(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
Y M Tang, L Zhang, S Z Zhu, J J Pan, S H Zhou, T J He, Q Li
OBJECTIVE: The aim of the study was to estimate the gout burden and risk factors in China from 1990 to 2017. STUDY DESIGN: The Global Burden of Disease (GBD) Study uses various analytical tools and a diverse set of data sources to generate comparable estimates of deaths and mortality rates broken down by age, sex, cause, year, and geography. METHODS: We used the results from the GBD Study 2017 to compare disability-adjusted life years (DALYs), prevalence, incidence, and risk factors of gout in China...
January 19, 2021: Public Health
Taina Lee, Kenneth D'Souza, Ahmer Hameed, Jinna Yao, Susanna Lam, Steven Chadban, Tracey Ying, David Celermajer, Charbel Sandroussi, Henry Claud Capron Pleass, Jerome Martin Laurence
OBJECTIVES: A significant proportion of renal transplant patients have cardiovascular comorbidities for which they receive treatment with antiplatelet agents. The aim of this study was to systematically review the current literature reporting perioperative outcomes for patients receiving dual antiplatelet therapy compared to single antiplatelet therapy at the time of kidney transplantation with particular reference to the risks of postoperative haemorrhage. MATERIALS AND METHODS: Embase, Medline and Cochrane databases were utilized to identify articles reporting outcomes of renal transplant recipients on single antiplatelet therapy and dual antiplatelet therapy...
December 26, 2020: Transplantation Reviews
Pi-I D Lin, Andres Cardenas, Russ Hauser, Diane R Gold, Ken P Kleinman, Marie-France Hivert, Antonia M Calafat, Thomas F Webster, Edward S Horton, Emily Oken
Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in populations worldwide and may hinder kidney function. The objective of the study was to determine longitudinal associations of plasma PFAS concentrations with estimated glomerular filtration rate (eGFR) and evaluate whether a lifestyle intervention modify the associations. We studied 875 participants initially randomized to the lifestyle or placebo arms in the Diabetes Prevention Program (DPP, 1996-2002) trial and Outcomes Study (DPPOS, 2002-2014)...
January 19, 2021: Environment International
Pablo Vicente Torres-Ortega, Cristian Smerdou, Eduardo Ansorena, María Cristina Ballesteros-Briones, Eva Martisova, Elisa Garbayo, María J Blanco-Prieto
Human glial cell line-derived neurotrophic factor (hGDNF) is the most potent dopaminergic factor described so far, and it is therefore considered a promising drug for Parkinson's disease (PD) treatment. However, the production of therapeutic proteins with a high degree of purity and a specific glycosylation pattern is a major challenge that hinders its commercialization. Although a variety of systems can be used for protein production, only a small number of them are suitable to produce clinical-grade proteins...
January 19, 2021: European Journal of Pharmaceutical Sciences
Melina A Pagotto, María L Roldán, Sara M Molinas, Trinidad Raices, Gerardo B Pisani, Omar P Pignataro, Liliana A Monasterolo
Accumulating evidence indicates the association between changes in circulating sex steroid hormone levels and the development of diabetic nephropathy. However, the renal synthesis of steroid hormones during diabetes is essentially unknown. Male Wistar rats were injected with streptozotocin (STZ) or vehicle. After one week, no changes in functional or structural parameters related to kidney damage were observed in STZ group; however, a higher renal expression of proinflammatory cytokines and HSP70 was found...
January 19, 2021: Molecular and Cellular Endocrinology
Xiaozhou Li, Ye Yang, Fan Yang, Feihe Wang, Hong Li, Huayu Tian, Guiyun Wang
We reported previously a recombinant protein (rP-HSP90C) containing epitope C from heat shock protein 90 of Candida albicans mediates protective immune responses against systemic candidiasis. However, it exhibits weak immunogenicity. Therefore, we evaluated the potential and mechanisms of thermosensitive chitosan hydrogel (CH-HG) as an adjuvant in rP-HSP90C vaccine. CH-HG synthesized by ionic cross-linking showed buffering capacity and control-released rP-HSP90C in vitro. In comparison to naked rP-HSP90C, CH-HG-loaded rP-HSP90C (CH-HG/rP-HSP90C) not only evoked a long-lasting rP-HSP90C-specific IgG, but also enhanced Th1, Th2, Th17 responses and the ratio of Th1/Th2 in vivo; Meanwhile, CH-HG/rP-HSP90C provoked a stronger CTL response than rP-HSP90C...
