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https://read.qxmd.com/read/100001002/kdigo-2013-clinical-practice-guideline-for-lipid-management-in-chronic-kidney-disease-full-guidelines
#1
(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
https://read.qxmd.com/read/100001001/summary-of-recommendation-statements-kdigo-2013-clinical-practice-guideline-for-lipid-management-in-chronic-kidney-disease
#2
(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
https://read.qxmd.com/read/34293750/redefining-the-role-of-donor-biopsies-in-the-process-of-kidney-graft-assessment
#3
Camillo Carrara, Piero Ruggenenti, Giuseppe Remuzzi
No abstract text is available yet for this article.
July 22, 2021: Nephron
https://read.qxmd.com/read/34293749/a-case-of-hypophosphatemia-due-to-oncogenic-osteomalacia-in-a-patient-with-natural-killer-t-cell-lymphoma
#4
Guoliang Zheng, Swetha Rani Kanduri, John P Canterbury, Thuy Nguyen, Juan Carlos Q Velez
INTRODUCTION: Oncogenic osteomalacia (Onc-Ost) is a paraneoplastic phenomenon characterized by hypophosphatemia due to elevated fibroblast growth factor-23 (FGF-23). Onc-Ost has been previously reported in patients with germ line mesenchymal tumors and solid organ malignancies. This is the first report of aggressive natural killer (NK) T-cell lymphoma presenting as Onc-Ost. CASE DESCRIPTION: A 33-year-old Vietnamese female with active hepatitis B and Mycobacterium avium complex, on ongoing therapy with tenofovir disoproxil, azithromycin, and ethambutol, presented with persistent fevers and developed refractory hypophosphatemia...
July 22, 2021: Kidney & Blood Pressure Research
https://read.qxmd.com/read/34293738/ferric-citrate-dosing-in-iron-deficiency-anemia-in-nondialysis-dependent-chronic-kidney-disease
#5
Pablo E Pergola, Diogo Belo, Paul Crawford, Moustafa Moustafa, Wenli Luo, Alexander Goldfarb-Rumyantzev, Youssef M K Farag
INTRODUCTION: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). METHODS: In this phase 4, randomized, open-label, multicenter study, patients with anemia with NDD-CKD (estimated glomerular filtration rate, ≥20 mL/min and <60 mL/min) were randomized 1:1 to one FC tablet (1-g equivalent to 210 mg ferric iron) TID (3 g/day) or 2 tablets twice daily (BID; 4 g/day)...
July 22, 2021: American Journal of Nephrology
https://read.qxmd.com/read/34293637/threatening-blindness-in-a-child-with-typical-hemolytic-uremic-syndrome
#6
Anaïs Corgier-Pattberg, Marie Beylerian, Stephanie Clave, Mathilde Cailliez, Benoit Testud, Beatrice Desnous
BACKGROUND: Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children younger than five years. Central nervous system involvement occurs in 15% of patients, with clinical manifestations including confusion, coma, seizures, stroke, and cortical blindness. Ocular involvement in children with HUS is rare, but retinal and choroidal hemorrhages as well as ischemic retinopathy due to thrombotic microangiopathic lesions have been documented. PATIENT DESCRIPTION: We describe a 26-month-old girl with typical HUS who experienced severe visual loss likely resulting from cytotoxic injury of both lateral geniculate nuclei with bilateral damage to optic pathways coupled with macular thrombotic microangiopathic lesions...
June 25, 2021: Pediatric Neurology
https://read.qxmd.com/read/34293479/two-newly-isolated-gvi-lineage-infectious-bronchitis-viruses-in-china-show-unique-molecular-and-pathogenicity-characteristics
#7
Lu Sun, Xinyan Tang, Jingyi Qi, Chunyan Zhang, Jing Zhao, Guozhong Zhang, Ye Zhao
During 2016 to 2020, GVI-1 type infectious bronchitis virus (IBV) strains were sporadically reported across China, indicating a new epidemic trend of the virus. Here we investigated the molecular characteristics and pathogenicity of two newly isolated GVI-1 type IBV virus strains (CK/CH/TJ1904 and CK/CH/NP2011) from infected chicken farms in China. Genetic evolution analysis of the S1 gene showed the highest homology with the GVI-1 representative strain, TC07-2. Phylogenetic analysis and recombination analysis of the virus genomes indicated that newly isolated strains in China may be independently derived from recombination events that occurred between GI-19 and GI-22 strains and early GVI-1 viruses...
July 19, 2021: Infection, Genetics and Evolution
https://read.qxmd.com/read/34293456/wu-zi-yan-zong-wan-protects-mouse-blood-testis-barrier-from-tripterygium-wilfordii-hook-f-multiglycoside-induced-disruption-by-regulating-proinflammatory-cytokines
#8
Zhenkun Pan, Yunxiao Gao, Shuang Liu, Zhenghao Ke, Jianqiang Guo, Wenjing Ma, Tianwei Cui, Baoxing Liu, Xiuping Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Wu-Zi-Yan-Zong-Wan (WZYZW) is a classical traditonal Chinese herbal formula and a Chinese patent medicine used to treat male infertility. However, the chemical components of WZYZW and its mechanism are not yet fully clarified. AIM OF THE STUDY: The purpose of this study is to observe the effect and underlying mechanism of WZYZW on ameliorating blood-testis barrier (BTB) dysfunction in mice with spermatogenic dysfunction induced by administration of Tripterygium wilfordii Hook...
July 19, 2021: Journal of Ethnopharmacology
https://read.qxmd.com/read/34293394/upper-reference-limits-for-high-sensitivity-cardiac-troponin-t-and-n-terminal-fragment-of-the-prohormone-brain-natriuretic-peptide-in-patients-with-ckd
#9
Nisha Bansal, Leila Zelnick, Christie Ballantyne, Paulo Chaves, Robert Christenson, Joseph Coresh, Chris deFilippi, James de Lemos, Lori Daniels, Alan S Go, Jiang He, Susan Heydati, Kuni Matsushita, Vijay Nambi, Michael Shlipak, Jonathan Taliercio, Stephen Seliger
RATIONALE & OBJECTIVE: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: We studied participants of the Chronic Renal Insufficiency Cohort with CKD and no self-reported history of cardiovascular disease (CVD)...
July 19, 2021: American Journal of Kidney Diseases
https://read.qxmd.com/read/34293376/complementary-and-alternative-medicine-use-in-first-time-and-recurrent-kidney-stone-formers
#10
Aditya Joshi, Jacob E Tallman, Joshua K Calvert, Taylor Brewer, Nicole L Miller, Lee Yang, John R Asplin, Ryan S Hsi
OBJECTIVE: To describe the patterns of complementary and alternative medicine (CAM) among patients with kidney stones and analyze the alkali content of commonly used CAM therapies. METHODS: We prospectively conducted structured interviews with patients who presented to a specialty stone clinic for the management of kidney stones. Open-ended questions were used to elicit information regarding CAM knowledge, formulation/dosing, and patterns of use. Several common CAM therapies were then analyzed for their alkali, organic anion, and sugar content...
July 19, 2021: Urology
https://read.qxmd.com/read/34293206/seasonal-variations-in-the-diagnosis-of-the-top-10-cancers-in-korea-a-nationwide-population-based-study-using-a-common-data-model
#11
Jin Young Yoon, Min Seob Kwak, Ha Il Kim, Jae Myung Cha
BACKGROUND AND AIM: A better understanding of seasonal variations in cancer diagnosis may be the first step toward optimal resource distribution in the National Cancer Screening Program (NCSP). This study aimed to identify seasonal variations in the diagnosis of the top 10 major cancers in Korea. STUDY: We conducted a retrospective, observational cohort study in participants aged ≥ 20 years between 2012 and 2016 from the Health Insurance Review and Assessment-National Patient Sample database, previously converted to a common data model...
