(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
(no author information available yet)
No abstract text is available yet for this article.
2013: Kidney International Supplements
Yurong Feng, Shuai Xu, Haowei Guo, Tian-Bing Ren, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Acute kidney injury (AKI) is a common medical condition with high morbidity and mortality. Although urinalysis provides a noninvasive and convenient diagnostic method for AKI at the molecular level, the low sensitivity of current chemical probes used in urinalysis hinders the time diagnosis of AKI. Herein, we achieved the sensitive and early diagnosis of AKI by the development of a chemiluminescent probe CL-Pa suitable for detection of urinary Vanin-1. Vanin-1 is considered as an early and sensitive biomarker for AKI, while few chemical probes have been applied to for its efficient detection...
September 21, 2023: Analytical Chemistry
Kylie M Taylor, Amy Ym Au, Sanjeeva Herath, Lena Succar, Jasmine Wong, Jonathan Erlich, Zoltan H Endre
Significant loss of kidney function is not easily identified by serum creatinine (sCr)-based measurements. In the presence of normal sCr, decreased KFR may identify significant loss of function. We evaluated KFR in experimental subclinical chronic kidney disease (sCKD) before and after brief ischemia-reperfusion injury (IRI). Using fluorescein isothiocyanate (FITC)-labelled sinistrin, GFR was measured transcutaneously before and after adenine induced sCKD, and 1 and 2 weeks after brief IRI, and compared with urinary kidney damage biomarkers...
September 21, 2023: American Journal of Physiology. Renal Physiology
Xiying Hou, Binbin Cui, Andong Qiu, Na Liu, Shougang Zhuang
Mixed lineage leukemia 1 (MLL1) is a methyltransferase that induces histone H3 lysine 4 trimethylation (H3K4me3) and partially exerts its untoward functional effects by interacting with multiple subunits including Menin and WD repeat-containing protein 5 (WDR5). In this study, we investigated the role and mechanisms of MLL1 in murine models of acute kidney injury (AKI) induced by folic acid (FA) and ischemia/reperfusion (I/R). Injury to the kidney elevated expression of MLL1, Menin, WDR5 and H3K4Me3, which was accompanied by increased serum creatinine (Scr) and blood urea nitrogen (BUN), renal tubular injury and apoptosis...
September 21, 2023: American Journal of Physiology. Renal Physiology
Mark D Davies, Felicity Hughes, Aamer Sandoo, Abdulfattah Alejmi, Jamie Hugo Macdonald
Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by traditional risk factors such as hypertension. Endothelial dysfunction and arterial stiffness have been suggested as factors which explain some of the increased risk, and are independently associated with important cardiovascular outcomes in CKD patients. Studies in other disease populations have shown positive effects of exercise on vascular dysfunction. The aim of this review was to determine whether exercise training interventions improve measures of vascular function and morphology in patients across the spectrum of CKD and which exercise training interventions are most efficacious...
September 21, 2023: American Journal of Physiology. Renal Physiology
Md Sajjadul Haque Ripon, Shakil Ahmed, Tanjina Rahman, Harun-Ur Rashid, Tilakavati Karupaiah, Pramod Khosla, Zulfitri Azuan Mat Daud, Shakib Uz Zaman Arefin, Abdus Salam Osmani
Hemodialysis (HD) is a treatment for ensuring the survival of end-stage kidney disease (ESKD) patients, and nutrition care is integral to their management. We sent questionnaires to evaluate the total dialysis service capacity and nutrition services across all dialysis facilities (DF) in Bangladesh, with responses from 149 out of 166 active DFs. Survey results revealed that 49.7% of DFs operated two shifts, and 42.3% operated three shifts daily, with 74.5% holding between one and ten dialysis machines. Sixty-three percent of DFs served between one and 25 patients per week, and 77% of patients received twice-weekly dialysis...
2023: PloS One
Hiroyuki Ito, Hideyuki Inoue, Takuma Izutsu, Suzuko Matsumoto, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane
BACKGROUND: The changes in the estimated glomerular filtration rate (eGFR) and predictors of the renal prognosis were retrospectively assessed over the 12 months after the initiation of tofogliflozin, which has the shortest half-life among sodium-glucose cotransporter 2 (SGLT2) inhibitors, in Japanese patients with type 2 diabetes and renal impairment. METHODS: In total, 158 patients treated with tofogliflozin between 2019 and 2021 were studied as the safety analysis set...
