Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Muhammad M Mohiuddin, Avneesh K Singh, Linda Scobie, Corbin E Goerlich, Alison Grazioli, Kapil Saharia, Claire Crossan, Allen Burke, Cinthia Drachenberg, Cihan Oguz, Tianshu Zhang, Billeta Lewis, Alena Hershfeld, Faith Sentz, Ivan Tatarov, Sarah Mudd, Gheorghe Braileanu, Kathryn Rice, John F Paolini, Kent Bondensgaard, Todd Vaught, Kasinath Kuravi, Lori Sorrells, Amy Dandro, David Ayares, Christine Lau, Bartley P Griffith
BACKGROUND: A genetically engineered pig cardiac xenotransplantation was done on Jan 7, 2022, in a non-ambulatory male patient, aged 57 years, with end-stage heart failure, and on veno-arterial extracorporeal membrane oxygenation support, who was ineligible for an allograft. This report details our current understanding of factors important to the xenotransplantation outcome. METHODS: Physiological and biochemical parameters critical for the care of all heart transplant recipients were collected in extensive clinical monitoring in an intensive care unit...
July 29, 2023: Lancet
#22
JOURNAL ARTICLE
Ana P M Canton, Flávia R Tinano, Leonardo Guasti, Luciana R Montenegro, Fiona Ryan, Deborah Shears, Maria Edna de Melo, Larissa G Gomes, Mariana P Piana, Raja Brauner, Rafael Espino-Aguilar, Arancha Escribano-Muñoz, Alyssa Paganoni, Jordan E Read, Márta Korbonits, Carlos E Seraphim, Silvia S Costa, Ana Cristina Krepischi, Alexander A L Jorge, Alessia David, Lena R Kaisinger, Ken K Ong, John R B Perry, Ana Paula Abreu, Ursula B Kaiser, Jesús Argente, Berenice B Mendonca, Vinicius N Brito, Sasha R Howard, Ana Claudia Latronico
BACKGROUND: Identification of genetic causes of central precocious puberty have revealed epigenetic mechanisms as regulators of human pubertal timing. MECP2, an X-linked gene, encodes a chromatin-associated protein with a role in gene transcription. MECP2 loss-of-function mutations usually cause Rett syndrome, a severe neurodevelopmental disorder. Early pubertal development has been shown in several patients with Rett syndrome. The aim of this study was to explore whether MECP2 variants are associated with an idiopathic central precocious puberty phenotype...
June 26, 2023: Lancet Diabetes & Endocrinology
#23
REVIEW
Bruce C Carleton, Daniel A Salmon, Patrick Ip, Ian C K Wong, Francicso T T Lai
Studies of myocarditis/pericarditis following mRNA COVID-19 vaccines in Hong Kong have been published. Data are consistent with data from other active surveillance or healthcare databases. The mRNA COVID-19 vaccines have been shown to rarely increase risk of myocarditis, with the highest risk among males aged 12-17 after the second dose. An increased risk of pericarditis has also been shown after the second dose, though less common than myocarditis and more evenly distributed among different sex and age groups...
May 19, 2023: The Lancet Regional Health. Western Pacific
#24
JOURNAL ARTICLE
Marta Bertran, Joshua C D'Aeth, Erjola Hani, Zahin Amin-Chowdhury, Norman K Fry, Mary E Ramsay, David J Litt, Shamez N Ladhani
BACKGROUND: Invasive Haemophilus influenzae serotype a (Hia) disease is rare, with most cases reported among Indigenous populations in North America. In England, national surveillance was enhanced following an increase in laboratory-confirmed invasive Hia disease since the 2016-17 epidemiological year. This study aimed to describe the epidemiological trends, clinical characteristics of cases, and assess potential genomic drivers. METHODS: Hospital laboratories in England routinely submit invasive H influenzae isolates to the UK Health Security Agency for confirmation and serotyping...
October 2023: Lancet Infectious Diseases
#25
JOURNAL ARTICLE
Dan Yamin, Matan Yechezkel, Ronen Arbel, Tanya Beckenstein, Ruslan Sergienko, Hadar Duskin-Bitan, Shlomit Yaron, Alon Peretz, Doron Netzer, Erez Shmueli
BACKGROUND: COVID-19 continues to be a major health threat, particularly among at-risk groups, including individuals aged 60 years or older and people with particular medical conditions. Nevertheless, the absence of sufficient vaccine safety information is one of the key contributors to vaccine refusal. We aimed to assess the short-term safety profile of the BNT162b2 mRNA COVID-19 vaccine booster doses. METHODS: In this self-controlled case series study, we used a database of members of the largest health-care organisation in Israel...
June 20, 2023: Lancet Infectious Diseases
#26
JOURNAL ARTICLE
Lu Zhang, Yu-Jun Dong, Hong-Ling Peng, Hao Li, Ming-Zhi Zhang, Hui-Han Wang, Qin-Hua Liu, Li-Ping Su, Li-Ye Zhong, Wen-Jun Wu, Liang Huang, Xiao-Jing Yan, Lei Fan, Wen-Jiao Tang, Zhen-Ling Li, Lin-Tao Bi, Yan Li, Guang-Xun Gao, Li Gao, Ting-Bo Liu, Yong-Qiang Wei, Yao Liu, Li Yu, Hui Zhou, Chun-Yan Sun, Wen-Bin Qian, De-Hui Zou, Hui-Lai Zhang, Kai-Yang Ding, Xiao-Bo Wang, Ou Bai, Wen-Rong Huang, Bing Chen, Lin Yang, Jia Song, Da Gao, Tong Chen, Jun Luo, Shu-Ye Wang, Liang-Ming Ma, David C Fajgenbaum, Jian Li
BACKGROUND: Castleman disease (CD) is a group of rare and heterogenous lymphoproliferative disorders including unicentric CD (UCD), human herpesvirus-8(HHV-8)-associated multicentric CD (HHV8-MCD), and HHV-8-negative/idiopathic multicentric CD (iMCD). Knowledge of CD mainly comes from case series or retrospective studies, but the inclusion criteria of these studies vary because the Castleman Disease Collaborative Network (CDCN) diagnostic criteria for iMCD and UCD were not available until 2017 and 2020, respectively...
May 2023: The Lancet Regional Health. Western Pacific
#27
JOURNAL ARTICLE
Chloe Puett, John D Anderson, Karoun H Bagamian, Farzana Muhib, Suzanne Scheele, William P Hausdorff, Clint Pecenka
BACKGROUND: Linear growth is an important outcome of child development with implications for economic productivity. Enteric infections, particularly Shigella, have been linked to linear growth faltering (LGF). However, benefits from potential reductions in LGF are rarely included in economic analyses of enteric infections. We aimed to quantify the economic benefits of vaccination related to reduced Shigella-attributable disease and associated LGF compared with the net costs of a vaccine programme...
June 2023: Lancet Global Health
#28
JOURNAL ARTICLE
Adèle de Masson, Marie Beylot-Barry, Caroline Ram-Wolff, Jean-Baptiste Mear, Stéphane Dalle, Michel d'Incan, Saskia Ingen-Housz-Oro, Corentin Orvain, Julie Abraham, Olivier Dereure, Amandine Charbonnier, Jérôme Cornillon, Christine Longvert, Stéphane Barete, Serge Boulinguez, Ewa Wierzbicka-Hainaut, François Aubin, Marie-Thérèse Rubio, Marc Bernard, Aline Schmidt-Tanguy, Roch Houot, Anne Pham-Ledard, David Michonneau, Pauline Brice, Hélène Labussière-Wallet, Jean-David Bouaziz, Florent Grange, Hélène Moins-Teisserenc, Katayoun Jondeau, Laurence Michel, Samia Mourah, Maxime Battistella, Etienne Daguindau, Michael Loschi, Alexandra Picard, Nathalie Franck, Natacha Maillard, Anne Huynh, Stéphanie Nguyen, Ambroise Marçais, Guillaume Chaby, Patrice Ceballos, Yannick Le Corre, Sébastien Maury, Jacques-Olivier Bay, Henri Adamski, Emmanuel Bachy, Edouard Forcade, Gérard Socié, Martine Bagot, Sylvie Chevret, Régis Peffault de Latour
BACKGROUND: Advanced-stage cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and fatal diseases. Case series have suggested that allogeneic haematopoietic stem cell transplantation (HSCT) might improve the prognosis of advanced-stage CTCLs. The objective of this study was to investigate the effect of allogeneic HSCT compared with non-HSCT therapy on the outcome of individuals with advanced-stage CTCLs. METHODS: In this prospective, multicentre, matched controlled trial, conducted at 30 hospitals, participants with advanced CTCLs were allocated treatment: if they had an available compatible related donor they were assigned to allogeneic HSCT, or if not they were allocated to non-allogeneic HSCT therapy...
June 10, 2023: Lancet
#29
JOURNAL ARTICLE
Emily Lai-Ho MacLean, Luz Villa-Castillo, Patricia Espinoza-Lopez, Tatiana Caceres, Giorgia Sulis, Mikashmi Kohli, Madhukar Pai, César Ugarte-Gil
BACKGROUND: Integrated molecular testing could be an opportunity to detect and provide care for both tuberculosis and COVID-19. Many high tuberculosis burden countries, such as Peru, have existing GeneXpert systems for tuberculosis testing with GeneXpert Xpert MTB/RIF Ultra (Xpert Ultra), and a GeneXpert SARS-CoV-2 assay, GeneXpert Xpert Xpress SARS-CoV-2 (Xpert Xpress), is also available. We aimed to assess the feasibility of integrating tuberculosis and COVID-19 testing using one sputum specimen with Xpert Ultra and Xpert Xpress in Lima, Peru...