July 22, 2021: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/34293185/trends-in-home-dialysis-use-differ-among-age-categories-in-past-two-decades-a-dutch-registry-study
#12
Anna A Bonenkamp, Tiny Hoekstra, Marc H Hemmelder, Anita van Eck van der Sluijs, Alferso C Abrahams, Frans J van Ittersum, Brigit C van Jaarsveld
BACKGROUND: Although the number of patients with end stage kidney disease is growing, the number of patients that perform dialysis at home has decreased during the past two decades. The aim of this study is to explore time trends in the use of home dialysis in the Netherlands. METHODS: Dialysis episodes of patients who started dialysis treatment were studied using Dutch registry data (RENINE). The uptake of home dialysis between 1997 through 2016 was evaluated in time periods of 5 years...
July 22, 2021: European Journal of Clinical Investigation
https://read.qxmd.com/read/34292971/socs3-deficiency-in-cardiomyocytes-elevates-sensitivity-of-ischemic-preconditioning-that-synergistically-ameliorates-myocardial-ischemia-reperfusion-injury
#13
Shoichiro Nohara, Mai Yamamoto, Hideo Yasukawa, Takanobu Nagata, Jinya Takahashi, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Daiki Akagaki, Kazutoshi Mawatari, Yoshihiro Fukumoto
Ischemic preconditioning (IPC) is the most powerful endogenous cardioprotective form of cellular adaptation. However, the inhibitory or augmenting mechanism underlying cardioprotection via IPC remains largely unknown. Suppressor of cytokine signaling-3 (SOCS3) is a cytokine-inducible potent negative feedback regulator of the signal transducer and activator of transcription-3 (STAT3) signaling pathway. Here, we aimed to determine whether cardiac SOCS3 deficiency and IPC would synergistically reduce infarct size after myocardial ischemia reperfusion injury...
2021: PloS One
https://read.qxmd.com/read/34292875/endocrinology-in-the-time-of-covid-19-2021-updates-the-management-of-diabetes-insipidus-and-hyponatraemia
#14
REVIEW
Mirjam Christ-Crain, Ewout J Hoorn, Chris J Thompson, John A H Wass, Mark Sherlock
COVID-19 has changed the nature of medical consultations, emphasizing virtual patient counseling, with relevance for patients with diabetes insipidus (DI) or hyponatremia. The main complication of desmopressin treatment in DI is dilutional hyponatraemia. Since plasma sodium monitoring is not always possible in times of COVID-19, we recommend to delay the desmopressin dose once a week until aquaresis occurs allowing excess retained water to be excreted. Patients should measure their body weight daily. Patients with DI admitted to the hospital with COVID-19 have a high risk for mortality due to volume depletion...
July 1, 2021: European Journal of Endocrinology
https://read.qxmd.com/read/34292818/risk-factors-for-mortality-after-uncemented-bipolar-hemiarthroplasty-for-geriatric-displaced-femoral-neck-fracture
#15
Kun Liu, Jun Sheng, Huiyu Zhang, Liu Liu, Yu Tang, Zexing Zhu, Lin Qiao, Ziqi Sun, Yuan Yao
Uncemented bipolar hemiarthroplasty (UBHA) has been widely used to treat geriatric displaced femoral neck fracture (GDFNF), which results in a high 30-day mortality rate among the elderly. To date, few studies have focused on the risk factors for mortality after UBHA for GDFNF. In this retrospective study, elderly patients (age ≥70 years) who underwent UBHA for GDFNF were studied in order to provide helpful insight into the risk factors for mortality postoperatively. This retrospective study enrolled 835 elderly patients who underwent UBHA for GDFNF from January 2010 to December 2017...
July 2021: Orthopedics
https://read.qxmd.com/read/34292722/-de-novo-sequencing-of-antibody-light-chain-proteoforms-from-patients-with-multiple-myeloma
#16
Mathieu Dupré, Magalie Duchateau, Rebecca Sternke-Hoffmann, Amelie Boquoi, Christian Malosse, Roland Fenk, Rainer Haas, Alexander K Buell, Martial Rey, Julia Chamot-Rooke
In multiple myeloma diseases, monoclonal immunoglobulin light chains (LCs) are abundantly produced, with, as a consequence in some cases, the formation of deposits affecting various organs, such as the kidney, while in other cases remaining soluble up to concentrations of several g·L-1 in plasma. The exact factors crucial for the solubility of LCs are poorly understood, but it can be hypothesized that their amino acid sequence plays an important role. Determining the precise sequences of patient-derived LCs is therefore highly desirable...
