Yehui Duan, Yinzhao Zhong, Hao Xiao, Changbing Zheng, Bo Song, Wenlong Wang, Qiuping Guo, Yuying Li, Hui Han, Jing Gao, Kang Xu, Tiejun Li, Yulong Yin, Fengna Li, Jie Yin, Xiangfeng Kong
Obesity increases the risk of developing insulin resistance and diabetes and is a major public health concern. Our previous study shows that dietary β-hydroxy-β-methylbutyrate (HMB) improves lipid metabolism in a pig model. However, it remains unclear whether HMB blocks obesity through gut microbiota. In this study, we found that HMB reduced body weight, alleviated the whitening of brown adipose tissue, and improved insulin resistance in mice fed a high-fat diet (HFD). High-throughput pyrosequencing of the 16S rRNA demonstrated that HMB administration significantly reversed the gut microbiota dysbiosis in HFD-fed mice, including the diversity of gut microbiota and relative abundances of Bacteroidetes and Firmicutes ...
September 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology