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2013: Kidney International Supplements
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2013: Kidney International Supplements
T Avni, H Hammud, O Itzhaki, A Gafter-Gvili, B Rozen-Zvi, H Ben-Zvi, J Bishara, A Atamna
OBJECTIVE: Clostridioides difficile infection (CDI) may present as sepsis with acute kidney injury (AKI). Herein, we aimed to evaluate the clinical outcomes of patients with AKI complicating CDI. METHODS: All consecutive adult patients hospitalized in Rabin Medical Center between January 1, 2013 and December 31, 2018 with laboratory confirmed CDI, were included in the study. Subjects were divided into two groups: patients with AKI and controls. Primary outcome was all-cause mortality at 30 days after the CDI episode...
October 24, 2020: International Journal of Clinical Practice
Han Ro, Jong Cheol Jeong, Jin Min Kong, Ji Won Min, Sung Kwang Park, Joongyub Lee, Tai Yeon Koo, Jaeseok Yang, Myoung Soo Kim, Seungsik Hwang, Curie Ahn
BACKGROUND: Tacrolimus is a key drug in kidney transplantation (KT) with a narrow therapeutic index. The association between the tacrolimus metabolism rate and KT outcomes have not been investigated in large-scale multi-center studies. METHODS: The Korean Organ Transplantation Registry (KOTRY) datasets were used. A total of 3,456 KT recipients were analyzed. The tacrolimus metabolism rate was defined as blood trough concentration of tacrolimus (C0 ) divided by the daily dose (D)...
October 24, 2020: Transplant International
Zi Li, Maki Murakoshi, Saki Ichikawa, Takeo Koshida, Eri Adachi, Chigure Suzuki, Seiji Ueda, Tomohito Gohda, Yusuke Suzuki
Trials on cardiovascular and renal outcomes in patients with type 2 diabetes have consistently demonstrated that sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of diabetic kidney disease (DKD) progression. However, their renal protective mechanisms have yet to be completely understood and the effect on albuminuria reduction in animal models is controversial. Here, we investigated these issues using KK and KK-Ay mice as a control (CTRL) and as a model for type 2 diabetes (DKD), respectively...
October 24, 2020: FEBS Open Bio
Muriel Girard, Claire Douillard, Dominique Debray, Florence Lacaille, Manuel Schiff, Sandrine Vuillaumier-Barrot, Thierry Dupré, Monique Fabre, Lena Damaj, Alice Kuster, Stéphanie Torre, Karine Mention, Valérie McLin, Dries Dobbelaere, Delphine Borgel, Eric Bauchard, Nathalie Seta, Arnaud Bruneel, Pascale De Lonlay
BACKGROUND: Mannose Phosphate Isomerase MPI-CDG (formerly CDG-1b) is a potentially fatal inherited metabolic disease which is readily treatable with oral D-mannose. We retrospectively reviewed long-term outcomes of patients with MPI-CDG, all but one of whom were treated with D-mannose. METHODS: Clinical, biological and histological data were reviewed at diagnosis and on D-mannose treatment. RESULTS: Nine patients were diagnosed with MPI-CDG at a median age of 3 months...
July 17, 2020: Journal of Inherited Metabolic Disease
Chibuisi G Alimba, Olusoji O Adewumi, Olufisayo M Binuyo, Peter G C Odeigah
Wild black rats (Rattus rattus) inhabiting Abule Egba landfill (AEL) were used as zoomonitor to assess health risk associated with exposure to hazardous chemicals from landfills. Twenty five R. rattus (16♂ and 9♀) captured within AEL and 15 (9♂ and 6♀) (control) caught from Iyano Ipaja (10 km away from AEL) were examined for bone marrow micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio, abnormal sperm morphology, alterations in hematological indices and erythrocyte morphology, and histopathology of the viscera using standard protocols...
October 24, 2020: Environmental Science and Pollution Research International
Boris Zingerman, Arie Erman, Tiki Mashraki, Avry Chagnac, Benaya Rozen-Zvi, Ruth Rahamimov
BACKGROUND: Increased albuminuria is a predictor of graft loss in kidney graft recipients. It is unknown whether obesity is an independent risk factor for the development of increased albuminuria in this population. The aim of this study was to elucidate the association between obesity and albuminuria in renal transplant recipients. METHODS: We enrolled 330 renal transplant recipients and prospectively collected demographic, anthropomorphic, clinical and laboratory variables susceptible to influence albumin excretion...
October 24, 2020: Journal of Nephrology
K V Sivak, K I Stosman, T A Rassokha, A G Aleksandrov, N N Kuzmich, Ya R Orshanskaya, T N Savateeva-Lubimova, E E Lesiovskaya
The effects of TLR4 blocker on blood cell morphology, concentrations proinflammatory cytokines, and functional state of the liver and kidneys were studied in outbred male rats (n=60) after intravenous injection of 20 mg/kg LPS isolated from opportunistic Proteus mirabilis strain ATCC 51393. TLR4 blocker TLR4-IN-C34 was injected intravenously in a dose of 1 mg/kg/day over 3 days. Systemic inflammatory reaction induced by LPS was characterized by elevation of serum TNFα, IL-1β, IL-6, erythrocyte sedimentation rate, leukocytosis, and thrombocytosis...
October 24, 2020: Bulletin of Experimental Biology and Medicine
Stefanie J Hectors, Sadjad Riyahi, Hreedi Dev, Karthik Krishnan, Daniel J A Margolis, Martin R Prince
PURPOSE: To develop and externally validate a multivariate prediction model for the prediction of acute kidney injury (AKI) in COVID-19, based on baseline renal perfusion from contrast-enhanced CT together with clinical and laboratory parameters. METHODS: In this retrospective IRB-approved study, we identified COVID-19 patients who had a standard-of-care contrast-enhanced abdominal CT scan within 5 days of their COVID-19 diagnosis at our institution (training set; n = 45, mean age 65 years, M/F 23/22) and at a second institution (validation set; n = 41, mean age 61 years, M/F 22/19)...
October 24, 2020: Abdominal Radiology
Xiayu Xu, Bin Gao, Wenxiang Ding, Qiong Wang, Maiye Zhang, Tao Tan, Fei Sun, Jianqin Lei, Qiuhe Ji, Feng Xu
AIMS: Retinal and renal microcirculations are known to share similar physiological changes during early diabetes because of abnormal glucose metabolism and other processes. The retinal vasculature therefore may serve as potential biomarker for the early identification of those at high risk of chronic kidney disease (CKD) in diabetes. METHODS: Data from 1925 patients (aged 49.0 ± 10.3) with type 2 diabetes were analyzed. Various retinal image measurements (RIMs) were collected using a validated fully automated computer program...
October 24, 2020: Acta Diabetologica
Christine P Limonte, Leila R Zelnick, John Ruzinski, Andrew N Hoofnagle, Ravi Thadhani, Michal L Melamed, I-Min Lee, Julie E Buring, Howard D Sesso, JoAnn E Manson, Ian H de Boer
AIMS/HYPOTHESIS: Interventions that reduce inflammation may delay progression of microvascular and macrovascular complications in diabetes. We examined the effects of vitamin D3 and/or n-3 fatty acid supplementation vs placebo on 5 year changes in serum inflammatory and cardiac biomarkers in adults with type 2 diabetes. METHODS: This study reports pre-specified secondary outcomes of the Vitamin D and Omega-3 Trial to Prevent and Treat Diabetic Kidney Disease, in which 1312 US adults with type 2 diabetes and without known cardiovascular disease, malignancy, or end-stage kidney disease were randomised using computer-generated random numbers in blocks of eight to vitamin D3 (2000 IU/day) vs placebo and n-3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]; 1 g/day) vs placebo in a 2 × 2 factorial design...
October 24, 2020: Diabetologia
Pieter Evenepoel, John Cunningham, Serge Ferrari, Mathias Haarhaus, Muhammad Kassim Javaid, Marie-Hélène Lafage-Proust, Daniel Prieto-Alhambra, Pablo Ureña Torres, Jorge Cannata-Andia
Controlling the excessive fracture burden in patients with chronic kidney disease (CKD) Stages G4-G5D remains an impressive challenge. The reasons are 2-fold. First, the pathophysiology of bone fragility in patients with CKD G4-G5D is complex and multifaceted, comprising a mixture of age-related (primary male/postmenopausal), drug-induced and CKD-related bone abnormalities. Second, our current armamentarium of osteoporosis medications has not been developed for, or adequately studied in patients with CKD G4-G5D, partly related to difficulties in diagnosing osteoporosis in this specific setting and fear of complications...
October 24, 2020: Nephrology, Dialysis, Transplantation
Nadia Hossein-Zadeh, Morteza Bagheri, Isa Abdi Rad, Marziyeh Lozeie, Mahdieh Nasir-Zadeh
Background: 3,4-Methylenedioxymethamphetamine (MDMA) disrupts function of the endocrine system and different organs such as heart, blood vessels, kidney, liver and nervous systems. This revision was conducted to evaluate impact of MDMA on apoptosis and Zinc in the MDMA-induced apoptosis of cultured Sertoli cells by measuring Caspase-3 gene expression. Materials and Methods: In this experimental study, Sertoli cells were incubated with MDMA (0, 0.5, 1, 3 and 5 mM), Zinc (0, 8, 16, 32, 64 μM) and Zinc (8 μM) prior to adding MDMA (5 mM) for 24 and 48 hours...
