Gargi Kapatia, Arvind Rajwanshi
A 28-year old female presented with complaints of abdominal pain for 2 weeks and vomiting for 1 week. Abdominal ultrasonography (USG) revealed a 3x3 cm space-occupying solid lesion with necrotic areas in the pancreas. The patient was a known case of Ewing sarcoma of the pubic bone, diagnosed one year previously. USG guided fine-needle aspiration (FNA) from the pancreatic lesion was performed and smears were prepared, which were then stained with May-Grunwald-Giemsa (MGG) stain.
August 7, 2020: Cytopathology: Official Journal of the British Society for Clinical Cytology
Chikanori Tsutsumi, Toshiya Abe, Yusuke Sawatsubashi, Sadafumi Tamiya, Daisuke Kakihara, Kazuyoshi Nishihara, Toru Nakano
BACKGROUND: Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare neoplasm with a favorable prognosis. On the other hand, pancreatic invasive ductal carcinoma (IDC) is known to be an aggressive malignancy. To the best of our knowledge, there is no report of SPN combined with IDC of the pancreas. CASE PRESENTATION: A 66-year-old woman presented with abnormal genital bleeding and was diagnosed with inoperable cervical cancer. During computed tomography for cancer staging, the patient was incidentally diagnosed with pancreatic cancer...
August 7, 2020: Surgical Case Reports
Gergely Gyimesi, Jonai Pujol-Giménez, Yoshikatsu Kanai, Matthias A Hediger
Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5. This family includes 12 different members in human that mediate the transport of sugars, vitamins, amino acids, or smaller organic ions such as choline. The SLC5 family belongs to the sodium symporter family (SSS), which encompasses transporters from all kingdoms of life. It furthermore shares similarity to the structural fold of the APC (amino acid-polyamine-organocation) transporter family. Three decades after the first molecular identification of the intestinal Na+ -glucose cotransporter SGLT1 by expression cloning, many new discoveries have evolved, from mechanistic analysis to molecular genetics, structural biology, drug discovery, and clinical applications...
August 7, 2020: Pflügers Archiv: European Journal of Physiology
Olivia S Kates, Brandy M Haydel, Sander S Florman, Meenakshi M Rana, Zohra S Chaudhry, Mayur S Ramesh, Kassem Safa, Camille Nelson Kotton, Emily A Blumberg, Behdad D Besharatian, Sajal D Tanna, Michael G Ison, Maricar Malinis, Marwan M Azar, Robert M Rakita, Jose A Morillas, Aneela Majeed, Afrah S Sait, Mario Spaggiari, Vagish Hemmige, Sapna A Mehta, Henry Neumann, Abbasali Badami, Jason D Goldman, Anuradha Lala, Marion Hemmersbach-Miller, Margaret E McCort, Valida Bajrovic, Carlos Ortiz-Bautista, Rachel Friedman-Moraco, Sameep Sehgal, Erika D Lease, Cynthia E Fisher, Ajit P Limaye
BACKGROUND: The COVID-19 pandemic has led to significant reductions in transplantation, motivated in part by concerns of disproportionately more severe disease among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors of mortality in SOT recipients are not well-described. METHODS: We performed a multi-center cohort study of SOT recipients with laboratory-confirmed COVID-19. Data were collected using standardized intake and 28-day follow-up electronic case report forms...
August 7, 2020: Clinical Infectious Diseases
Mihir M Shah, Rachel E NeMoyer, Stephanie H Greco, Chunxia Chen, Dirk F Moore, Miral S Grandhi, Russell C Langan, Timothy J Kennedy, Parisa Javidian, Salma K Jabbour, H Richard Alexander, David A August, Darren R Carpizo
Purpose: According to the American Joint Committee on Cancer (AJCC) 7th edition, T1 staging of pancreatic adenocarcinoma (PC) is defined as tumor limited to the pancreas, ≤2 cm. The AJCC 8th edition subcategorizes T1 staging into T1a (≤5 mm), T1b (≤1 cm), and T1c (≤2 cm) for PC despite the absence of supporting evidence. We sought to determine whether this new subcategorization has prognostic significance. Methods: A retrospective review of patients undergoing definitive surgery for PC was performed by using the National Cancer Database (NCDB) from 2004 to 2014...
2020: Journal of Pancreatic Cancer
Angela C Webster, James A Hedley, Patricia F Anderson, Wayne J Hawthorne, Toni Radford, Chris Drogemuller, Natasha Rogers, David Goodman, Melissa H Lee, Thomas Loudovaris, Patrick J Kelly
No abstract text is available yet for this article.
July 2020: Transplantation Direct
Angela C Webster, James Hedley, Paul Robertson, William R Mulley, Helen L Pilmore, Henry Pleass, Patrick J Kelly
No abstract text is available yet for this article.
July 2020: Transplantation Direct
Erik Almazan, Thomas Runge, Qing Kay Li, Saowanee Ngamruengphong
Heterotopic pancreas is pancreatic tissue present outside of the normal location of the pancreas. In the presence of cystic degeneration, heterotopic pancreas is clinically significant because of the symptoms it causes and its physical resemblance to cancerous growth. A diagnosis of heterotopic pancreas is achieved with the aid of various endoscopic techniques for tissue removal. Submucosal tunneling endoscopic resection has proven successful for the resection of gastric subepithelial masses. We present a 53-year-old woman undergoing submucosal tunneling endoscopic resection for the resection of a subepithelial gastric cyst caused by heterotopic pancreas with cystic degeneration...
July 2020: ACG Case Reports Journal
Hanlin Wang, Yingjian Jiang, Hongbo Li, Jiang Wang, Chang Li, Dianliang Zhang
The present study aimed to investigate the effect of carbachol on the intestinal tight-junction barrier in a rat model of severe acute pancreatitis (SAP) without aggravating pancreatic injury, and to determine whether cell division cycle 42 (Cdc42)/F-actin could have a regulatory role. Rats were separated into a sham-operation (SO) group (n=10), SO + carbachol group (n=10), SAP group (n=60) and SAP + carbachol group (n=60). Sodium taurocholate (5%) was retrogradely injected into the biliopancreatic duct of rats to induce SAP...
September 2020: Experimental and Therapeutic Medicine
Masatsugu Hiraki, Atsushi Miyoshi, Eiji Sadashima, Yukio Shinkai, Michio Yasunami, Tatsuya Manabe, Kenji Kitahara, Hirokazu Noshiro
Postoperative pancreatic fistula (PF) is a major and serious complication that occurs after pancreaticoduodenectomy (PD). The aim of the current study was to evaluate the use of a novel biomarker, presepsin, for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after PD. A prospective pilot study was conducted using 30 consecutive patients who underwent PD. Risk factors and candidates for predictive biomarkers for CR-POPF were statistically analyzed. CR-POPF (grade B and C; determined according to the guidelines of the International Study Group of Pancreatic Fistula) occurred in 15 patients (50%)...
September 2020: Experimental and Therapeutic Medicine
Avishekh Gautam, Madhav Akauliya, Bikash Thapa, Byoung Kwon Park, Dongbum Kim, Jinsoo Kim, Keunwook Lee, Kyung Chan Choi, Joon-Yong Bae, Man-Seong Park, Younghee Lee, Hyung-Joo Kwon
In humans, respiratory infections with influenza A viruses can be lethal, but it is unclear whether non-respiratory influenza A infections can be equally lethal. Intraperitoneal infection makes the abdominal and pelvic organs accessible to pathogens because of the circulation of peritoneal fluid throughout the pelvis and abdomen. We found that high-dose intraperitoneal infection in mice with influenza A viruses resulted in severe sclerosis and structural damage in the pancreas, disruption of ovarian follicles, and massive infiltration of immune cells in the uterus...
2020: Frontiers in Microbiology
Denes Toth, Edina Szabo, Andrea Tamas, Tamas Juhasz, Gabriella Horvath, Eszter Fabian, Balazs Opper, Dora Szabo, Grazia Maugeri, Agata G D'Amico, Velia D'Agata, Viktoria Vicena, Dora Reglodi
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is also expressed in peripheral organs but its peripheral protective effects have not been summarized so far. Therefore, the aim of the present paper is to review the existing literature regarding the cytoprotective effects of PACAP in non-neuronal cell types, peripheral tissues, and organs. Among others, PACAP has widespread expression in the digestive system, where it shows protective effects in various intestinal pathologies, such as duodenal ulcer, small bowel ischemia, and intestinal inflammation...
2020: Frontiers in Endocrinology
He Song, Ming Dong
Introduction: Solid pseudopapillary tumors of pancreas (SPTP) is an indolent rare tumor with malignant potential. The prediction of malignancy is an enigma. The aim of this study is to explore the relationship between operative measurements and malignancy prognosis of SPTP patients. Methods: A cohort of consecutive 102 patients were enrolled in this study. Preoperative measurements and clinical outcomes were analyzed. Results: Eighteen patients (17...
2020: Cancer Management and Research
Ashenafi Bulle, Jeroen Dekervel, Lise Deschuttere, David Nittner, Eric Van Cutsem, Chris Verslype, Jos van Pelt
Purpose: All currently available therapies for the treatment of pancreatic ductal adenocarcinoma (PDAC) show limited success. PDACs fast progression depends on the tumor characteristics and can be influenced by the microenvironment. The antibacterial drug acriflavine (ACF) has been shown to have anti-cancer activities in cell lines. Materials and Methods: To understand the working mechanism of ACF on cancer progression and tumor-stromal interplay, we evaluated pancreatic cancer in cell culture (Panc-1) (morphology, cell invasion and RNA expression) and the macrophage cell line THP1 (representing innate immune stromal cells)...
2020: OncoTargets and Therapy
George K Michalopoulos, Bharat Bhushan
The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid organs (such as the lungs, kidneys and pancreas) adjust to tissue loss but do not return to 100% of normal. The current state of knowledge of the regenerative pathways that underlie this 'hepatostat' will be presented in this Review. Liver regeneration from acute injury is always beneficial and has been extensively studied. Experimental models that involve partial hepatectomy or chemical injury have revealed extracellular and intracellular signalling pathways that are used to return the liver to equivalent size and weight to those prior to injury...
August 6, 2020: Nature Reviews. Gastroenterology & Hepatology
Luiz O Leiria, Yu-Hua Tseng
Adipose tissue exerts multiple vital functions that critically maintain energy balance, including storing and expending energy, as well as secreting factors that systemically modulate nutrient metabolism. Since lipids are the major constituents of the adipocytes, it is unsurprising that the lipid composition of these cells plays a critical role in maintaining their functions and communicating with other organs and cells. In both positive and negative energy balance conditions, lipids and free fatty acids secreted from adipocytes exert either beneficial or detrimental effects in other tissues, such as the liver, pancreas and muscle...
August 4, 2020: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
Hirokazu Momose, Yutaka Suzuki, Junji Shibahara, Yoshihiro Sakamoto
No abstract text is available yet for this article.
August 6, 2020: Japanese Journal of Clinical Oncology
Shashi Anand, Mohammad Aslam Khan, Moh'd Khushman, Santanu Dasgupta, Seema Singh, Ajay Pratap Singh
RAB proteins (RABs) represent the largest subfamily of Ras-like small GTPases that regulate a wide variety of endosomal membrane transport pathways. Their aberrant expression has been demonstrated in various malignancies and implicated in pathogenesis. Using The Cancer Genome Atlas (TCGA) database, we analyzed the differential expression and clinicopathological association of RAB genes in pancreatic ductal adenocarcinoma (PDAC). Of the 62 RAB genes analyzed, five (RAB3A, RAB26, RAB25, RAB21, and RAB22A ) exhibited statistically significant upregulation, while five ( RAB6B, RAB8B, RABL2A, RABL2B, and RAB32 ) were downregulated in PDAC as compared to the normal pancreas...
August 4, 2020: International Journal of Molecular Sciences
Usua Oyarbide, Arish N Shah, Wilmer Amaya-Mejia, Matthew Snyderman, Margaret Kell, Daniela Allende, Eliezer Calo, Jacek Topczewski, Seth Corey
Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic insufficiency, neutropenia, and skeletal abnormalities. Biallelic mutations in SBDS, which encodes a ribosome maturation factor, are found in 90% of SDS cases. Sbds-/- mice are embryonic lethal. Using CRISPR/Cas9 editing, we created sbds-deficient zebrafish strains. Sbds protein levels progressively decreased and became undetectable at 10 days post fertilization (dpf). Polysome analysis revealed decreased 80S ribosomes. Homozygous mutant fish developed normally until 15 dpf...
August 6, 2020: JCI Insight
Shivani M Desai, Avinash P Sanap, Ramesh R Bhonde
Management of Type 2 Diabetes (T2DM) with existing strategies of life style and pharmaceutical interventions has gained limited success as evidenced by its uncontrolled progression. Two key organs which are involved in pathophysiology of T2DM are liver and pancreas, both are the derivatives of endoderm with common precursor. In the invertebrates, hepatopancreas performs function of both liver and pancreas. It is known that derangement in glycolysis, neoglucogenesis, and glycogenolysis lead to hyperglycemia in T2DM although insulin levels are high...
June 24, 2020: Medical Hypotheses
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