Joshua F Baker, Marianna Olave, William Leach, Caleigh R Doherty, Rachel L Gillcrist, Daniel K White, Alexis Ogdie, Bryant R England, Katherine Wysham, Mercedes Quinones, Rui Xiao, Tuhina Neogi, Carla R Scanzello
OBJECTIVE: To quantify the effect of corticosteroids compared to lidocaine-only injections over 12 weeks among patients with knee osteoarthritis (KOA). METHODS: Participants with KOA were randomized to receive a knee injection of methylprednisolone acetate 1 mL (40 mg) plus 2 mL lidocaine (1%) or 1 mL saline and 2 mL lidocaine. Participants and providers were blinded to treatment allocation using an opacified syringe. The outcome was the average change from baseline of the total Knee Injury and Osteoarthritis Outcome Score (KOOS) (range 0-100) assessed at 2-week intervals over 12 weeks...
September 22, 2023: ACR open rheumatology