Zhen Cao, F Aharonian, Axikegu, Y X Bai, Y W Bao, D Bastieri, X J Bi, Y J Bi, W Bian, A V Bukevich, Q Cao, W Y Cao, Zhe Cao, J Chang, J F Chang, A M Chen, E S Chen, H X Chen, Liang Chen, Lin Chen, Long Chen, M J Chen, M L Chen, Q H Chen, S Chen, S H Chen, S Z Chen, T L Chen, Y Chen, N Cheng, Y D Cheng, M Y Cui, S W Cui, X H Cui, Y D Cui, B Z Dai, H L Dai, Z G Dai, Danzengluobu, X Q Dong, K K Duan, J H Fan, Y Z Fan, J Fang, J H Fang, K Fang, C F Feng, H Feng, L Feng, S H Feng, X T Feng, Y Feng, Y L Feng, S Gabici, B Gao, C D Gao, Q Gao, W Gao, W K Gao, M M Ge, L S Geng, G Giacinti, G H Gong, Q B Gou, M H Gu, F L Guo, X L Guo, Y Q Guo, Y Y Guo, Y A Han, M Hasan, H H He, H N He, J Y He, Y He, Y K Hor, B W Hou, C Hou, X Hou, H B Hu, Q Hu, S C Hu, D H Huang, T Q Huang, W J Huang, X T Huang, X Y Huang, Y Huang, X L Ji, H Y Jia, K Jia, K Jiang, X W Jiang, Z J Jiang, M Jin, M M Kang, I Karpikov, D Kuleshov, K Kurinov, B B Li, C M Li, Cheng Li, Cong Li, D Li, F Li, H B Li, H C Li, Jian Li, Jie Li, K Li, S D Li, W L Li, W L Li, X R Li, Xin Li, Y Z Li, Zhe Li, Zhuo Li, E W Liang, Y F Liang, S J Lin, B Liu, C Liu, D Liu, D B Liu, H Liu, H D Liu, J Liu, J L Liu, M Y Liu, R Y Liu, S M Liu, W Liu, Y Liu, Y N Liu, Q Luo, Y Luo, H K Lv, B Q Ma, L L Ma, X H Ma, J R Mao, Z Min, W Mitthumsiri, H J Mu, Y C Nan, A Neronov, L J Ou, P Pattarakijwanich, Z Y Pei, J C Qi, M Y Qi, B Q Qiao, J J Qin, A Raza, D Ruffolo, A Sáiz, M Saeed, D Semikoz, L Shao, O Shchegolev, X D Sheng, F W Shu, H C Song, Yu V Stenkin, V Stepanov, Y Su, D X Sun, Q N Sun, X N Sun, Z B Sun, J Takata, P H T Tam, Q W Tang, R Tang, Z B Tang, W W Tian, C Wang, C B Wang, G W Wang, H G Wang, H H Wang, J C Wang, Kai Wang, Kai Wang, L P Wang, L Y Wang, P H Wang, R Wang, W Wang, X G Wang, X Y Wang, Y Wang, Y D Wang, Y J Wang, Z H Wang, Z X Wang, Zhen Wang, Zheng Wang, D M Wei, J J Wei, Y J Wei, T Wen, C Y Wu, H R Wu, Q W Wu, S Wu, X F Wu, Y S Wu, S Q Xi, J Xia, G M Xiang, D X Xiao, G Xiao, Y L Xin, Y Xing, D R Xiong, Z Xiong, D L Xu, R F Xu, R X Xu, W L Xu, L Xue, D H Yan, J Z Yan, T Yan, C W Yang, C Y Yang, F Yang, F F Yang, L L Yang, M J Yang, R Z Yang, W X Yang, Y H Yao, Z G Yao, L Q Yin, N Yin, X H You, Z Y You, Y H Yu, Q Yuan, H Yue, H D Zeng, T X Zeng, W Zeng, M Zha, B B Zhang, F Zhang, H Zhang, H M Zhang, H Y Zhang, J L Zhang, Li Zhang, P F Zhang, P P Zhang, R Zhang, S B Zhang, S R Zhang, S S Zhang, X Zhang, X P Zhang, Y F Zhang, Yi Zhang, Yong Zhang, B Zhao, J Zhao, L Zhao, L Z Zhao, S P Zhao, X H Zhao, F Zheng, W J Zhong, B Zhou, H Zhou, J N Zhou, M Zhou, P Zhou, R Zhou, X X Zhou, X X Zhou, B Y Zhu, C G Zhu, F R Zhu, H Zhu, K J Zhu, Y C Zou, X Zuo
We present the measurements of all-particle energy spectrum and mean logarithmic mass of cosmic rays in the energy range of 0.3-30 PeV using data collected from LHAASO-KM2A between September 2021 and December 2022, which is based on a nearly composition-independent energy reconstruction method, achieving unprecedented accuracy. Our analysis reveals the position of the knee at 3.67±0.05±0.15  PeV. Below the knee, the spectral index is found to be -2.7413±0.0004±0.0050, while above the knee, it is -3...