2023: PloS One
Marta Kelava, Adam J Milam, Junhui Mi, Andrej Alfirevic, Patrick Grady, Shinya Unai, Haytham Elgharably, Kenneth McCurry, Marijan Koprivanac, Andra Duncan
BACKGROUND: Arterial hyperoxemia may cause end-organ damage secondary to the increased formation of free oxygen radicals. The clinical evidence on postoperative lung toxicity from arterial hyperoxemia during cardiopulmonary bypass (CPB) is scarce, and the effect of arterial partial pressure of oxygen (Pao2) during cardiac surgery on lung injury has been underinvestigated. Thus, we aimed to examine the relationship between Pao2 during CPB and postoperative lung injury. Secondarily, we examined the relationship between Pao2 and global (lactate), and regional tissue malperfusion (acute kidney injury)...
September 21, 2023: Anesthesia and Analgesia
Monalisa Sahoo, Rajendra Singh, Pawan Kumar, Asok Kumar Mariappan, Palanivelu Munnuswamy, Karampal Singh, Mani Saminathan, Kuldeep Dhama, Ganesh Kondabattula, Tareni Das, Jigarji Chaturji Thakor, Gayatri Kashyap, Nihar Ranjan Sahoo
The Foot-and-Mouth disease is highly contagious acute viral disease of livestock inflicting huge economic loss to the farmers. The limited knowledge regarding the pathological lesions vis-a-vis distribution of the FMDV in in lesser explored endocrine glands and important vital organs other than the target organs of infected calves prompted us to take the present investigation to have detailed insight into the pathogenesis. The systematic necropsy of 37 dead calves (cattle-28 and buffalo-9) was conducted, and thin representative tissue pieces from the affected organs were collected in 10% neutral buffered formalin (NBF) for pathological and immunohistochemical investigations...
September 21, 2023: Veterinary Quarterly
Thierry Hannedouche, Patrick Rossignol, Patrice Darmon, Jean-Michel Halimi, Patrick Vuattoux, Albert Hagege, Ludivine Videloup, Francis Guinard
Diabetes is the leading cause of end-stage kidney disease (ESKD), accounting for approximately 50% of patients starting dialysis. However, the management of these patients at the stage of chronic kidney disease (CKD) remains poor, with fragmented care pathways among healthcare professionals (HCPs). Diagnosis of CKD and most of its complications is based on laboratory evidence. This article provides an overview of critical laboratory evidence of CKD and their limitations, such as estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), Kidney Failure Risk Equation (KFRE), and serum potassium...
September 21, 2023: Postgraduate Medicine
Xinyue Wang, Hongjian Huang, Renfeng Xu, Yan Fang, Yunxiang Weng, Zhengchao Wang, Xiaopeng Xiong, Haiqing Liu
Adhesives with robust but readily detachable wet tissue adhesion are of great significance for wound closure. Polyelectrolyte complex adhesive (PECA) is an important wet tissue adhesive. However, its relatively weak cohesive and adhesive strength cannot satisfy clinical applications. Herein, modified tannic acid (mTA) with a catechol group, a long alkyl hydrophobic chain, and a phenyl group was prepared first, and then, it was mixed with acrylic acid (AA) and polyethylenimine (PEI), followed by UV photopolymerization to make a wet tissue adhesive hydrogel with tough cohesion and adhesion strength...
September 21, 2023: ACS Applied Materials & Interfaces
Lesley A Inker, Juhi Chaudhari, Tom Greene, Anthony Gucciardo, Hiddo J L Heerspink
No abstract text is available yet for this article.
September 21, 2023: Journal of the American Society of Nephrology: JASN
Dorota Marchel, Howard Trachtman, Maria Larkina, Margaret Helmuth, Jennifer Y Lai Yee, Damian Fermin, Andrew S Bomback, Pietro A Canetta, Debbie S Gipson, Amy K Mottl, Rulan S Parekh, Manish K Saha, Matthew G Sampson, Richard A Lafayette, Laura H Mariani
BACKGROUND: Hematuria is frequently present in podocytopathies, but its significance and prognostic value is not well described in these proteinuric kidney diseases. This study describes the prevalence and association between hematuria and kidney-related outcomes in these disorders. METHODS: Hematuria was assessed at the initial urinalysis in participants with the following podocytopathies, membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis, in the Nephrotic Syndrome Study Network (NEPTUNE) and Cure Glomerulonephropathy (CureGN) cohorts with >24 months of follow-up...
