Jie Hao, Chengxiang Liu, Ling Zhou, Nan Wu, Mengyi Sun, Jianren Kuang, Hang Pan, Yu Lian, Jing Li, Yan Dong, Liqing Cheng
Currently, the treatment of diabetic wounds in clinical practice is still unsatisfactory due to the risks of oxidative damage and bacterial infection during the healing process. An optimal wound dressing should exhibit robust capabilities in scavenging reactive oxygen species (ROS) and combatting bacterial growth. In this study, we utilized borax as a crosslinker and prepared a pH/glucose dual-responsive composite hydrogel based on poly(vinyl alcohol) (PVA), sodium alginate (SA), and tannic acid (TA). This hydrogel, loaded with cerium dioxide, serves as an effective ROS scavenger, promoting wound closure by reducing the level of ROS in the wound area...
June 4, 2024: International Journal of Biological Macromolecules