Juan Pedro-Botet, Juan F Ascaso, Mariano Blasco, Ángel Brea, Ángel Díaz, Antonio Hernández-Mijares, Xavier Pintó, Jesús Millán
In general, both European and American clinical guidelines have addressed the management of atherogenic dyslipidaemia in an unconvincing and even superficial way, largely because of the available therapeutic limitations. Consequently, this type of dyslipidaemia is underdiagnosed, under-treated, and under-controlled. Given the recent presentation of the 2019 guidelines of the European Atherosclerosis Society and the European Society of Cardiology on the management of dyslipidaemias, it seems appropriate to examine its position with respect to atherogenic dyslipidaemia and/or its main components, the increase in triglyceride-rich lipoproteins, and the decrease of high-density lipoprotein cholesterol...
February 6, 2020: Clínica e Investigación en Arteriosclerosis
Dilay Karabulut, Umut Karabulut, Fatma Nihan Cağlar, Mithat Ekşi, Mustafa Gurkan Yenice, Ekrem Guner, Esra Donmez İşler, Ersan Oflar, Ali İhsan TaşcI, Faruk Akturk
PURPOSE: This study aims to assess the association between CHA2DS2-VASc score and erectile dysfunction in patients who were admitted to cardiology outpatient clinics. MATERIALS AND METHODS: One hundred and two male patients who were admitted to the cardiology outpatient clinic were included to the study. Erectile dysfunction was evaluated in the urology outpatient clinic in the same hospital and scored using Turkish Version of The International Index of Erectile Function...
November 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Mariano Blasco, Juan F Ascaso
The importance of overall lipid control in cardiovascular prevention is reviewed. Several studies and meta-analyses show that the control of LDL cholesterol (LDL-C) still maintains a high cardiovascular risk, which is related to the presence of triglyceride-rich lipoproteins, and therefore with an increase in plasma triglycerides and the values of apolipoprotein B (apoB) containing these lipoproteins. The importance of this relationship is due to the change in the lipid profile of our population in recent years...
December 2019: Clínica e Investigación en Arteriosclerosis
Lourdes Barbosa-Cortés, Miguel Ángel Villasis-Keever, Irene Montalvo-Valverde, Alejandra Aguilar-Kitsu, Karina Díaz de León-Félix, Eos Eunice Gómez-López, Jessie Nallely Zurita-Cruz
Introducción: los pacientes con enfermedad renal crónica (ERC) deben ser considerados como un grupo de alto riesgo cardiovascular, ya que existen múltiples factores que incrementan la presencia de dislipidemia. Objetivo: determinar si el cociente androide/ginecoide (CA/G) tiene utilidad como factor cardiometabólico para dislipidemia en pacientes pediátricos con insuficiencia renal crónica Materiales y métodos: estudio de una cohorte. Se incluyeron pacientes con ERC terminal en diálisis peritoneal y hemodiálisis...
June 13, 2019: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Antoaneta T Gateva, Tsvetelina V Velikova, Zdravko A Kamenov
BACKGROUND: Peroxiredoxin 4 is a part of endogen antioxidant system and its levels are elevated in increased oxidative stress conditions. It is found to be positively associated with cardiovascular risk. The aim of the study was to investigate peroxiredoxin 4 levels in women with polycystic ovarian syndrome (PCOS) and/or obesity. METHODS: In this cros-sesctional study were included 80 patients. Anthropometric measurements and biochemical tests, including peroxiredoxin 4 measurement, were performed...
April 10, 2019: Journal of Gynecology Obstetrics and Human Reproduction
Oscar Geovanny Enríquez Martínez, Vivian Cristine Luft, Carolina Perim de Faria, Maria Del Carmen Bisi Molina
Introducción: las dislipidemias son definidas comúnmente por niveles bajos de HDL-c y altos niveles de triglicéridos y LDL-c. Son varios los factores relacionados con esta patogénesis y uno de ellos es el consumo de alcohol, presentado divergencias entre la cantidad y el tipo de bebida alcohólica que debe consumirse para encontrar efectos de asociación con los parámetros lipídicos. Objetivo: investigar la relación entre el consumo de alcohol y el tipo de bebida alcohólica y los parámetros lipídicos HDL-c y triglicéridos en participantes del Estudio Longitudinal de Salud del Adulto (ELSA-Brasil)...
