we describe a protocol for the preparation of nanoparticles (NPs) combined with the phase transitional material perfluorohexane (PFH) and with dextran sulfate (DS) targeting class A scavenger receptors (SR-A) for the diagnosis and treatment of atherosclerotic vulnerable plaques...
February 20, 2019: ACS Applied Materials & Interfaces
Xiaoling Xu, Liuhong Shi, Xiuqing Ma, Hua Su, Guofeng Ma, Xiaohong Wu, Kejing Ying, Ruifeng Zhang
INTRODUCTION: Acute pulmonary embolism (APE) is a cardiovascular disease with high morbidity and mortality. Although the anatomical obstruction of the pulmonary vascular bed initiates APE, recent studies have suggested that vasoconstrictors in the renin-angiotensin system (RAS) play a role in the severity of APE. MATERIALS AND METHODS: We performed a 5-year retrospective clinical study to analyze the key RAS components in APE patients, including angiotensin converting enzyme (ACE), ACE2, angiotensin II (Ang II) and angiotensin 1-7(Ang(1-7))...
February 15, 2019: Thrombosis Research
Qian Yang, Kang Chen, Hanlin Zhang, Wanying Zhang, Changlin Gong, Qing Zhang, Pan Liu, Tianyi Sun, Yuanyuan Xu, Xiaojing Qian, Wenying Qiu, Chao Ma
In this study, the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4.482, P = 0...
February 19, 2019: Neuroscience Bulletin
Xiaoli Wu
In the present study, candidate genes affected by rosiglitazone to exert glycemic control in the treatment of type 2 diabetes mellitus (T2DM) and associated with its adverse cardiovascular effects were identified using a bioinformatics analysis. The gene expression profiles of the dataset GSE36875 from the Gene Expression Omnibus database, including heart samples from 5 non-diabetic control mice (NC), 5 untreated diabetic mice (NH) and 5 rosiglitazone-treated diabetic mice (TH), were used to identify differentially expressed genes (DEGs) in the NC vs...
March 2019: Experimental and Therapeutic Medicine
Dominique Dos Reis, Laurie Fraticelli, Adrien Bassand, Stéphane Manzo-Silberman, Nicolas Peschanski, Sandrine Charpentier, Meyer Elbaz, Dominique Savary, Eric Bonnefoy-Cudraz, Said Laribi, Patrick Henry, Abdallah Guerraoui, Karim Tazarourte, Tahar Chouihed, Carlos El Khoury
OBJECTIVES: Cardiorenal syndrome (CRS) is the combination of acute heart failure syndrome (AHF) and renal dysfunction (creatinine clearance (CrCl) ≤60 mL/min). Real-life data were used to compare the management and outcome of AHF with and without renal dysfunction. DESIGN: Prospective, multicentre. SETTING: Twenty-six academic, community and regional hospitals in France. PARTICIPANTS: 507 patients with AHF were assessed in two groups according to renal function: group 1 (patients with CRS (CrCl ≤60 mL/min): n=335) and group 2 (patients with AHF with normal renal function (CrCl >60 mL/min): n=172)...
January 15, 2019: BMJ Open
Ruirong Pan, Yanyan Li, Hongwen Zhou
This study aimed to conduct a network meta-analysis of the efficacy and safety of different doses of alirocumab in reducing low-density lipoprotein cholesterol levels. In the present study, a total of 16 studies were selected, published between January 2012 and October 2016. Pair-wise and network meta-analyses was used to carry out a direct and indirect comparison of the three treatment strategies of alirocumab in patients with hypercholesterolemia. The efficacy and safety of these different treatment strategies were analyzed...
January 1, 2019: Die Pharmazie
Luca de Palma, Nicola Pietrafusa, Francesca Gozzo, Carmen Barba, Giusy Carfi-Pavia, Massimo Cossu, Alessandro De Benedictis, Lorenzo Genitori, Flavio Giordano, Giorgio Lo Russo, Carlo Efisio Marras, Veronica Pelliccia, Susanna Rizzi, Camilla Rossi-Espagnet, Federico Vigevano, Renzo Guerrini, Laura Tassi, Nicola Specchio
OBJECTIVE: The objective of the study was to evaluate clinical characteristics and outcome of hemispherotomy in children and adolescents with hemispheric refractory epilepsy in an Italian cohort of patients. METHODS: We retrospectively evaluated the clinical course and outcome of 92 patients with refractory epilepsy who underwent hemispherotomy in three Italian epilepsy centers between 2006 and 2016. Three different approaches for hemispherotomy were used: parasagittal, modified parasagittal, and lateral...
