(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
(no author information available yet)
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2013: Kidney International Supplements
Laongdao Thongnak, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Krit Jaikumkao, Anusorn Lungkaphin
Insulin signaling and lipid metabolism are disrupted by long-term consumption of a high-fat diet (HFD). This disruption can lead to insulin resistance, dyslipidemia and subsequently renal dysfunction as a consequence of the inactivation of the AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-α (PPARα) or AMPK/PPARα pathways. We investigated the impact of metformin on the prevention of renal dysfunction through the modulation of AMPK-regulated PPARα-dependent pathways in insulin-resistant rats induced by a HFD...
March 26, 2023: Archives of Pharmacal Research
Hasan Yilmaz, Naci Burak Cinar, Ibrahim Erkut Avci, Enes Malik Akdas, Kerem Teke, Ozdal Dillioglugil
PURPOSE: We aimed to evaluate the benefits of Comprehensive Complication Index (CCI) compared with the Clavien-Dindo Classification (CDC) in the reporting of radical cystectomy (RC) complications. MATERIALS AND METHODS: We retrospectively analyzed post-operative complications of 251 consecutive RC patients between 2009 and 2021. Patient demographics and causes of mortality were noted. Oncologic outcomes included the recurrence, time to recurrence, cause of all deaths, and time to death...
March 26, 2023: International Urology and Nephrology
Difan Lu, Wenchao Mao
BACKGROUND: This study explored the efficacy of hydrocortisone combined with vitamin C and thiamine (HVT) in the treatment of sepsis/septic shock. METHODS: PubMed, EMBASE and Web of Science were searched (establishment of the database to October 31, 2022). The meta-analysis included randomized controlled trials (RCTs); comparing the efficacy of HVT regimen and placebo in the treatment of sepsis/septic shock. The Cochrane Handbook for Systematic Reviews of Interventions was used to assess the risk of bias...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Francisca Samsing, William Zhang, Ruth N Zadoks, Richard Whittington, Carola Venturini, Carla Giles, Jeremy Carson, Joy A Becker
Most diseases in aquaculture are caused by opportunistic pathogens. One of them, Vibrio harveyi, is a widespread Gram-negative bacterium that has become an important pathogen of aquatic species in marine environments. Here, we propose the use of the causal pie model as a framework to conceptualize the causation of vibriosis in juvenile barramundi (Lates calcarifer) and to establish an effective challenge model. In the model, a sufficient cause, or the causal pie, is a constellation of component causes that lead to an outcome (e...
March 26, 2023: Journal of Fish Diseases
Jiaming Liao, Xin Zhang, Shaozhu Kang, Luhao Zhang, Dongzhuo Zhang, Zhuqing Xu, Qiwei Qin, Jingguang Wei
Cells are important in the study of virus isolation and identification, viral pathogenic mechanisms and antiviral immunity. The spotted knifejaw (Oplegnathus punctatus) is a significant farmed fish in China that has been greatly affected by diseases in recent years. In this study, a new cell line derived from the spotted knifejaw brain (SKB) was established and characterized. SKB cells multiplied well in Leibovitz's L-15 medium supplemented with 10% fetal bovine serum at 28°C. Chromosome analysis revealed that modal chromosome number was 48 for SKB...
March 26, 2023: Journal of Fish Diseases
Zi-Hao Zhang, Yue Wang, Ya Zhang, Sheng-Feng Zheng, Tao Feng, Xi Tian, Mierxiati Abudurexiti, Zhen-Da Wang, Wen-Kai Zhu, Jia-Qi Su, Hai-Liang Zhang, Guo-Hai Shi, Zi-Liang Wang, Da-Long Cao, Ding-Wei Ye
Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs (CircRNAs), special non-coding RNAs with a stabile structure and a unique back-splicing loop-forming ability, have received recent scientific attention. CircRNAs are widely distributed within the body, with important biologic functions such as sponges for microRNAs, as RNA binding proteins, and as templates for regulation of transcription and protein translation. The abnormal expression of circRNAs in vivo is significantly associated with the development of urologic tumors...
March 25, 2023: Molecular Cancer
Hiroaki Io, Masahiro Muto, Yu Sasaki, Masanori Ishizaka, Toshiki Kano, Haruna Fukuzaki, Takuya Maeda, Yuki Shimizu, Junichiro Nakata, Yusuke Suzuki
BACKGROUND: Anemia in patients with chronic kidney disease (p-CKDs) may initiate or exacerbate left ventricular hypertrophy (LVH). This study aimed to determine whether treatment using long-acting erythropoietin-stimulating agents (L-ESAs) is independently associated with LVH during the pre-dialysis to maintenance dialysis period in p-CKDs. METHODS: Physical and laboratory examinations were performed 120 days before initiating dialysis in p-CKDs (baseline)...
March 25, 2023: BMC Nephrology
Dingyang Lv, Huiyu Zhou, Fan Cui, Jie Wen, Weibing Shuang
OBJECTIVE: To explore the characteristics of renal artery variation in patients with renal cell carcinoma and to evaluate the predicting value of accessory renal artery in the pathological grading of renal cell carcinoma. METHODS: The clinicopathological data of patients with clear cell renal cell carcinoma diagnosed in the Department of Urology of the First Hospital of Shanxi Medical University from September 2019 to March 2023 were retrospectively analyzed. All patients underwent visual three-dimensional model reconstruction from computed tomography images...
March 25, 2023: BMC Cancer
Jun Lu, Liang-Min Fu, Yun Cao, Yong Fang, Jia-Zheng Cao, Yi-Hui Pan, Jun-Jie Cen, Yan-Ping Liang, Zhen-Hua Chen, Jin-Huan Wei, Yong Huang, Mukhtar Adan Mumin, Quan-Hui Xu, Ying-Han Wang, Jiang-Quan Zhu, Hui Liang, Zhu Wang, Qiong Deng, Wei Chen, Xiao-Han Jin, Zhi-Ping Liu, Jun-Hang Luo
LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unknown. Here we hypothesized a tumor suppressive function of LZTFL1 in clear cell renal cell carcinoma (ccRCC) and its mechanism of action based on extensive bioinformatics analysis of patients' tumor data and validated it using both gain- and loss-functional studies in kidney tumor cell lines and patient-derive xenograft (PDX) model systems...
March 25, 2023: Oncogene
Seth Bollenbecker, Kylie Heitman, Brian Czaya, Molly Easter, Meghan June Hirsch, Shia Vang, Elex Harris, E Scott Helton, Jarrod W Barnes, Christian Faul, Stefanie Krick
An elevation in serum phosphate-also called hyperphosphatemia-is associated with reduced kidney function in chronic kidney disease (CKD). Reports show CKD patients are more likely to develop lung disease and have poorer kidney function that positively correlates with pulmonary obstruction. However, the underlying mechanisms are not well understood. Here, we report that two murine models of CKD, which both exhibit increased serum levels of phosphate and fibroblast growth factor (FGF) 23, a regulator of phosphate homeostasis, develop concomitant airway inflammation...
March 25, 2023: Scientific Reports
Wuping Yang, Zedan Zhang, Lei Li, Kenan Zhang, Yawei Xu, Mancheng Xia, Jingcheng Zhou, Yanqing Gong, Jinchao Chen, Kan Gong
Recent evidences have suggested that Zinc finger protein 582 (ZNF582) plays different important roles in various tumors, but its clinical role, biological function and regulatory mechanism in clear cell renal cell carcinoma (ccRCC) are still vague. Through analyzing GEO and TCGA-KIRC data and validation with local samples, we identified the low expression pattern of ZNF582 in ccRCC. Decreased ZNF582 expression is correlated with higher tumor stage and grade, distant metastasis and poor prognosis. By analyzing the DNA methylation data of ccRCC in TCGA-KIRC and using Massarray DNA methylation and demethylation analysis, we confirmed the hypermethylation status of ZNF582 in ccRCC and its negative regulation on ZNF582 expression...
March 25, 2023: Cell Death & Disease
Boris Babenko, Ilana Traynis, Christina Chen, Preeti Singh, Akib Uddin, Jorge Cuadros, Lauren P Daskivich, April Y Maa, Ramasamy Kim, Eugene Yu-Chuan Kang, Yossi Matias, Greg S Corrado, Lily Peng, Dale R Webster, Christopher Semturs, Jonathan Krause, Avinash V Varadarajan, Naama Hammel, Yun Liu
BACKGROUND: Photographs of the external eye were recently shown to reveal signs of diabetic retinal disease and elevated glycated haemoglobin. This study aimed to test the hypothesis that external eye photographs contain information about additional systemic medical conditions. METHODS: We developed a deep learning system (DLS) that takes external eye photographs as input and predicts systemic parameters, such as those related to the liver (albumin, aspartate aminotransferase [AST]); kidney (estimated glomerular filtration rate [eGFR], urine albumin-to-creatinine ratio [ACR]); bone or mineral (calcium); thyroid (thyroid stimulating hormone); and blood (haemoglobin, white blood cells [WBC], platelets)...