March 29, 2024: Physical Review Letters
Julia S Retzky, Connor Fletcher, Morgan Rizy, Alissa Burge, Sabrina M Strickland
PURPOSE: The primary aim is to evaluate the relationship between MOCART scores and patient satisfaction, as evaluated by achievement of (1) the Patient Acceptable Symptomatic State (PASS) and (2) the minimal clinically important difference (MCID) for Knee Injury and Osteoarthritis Score Quality of Life (KOOS QoL), for patients undergoing autologous chondrocyte implantation (ACI) for focal Grade IV patellofemoral chondral defects. The secondary aim is to determine the threshold MOCART score which predicts the ability to meet the PASS and the MCID for KOOS QoL...
April 13, 2024: Cartilage
Yavuz Şahbat, Te-Feng Arthur Chou, Jae-Sung An, Fırat Gülağacı, Matthieu Ollivier
PURPOSE: Accurate assessment of the knee joint line is essential for surgeries involving the knee. The knee joint line obliquity (KJLO) is a radiological measurement that evaluates the position of the knee joint relative to the ground and is frequently used in preoperative planning and clinical follow-up. On the other hand, coronal plane alignment of the knee (CPAK) classifications assesses the joint line as the summation of the medial proximal tibial angle (MPTA) and mechanical lateral distal femoral angle (mLDFA)...
April 12, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
Maho Tsuchiya, Yoshihisa Ohashi, Kensuke Fukushima, Yusei Okuda, Arisa Suto, Takashi Matsui, Yoshio Kodera, Masashi Sato, Ayumi Tsukada, Gen Inoue, Masashi Takaso, Kentaro Uchida
Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by cartilage erosion, structural changes, and inflammation. Synovial fibroblasts play a crucial role in OA pathophysiology, with abnormal fibroblastic cells contributing significantly to joint pathology. Fibrocytes, expressing markers of both hematopoietic and stromal cells, are implicated in inflammation and fibrosis, yet their marker and role in OA remain unclear. ENTPD1, an ectonucleotidase involved in purinergic signaling and expressed in specific fibroblasts in fibrotic conditions, led us to speculate that ENTPD1 plays a role in OA pathology by being expressed in fibrocytes...
April 6, 2024: International Journal of Molecular Sciences
Elena V Tchetina, Kseniya E Glemba, Galina A Markova, Svetlana I Glukhova, Maksim A Makarov, Aleksandr M Lila
UNLABELLED: Knee osteoarthritis (KOA) is characterized by low-grade inflammation, loss of articular cartilage, subchondral bone remodeling, synovitis, osteophyte formation, and pain. Strong, continuous pain may indicate the need for joint replacement in patients with end-stage OA, although postoperative pain (POP) of at least a two-month duration persists in 10-40% of patients with OA. STUDY PURPOSE: The inflammation observed in joint tissues is linked to pain caused by the production of proinflammatory cytokines...
March 29, 2024: International Journal of Molecular Sciences
Matteo Berni, Gregorio Marchiori, Massimiliano Baleani, Gianluca Giavaresi, Nicola Francesco Lopomo
The damping system ensured by the osteochondral (OC) unit is essential to deploy the forces generated within load-bearing joints during locomotion, allowing furthermore low-friction sliding motion between bone segments. The OC unit is a multi-layer structure including articular cartilage, as well as subchondral and trabecular bone. The interplay between the OC tissues is essential in maintaining the joint functionality; altered loading patterns can trigger biological processes that could lead to degenerative joint diseases like osteoarthritis...
April 8, 2024: Materials
Zhiwei Chen, Ruxin Zhang, Shouwei Zhao, Bing Li, Shuo Wang, Wenhui Lu, Deyi Zhu
Gelatin-based hydrogels with excellent mechanical properties and conductivities are desirable, but their fabrication is challenging. In this work, an innovative approach for the preparation of gelatin-based conductive hydrogels is presented that improves the mechanical and conductive properties of hydrogels by integrating Z-Gln-Gly into gelatin polymers via enzymatic crosslinking. In these hydrogels (Gel-TG-ZQG), dynamic π-π stacking interactions are created by the introduction of carbobenzoxy groups, which can increase the elasticity and toughness of the hydrogel and improve the conductivity sensitivity by forming effective electronic pathways...
April 5, 2024: Polymers
Marta Mifsut-Aleixandre, Damián Mifsut, Eva María González-Soler, Arantxa Blasco-Serra, Alfonso Amador Valverde
Background : One of the main challenges of orthopedic surgery is adequate pain management after total knee arthroplasty. This work aimed to determine the anatomical safety area for infiltration through the posterior capsule of the knee in prosthetic surgery using Magnetic Resonance Imaging (MRI). Methods : A descriptive, observational, cross-sectional study was performed on 126 knee MRIs. The variables studied were age, sex, and distance between different neurovascular structures of the popliteal fossa (tibial nerve, common peroneal nerve, and vascular bundle)...
April 6, 2024: Journal of Clinical Medicine
Yuichi Miyairi, Hiroaki Nakashima, Sadayuki Ito, Naoki Segi, Jun Ouchida, Ryotaro Oishi, Ippei Yamauchi, Masaaki Machino, Taisuke Seki, Shinya Ishizuka, Yasuhiko Takegami, Yukiharu Hasegawa, Shiro Imagama
(1) Background: Patients with primary vertebral fracture (VF) are at high risk of re-fracture and mortality. However, approximately two-thirds of patients with VFs receive minimal clinical attention. (2) Methods: The current study aimed to investigate the factors associated with asymptomatic VFs in middle-aged and elderly individuals who underwent resident health examinations. (3) Results: The current study included 217 participants aged > 50 years. VFs were diagnosed based on lateral radiographic images using Genant's semiquantitative (SQ) method...
April 2, 2024: Journal of Clinical Medicine
Luigi Cianni, Emidio Di Gialleonardo, Donato Coppola, Giacomo Capece, Eugenio Libutti, Massimiliano Nannerini, Giulio Maccauro, Raffaele Vitiello
(1) Background: Osteoarthritis (OA) significantly impacts patients' quality of life and negatively affects public healthcare costs. The aim of this systematic review is to identify the effectiveness of pulsed electromagnetic fields (PEMFs) in OA treatment across different anatomical districts, determining pain reduction and overall improvement in the patient's quality of life. (2) Methods: In this systematic review following PRISMA guidelines, PubMed and Google Scholar were searched for randomized controlled trials involving patients with osteoarthritis undergoing PEMF therapy...
March 28, 2024: Journal of Clinical Medicine
Charles Rapp, Feriel Boudif, Charlotte Bourgoin, Anne Lohse, Thierry Conrozier
Background: An advanced radiological stage and obesity are predictive of poorer and shorter responses to viscosupplementation in patients with knee osteoarthritis (OA). Very little is known regarding the impact of other factors such as sport practice, comorbidities, or anatomical features of OA. Methods: This study aimed to investigate patients' and OA characteristics associated with the duration of the effectiveness (DE) of viscosupplementation in patients with knee OA. It was a cross-sectional, single-centre clinical trial in patients with knee OA treated with intra-articular (IA) hyaluronic acid (HA) injection(s) within the previous 3 years...
March 27, 2024: Journal of Clinical Medicine
Tomoyoshi Sakaguchi, Naveen Sake, Masato Tanaka, Yoshihiro Fujiwara, Shinya Arataki, Takuya Taoka, Yuya Kodama, Kazuhiko Takamatsu, Yosuke Yasuda, Masami Nakagawa, Kayo Utsunomiya, Hiroki Tomiyama
Background : Adult spinal deformity is a complex condition that causes lower back pain, causing spinal imbalance and discomfort in activities of daily life. After corrective spinal surgery, patients' gait and balance abilities might not revert to normalcy and they might be at increased risk of falling. Therefore, early evaluation of such a risk is imperative to prevent further complications such as a fall, or even worse, fractures in post-surgery ASD patients. However, there has been no report of an investigation of such early changes in gait sway before and after ASD surgery...
March 26, 2024: Journal of Clinical Medicine
Mariusz Drużbicki, Łucja Kitrys, Jarosław Jabłoński, Damian Filip, Lidia Perenc, Agnieszka Guzik
(1) Background : Total knee arthroplasty (TKA) performed on working-age patients significantly affects the participation of such patients in social life. A retrospective study was conducted to determine the return to work (RTW) rate after TKA. The goal of this study was to provide reference data for the Polish population and identify the factors impacting patients' decisions to return to or resign from work, relative to their functional performance. (2) Methods : This retrospective study involved 48 patients...