April 8, 2019: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Deniz Özalp Kızılay, Semra Şen, Betül Ersoy
Objective: The aim of this study was to assess the association between serum uric acid concentration (SUAC) and the parameters of the metabolic syndrome (MetS) and insulin resistance (IR). The secondary aim was to evaluate whether hyperuricemia is associated with renal injury and cardiovascular risk in obese (OB) and overweight (OW) children. Methods: The subjects of this study consisted of OB/OW children and adolescents (ages: 8-18 years). Sex and age specific serum uric acid (SUA) olarak değiştirilecek percentiles were used and a SUA >75th percentile was accepted as hyperuricemia...
September 3, 2019: Journal of Clinical Research in Pediatric Endocrinology
Antonio Bruno, Rocco Antonio Zoccali, Gianluca Pandolfo, Clemente Cedro, Carlo Guarna, Maria Rosaria Anna Muscatello
Introduzione. La frazione polifenolica del bergamotto (BPF) ha dimostrato di possedere buona efficacia nel trattamento dei pazienti affetti da sindrome metabolica (SM) e pertanto potrebbe rappresentare una strategia promettente nel trattamento degli effetti collaterali indotti da antipsicotici di seconda generazione (SGA) in soggetti schizofrenici in trattamento con tali farmaci. Materiali e metodi. A 15 pazienti schizofrenici in trattamento stabilizzato con SGA e 15 soggetti di controllo non affetti da patologie psichiatriche, che presentavano valori ematici di colesterolo totale compresi tra 200 e 239 mg/dl, è stato somministrato un integratore contenente BPF (1000 mg) per un periodo di 60 giorni...
September 2018: Rivista di Psichiatria
Pijun Yan, Yong Xu, Zhihong Zhang, Chenlin Gao, Jianhua Zhu, Hua Li, Qin Wan
Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to investigate the relationship between circulating Nrg4 and DPN in a cross-sectional study. Circulating Nrg4 levels were determined with an enzyme-linked immunosorbent assays kit in 132 newly diagnosed type 2 diabetes mellitus (nT2DM) patients and 41 normal controls (NC group)...
October 12, 2018: Cytokine
Gamze Akkus, Mehtap Evran, Murat Sert, Tamer Tetiker
OBJECTIVE: Adrenal incidentalomas are diagnosed incidentally during radiological screenings and requires endocrinological investigations for hormonal activity and malignancy. In certain studies, it has been reported that non-functional incidentalomas can be associated with high adipocytokines levels affecting the insulin resistance just like the adipose tissue with metabolic syndrome. Here, we studied serum adipocytokine levels including leptin, resistin, visfatin, omentin 1 and adiponectin in subjects with non-functional adrenal incidentaloma...
October 9, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Antonio Hernández-Mijares, Juan F Ascaso, Mariano Blasco, Ángel Brea, Ángel Díaz, Teresa Mantilla, Juan Pedro-Botet, Xavier Pintó, Jesús Millán
There is no doubt about the relationship between LDL-c and cardiovascular risk, as well as about the benefits of statin treatment. Once the objective of LDL-c has been achieved, the evidences that demonstrate the persistence of a high cardiovascular risk, a concept called residual risk, are notable. The residual risk of lipid origin is based on atherogenic dyslipidemia, characterized by an increase in triglycerides and triglyceride-rich lipoproteins, a decrease in HDL-c and qualitative alterations in LDL particles...
March 2019: Clínica e Investigación en Arteriosclerosis
Dibyendu Das, Sanjib Sarkar, Jijnasa Bordoloi, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Over the last decades, the incidence of type 2 diabetes (T2D) is increasing substantially. Emerging evidences from epidemiological studies have shown the association between higher intake of soy isoflavones and reduced risk of T2D and its associated health risks. Daidzein, a soy isoflavone, has been found to have a promising therapeutic potential in managing T2D pathophysiology. Fermented soybean is the major source of daidzein; however, it can also be formed via the consumption of its glycosylated moiety, daidzin with subsequent hydrolysis by intestinal bacterial enzyme...
September 2018: BioFactors
Teresa Padró, Gemma Vilahur, Lina Badimon
Dyslipidemia is widely accepted as one of the major risk factors in cardiovascular disease mainly due to its contribution in the pathogenesis of atherosclerosis in medium-sized and large arteries. However, it has become increasingly accepted that high-cholesterol levels can also adversely affect the microvasculature prior to the development of overt atherosclerosis. Moreover, hypercholesterolemia has shown, in preclinical animal models, to exert detrimental effects beyond the vascular tree leading to larger infarcts and adverse cardiac remodeling post-myocardial infarction...