September 21, 2023: Clinical Journal of the American Society of Nephrology: CJASN
Sundar Jagannath, Mark A Anderson, Andrew J Yee, Robert P Hasserjian
New England Journal of Medicine, Volume 389, Issue 12, Page 1133-1143, September 2023.
September 21, 2023: New England Journal of Medicine
Jinxi Zhao, Shidong Wang, Xiaoran Li, Guangde Zhang, Yuan Xu, Xianling Zheng, Jian Guo, Zhenxian Zhang
Background: To evaluate the efficacy and safety of Keluoxin (KLX) capsules and provide validated evidence for the application of KLX in the treatment of diabetic kidney disease (DKD). Methods: A multicenter, randomized, double-blind, placebo-controlled trial design was used to screen 129 patients with DKD (urinary albumin-to-creatinine ratio [UACR]: male, 2.5-30 mg/mmol; female, 3.5-30 mg/mmol) and with Qi and Yin deficiency and blood stasis symptoms. Written informed consent was obtained from all patients...
September 21, 2023: J Integr Complement Med
Drusus A Johnson, Mark P Funnell, Liam M Heaney, Thomas G Cable, Patrick C Wheeler, Stephen J Bailey, Tom Clifford, Lewis J James
Introduction: Cannabidiol (CBD) is a nonintoxicating phytocannabinoid used in clinical treatments and sold widely in consumer products. CBD products may be designed for sublingual or oral delivery, but it is unclear whether either is advantageous for CBD absorption. This study compared CBD pharmacokinetics after providing CBD oil as sublingual drops and within orally ingested gelatin capsules, at a dose relevant to consumer products. Materials and Methods: Eight males completed three conditions in a participant-blinded, randomized crossover design...
September 22, 2023: Cannabis and Cannabinoid Research
Yoko Shirai, Kenichiro Miura, Riku Hamada, Kenji Ishikura, Shinji Kunishima, Motoshi Hattori
BACKGROUND: MYH9-related disease (MYH9-RD) is characterized by congenital macrothrombocytopenia, Döhle body-like granulocyte inclusions, and nephropathy, which may progress to end-stage kidney disease (ESKD). However, information on the effects of renin-angiotensin system (RAS) inhibitors on kidney survival is currently lacking and the outcomes of kidney replacement therapy (KRT) in MYH9-RD are largely unknown. METHODS: We conducted a cross-sectional nationwide survey by sending questionnaires to 145 institutions in Japan and analyzed data for 49 patients...
September 21, 2023: Clinical and Experimental Nephrology
Olivia Wegrzyniak, Bo Zhang, Johanna Rokka, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Jonas Persson, Helena Nordström, John Löfblom, Fredrik Pontén, Fredrik Y Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson
BACKGROUND: Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFRβ could potentially allow the quantification of fibrogenesis in fibrotic livers. This study aims to evaluate a fluorine-18 radiolabeled Affibody molecule ([18 F]TZ-Z09591) as a PET tracer for imaging liver fibrogenesis. RESULTS: In vitro specificity studies demonstrated that the trans-Cyclooctenes (TCO) conjugated Z09591 Affibody molecule had a picomolar affinity for human PDGFRβ...
September 21, 2023: EJNMMI Radiopharmacy and Chemistry
Wenyuan Gan, Jian Chen, Fan Zhu, Xun Fang, Xingruo Zeng, Wei Xiao, Wenli Chen
BACKGROUND: As a novel marker of inflammation, the neutrophil-to-lymphocyte ratio (NLR) has been studied in various diseases. However, NLR in idiopathic membranous nephropathy (IMN) has been rarely studied. We sought to assess the role of NLR in predicting proteinuria remission in IMN. METHODS: This retrospective study involved 561 patients with IMN from January 2018 to December 2022 in Department of Nephrology of Wuhan Central Hospital. All baseline data were collected before the immunosuppressive regiment was administered...
September 21, 2023: International Urology and Nephrology
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