March 23, 2023: The Lancet. Digital health
Katarzyna Ceglarz, Jolanta Gozdowska, Robert Świder, Maciej Kosieradzki, Dorota Zduńczyk, Magdalena Durlik
BACKGROUND: Amyloidosis is a very heterogeneous disease. Correct diagnosis is extremely important because of the various treatment options for different types of amyloidosis. This study presents a case report and literature review of the misdiagnosis of fibrinogen Aα-chain amyloidosis (AFib amyloidosis). CASE PRESENTATION: We report a 65-year-old man diagnosed with proteinuria in 2009. The kidney biopsy revealed the presence of Congo red-stained amyloid deposits...
March 23, 2023: Transplantation Proceedings
Kristen McAlpine, Keith Lawson, Olli Saarela, Bo Chen, Brigid Wilson, Robert Abouassaly, Madhur Nayan, Antonio Finelli
PURPOSE: To determine whether variance in kidney cancer surgery quality indicators (QIs) is most impacted by surgeon-level or hospital-level factors in order to inform quality improvement initiatives. MATERIALS AND METHODS: The ICES and Veterans Affairs (VA) databases were queried for patients undergoing surgery for localized kidney cancer. Kidney cancer surgery QIs were defined within each cohort. Quality of care was benchmarked at a surgeon- vs. hospital-level to identify statistical outliers, using available clinicopathological data to adjust for differences in case-mix...
March 23, 2023: Urologic Oncology
B Bañuelos Marco, I Donmez, T Geppert, T Prudhomme, R Campi, B Mesnard, V Hevia, R Boissier, A Pecoraro, A Territo
INTRODUCTION AND OBJECTIVE: Renal transplantation in the pediatric population differs from adults in many aspects. This review will focus on the unique issues of the pediatric recipient. MATERIAL AND METHODS: A narrative review on the scarce literature regarding preoperative evaluation before kidney transplantation of the paediatric recipient with an educational focus was conducted. The literature search allowed for identification of publications in English from January 2000 to October 2022...
March 23, 2023: Actas urologicas españolas
A Territo, A S Bajeot, B Mesnard, R Campi, A Pecoraro, V Hevia, A Piana, N Doumerc, A Breda, R Boissier, T Prudhomme
INTRODUCTION: In the last 20 years, robotic assisted procedures were evaluated in the field of kidney transplantation to provide a mini-invasive approach for this particularly fragile population. As a relatively new issue, few studies compared open kidney transplantation (OKT) and robotic-assisted kidney transplantation (RAKT), mostly in small cohorts. To improve current knowledge, we wanted here to gather comparative data of OKT vs RAKT in a systematic review. METHODS: A systematic review was performed according to preferred reporting items for systematic reviews and meta-analyses...
March 23, 2023: Actas urologicas españolas
J Lisa Hoogenboom, Marty Kwok-Shing Wong, Susumu Hyodo, W Gary Anderson
As part of their osmoregulatory strategy, marine elasmobranchs retain large quantities of urea to balance the osmotic pressure of the marine environment. The main source of nitrogen used to synthesize urea comes from the digestion and absorption of food across the gastrointestinal tract. In this study we investigated possible mechanisms of nitrogen movement across the spiral valve of the cloudy catshark (Scyliorhinus torazame) through the molecular identification of two Rhesus glycoprotein ammonia transporters (Rhp2 and Rhbg) and a urea transporter (UT)...
March 23, 2023: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Soie Kwon, Yong Chul Kim, Hyunwook Kwon, Jang-Hee Cho, Chan-Duck Kim, Hyung-Eun Son, Jong-Cheol Jeong, In Mok Jung, Kyung Don Yoo, Yeonjin Kim, Woojoo Lee, Jong Soo Lee, Hajeong Lee, Chun Soo Lim, Yon Su Kim, Young Hoon Kim, Jung Pyo Lee
RATIONALE & OBJECTIVE: Metformin has been recommended for some patients with advanced chronic kidney disease. However, the value of metformin in kidney transplant recipients (KTRs) with pre-transplant diabetes mellitus (DM) or post-transplant diabetes mellitus (PTDM) is uncertain. We investigated the clinical effects of metformin in KTRs. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: A total of 1,995 KTRs with diabetes from six tertiary referral centers in the Republic of Korea...
March 23, 2023: American Journal of Kidney Diseases
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