Emily A McGlade, Gerardo G Herrera, Kalli K Stephens, Sierra L W Olsen, Sarayut Winuthayanon, Joie Guner, Sylvia C Hewitt, Kenneth S Korach, Francesco J DeMayo, John P Lydon, Diana Monsivais, Wipawee Winuthayanon
One of the endogenous estrogens, 17β-estradiol (E2 ) is a female steroid hormone secreted from the ovary. It is well established that E2 causes biochemical and histological changes in the uterus. However, it is not completely understood how E2 regulates the oviductal environment in vivo. In this study, we assessed the effect of E2 on each oviductal cell type, using an ovariectomized-hormone-replacement mouse model, single-cell RNA-sequencing (scRNA-seq), in situ hybridization, and cell-type-specific deletion in mice...
May 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology