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2013: Kidney International Supplements
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2013: Kidney International Supplements
Ismail Eş, Ana-Maria Theodora Ionescu, Burak M Görmüş, Fatih Inci, Marco P C Marques, Nicolas Szita, Lucimara Gaziola de la Torre
Tumor spheroid models have garnered significant attention in recent years as they can efficiently mimic in vivo models, and in addition, they offer a more controlled and reproducible environment for evaluating the efficacy of cancer drugs. In this study, we present the design and fabrication of a micromold template to form multicellular spheroids in a high-throughput and controlled-sized fashion. Briefly, polydimethylsiloxane-based micromolds at varying sizes and geometry were fabricated via soft lithography using 3D-printed molds as negative templates...
April 13, 2024: Biotechnology Progress
Nattaya Thongsepee, Wanwisa Himakhun, Ratsikan Parachat, Pongsakorn Martviset, Pathanin Chantree, Phornphan Sornchuer, Kant Sangpairoj, Siriphun Hiranyachattada
Garcinia dulcis (GD) extract possesses anti-hypertensive property that are poorly characterized. This study aimed to investigate an anti-inflammatory effect of GD flower extract in the 2-kidney-1-clip (2K1C) hypertensive compared to sham operative (SO) rat. Male Wistar rats were divided into 2 groups; the 2K1C group in which a silver clip was placed around renal artery to induce hypertension, and the SO normotensive group. Four weeks later, each group of rats were further divided into 2 subgroups, each subgroup was orally gavaged of either corn oil (vehicle) or 50 mg/kg BW GD extract daily for 4 weeks...
2024: Journal of Evidence-Based Integrative Medicine
Yisheng Zhang, Liu Yang, Shan Xue, Yichang Zhang, Zihan Li, Min Zhang, Guoyin Kai, Juan Li
Curcuma longa, best known for its culinary application as the main constituent of curry powder, has shown potential impact on the reproductive system. This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage...
April 2024: Journal of Cellular and Molecular Medicine
Gang Wu, Yongli Yang, Liangjin Liu
BACKGROUND: Non-invasive imaging methods are still lacking for evaluating bone changes in chronic kidney diseases (CKD). PURPOSE: To investigate the feasibility of chest CT radiomics in evaluating bone changes caused by CKD. MATERIAL AND METHODS: In total, 75 patients with stage 1 CKD (CKD1) and 75 with stage 5 CKD (CKD5) were assessed using the chest CT radiomics method. Radiomics features of bone were obtained using 3D Slicer software and were then compared between CKD1 and CKD5 cases...
April 13, 2024: Acta Radiologica
Zengyu Xun, Tianqi Li, Xue Xue
Liposomes-microscopic phospholipid bubbles with bilayered membrane structure-have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ-specific diseases...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Guixin Ding, Tianqi Wang, Hongquan Liu, Qingsong Zou, Jitao Wu
Adenoid cystic carcinoma (ACC), a rare malignancy, typically originates in salivary glands and is rarely found in other locations. In this case report, we describe a 54-year-old male patient who was presented to the Urology Department of Yantai Yuhuangding hospital with right-sided waist pain. The patient underwent percutaneous ultrasound-guided biopsies of lesions in the kidney and lung, which were histologically confirmed as primary adenoid cystic carcinoma of the lung and metastatic renal adenoid cystic carcinoma, respectively...
2024: American Journal of Men's Health
Anastasios Apostolos, Nikolaos Ktenopoulos, Dimitrios-David Chlorogiannis, Odysseas Katsaros, Konstantinos Konstantinou, Maria Drakopoulou, Sotirios Tsalamandris, Antonios Karanasos, Andreas Synetos, Georgios Latsios, Constantina Aggeli, Vasileios Panoulas, Costas Tsioufis, Konstantinos Toutouzas
Patients with severe aortic stenosis (AoS) often present with acute heart failure and compensation, frequently leading to cardiogenic shock. Transcatheter Aortic Valve Replacement (TAVR) has been recently performed as a bailout treatment in such patients. The aim of our meta-analysis is to compare urgent TAVR with elective procedures. We systematically screened three databases searching for studies comparing urgent vs elective TAVR. Primary endpoint is the 30-days mortality. Secondary endpoints included in-hospital mortality, device success, periprocedural vascular complications, 30-days stroke, 30-days acute kidney injury (AKI), permanent pacemaker implantation (PPM), moderate or severe paravalvular leakage, and 30-days bleeding...
April 13, 2024: Angiology
Vi Nguyen, Elaine G Taine, Dehao Meng, Taixing Cui, Wenbin Tan
Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects in response to a variety of pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders and diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation of cardiovascular disorders, skin diseases, diabetes mellitus, liver and kidney injuries, and anti-tumor activities...
March 23, 2024: Nutrients
Susana Coimbra, Susana Rocha, Nícia Reis Sousa, Cristina Catarino, Luís Belo, Elsa Bronze-da-Rocha, Maria João Valente, Alice Santos-Silva
Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important...
April 6, 2024: International Journal of Molecular Sciences
Sara H Ksiazek, Lilio Hu, Sebastiano Andò, Markus Pirklbauer, Marcus D Säemann, Chiara Ruotolo, Gianluigi Zaza, Gaetano La Manna, Luca De Nicola, Gert Mayer, Michele Provenzano
Renin-angiotensin-aldosterone system (RAAS) inhibitors are standard care in patients with hypertension, heart failure or chronic kidney disease (CKD). Although we have studied the RAAS for decades, there are still circumstances that remain unclear. In this review, we describe the evolution of the RAAS and pose the question of whether this survival trait is still necessary to humankind in the present age. We elucidate the benefits on cardiovascular health and kidney disease of RAAS inhibition and present promising novel medications...
April 4, 2024: International Journal of Molecular Sciences
Katarzyna Stępnik, Wirginia Kukula-Koch, Anna Boguszewska-Czubara, Kinga Gawel
Many people around the world suffer from neurodegenerative diseases associated with cognitive impairment. As life expectancy increases, this number is steadily rising. Therefore, it is extremely important to search for new treatment strategies and to discover new substances with potential neuroprotective and/or cognition-enhancing effects. This study focuses on investigating the potential of astragaloside IV (AIV), a triterpenoid saponin with proven acetylcholinesterase (AChE)-inhibiting activity naturally occurring in the root of Astragalus mongholicus , to attenuate memory impairment...
April 4, 2024: International Journal of Molecular Sciences
Gaelle Brideau, Lydie Cheval, Camille Griveau, Wung-Man Evelyne Ling, Loïc Lievre, Gilles Crambert, Dominik Müller, Jovana Broćić, Emeline Cherchame, Pascal Houillier, Caroline Prot-Bertoye
Many genomic, anatomical and functional differences exist between the medullary (MTAL) and the cortical thick ascending limb of the loop of Henle (CTAL), including a higher expression of claudin-10 (CLDN10) in the MTAL than in the CTAL. Therefore, we assessed to what extent the Cldn10 gene expression is a determinant of differential gene expression between MTAL and CTAL. RNAs extracted from CTAL and MTAL microdissected from wild type (WT) and Cldn10 knock out mice (cKO) were analyzed by RNAseq. Differential and enrichment analyses (GSEA) were performed with interactive R Shiny software...
April 3, 2024: International Journal of Molecular Sciences
Alessio Mazzieri, Francesca Porcellati, Francesca Timio, Gianpaolo Reboldi
Diabetic kidney disease (DKD) is a chronic microvascular complication in patients with diabetes mellitus (DM) and the leading cause of end-stage kidney disease (ESKD). Although glomerulosclerosis, tubular injury and interstitial fibrosis are typical damages of DKD, the interplay of different processes (metabolic factors, oxidative stress, inflammatory pathway, fibrotic signaling, and hemodynamic mechanisms) appears to drive the onset and progression of DKD. A growing understanding of the pathogenetic mechanisms, and the development of new therapeutics, is opening the way for a new era of nephroprotection based on precision-medicine approaches...
April 3, 2024: International Journal of Molecular Sciences
Yuan-Chi Huang, Chan-Jung Liu, Ze-Hong Lu, Ho-Shiang Huang
Excessive sodium intake is associated with nephrolithiasis, but the impact of sodium-deficient (SD) diets is unknown. Hence, we investigated the effects of short- and long-term SD diets on the expression of renal aquaporins and sodium transporters, and thus calcium oxalate (CaOx) crystal formation in hyperoxaluria rats. In a short-term sodium balance study, six male rats received drinking water and six received 0.75% ethylene glycol (EG) to induce hyperoxaluria. After a 30-day period of feeding on normal chow, both groups were treated with a normal-sodium diet for 5 days, followed by a sodium-free diet for the next 5 days...
April 1, 2024: International Journal of Molecular Sciences
Taro Yasuma, Esteban C Gabazza
Tissue fibrosis is characterized by the excessive accumulation of extracellular matrix in various organs, including the lungs, liver, skin, kidneys, pancreas, and heart, ultimately leading to organ failure [...].
April 1, 2024: International Journal of Molecular Sciences
Bogdan Adrian Buhas, Valentin Toma, Jean-Baptiste Beauval, Iulia Andras, Răzvan Couți, Lucia Ana-Maria Muntean, Radu-Tudor Coman, Teodor Andrei Maghiar, Rareș-Ionuț Știufiuc, Constantin Mihai Lucaciu, Nicolae Crisan
The advent of Surface-Enhanced Raman Scattering (SERS) has enabled the exploration and detection of small molecules, particularly in biological fluids such as serum, blood plasma, urine, saliva, and tears. SERS has been proposed as a simple diagnostic technique for various diseases, including cancer. Renal cell carcinoma (RCC) ranks as the sixth most commonly diagnosed cancer in men and is often asymptomatic, with detection occurring incidentally. The onset of symptoms typically aligns with advanced disease, aggressive histology, and unfavorable prognosis, and therefore new methods for an early diagnosis are needed...
March 31, 2024: International Journal of Molecular Sciences
Jelena Nesovic Ostojic, Sanjin Kovacevic, Milan Ivanov, Predrag Brkic, Maja Zivotic, Nevena Mihailovic-Stanojevic, Danijela Karanovic, Una Jovana Vajic, Rada Jeremic, Djurdjica Jovovic, Zoran Miloradovic
The central exacerbating factor in the pathophysiology of ischemic-reperfusion acute kidney injury (AKI) is oxidative stress. Lipid peroxidation and DNA damage in ischemia are accompanied by the formation of 3-nitrotyrosine, a biomarker for oxidative damage. DNA double-strand breaks (DSBs) may also be a result of postischemic AKI. γH2AX(S139) histone has been identified as a potentially useful biomarker of DNA DSBs. On the other hand, hypoxia-inducible factor (HIF) is the "master switch" for hypoxic adaptation in cells and tissues...
March 30, 2024: International Journal of Molecular Sciences
Luís Ramalhete, Miguel Bigotte Vieira, Rúben Araújo, Emanuel Vigia, Inês Aires, Aníbal Ferreira, Cecília R C Calado
Kidney transplantation is an essential medical procedure that significantly enhances the survival rates and quality of life for patients with end-stage kidney disease. However, despite advancements in immunosuppressive therapies, allograft rejection remains a leading cause of organ loss. Notably, predictions of cellular rejection processes primarily rely on biopsy analysis, which is not routinely performed due to its invasive nature. The present work evaluates if the serum proteomic fingerprint, as acquired by Fourier Transform Infrared (FTIR) spectroscopy, can predict cellular rejection processes...
March 29, 2024: International Journal of Molecular Sciences
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