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JOURNAL ARTICLE
Rachel S Gross, Tanayott Thaweethai, Erika B Rosenzweig, James Chan, Lori B Chibnik, Mine S Cicek, Amy J Elliott, Valerie J Flaherman, Andrea S Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L Jernigan, Elizabeth W Karlson, Stuart D Katz, Patricia A Kinser, Lawrence C Kleinman, Michelle F Lamendola-Essel, Joshua D Milner, Sindhu Mohandas, Praveen C Mudumbi, Jane W Newburger, Kyung E Rhee, Amy L Salisbury, Jessica N Snowden, Cheryl R Stein, Melissa S Stockwell, Kelan G Tantisira, Moriah E Thomason, Dongngan T Truong, David Warburton, John C Wood, Shifa Ahmed, Almary Akerlundh, Akram N Alshawabkeh, Brett R Anderson, Judy L Aschner, Andrew M Atz, Robin L Aupperle, Fiona C Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C Bind, Amanda L Bogie, Tamara Bradford, Natalie C Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Maryanne Chrisant, Duncan B Clark, Rebecca G Clifton, Katharine N Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Audrey Dionne, Kirsten B Dummer, Matthew D Elias, Shari Esquenazi-Karonika, Danielle N Evans, E Vincent S Faustino, Alexander G Fiks, Daniel Forsha, John J Foxe, Naomi P Friedman, Greta Fry, Sunanda Gaur, Dylan G Gee, Kevin M Gray, Stephanie Handler, Ashraf S Harahsheh, Keren Hasbani, Andrew C Heath, Camden Hebson, Mary M Heitzeg, Christina M Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R Horowitz, Daniel S Hsia, Matthew Huentelman, Kathy D Hummel, Katherine Irby, Joanna Jacobus, Vanessa L Jacoby, Pei-Ni Jone, David C Kaelber, Tyler J Kasmarcak, Matthew J Kluko, Jessica S Kosut, Angela R Laird, Jeremy Landeo-Gutierrez, Sean M Lang, Christine L Larson, Peter Paul C Lim, Krista M Lisdahl, Brian W McCrindle, Russell J McCulloh, Kimberly McHugh, Alan L Mendelsohn, Torri D Metz, Julie Miller, Elizabeth C Mitchell, Lerraughn M Morgan, Eva M Müller-Oehring, Erica R Nahin, Michael C Neale, Manette Ness-Cochinwala, Sheila M Nolan, Carlos R Oliveira, Onyekachukwu Osakwe, Matthew E Oster, R Mark Payne, Michael A Portman, Hengameh Raissy, Isabelle G Randall, Suchitra Rao, Harrison T Reeder, Johana M Rosas, Mark W Russell, Arash A Sabati, Yamuna Sanil, Alice I Sato, Michael S Schechter, Rangaraj Selvarangan, S Kristen Sexson Tejtel, Divya Shakti, Kavita Sharma, Lindsay M Squeglia, Shubika Srivastava, Michelle D Stevenson, Jacqueline Szmuszkovicz, Maria M Talavera-Barber, Ronald J Teufel, Deepika Thacker, Felicia Trachtenberg, Mmekom M Udosen, Megan R Warner, Sara E Watson, Alan Werzberger, Jordan C Weyer, Marion J Wood, H Shonna Yin, William T Zempsky, Emily Zimmerman, Benard P Dreyer
IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative...
2024: PloS One
#42
JOURNAL ARTICLE
Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice.
Gholson J Lyon, Joseph Longo, Andrew Garcia, Fatima Inusa, Elaine Marchi, Daniel Shi, Max Dörfel, Thomas Arnesen, Rafael Aldabe, Scott Lyons, Melissa A Nashat, David Bolton
Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene, NAA10, encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A (NatA) complex. There is extensive genetic variation in humans with missense, splice-site, and C-terminal frameshift variants in NAA10. In mice, Naa10 is not an essential gene, as there exists a paralogous gene, Naa12, that substantially rescues Naa10 knockout mice from embryonic lethality, whereas double knockouts (Naa10-/Y Naa12-/-) are embryonic lethal...
2024: PloS One
#43
JOURNAL ARTICLE
Sharon N Mokua, Lorraine Ombogo, David Mathu, Prisca Otambo, Lilian Nyandieka, Stephen N Onteri, Schiller J Mbuka, James Kariuki, Ismail Ahmed, Violet Wanjihia, Joseph Mutai, Zipporah Bukania
The achievement of Universal Health Coverage (UHC) requires equitable access and utilization of healthcare services across all population groups, including men. However, men often face unique barriers that impede their engagement with health systems which are influenced by a myriad of socio-cultural, economic, and systemic factors. Therefore, understanding men's perspectives and experiences is crucial to identifying barriers and facilitators to their healthcare-seeking behaviour under UHC initiatives. This qualitative study sought to explore men's perceptions, experiences, healthcare needs and potential strategies to inform an impartial implementation of Universal Health Coverage (UHC) in Kenya...
2024: PLOS Glob Public Health
#44
JOURNAL ARTICLE
Norbert J van Dijk, Dawit Gebreegziabiher Hagos, Daniela M Huggins, Eugenia Carrillo, Sophia Ajala, Carmen Chicharro, David Kiptanui, Jose Carlos Solana, Edwin Abner, Dawit Wolday, Henk D F H Schallig
BACKGROUND: Diagnosis of visceral leishmaniasis (VL) in resource-limited endemic regions is currently based on serological testing with rK39 immunochromatographic tests (ICTs). However, rK39 ICT frequently has suboptimal diagnostic accuracy. Furthermore, treatment monitoring and detection of VL relapses is reliant on insensitive and highly invasive tissue aspirate microscopy. Miniature direct-on-blood PCR nucleic acid lateral flow immunoassay (mini-dbPCR-NALFIA) is an innovative and user-friendly molecular tool which does not require DNA extraction and uses a lateral flow strip for result read-out...
May 2024: PLoS Neglected Tropical Diseases
#45
JOURNAL ARTICLE
Mathieu Malherbe, Liran Samuni, Sonja J Ebel, Kathrin S Kopp, Catherine Crockford, Roman M Wittig
Tool use is considered a driving force behind the evolution of brain expansion and prolonged juvenile dependency in the hominin lineage. However, it remains rare across animals, possibly due to inherent constraints related to manual dexterity and cognitive abilities. In our study, we investigated the ontogeny of tool use in chimpanzees (Pan troglodytes), a species known for its extensive and flexible tool use behavior. We observed 70 wild chimpanzees across all ages and analyzed 1,460 stick use events filmed in the Taï National Park, Côte d'Ivoire during the chimpanzee attempts to retrieve high-nutrient, but difficult-to-access, foods...
May 2024: PLoS Biology
#46
JOURNAL ARTICLE
Shanwei Shen, Senthil K Radhakrishnan, J Chuck Harrell, Madhavi Puchalapalli, Jennifer Koblinski, Charles Clevenger
Prolactin and its receptor (PRLr) in humans are significantly involved in breast cancer pathogenesis. The intermediate form of human PRLr (hPRLrI) is produced by alternative splicing and has a novel 13 amino acid tail ("I-tail") gain. hPRLrI induces significant proliferation and anchorage-independent growth of normal mammary epithelia in vitro when coexpressed with the long form hPRLr (hPRLrL). hPRLrL and hPRLrI coexpression is necessary to induce the transformation of mammary epithelia in vivo. The I-tail is associated with the ubiquitin-like protein neural precursor cell expressed developmentally downregulated protein 8...
April 29, 2024: Endocrinology
#47
JOURNAL ARTICLE
Haoyi Wang, Hanne M L Zimmermann, David van de Vijver, Kai J Jonas
Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is efficacious in preventing HIV among men-who-have-sex-with-men (MSM) and will be soon available in Europe. This study investigated the intention and preference to use LAI-PrEP among MSM in the Netherlands by employing a diffusion of innovation approach. This study had a cross-sectional design nested within a cohort study established in 2017 to understand oral PrEP use among MSM. 309 MSM completed the survey on their awareness, interest, intention, and preference for LAI-PrEP in June 2022...
May 7, 2024: AIDS Care
#48
JOURNAL ARTICLE
Viraj Doddihal, Frederick G Mann, Eric J Ross, Mary C McKinney, Carlos Guerrero-Hernández, Carolyn E Brewster, Sean A McKinney, Alejandro Sánchez Alvarado
Successful regeneration of missing tissues requires seamless integration of positional information along the body axes. Planarians, which regenerate from almost any injury, use conserved, developmentally important signaling pathways to pattern the body axes. However, the molecular mechanisms which facilitate cross talk between these signaling pathways to integrate positional information remain poorly understood. Here, we report a p21-activated kinase ( smed-pak1 ) which functionally integrates the anterior-posterior (AP) and the medio-lateral (ML) axes...