January 19, 2021: International Journal of Biological Macromolecules
Nahla N Younis, Hoda E Mohamed, Mohamed A Shaheen, Asmaa M Abdelghafour, Sally K Hammad
Infliximab (IFX), a chimeric monoclonal antibody against tumor necrosis factor-α (TNF-α), is widely used to treat autoimmune diseases and chronic diseases associated with inflammation. TNF-α was reported to inhibit klotho, reactivate β-catenin and cause tubular cell injury in vitro. Whether the inhibition of TNF-α can regulate Wnt/β-catenin pathway via klotho in CKD in vivo is not studied yet. We aimed to investigate the impact of IFX on Wnt/β-catenin pathway in doxorubicin (DOX)-induced nephropathy...
January 19, 2021: Biochemical Pharmacology
Satoshi Endo, Toshiyuki Matsunaga, Akira Hara
Rat genes, akr1c19 and RGD1564865, encode members (R1C19 and 20HSDL, respectively) of the aldo-keto reductase (AKR) 1C subfamily, whose functions, however, remain unknown. Here, we show that recombinant R1C19 and 20HSDL exhibit NAD+ -dependent dehydrogenase activity for prostaglandins (PGs) with 9α-hydroxy group (PGF2α , its 13,14-dihydro- and 15-keto derivatives, 9α,11β-PGF2 and PGD2 ). 20HSDL oxidized the PGs with much lower Km (0.3-14 μM) and higher kcat /Km values (0.064-2.6 min-1 μM-1 ) than those of R1C19...
January 19, 2021: Archives of Biochemistry and Biophysics
Alberto Ortiz, Maria Dolores Sanchez-Niño
Chronic kidney disease (CKD) is projected to become the fifth global cause of death by 2040, the second before the end of the century in some countries with long life expectancy (1,2). It is additionally the most common risk factor for lethal coronavirus disease-2019 (COVID-19) and the factor that most increased the risk of death in COVID-19 patients (3). The increased risk of death associated with CKD is observed throughout all CKD stages, from early stages in which glomerular filtration is still preserved (and the risk of premature death is thought to be related to decreased kidney production of protective and anti-aging factors such as Klotho) to advanced CKD in which decreased filtration of so-called uremic toxins is thought to be a key driving force (4, 5)...
January 22, 2021: Journal of Internal Medicine
Marco Proietti, Marco Vitolo, Gregory Y H Lip
BACKGROUND: Integrated care for management of atrial fibrillation (AF) patients has been associated with a reduction in adverse events. The 'Atrial fibrillation Better Care (ABC) pathway' has been proposed to streamline such integrated management. In this paper we analysed the impact of ABC pathway adherent clinical management on outcomes in AF patients with high-risk 'metabolic' comorbidities (i.e. diabetes mellitus [DM], chronic kidney disease [CKD], metabolic syndrome [MetS]. METHODS: Patients from the SPORTIF III and V trials and with available data to evaluate ABC criteria were analysed...
January 9, 2021: European Journal of Clinical Investigation
Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet
Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period...
2021: PloS One
Théo Delbove, François Gueyffier, Laurent Juillard, Emilie Kalbacher, Delphine Maucort-Boulch, Patrice Nony, Brigitte Grosgogeat, Kerstin Gritsch
AIM: To assess the effect of periodontal treatment (PT) on glomerular filtration rate (GFR), systemic inflammation, or mortality in patients with chronic kidney disease (CKD). METHODS: A literature search was performed on PubMed and Web of Science databases on articles published until December 2019. The PRISMA guidelines were used throughout the manuscript. RESULTS: Of the total studies found, only 18 met the inclusion criteria; four retrospective and 14 prospective studies (including 3 randomized controlled trials-RCT)...
2021: PloS One
Midori Hasegawa, Jin Iwasaki, Satoshi Sugiyama, Takuma Ishihara, Yoshihiro Yamamoto, Hiroaki Asada, Shigehisa Koide, Hiroki Hayashi, Kazuo Takahashi, Daijo Inaguma, Yukio Yuzawa, Naotake Tsuboi
INTRODUCTION: Degenerative aortic valve stenosis (AS) is a chronic progressive disease that resembles atherosclerosis development. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is reportedly associated with accelerated atherosclerosis. This study aimed to examine the development of AS in patients with myeloperoxidase-AAV (MPO-AAV) with renal involvement at more than 1 year after the onset of vasculitis. METHODS: We performed a retrospective review of clinical records of MPO-AAV patients with renal involvement without AS at the onset of vasculitis who were treated in three hospitals and three dialysis clinics...
2021: PloS One
Abhijit Jagdale, Vineeta Kumar, Douglas J Anderson, Jayme E Locke, Michael J Hanaway, Devin E Eckhoff, Hayato Iwase, David K C Cooper
No abstract text is available yet for this article.
January 20, 2021: Transplantation
Jie Hu, Emanuele Rezoagli, Francesco Zadek, Edward A Bittner, Chong Lei, Lorenzo Berra
BACKGROUND: Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a high risk of postoperative acute kidney injury (AKI). Due to limitations of current diagnostic strategies, we sought to determine whether free hemoglobin (fHb) ratio (ie, levels of fHb at the end of CPB divided by baseline fHb) could predict AKI after on-pump cardiac surgery. METHODS: This is a secondary analysis of a randomized controlled trial comparing the effect of nitric oxide (intervention) versus nitrogen (control) on AKI after cardiac surgery (NCT01802619)...
January 21, 2021: Anesthesia and Analgesia
S A Martynov, A S Severina, I I Larina, M S Shamhalova, S V Arzumanov, A V Pinchuk, M V Shestakova
Kidney transplantation is unique method of renal replacement therapy, allowing to improve quality and duration of life for patients with diabetes mellitus type 1 (DM1) and end-stage renal disease (ESRD) on dialysis therapy. Recently using of innovation technologies for diabetes management and modern immunosuppression enable achieving better results of posttransplant rehabilitation for patients with DM1, especially if kidney transplantation is performed early after initiation of dialysis. Detailed examination of patient with DM1 before potential kidney transplantation is very important to reduce of early and late postoperative complications...
December 20, 2020: Problemy E̊ndokrinologii
Federico Marin, Simone Fezzi, Alessia Gambaro, Francesco Ederle, Gianluca Castaldi, Maddalena Widmann, Concetta Gangemi, Valeria Ferrero, Gabriele Pesarini, Michele Pighi, Flavio L Ribichini
AIMS: To evaluate the safety and efficacy of catheter-based radiofrequency renal sympathetic denervation (RSD) in a daily practice population of patients with uncontrolled resistant hypertension, on top of medical therapy. METHODS: Consecutive unselected patients with uncontrolled resistant hypertension undergoing RSD were enrolled. Office and ambulatory blood pressure (BP) measurements were collected at baseline and 3, 6 and 12 months after RSD. Efficacy was assessed even in patients with an estimated glomerular filtration rate (eGFR) below 45 mL/min/1...
January 22, 2021: Journal of Nephrology
Irene Faravelli, Daniele Velardo, Manuel Alfredo Podestà, Claudio Ponticelli
A large number of neurological disorders can affect renal transplant recipients, potentially leading to disabling or life-threatening complications. Prevention, early diagnosis and appropriate management of these conditions are critical to avoid irreversible lesions. A pivotal role in the pathogenesis of common post-transplant neurological disorders is played by immunosuppressive therapy. The most frequently administered regimen consists of triple immunosuppression, which comprises a calcineurin inhibitor (CNI), a purine synthesis inhibitor and glucocorticoids...
January 22, 2021: Journal of Nephrology
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