2018: Current Pharmaceutical Design
Patricio López-Jaramillo, Carlos Calderón, Jorge Castillo, Iván Darío Escobar, Enrique Melgarejo, Gustavo Adolfo Parra
The prevalence of Prediabetes in Colombia is high, and despite being recognized and categorized in the main Medical Guidelines and included in the International Classification of Diseases in Colombia, knowledge and awareness of it is limited amongst healthcare professionals and in the community. Our expert group recommends that educational programs emphasize a global approach to risk which includes a recognition of the importance of prediabetes and its evaluation along with and other risk factors such as a family history of DM2, overweight and obesity, dislipidemia and hypertension...
December 30, 2017: Colombia Médica: CM
Joao Sequeira Duarte, Carlos Bello, Rute Ferreira, Clotilde Limbert, Manuela Oliveira, Jorge Azinheira, Carlos Vasconcelos
No abstract text is available yet for this article.
August 2017: Atherosclerosis
L Engelbrechtsen, J Lundgren, N J Wewer Albrechtsen, Y Mahendran, E W Iepsen, P Finocchietto, A E Jonsson, S Madsbad, J J Holst, H Vestergaard, T Hansen, S S Torekov
Background: Dislipidaemia and increased levels of apolipoprotein B (apoB) in individuals with obesity are risk factors for development of cardiovascular disease (CVD). The aim of this study was to investigate the effect of weight loss and weight maintenance with and without liraglutide treatment on plasma lipid profiles and apoB. Methods: Fifty-eight individuals with obesity (body mass index 34.5 ± 3.0 kg/m2 [mean ± SD]) were included in this study. After 8 weeks on a very low-calorie diet (800 kcal/day), participants were randomized to weight maintenance with meal replacements with or without liraglutide (1...
December 2017: Obesity Science & Practice
Akram Ahangarpour, Hamid Heidari, Majid Salehizade Junghani, Reza Absari, Mehdi Khoogar, Ehsan Ghaedi
Type 2 diabetes often leads to dislipidemia and abnormal activity of hepatic enzymes. The purpose of this study was to evaluate the antidiabetic and hypolipidemic properties of Rhus coriaria (R. coriaria) seed extrac on nicotinamide-streptozotocin induced type 2 diabetic mice. In this experimental study, 56 male Naval Medical Research Institute mice (30-35 g) were randomly separated into seven groups: control, diabetic group, diabetic mice treated with glibenclamide (0.25 mg/kg, as standard antidiabetic drug) or R...
October 2017: Research in Pharmaceutical Sciences
Boris Rosin, Tareq Jaouni
PURPOSE: A case report of a patient with severe proliferative retinopathy due to congenital lipodystrophy. METHODS: We reviewed the medical history, imaging, and surgical procedures of a 25-year-old woman with a history of congenital lipodystrophy, presenting with bilateral combined tractional and exudative retinal detachment, poorly controlled diabetes mellitus, and extreme dislipidemia. RESULTS: The patient underwent retinal detachment repair surgery both eyes...
August 21, 2017: Retinal Cases & Brief Reports
Fernando Henpin Yue Cesena, Antonio Gabriele Laurinavicius, Viviane A Valente, Raquel D Conceição, Raul D Santos, Marcio S Bittencourt
Background: The best way to select individuals for lipid-lowering treatment in the population is controversial. Objective: In healthy individuals in primary prevention: to assess the relationship between cardiovascular risk categorized according to the V Brazilian Guideline on Dyslipidemia and the risk calculated by the pooled cohort equations (PCE); to compare the proportion of individuals eligible for statins, according to different criteria. Methods: In individuals aged 40-75 years consecutively submitted to routine health assessment at one single center, four criteria of eligibility for statin were defined: BR-1, BR-2 (LDL-c above or at least 30 mg/dL above the goal recommended by the Brazilian Guideline, respectively), USA-1 and USA-2 (10-year risk estimated by the PCE ≥ 5...
June 2017: Arquivos Brasileiros de Cardiologia
Anderson DA Silva Rêgo, Aline Zulin, Sandro Scolari, Sônia Silva Marcon, Cremilde Aparecida Trindade Radovanovic
Objective: to compare the clinical conditions of obese patients in the pre and postoperative period of bariatric surgery. Methods: we carried out a descriptive, retrospective, quantitative study by consulting the charts of 134 patients who underwent bariatric surgery in the period from 2009 to 2014. We collected the data between September and November 2015. We performed a descriptive statistical analysis and comparative analysis of anthropometric, metabolic, biochemical and clinical variables, considering six months before and after surgery...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
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