February 16, 2019: Epilepsy & Behavior: E&B
Takayuki Ohwada, Takayuki Sakamoto, Yuki Kanno, Sayoko Yokokawa, Kazuaki Amami, Kazuhiko Nakazato, Yasuchika Takeishi, Kenichi Watanabe
OBJECTIVE: To determine the relationship between plaque composition and low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (Apo-B), and Apo-A1 using virtual-histology intravascular ultrasound (VH-IVUS). METHODS: We assessed plaque composition in patients with stable coronary artery disease (SCD) admitted to our hospital for percutaneous coronary intervention (PCI) between November 1, 2012, and March 10, 2015...
2019: PloS One
Fabrizia D'Antonio, Suzanne Reeves, Yucheng Sheng, Emma McLachlan, Carlo de Lena, Robert Howard, Julie Bertrand
The presence of psychosis is associated with more rapid decline in Alzheimer's disease (AD), but the impact of paranoid (persecutory delusions) and misidentification (misperceptions and/or hallucinations) subtypes of psychosis on the speed of decline in AD is still unclear. Here we analysed data on Alzheimer's Disease Neuroimaging Initiative (ADNI)2 participants with late mild cognitive impairment or AD and we described individual trajectories of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) scores using a semi-mechanistic, logistic model, with a mixed effects based approach, which accounted for drop-out, and adjusted for baseline Mini Mental State Examination scores...
February 19, 2019: CPT: Pharmacometrics & Systems Pharmacology
Collin T Zahler, Bryan F Shaw
The net electrostatic charge (Z) of a folded protein in solution represents a bird's eye view of its surface potentials-including contributions from tightly bound metal, solvent, buffer, and cosolvent ions-and remains one of its most enigmatic properties. Few tools are available to the average biochemist to rapidly and accurately measure Z at pH ≠ pI. Tools that have been developed more recently seem to go unnoticed. Most scientists are content with this void and estimate the net charge of a protein from its amino acid sequence, using textbook values of pKa...
February 18, 2019: Chemistry: a European Journal
Karim Belmokhtar, Jeremy Ortillon, Stéphane Jaisson, Ziad A Massy, Camille Boulagnon Rombi, Manon Doué, Pascal Maurice, Günter Fritz, Philippe Gillery, Ann Marie Schmidt, Philippe Rieu, Fatouma Touré
BACKGROUND: Chronic kidney disease (CKD) is associated with increased cardiovascular mortality, frequent vascular calcification (VC) and accumulation of uraemic toxins. Advanced glycation end products and S100 proteins interact with the receptor for advanced glycation end products (RAGE). In the present work, we aimed to investigate the role(s) of RAGE in the CKD-VC process. METHODS: Apoe-/- or Apoe-/-Ager (RAGE)-/- male mice were assigned to CKD or sham-operated groups...
February 18, 2019: Nephrology, Dialysis, Transplantation
Lijie Ren, Lei Wang, Tao You, Yifei Liu, Fan Wu, Li Zhu, Chaojun Tang
OBJECTIVE: Emerging evidence shows that perivascular adipose tissue (PVAT) is crucially involved in inflammation and cardiovascular diseases. However, controversial results have been reported regarding the effect of PVAT in atherosclerosis. This study aimed to determine the role of PVAT in disturbed blood flow (d-flow)-induced carotid plaque formation. METHODS: ApoE-/- male mice underwent partial carotid ligation (PCL) to induce d-flow in the left carotid artery (LCA) and were fed a high-fat diet for 2 weeks...