April 14, 2023: The Lancet. Microbe
#30
JOURNAL ARTICLE
Audrey Duval, Lulla Opatowski, Sylvain Brisse
BACKGROUND: Epidemiological surveillance relies on microbial strain typing, which defines genomic relatedness among isolates to identify case clusters and their potential sources. Although predefined thresholds are often applied, known outbreak-specific features such as pathogen mutation rate and duration of source contamination are rarely considered. We aimed to develop a hypothesis-based model that estimates genetic distance thresholds and mutation rates for point-source single-strain food or environmental outbreaks...
March 29, 2023: The Lancet. Microbe
#31
JOURNAL ARTICLE
Ling Zhang, Bijal Shah, Yumeng Zhang, Hammad Tashkandi, Wenbin Xiao, Sebastian Fernandez-Pol, Maria Vergara-Lluri, Mohammad Hussaini, Jinming Song, Jeffrey Lancet, Lynn Moscinski, Seongseok Yun, Chuanyi M Lu, L Jeffrey Medeiros, Guilin Tang
JAK2 rearrangement (JAK2-R) in acute lymphoblastic leukemia (ALL) is rare and often categorized as B-ALL with BCR::ABL1-like features based on the World Health Organization classification. We report 10 patients with JAK2-R ALL, 9 males and 1 female, with a median age 40.5 years. Eight patients presented with marked leukocytosis (median WBC, 63 × 10 9 /L) and hypercellular (>95%) bone marrow with increased lymphoblasts (72%-95%). There was no evidence of bone marrow fibrosis or hypereosinophilia. Immunophenotypic analysis showed 9 B-cell and 1 T-cell neoplasms...
March 21, 2023: Human Pathology
#32
JOURNAL ARTICLE
Kemi Ogunlana, Kerrie Stevenson, Yusuf Ciftci, Marian Knight, Robert Aldridge, Fiona Stevenson
BACKGROUND: In the UK, one-in-three births are to a non-UK born woman. A gap exists in co-produced research to understand their experiences. The UK National Institute for Health and Care Research (NIHR) defines co-production as "an approach in which researchers, practitioners, and members of the public work together, sharing power and responsibility". This project co-produced a grant proposal to improve maternity care for underserved migrant women in the UK. We reflect on transferrable learning for engaging those whose voices are less-often-heard in grant writing...
November 2022: Lancet
#33
JOURNAL ARTICLE
Francesca Cavallaro, Rebecca Cannings-John, Fiona Lugg-Widger, Sally Kendall, Jan van der Meulen, Eilis Kennedy, Emma Howarth, Mike Robling, Ruth Gilbert, Katie Harron
BACKGROUND: The Family Nurse Partnership (FNP) is an early intervention aiming to support adolescent mothers and their children. The FNP has been evaluated in England and Scotland in two separate studies using linked administrative data from health, education, and social care. We aimed to make recommendations for studies using linked administrative data to evaluate public health interventions. METHODS: We constructed two cohorts of all mothers aged 13-19 years giving birth in NHS hospitals between 2010 and 2016-17 using data from Hospital Episode Statistics (England) and Maternity Inpatient and Day Case (Scotland)...
November 2022: Lancet
#34
REVIEW
Wilmar M Wiersinga, Kris G Poppe, Grigoris Effraimidis
Hyperthyroidism is a common condition with a global prevalence of 0·2-1·3%. When clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg, low TSH, high free thyroxine [FT4 ], or high free tri-iodothyonine [FT3 ]). If hyperthyroidism is confirmed by biochemical tests, a nosological diagnosis should be done to find out which disease is causing the hyperthyroidism. Helpful tools are TSH-receptor antibodies, thyroid peroxidase antibodies, thyroid ultrasonography, and scintigraphy...
April 2023: Lancet Diabetes & Endocrinology
#35
JOURNAL ARTICLE
Lise Folon, Morgane Baron, Bénédicte Toussaint, Emmanuel Vaillant, Mathilde Boissel, Victoria Scherrer, Hélène Loiselle, Audrey Leloire, Alaa Badreddine, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Soulaimane Aboulouard, Michel Salzet, Mickaël Canouil, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond
BACKGROUND: Rare biallelic pathogenic mutations in PCSK1 (encoding proprotein convertase subtilisin/kexin type 1 [PC1/3]) cause early-onset obesity associated with various endocrinopathies. Setmelanotide has been approved for carriers of these biallelic mutations in the past 3 years. We aimed to perform a large-scale functional genomic study focusing on rare heterozygous variants of PCSK1 to decipher their putative impact on obesity risk. METHODS: This case-control study included all participants with overweight and obesity (ie, cases) or healthy weight (ie, controls) from the RaDiO study of three community-based and one hospital-based cohort in France recruited between Jan 1, 1995, and Dec 31, 2000...
