Meredith A Atkinson, Eric B Jelin, Ahmet Baschat, Yair J Blumenfeld, Ramen H Chmait, Elizabeth O'Hare, Julie S Moldenhauer, Michael V Zaretsky, Russell S Miller, Rodrigo Ruano, Juan M Gonzalez, Anthony Johnson, W Andrew Mould, Jonathan M Davis, Daniel F Hanley, Amaris M Keiser, Mara Rosner, Jena L Miller
PURPOSE: Anhydramnios secondary to anuria before 22 weeks of gestational age and congenital bilateral renal agenesis before 26 weeks of gestational age are collectively referred to as early-pregnancy renal anhydramnios. Early-pregnancy renal anhydramnios occurs in at least 1 in 2000 pregnancies and is considered universally fatal when left untreated because of severe pulmonary hypoplasia precluding ex utero survival The Renal Anhydramnios Fetal Therapy (RAFT) trial is a nonrandomized, nonblinded, multicenter clinical trial designed to assess the efficacy, safety, and feasibility of amnioinfusions for patients with pregnancies complicated by early-pregnancy renal anhydramnios...
July 30, 2022: Clinical Therapeutics