February 15, 2019: Journal of Vascular Surgery
H Geut, L J M Vergouw, Y Galis, A Ingrassia, F J de Jong, M Quadri, V Bonifati, A W Lemstra, A J M Rozemuller, W D J van de Berg
INTRODUCTION: The disease course of dementia with Lewy bodies (DLB) can be rapidly progressive, clinically resembling Creutzfeldt-Jakob's disease (CJD). To better understand factors contributing to this rapidly progressive disease course, we describe load and distribution of neuropathology, and the presence of possible disease-associated genetic defects in a post-mortem series of DLB cases clinically suspected of CJD. METHODS: We included pathologically confirmed DLB cases with a disease duration of 3...
February 13, 2019: Parkinsonism & related Disorders
Lars I Eriksson, Cecilia Lundholm, Kaavya Narasimhalu, Rolf Sandin, Ya-Ping Jin, Margaret Gatz, Nancy L Pedersen
INTRODUCTION: We evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer's disease. METHODS: A clinical sample (843 clinically diagnosed dementia cases; 1686 matched nondemented individuals) was identified from Swedish Twin Registry studies. A register-based sample (4293 cases; 21,465 matched controls) was identified by linkage of Swedish Twin Registry to Swedish Patient Registry records. Apolipoprotein E (APOE) status and within-pair comparisons of dementia discordant twins indicated genetic susceptibility...
February 15, 2019: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Denis Malvy, Anita K McElroy, Hilde de Clerck, Stephan Günther, Johan van Griensven
Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic disease in man and great apes. Four species of ebolaviruses have been identified in west or equatorial Africa. Once the more virulent forms enter the human population, transmission occurs primarily through contact with infected body fluids and can result in major epidemics in under-resourced settings. These viruses cause a disease characterised by systemic viral replication, immune suppression, abnormal inflammatory responses, major fluid and electrolyte losses, and high mortality...
February 15, 2019: Lancet
Alexandra M Wennberg, Jennifer L Whitwell, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Mary M Machulda, Leonard Petrucelli, Michelle M Mielke, Clifford R Jack, David S Knopman, Joseph E Parisi, Ronald C Petersen, Dennis W Dickson, Keith A Josephs
Many individuals live to older ages without clinical impairment. It is unknown whether brain pathologies in these individuals are associated with subtle clinical deficits. We analyzed the brains of 161 clinically normal (Clinical Dementia Rating score = 0) older individuals enrolled in the Mayo Clinic Patient Registry or Study of Aging. We assessed for the presence and burden of beta-amyloid, tau, alpha-synuclein, TDP-43, and vascular pathology. We investigated whether pathologies were associated with antemortem cognitive and motor function, depression, MRI volumetric measures, or the apolipoprotein E (APOE) ε4 allele...
January 21, 2019: Neurobiology of Aging
Menno Hoekstra, Joya E Nahon, Laura M de Jong, Mara J Kröner, Lidewij R de Leeuw, Miranda Van Eck
The nuclear receptor liver X receptor (LXR) impacts on cholesterol metabolism as well as hepatic lipogenesis via transcriptional regulation. It is proposed that inhibition of the protein arginine methyltransferase 3 (PRMT3) uncouples these two transcriptional pathways in vivo by acting as a specific lipogenic coactivator of LXR. Here we validated the hypothesis that treatment with the allosteric PRMT3 inhibitor SGC707 will diminish the hepatic steatosis extent, while leaving global cholesterol metabolism, important in cholesterol-driven pathologies like atherosclerosis, untouched...
February 15, 2019: Biochimica et biophysica acta. Molecular basis of disease
Cécile Breyton, Waqas Javed, Annelise Vermot, Charles-Adrien Arnaud, Christine Hajjar, Jérôme Dupuy, Isabelle Petit-Hartlein, Aline Le Roy, Anne Martel, Michel Thépaut, Cédric Orelle, Jean-Michel Jault, Franck Fieschi, Lionel Porcar, Christine Ebel
Laurylmaltose neopentylglycol (LMNG) bears two linked hydrophobic chains of equal length and two hydrophilic maltoside groups. It arouses a strong interest in the field of membrane protein biochemistry, since it was shown to efficiently solubilize and stabilize membrane proteins often better than the commonly used dodecylmaltopyranoside (DDM), and to allow structure determination of some challenging membrane proteins. However, LMNG was described to form large micelles, which could be unfavorable for structural purposes...
February 15, 2019: Biochimica et biophysica acta. Biomembranes
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