Kunlei Wang, Anbang Zhao, Dilinigeer Tayier, Kai Tan, Wenjing Song, Qian Cheng, Xinyin Li, Zhinan Chen, Qifeng Wei, Yufeng Yuan, Zhiyong Yang
Obese people with acute pancreatitis (AP) have an increased risk of developing severe acute pancreatitis (SAP), which prolongs the length of hospital stay and increases mortality. Thus, elucidation of the mechanisms through which SAP occurs in obese individuals will provide clues for possible treatment targets. Differences in early events in obese or lean patients with AP have not been conclusively reported. We selected C57BL/6 mice as lean mice models, ob/ob mice or diet induced obese (DIO) mice as obese mice models and then induced experimental AP in mice via injections of caerulein...
September 30, 2023: Cell Death Discovery
Anna E Mangus, Chandrashekhar A Kubal, Burcin Ekser, Plamen Mihaylov, Andrew J Lutz, Jonathan A Fridell, Richard S Mangus
BACKGROUND: Histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solutions are the two primary solid-organ preservation solutions used in the United States (>95%), but flush volumes vary markedly by region and center. This study analyzes data from a single organ procurement organization (OPO) to determine the actual clinical flush volumes used for HTK and UW for liver and pancreas grafts. METHODS: All procurements at Indiana Donor Network were analyzed (2016-2020), and data were extracted from the on-site records...
September 28, 2023: Transplantation Proceedings
Jana Doering, Markus Perl, Daniela Weber, Bernhard Banas, Christian Schulz, Okka W Hamer, Klemens Angstwurm, Ernst Holler, Wolfgang Herr, Matthias Edinger, Daniel Wolff, Matthias A Fante
BACKGROUND: Chronic graft-versus-host disease (cGvHD) is the leading cause of late non-relapse mortality (NRM) after allogeneic stem cell transplantation (alloHSCT) and defined by eight diagnostic target organs. Recently, provisional criteria for atypical manifestations of cGvHD were proposed by an NIH taskforce (Cuvelier et al., TCT 2022), which include manifestations in non-classic organs as well as atypical manifestations in NIH-defined organs. OBJECTIVES: Since little is known about the incidence, risk factors and impact on survival of atypical cGvHD, the aim of the study was to analyze these parameters in a sequential patient population...
September 28, 2023: Transplantation and cellular therapy
Hui Ling Wu, Li Wen Yao, Hui Ying Shi, Lian Lian Wu, Xun Li, Chen Xia Zhang, Bo Ru Chen, Jun Zhang, Wei Tan, Ning Cui, Wei Zhou, Ji Xiang Zhang, Bing Xiao, Rong Rong Gong, Zhen Ding, Hong Gang Yu
BACKGROUND: Endoscopic ultrasonography (EUS) is a key procedure for the diagnosis of biliopancreatic diseases. However, the performance among EUS endoscopists varies greatly and leads to blind spots during the operation, which can impair the health outcomes of patients. We previously developed an artificial intelligence (AI) device that accurately identified EUS standard stations and significantly reduced the difficulty of ultrasonography image interpretation. In this study, we updated the device (named EUS-IREAD) and validated its performance in improving the quality of EUS procedures...
September 27, 2023: The Lancet. Digital health
Jincheng Han, Jiaqian Xu, Yonghong Liu, Shaoheng Liang, Kyle A LaBella, Deepavali Chakravarti, Denise J Spring, Yan Xia, Ronald A DePinho
Activating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial antitumor activity followed by recurrence due to cancer cell-intrinsic and immune-mediated paracrine mechanisms. Here, we explored the potential role of cancer-associated fibroblasts (CAFs) in enabling KRAS* bypass and identified CAF-derived NRG1 activation of cancer cell ERBB2 and ERBB3 receptor tyrosine kinases as a mechanism by which KRAS*-independent growth is supported...
September 29, 2023: Genes & Development
Ei-Xia Mussai, Zoe A Lofft, Ben Vanderkruk, Nicha Boonpattrawong, Joshua W Miller, Andre Smith, Teodoro Bottiglieri, Angela M Devlin
Epidemiological studies have reported discrepant findings on the relationship between folic acid intake during pregnancy and risk for gestational diabetes mellitus (GDM). To begin to understand how folic acid impacts metabolic health during pregnancy, we determined the effects of excess folic acid supplementation (5× recommendation) on maternal and fetal offspring metabolic health. Using a mouse (female C57BL/6J) model of diet-induced diabetes in pregnancy (western diet) and control mice, we show that folic acid supplementation improved insulin sensitivity in the female mice fed the western diet and worsened insulin sensitivity in control mice...
November 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Yohei Mano, Keishi Sugimachi, Tomonari Shimagaki, Takahiro Tomino, Emi Onishi, Lingaku Lee, Terumasa Hisano, Yutaka Koga, Kenichi Taguchi, Masaru Morita, Yasushi Toh
BACKGROUND: Liver metastasis of pure squamous cell carcinoma (SCC) from pancreatic ductal adenocarcinoma has not been previously reported. CASE PRESENTATION: A 66-year-old man underwent a computed tomography scan 3 years after surgery for pancreatic head cancer, and the scan revealed a mass lesion in the right lobe of the liver. A liver tumor biopsy was performed, and SCC was diagnosed. Whole sections of the pancreatic head cancer were re-evaluated, but no areas of SCC-like differentiation were identified...
September 29, 2023: Surgical Case Reports
Bin-Bin Li, Hui Zheng, Yi-Dan Lou, Wen-Wei Zhang, Song Zheng
INTRODUCTION: We present a case of a male patient with neurofibromatosis type 1 diagnosed with pancreatic divisum and several gastrointestinal tumors. A 55-year-old man was admitted to the hospital with recurrent chronic pancreatitis, indicating a large mass in the ampulla. In addition, genetic testing revealed two unique germline mutations in the neurofibromin (NF1) gene, and their potential interaction in promoting cancer was further investigated. CONCLUSION: The first similar case was reported in 2020...
September 29, 2023: Hereditary Cancer in Clinical Practice
Ji Chen, Helen Pham, Crystal Li, Christopher B Nahm, Emma Johnston, Michael John Hollands, Tony Pang, Henry Pleass, Vincent Lam, Arthur Richardson, Lawrence Yuen
BACKGROUND: Despite its proposed benefits, laparoscopic pancreaticoduodenectomy (LPD) has not been widely adopted due to its technical complexity and steep learning curve. The aim of this study was to report a single surgeon's experience in the stepwise implementation of LPD and evolution of technique over a nine-year period in a moderate-high volume unit. METHODS: Carefully selected patients underwent LPD initially by hybrid approach (laparoscopic resection and open reconstruction), which evolved into a total LPD (laparoscopic resection and reconstruction)...
September 29, 2023: ANZ Journal of Surgery
Ifeanyichukwu D Nwanji, Babatope L Awosusi, Alexander O Odigwe, Mustapha A Ajani
Diffuse large B-cell lymphoma is the most common lymphoma, accounting for 30% of all non-Hodgkin lymphomas; they can grow rapidly and often present as masses infiltrating tissues or obstructing organs. We report the case of a 58-year-old female who presented with a one-month history of generalized body weakness and weight loss with a two-week history of yellowness of the eyes, fever, dyspnea, and bilateral leg swelling. Examination at presentation revealed pallor, fever, jaundice, hepatomegaly, and bilateral pitting pedal edema...
August 2023: Curēus
Valentine S Alia, Ed W Alvarado, Edward M Diaz, Daniel Albo, Roger Galindo
The traumatic pancreatoduodenectomy, also known as the traumatic Whipple, is a specialized surgical procedure often reserved for extreme cases in which an individual suffers traumatic injuries to the pancreas, duodenum, or periampullary structures. Traditionally, a Whipple procedure is a complex surgery involving the removal of the head of the pancreas, duodenum, and a portion of both the bile duct and stomach, for the management of pancreatic head cancer. In underserved communities where limited access to healthcare is coupled with a higher incidence of trauma, the lack of specialized and supportive care for patients suffering from pancreatic injuries may lead to an increased morbidity and mortality rate...
December 2023: Trauma Case Reports
Melissa Asuaje Pfeifer, Hans Langehein, Katharina Grupe, Steffi Müller, Joana Seyda, Moritz Liebmann, Ingo Rustenbeck, Stephan Scherneck
Manifest diabetes, but also conditions of increased insulin resistance such as pregnancy or obesity can lead to islet architecture remodeling. The contributing mechanisms are as poorly understood as the consequences of altered cell arrangement. For the quantification of the different cell types but also the frequency of different cell-cell contacts within the islets, different approaches exist. However, few methods are available to characterize islet cell distribution in a statistically valid manner. Here we describe PyCreas, an open-source tool written in Python that allows semi-automated analysis of islet cell distribution based on images of pancreatic sections stained by immunohistochemistry or immunofluorescence...
2023: Frontiers in Endocrinology
Sara Peribañez-Dominguez, Zinnia P Parra-Guillen, Tomoko Freshwater, Iñaki F Troconiz
Introduction: Oncolytic viruses (OVs) represent a novel therapeutic strategy in oncology due to their capability to selectively infect and replicate in cancer cells, triggering a direct and/or immune-induced tumor lysis. However, the mechanisms governing OV pharmacokinetics are still poorly understood. This work aims to develop a physiologically based pharmacokinetic model of the novel OV, V937, in non-tumor-bearing mice to get a quantitative understanding of its elimination and tissue uptake processes. Materials and methods: Model development was performed using data obtained from 60 mice...
2023: Frontiers in Pharmacology
Stefan G Pierzynowski, Christine Stier, Kateryna Pierzynowska
The anti-incretin theory involving the abolishment of diabetes type (DT) II by some of methods used in bariatric surgery, first appeared during the early years of the XXI century and considers the existence of anti-incretin substances. However, to date no exogenous or endogenous anti-incretins have been found. Our concept of the acini-islet-acinar axis assumes that insulin intra-pancreatically stimulates alpha-amylase synthesis ("halo phenomenon") and in turn, alpha-amylase reciprocally inhibits insulin production, thus making alpha-amylase a candidate for being an anti-incretin...