March 2023: Lancet Diabetes & Endocrinology
#36
JOURNAL ARTICLE
Douglas L Fink, Helen Callaby, Akish Luintel, William Beynon, Helena Bond, Eleanor Y Lim, Effrossyni Gkrania-Klotsas, Jospeh Heskin, Margherita Bracchi, Balram Rathish, Iain Milligan, Geraldine O'Hara, Stephanie Rimmer, Joanna R Peters, Lara Payne, Nisha Mody, Bethany Hodgson, Penny Lewthwaite, Rebecca Lester, Stephen D Woolley, Ann Sturdy, Ashley Whittington, Leann Johnson, Nathan Jacobs, John Quartey, Brendan Ai Payne, Stewart Crowe, Ivo Am Elliott, Thomas Harrison, Joby Cole, Katie Beard, Tomas-Paul Cusack, Imogen Jones, Rishi Banerjee, Tommy Rampling, Jake Dunning
BACKGROUND: The scale of the 2022 global mpox (formerly known as monkeypox) outbreak has been unprecedented. In less than 6 months, non-endemic countries have reported more than 67 000 cases of a disease that had previously been rare outside of Africa. Mortality has been reported as rare but hospital admission has been relatively common. We aimed to describe the clinical and laboratory characteristics and outcomes of individuals admitted to hospital with mpox and associated complications, including tecovirimat recipients...
May 2023: Lancet Infectious Diseases
#37
REVIEW
Erin R Whitehouse, Anna Mandra, Jesse Bonwitt, Erin A Beasley, Joanna Taliano, Agam K Rao
Post-exposure prophylaxis (PEP) for rabies is widely administered and highly effective. Nevertheless, sporadic breakthrough infections (ie, rabies in people who have started PEP) have been reported. We conducted a systematic review of articles published between Jan 1, 1980 and June 1, 2022 to characterise breakthrough infections. After reviewing 3380 articles from across all continents, we identified 52 articles, which included a total of 122 breakthrough infections. We classified breakthrough infections on the basis of adherence to core practices (ie, wound cleaning and vaccine administration)...
May 2023: Lancet Infectious Diseases
#38
JOURNAL ARTICLE
Kemi Ogunlana, Kerrie Stevenson, Yusuf Ciftci, Marian Knight, Robert Aldridge, Fiona Stevenson
BACKGROUND: In the UK, one-in-three births are to a non-UK born woman. A gap exists in co-produced research to understand their experiences. The UK National Institute for Health and Care Research (NIHR) defines co-production as "an approach in which researchers, practitioners, and members of the public work together, sharing power and responsibility". This project co-produced a grant proposal to improve maternity care for underserved migrant women in the UK. We reflect on transferrable learning for engaging those whose voices are less-often-heard in grant writing...
November 2022: Lancet
#39
JOURNAL ARTICLE
Francesca Cavallaro, Rebecca Cannings-John, Fiona Lugg-Widger, Sally Kendall, Jan van der Meulen, Eilis Kennedy, Emma Howarth, Mike Robling, Ruth Gilbert, Katie Harron
BACKGROUND: The Family Nurse Partnership (FNP) is an early intervention aiming to support adolescent mothers and their children. The FNP has been evaluated in England and Scotland in two separate studies using linked administrative data from health, education, and social care. We aimed to make recommendations for studies using linked administrative data to evaluate public health interventions. METHODS: We constructed two cohorts of all mothers aged 13-19 years giving birth in NHS hospitals between 2010 and 2016-17 using data from Hospital Episode Statistics (England) and Maternity Inpatient and Day Case (Scotland)...
November 2022: Lancet
#40
REVIEW
Trine H Mogensen, Morten Kelder Skouboe, Ingolf Mølle
Human infection with parvovirus B19 causes a range of clinical manifestations, including benign erythema infectiosum in children, arthralgias in adults, aplastic crisis in patients with bone marrow failure, and potentially fatal congenital hydrops fetalis. Persistent parvovirus B19 infection is a rare disease presentation mostly seen in adult women or immunocompromised individuals. Treatment options include corticosteroids and intravenous immunoglobulin; however, viral clearance is difficult to obtain and rarely maintained...
April 2023: Lancet Infectious Diseases
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