October 2020: International Journal of Fertility & Sterility
Xuanshuo Liu, Shuli Man, Chen Luo, Yu Liu, Yan Liu, Changxiao Liu, Wenyuan Gao
Shunaoxin pills (SNX) have been used to treat cerebrovascular diseases in China since 2005. Hypertension is a major risk factor for cerebrovascular disease. This study aimed to explore the synergistic antihypertensive effect of SNX and nifedipine and whether SNX could alleviate nifedipine-induced renal lipotoxicity. During administration, systolic blood pressure was measured weekly. After 5 weeks administration, we examined pathological changes of kidney, renal function, the lipid metabolism index, and adipogenesis genes expression in the kidney tissues, and explored its underlying mechanism...
October 24, 2020: Environmental Toxicology
Habib Khoury, Nikhil Bellamkonda, Peyman Benharash, Jivianne T Lee, Marilene B Wang, Jeffrey D Suh
OBJECTIVES: To characterize the incidence, causes, risk factors, and costs of 30-day readmission after inpatient functional endoscopic sinus surgery (FESS) for patients with chronic rhinosinusitis. STUDY DESIGN: Retrospective cohort study. METHODS: The Nationwide Readmissions Database was used to characterize readmission after inpatient sinus surgery for chronic rhinosinusitis from 2015 to 2017. International Classification of Disease codes were used to identify the patient population, which included 5,644 patients...
October 24, 2020: Laryngoscope
Kristi K Fitzgerald, Nina Powell-Hamilton, Amanda J Shillingford, Bradley Robinson, Karen W Gripp
PBX1 encodes the pre-B cell leukemia homeobox transcription factor, a three amino acid loop extension (TALE) homeodomain transcription factor, which forms nuclear complexes with other TALE class homeodomain proteins that ultimately regulate target genes controlling organ patterning during embryogenesis. Heterozygous de novo pathogenic variants in PBX1 resulting in haploinsufficiency are associated with congenital anomalies of the kidneys and urinary tract, most commonly renal hypoplasia, as well as anomalies involving the external ear, branchial arch, heart, and genitalia, and they cause intellectual disability and developmental delay...
October 24, 2020: American Journal of Medical Genetics. Part A
John R Ferdinand, Sarah A Hosgood, Tom Moore, Ashley Ferro, Christopher J Ward, Tomas Castro-Dopico, Michael L Nicholson, Menna R Clatworthy
Transplantation is the optimal treatment for most patients with end stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to re-condition marginal organs however mechanisms by which NMP might benefit organs are not well understood. Using pairs of human kidneys obtained from the same donor, we compared the effect of NMP with that of cold storage on the global kidney transcriptome. We found that cold storage led to a global reduction in gene expression, including inflammatory pathway genes and those required for energy generation processes, such as oxidative phosphorylation (OXPHOS)...
October 23, 2020: American Journal of Transplantation
Elisabeth Coll, Mario Fernández-Ruiz, J Emilio Sánchez-Álvarez, José Ramón Martínez-Fernández, Marta Crespo, Jorge Gayoso, Teresa Bada-Bosch, Federico Oppenheimer, Francesc Moreso, María O López-Oliva, Edoardo Melilli, Mª Luisa Rodríguez-Ferrero, Elena Burgos, Carme Facundo, Inmaculada Lorenzo, Íñigo Yañez, Cristina Galeano, Ana Roca, Mercedes Cabello, Manuel Gómez-Bueno, Javier Graus, Laura Lladó, Alicia de Pablo, Carmelo Loinaz, Beatriz Aguado, Domingo Hernández, Beatriz Domínguez-Gil
We report the nationwide experience with solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients diagnosed with coronavirus disease 2019 (COVID-19) in Spain until 13 July 2020. We compiled information for 778 (423 kidney, 113 HSCT, 110 liver, 69 heart, 54 lung, 8 pancreas, 1 multivisceral) recipients. Median age at diagnosis was 61 years (interquartile range [IQR]: 52-70), and 66% were male. The incidence of COVID-19 in SOT recipients was two-fold higher compared to the Spanish general population...
October 23, 2020: American Journal of Transplantation
Shadan Li, Zhongli Huang, Xiaowei Li, Youguang Zhao, Xin Jiang, Yang Wen, Hao Luo, Liang Wang, Qiunong Guan, Irina Cafeeva, Donald E Brooks, Christopher Y C Nguan, Jayachandran N Kizhakkedathu, Caigan Du
Hyperbranched polyglycerol (HPG) is a biocompatible polyether polymer that is a potential colloid component in a preservation solution for suppressing interstitial edema during cold storage of a donor organ. This study evaluated the outcomes of kidney transplants after cold perfusion and storage with a HPG-based preservation solution (HPGS) in a pig model of kidney autotransplantation. The left kidneys of farm pigs (weighing 35-45 kg) were perfused with and stored in either cold HPGS or standard UW solution (UWS), followed by transplantation to the right side after right nephrectomy...
October 24, 2020: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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