March 25, 2024: Journal of Clinical Medicine
Marta Freitas, Francisco Pinho, Liliana Pinho, Sandra Silva, Vânia Figueira, João Paulo Vilas-Boas, Augusta Silva
Non-linear and dynamic systems analysis of human movement has recently become increasingly widespread with the intention of better reflecting how complexity affects the adaptability of motor systems, especially after a stroke. The main objective of this scoping review was to summarize the non-linear measures used in the analysis of kinetic, kinematic, and EMG data of human movement after stroke. PRISMA-ScR guidelines were followed, establishing the eligibility criteria, the population, the concept, and the contextual framework...
April 6, 2024: Sensors
Xincheng Wang, Hongbo Wang, Bo Zhang, Desheng Zheng, Hongfei Yu, Bo Cheng, Jianye Niu
Most lower limb rehabilitation robots are limited to specific training postures to adapt to stroke patients in multiple stages of recovery. In addition, there is a lack of attention to the switching functions of the training side, including left, right, and bilateral, which enables patients with hemiplegia to rehabilitate with a single device. This article presents an exoskeleton robot named the multistage hemiplegic lower-limb rehabilitation robot, which has been designed to do rehabilitation in multiple training postures and training sides...
April 5, 2024: Sensors
Sanchana Krishnakumar, Bert-Jan F van Beijnum, Chris T M Baten, Peter H Veltink, Jaap H Buurke
After an ACL injury, rehabilitation consists of multiple phases, and progress between these phases is guided by subjective visual assessments of activities such as running, hopping, jump landing, etc. Estimation of objective kinetic measures like knee joint moments and GRF during assessment can help physiotherapists gain insights on knee loading and tailor rehabilitation protocols. Conventional methods deployed to estimate kinetics require complex, expensive systems and are limited to laboratory settings. Alternatively, multiple algorithms have been proposed in the literature to estimate kinetics from kinematics measured using only IMUs...
March 28, 2024: Sensors
Tomoya Ishida, Mina Samukawa
Frontal and axial knee motion can affect the accuracy of the knee extension/flexion motion measurement using a wearable goniometer. The purpose of this study was to test the hypothesis that calibrating the goniometer on an individual's body would reduce errors in knee flexion angle during gait, compared to bench calibration. Ten young adults (23.2 ± 1.3 years) were enrolled. Knee flexion angles during gait were simultaneously assessed using a wearable goniometer sensor and an optical three-dimensional motion analysis system, and the absolute error (AE) between the two methods was calculated...
March 25, 2024: Sensors
Hikaru Sato, Hiroaki Kijima, Takehiro Iwami, Hiroaki Tsukamoto, Hidetomo Saito, Daisuke Kudo, Ryota Kimura, Yuji Kasukawa, Naohisa Miyakoshi
The purpose of this study was to investigate the relationship between clinical outcomes and lateral thrust before and after unicompartmental knee arthroplasty (UKA) using inertial measurement sensor units. Eleven knees were evaluated with gait analysis. The varus angular velocity was used to evaluate lateral thrust. The femorotibial angle (FTA) and hip-knee-ankle angle (HKA) were used to evaluate lower-limb alignment, and the Oxford Knee Score (OKS) and Japanese Orthopaedic Association Score (JOA) were used to evaluate clinical outcomes...
March 22, 2024: Sensors
Michele Mercurio, Giorgio Gasparini, Erminia Cofano, Andrea Zappia, Filippo Familiari, Olimpio Galasso
The aim of this systematic review was to investigate the outcomes of knee arthrodesis (KA) after periprosthetic joint infection (PJI) of the knee. Differences in clinical outcomes and complication rates among the intramedullary nailing (IMN), external fixation (EF), and compression plating (CP) procedures were compared. A total of 23 studies were included. Demographics, microbiological data, types of implants, surgical techniques with complications, reoperations, fusion, and amputation rates were reported. A total of 787 patients were evaluated, of whom 601 (76...
April 7, 2024: Healthcare (Basel, Switzerland)
Donato Di Gennaro, Giannantonio Coletta, Enrico Festa, Domenico De Mauro, Maria Rizzo, Luca Diana, Giovanni Balato, Massimo Mariconda
BACKGROUND: The gold standard treatment for periprosthetic joint infections is the two-stage revision that includes the spacer placement before definitive reimplantation. The management of PJI affects patients' joint function and, subsequently, their mental health. Even though significant advances have been achieved, little to no attention has been paid to the psychological implications. So, based on standardized patient-reported outcome measures (PROMs), this study aimed to clarify the effect of spacer treatment of infected hip and knee arthroplasties on patients' mental health...
April 6, 2024: Healthcare (Basel, Switzerland)
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