September 15, 2023: World Journal of Diabetes
Yuping Zhang, Xi Wu, Guodong Li, Haiyan Dong
Desmoid type fibromatosis (DTF) is a rare intermediate soft tissue tumor. Here we report a case of DTF located in the tail of pancreas. A 39-year-old female presented epigastric pain of 1 week duration. An abdominal magnetic resonance imaging revealed a 3.4-cm irregular contour solid mass in the tail of the pancreas that was interpreted by radiology as suspicious for a benign pancreatic tumor. Endoscopic ultrasound (EUS) showed an irregularly shaped hypoechoic, heterogeneous mass within the tail of pancreas invading the adjacent gastric wall, suggesting a diagnosis of malignant pancreatic tumor...
September 29, 2023: Revista Española de Enfermedades Digestivas
Li Guo, Yiying Qian
We present the case of a 17-year-old male who presented with pancreatic enlargement and abdominal discomfort. Imaging showed diffusely distributed cystic lesions in the pancreas, which led to the diagnosis of a case of Acinar Cystic Transformation, a rare cystic lesion of the pancreas.
September 29, 2023: Revista Española de Enfermedades Digestivas
Jun Xie, Wei Chen, Hongming Liu
A 52-year-old male diagnosed with severe acute pancreatitis developed persistent abdominal distension and intermittent emesis six weeks after treatment. Computed tomography (CT) showed that the shape of the pancreas was not clear, and a pseudocyst (11.2*6.6 cm) existed in the tail of the pancreas, which compressed the portal vein and led to local portal hypertension. A transpapillary pancreatic duct stent (7F*9 cm) was successfully placed for drainage of fluid collection despite pancreatic duct obstruction, with one end into the pseudocyst cavity and the other into the duodenum...
September 29, 2023: Revista Española de Enfermedades Digestivas
Jihoon Kwon, Michelle S Kim, Christina Blagojevic, Jaymie Mailloux, Samantha Medwid, Rommel G Tirona, Rennian Wang, Ute I Schwarz
An increased risk of new-onset diabetes mellitus has been recently reported for statin therapy, and experimental studies have shown reduced glucose-stimulated insulin secretion (GSIS) and mitochondrial dysfunction in beta cells with effects differing among agents. Organic anion transporting polypeptide (OATP) 2B1 contributes to hepatic uptake of rosuvastatin, atorvastatin and pravastatin, three known substrates. Since OATP2B1 is present in beta cells of the human pancreas, we investigated if OATP2B1 facilitates the local accumulation of statins in a rat beta cell model INS-1 832/13 (INS-1) thereby amplifying statin-induced toxicity...
September 28, 2023: Toxicology Mechanisms and Methods
Masahide Otani, Daisuke Ishii, Hiroyoshi Iwata, Yoshiyasu Satake, Yoko Okada, Asuka Toriumi, Masashi Imamura, Yuji Nishikawa, Naoto Matsuno
BACKGROUND: The University of Wisconsin (UW) solution is the gold standard for preserving the liver, kidneys, and pancreas. For renal preservation, the addition of the flavonoid, quercetin (QE), to the preservation solution reduces damage to renal tubular cells, and the addition of sucrose (Suc) is also beneficial for preservation. The aim of this study was to investigate the protective effects of QE and Suc on porcine livers in terms of warm and cold injury and to evaluate whether their use improves ischemia-reperfusion (I/R) injury after simple cold storage (CS)...
September 26, 2023: Transplantation Proceedings
Arvid Sandforth, Reiner Jumpertz von Schwartzenberg, Elsa Vazquez Arreola, Robert L Hanson, Gencer Sancar, Sarah Katzenstein, Karl Lange, Hubert Preißl, Simon I Dreher, Cora Weigert, Robert Wagner, Kostantinos Kantartzis, Jürgen Machann, Fritz Schick, Rainer Lehmann, Andreas Peter, Nikoletta Katsouli, Vasilis Ntziachristos, Corinna Dannecker, Louise Fritsche, Nikolaos Perakakis, Martin Heni, Peter Paul Nawroth, Stefan Kopf, Andreas F H Pfeiffer, Stefan Kabisch, Michael Stumvoll, Peter E H Schwarz, Hans Hauner, Andreas Lechner, Jochen Seissler, Iryna Yurchenko, Andrea Icks, Michele Solimena, Hans-Ulrich Häring, Julia Szendroedi, Annette Schürmann, Martin Hrabé de Angelis, Matthias Blüher, Michael Roden, Stefan R Bornstein, Norbert Stefan, Andreas Fritsche, Andreas L Birkenfeld
BACKGROUND: Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion. In this analysis, we aimed to investigate the mechanisms of weight loss- induced remission in people with prediabetes. METHODS: In this prespecified post-hoc analysis, weight loss-induced resolution of prediabetes in the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS) was assessed, and the results were validated against participants from the Diabetes Prevention Program (DPP) study...
September 25, 2023: Lancet Diabetes & Endocrinology
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