July 22, 2021: Analytical Chemistry
https://read.qxmd.com/read/34292634/outcomes-of-pregnancy-in-simultaneous-pancreas-and-kidney-transplant-recipients-a-single-center-retrospective-study
#17
Sai Rithin Punjala, Benedict Lyle Phillips, Paramit Chowdhury, Taryn Pile, Nikolaos Karydis, Nicos Kessaris, Jonathon Olsburgh, Kate Harding, Chris J Callaghan, Catherine Nelson-Piercy, Martin Drage
Simultaneous pancreas and kidney (SPK) transplantation, in uremic women with insulin-dependent diabetes, increases the chance of a successful pregnancy and minimizes the risk to infants. The aim of this study was to document pregnancy and explore the challenges in this cohort of women. Retrospective analysis of women who underwent pancreas transplantation between 01/01/1998 and 01/08/2019 was conducted. 17 pregnancies were identified in 13 women. Mean transplant-to-pregnancy interval was 4.6 years (range, 1...
July 22, 2021: Clinical Transplantation
https://read.qxmd.com/read/34292531/urinary-exosomal-circular-rnas-of-sex-chromosome-origin-are-associated-with-gender-related-risk-differences-of-clinicopathological-features-in-patients-with-iga-nephropathy
#18
Rumei Luan, Geng Tian, Hong Zhang, Xiaolei Shi, Jicui Li, Rui Zhang, Xuehong Lu
BACKGROUND: There are arguments for individualized treatments and the necessity of non-invasive biomarkers for patients with IgA nephropathy (IgAN) according to gender, but the rationale remains unclear. We aimed to investigate the relationship between urine exosomal circular RNA (circRNA) levels, related genes, clinical features, and renal pathological features in IgA nephropathy patients of different genders. METHODS: Clinicopathological data from patients of different genders from a multicenter cohort were retrospectively analyzed...
July 22, 2021: Journal of Nephrology
https://read.qxmd.com/read/34292526/relationship-between-antithymocyte-globulin-concentrations-and-lymphocyte-sub-populations-in-kidney-transplant-patients
#19
Nicolas Azzopardi, Hélène Longuet, David Ternant, Gilles Thibault, Valérie Gouilleux-Gruart, Yvon Lebranchu, Matthias Büchler, Philippe Gatault, Gilles Paintaud
BACKGROUND: Rabbit antithymocyte globulins (rATGs) are polyclonal antibodies used to prevent acute cellular rejection in kidney transplantation. Their dosing remains largely empirical and the question of an individualized dose is still unresolved. METHODS: Data from a prospective study in 17 kidney transplant patients were used to develop a model describing the dose-concentration-response relationship of rATG with T-lymphocyte subpopulation counts over time. The model was validated using an independent cohort of kidney transplant patients treated by rATG in the same center...
July 22, 2021: Clinical Pharmacokinetics
https://read.qxmd.com/read/34292493/efficacy-and-safety-of-onabotulinumtoxina-in-patients-with-overactive-bladder-subgroup-analyses-by-sex-and-by-serum-prostate-specific-antigen-levels-in-men-from-a-randomized-controlled-trial
#20
Osamu Yokoyama, Masashi Honda, Tomonori Yamanishi, Yuki Sekiguchi, Kenji Fujii, Kyoko Kinoshita, Takashi Nakayama, Akikazu Ueno, Takao Mogi
PURPOSE: We aimed to assess onabotulinumtoxinA treatment outcomes by sex in patients with overactive bladder (OAB) and then explore the impact of serum prostate-specific antigen (PSA) levels in men. METHODS: Patients inadequately managed with OAB medications were randomized to receive single-dose onabotulinumtoxinA (100 U) or placebo intravesical injection in a phase III trial in Japan. We performed subgroup analyses by sex and post-hoc subgroup analyses using male PSA categories...
July 22, 2021: International Urology and Nephrology
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