May 14, 2024: Proceedings of the National Academy of Sciences of the United States of America
#49
JOURNAL ARTICLE
Alberto Torcello-Requena, Andrew R J Murphy, Ian D E A Lidbury, Frances D Pitt, Richard Stark, Andrew D Millard, Richard J Puxty, Yin Chen, David J Scanlan
Marine picocyanobacteria of the genera Prochlorococcus and Synechococcus , the two most abundant phototrophs on Earth, thrive in oligotrophic oceanic regions. While it is well known that specific lineages are exquisitely adapted to prevailing in situ light and temperature regimes, much less is known of the molecular machinery required to facilitate occupancy of these low-nutrient environments. Here, we describe a hitherto unknown alkaline phosphatase, Psip1, that has a substantially higher affinity for phosphomonoesters than other well-known phosphatases like PhoA, PhoX, or PhoD and is restricted to clade III Synechococcus and a subset of high light I-adapted Prochlorococcus strains, suggesting niche specificity...
May 14, 2024: Proceedings of the National Academy of Sciences of the United States of America
#50
JOURNAL ARTICLE
Yun Han Kwon, Benjamin E Blass, Huaqing Wang, Jensine A Grondin, Suhrid Banskota, Kenneth Korzekwa, Min Ye, John C Gordon, Dennis Colussi, Kevin M Blattner, Daniel J Canney, Waliul I Khan
Inflammatory bowel disease (IBD) encompasses a number of debilitating chronic gastrointestinal (GI) inflammatory disorders, including Crohn's disease and ulcerative colitis. In both conditions, mucosal inflammation is a key clinical presentation and is associated with altered serotonin (5-hydroxytryptamine; 5-HT) signaling. This altered 5-HT signaling is also found across various animal models of colitis. Of the 14 known receptor subtypes, 5-HT receptor type 7 (5-HT7 ) is one of the most recently discovered...
May 7, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
#51
JOURNAL ARTICLE
Nicholas T Severyn, Patricia Esparza, Huanling Gao, Elizabeth A Mickler, Marjorie E Albrecht, Amanda J Fisher, Bakhtiyor Yakubov, Todd G Cook, James E Slaven, Avram D Walts, Robert S Tepper, Tim Lahm
Humans living at high-altitude (HA) have adapted to this environment by increasing pulmonary vascular and alveolar growth. RNA sequencing data from a novel murine model that mimics this phenotypical response to HA suggested estrogen signaling via estrogen receptor alpha (ERα) may be involved in this adaptation. We hypothesized ERα was a key mediator in the cardiopulmonary adaption to chronic hypoxia and sought to delineate the mechanistic role ERα contributes to this process by exposing novel loss-of-function ERα mutant (ERαMut) rats to simulated HA...
May 7, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
#52
MULTICENTER STUDY
Noor J Sissingh, Fleur E M de Rijk, Hester C Timmerhuis, Devica S Umans, Marie-Paule G F Anten, Stefan A W Bouwense, Foke van Delft, Brechje C van Eijck, Willemien G Erkelens, Wouter L Hazen, Sjoerd D Kuiken, Rutger Quispel, Tessa E H Romkens, Matthijs P Schwartz, Tom C Seerden, B W Marcel Spanier, Tessa Verlaan, Frank P Vleggaar, Rogier P Voermans, Robert C Verdonk, Jeanin E van Hooft
BACKGROUND: Data on the incidence and clinical relevance of gallstones in patients with suspected acute alcoholic pancreatitis are lacking and are essential to minimize the risk of recurrent acute pancreatitis. The aim of this study was to assess the incidence of gallstones and the associated rate of recurrent acute pancreatitis in patients with presumed acute alcoholic pancreatitis. METHODS: Between 2008 and 2019, 23 hospitals prospectively enrolled patients with acute pancreatitis...
May 3, 2024: British Journal of Surgery
#53
JOURNAL ARTICLE
Özer Makay, Orhan Agcaoglu, Claire Nominé-Criqui, Klaas Van Den Heede, Julia I Staubitz-Vernazza, Francesco Pennestrì, Laurent Brunaud, Marco Raffaelli, Maurizio Iacobone, Sam Van Slycke, Thomas J Musholt, Jesús Villar-Del-Moral
No abstract text is available yet for this article.
May 3, 2024: British Journal of Surgery
#54
JOURNAL ARTICLE
Lisa M Schilling, Brittney R Fraumeni, Amy S Nacht, Alison G Abraham, Hannah D Bauguess, Gregory Matesi, Melanie E Fringuello, Leah Rashidyan, Sarah J Billups
Current maternal care recommendations in the United States focus on monitoring fetal development, management of pregnancy complications, and screening for behavioral health concerns. Often missing from these recommendations is support for patients experiencing socioeconomic or behavioral health challenges during pregnancy. A Pregnancy Medical Home (PMH) is a multidisciplinary maternal health care team with nurse navigators serving as patient advocates to improve the quality of care a patient receives and health outcomes for both mother and infant...
May 2024: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
#55
JOURNAL ARTICLE
Sunil H Patel, Andrew T Gabrielson, Sin Chan, Deborah Schwartz, Connie Collins, Nirmish Singla, Bruce Trock, Trinity J Bivalacqua, Noah Hahn, Max R Kates
No abstract text is available yet for this article.
May 7, 2024: Journal of Urology
#56
JOURNAL ARTICLE
Alison Schaefer, Bing Yang, Holly A Schroeder, Dimple Harit, Mike S Humphry, Larry Zeitlin, Kevin J Whaley, Jacques Ravel, William A Fischer, Samuel K Lai
Abstract Vaginal transmission from semen of male Ebola virus (EBOV) survivors has been implicated as a potential origin of Ebola virus disease (EVD) outbreaks. While EBOV in semen must traverse cervicovaginal mucus (CVM) to reach target cells, the behavior of EBOV in CVM is poorly understood. CVM contains substantial quantities of IgG, and arrays of IgG bound to a virion can develop multiple Fc-mucin bonds, immobilizing the IgG/virion complex in mucus. Here, we measured the real-time mobility of fluorescent Ebola virus-like-particles (VLP) in 50 CVM specimens from 17 women, with and without ZMapp, a cocktail of 3 monoclonal IgGs against EBOV...
May 7, 2024: Emerging Microbes & Infections
#57
JOURNAL ARTICLE
Kyle Aitken, Luke Campagnola, Marina E Garrett, Shawn R Olsen, Stefan Mihalas
Detecting novelty is ethologically useful for an organism's survival. Recent experiments characterize how different types of novelty over timescales from seconds to weeks are reflected in the activity of excitatory and inhibitory neuron types. Here, we introduce a learning mechanism, familiarity-modulated synapses (FMSs), consisting of multiplicative modulations dependent on presynaptic or pre/postsynaptic neuron activity. With FMSs, network responses that encode novelty emerge under unsupervised continual learning and minimal connectivity constraints...
May 6, 2024: Cell Reports
#58
JOURNAL ARTICLE
Evan L Barrios, Jaimar C Rincon, Micah Willis, Valerie E Polcz, John Leary, Dijoia B Darden, Jeremy A Balch, Shawn D Larson, Tyler J Loftus, Alicia M Mohr, Shannon Wallet, Maigan A Brusko, Leandro Balzano-Nogueira, Guoshuai Cai, Ashish Sharma, Gilbert R Upchurch, Michael P Kladde, Clayton E Mathews, Robert Maile, Lyle L Moldawer, Rhonda Bacher, Philip A Efron
Post-sepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness (CCI) with suboptimal outcomes. The underlying immunological response that determines these clinical trajectories remains poorly defined at the transcriptomic level. As classical and non-classical monocytes are key leukocytes in both the innate and adaptive immune systems, we sought to delineate the transcriptomic response of these cell types...
May 2, 2024: Shock
#59
JOURNAL ARTICLE
Mayank V Golhar, Taylor L Bobrow, Saowanee Ngamruengphong, Nicholas J Durr
A major challenge in applying deep learning to medical imaging is the paucity of annotated data. This study explores the use of synthetic images for data augmentation to address the challenge of limited annotated data in colonoscopy lesion classification. We demonstrate that synthetic colonoscopy images generated by Generative Adversarial Network (GAN) inversion can be used as training data to improve polyp classification performance by deep learning models. We invert pairs of images with the same label to a semantically rich and disentangled latent space and manipulate latent representations to produce new synthetic images...
May 7, 2024: IEEE Journal of Biomedical and Health Informatics
#60
JOURNAL ARTICLE
Asim H Gazi, Jesus Antonio Sanchez-Perez, Georgia L Saks, Erick A Perez Alday, Ammer Haffar, Hashir Ahmed, Duaa Herraka, Nitya Tarlapally, Nicholas L Smith, J Douglas Bremner, Amit J Shah, Omer T Inan, Viola Vaccarino
BACKGROUND: Posttraumatic stress disorder (PTSD) causes heightened fight-or-flight responses to traumatic memories (i.e., hyperarousal). Although hyperarousal is hypothesized to cause irregular breathing (i.e., respiratory variability), no quantitative markers of respiratory variability have been shown to correspond with PTSD symptoms in humans. OBJECTIVE: In this study, we define interpretable markers of respiration pattern variability (RPV) and investigate whether these markers respond during traumatic memories, correlate with PTSD symptoms, and differ in patients with PTSD...
May 7, 2024: IEEE Journal of Biomedical and Health Informatics
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