Vladimir Kenis, Eugeniy Melchenko, Ilya Mazunin, Minna Pekkinen, Outi Mäkitie
Epiphyseal chondrodysplasia, Miura type (ECDM) is a skeletal dysplasia with tall stature and distinctive skeletal features caused by heterozygous NPR2 pathogenic variants. Only four families have been reported. We present a family with five affected individuals (mother, three sons, and daughter). The mother's phenotype was relatively mild: borderline tall stature and elongated halluces operated during childhood. The children were remarkably more severely affected with tall stature, scoliosis, and elongated toes and fingers leading to suspicion of Marfan syndrome...
October 19, 2020: American Journal of Medical Genetics. Part A
Leonardo Henrique Perinotto Abdalla, Ryan Michael Broxterman, Camila Coelho Greco, Benedito Sérgio Denadai
NEW FINDINGS: What is the central question of this study? Does creatine supplementation augment the total torque impulse accumulated above end-test torque (IET) during severe-intensity knee-extensor exercise by attenuating the rate of decrease in peak potentiated twitch torque (PT)? What is the main finding and its importance? Creatine augmented the IET and attenuated the rate of decrease in both voluntary activation and PT during severe-intensity exercise. The IET was related to the rate of decrease in PT...
October 18, 2020: Experimental Physiology
Stefan van Drongelen, Mariska Wesseling, Jana Holder, Andrea Meurer, Felix Stief
Reduced external knee adduction moments in the second half of stance after total hip replacement have been reported in hip osteoarthritis patients. This reduction is thought to shift the load from the medial to the lateral knee compartment and as such increase the risk for knee osteoarthritis. The knee adduction moment is a surrogate for the load distribution between the medial and lateral compartments of the knee and not a valid measure for the tibiofemoral contact forces which are the result of externally applied forces and muscle forces...
2020: Frontiers in Bioengineering and Biotechnology
Khalilalah Nazem, Mojtaba Baniasadi, Ghasem Mohammadsharifi, Shirvan Rastegar, Sina Talebi
Background: Lower extremity genu varum is a common deformity leading to imbalanced weight distribution on the knee joint and eventually significant disabilities due to medial compartment joint osteoarthritis. This study was aimed to assess the efficacy of a novel technique of high tibial open wedge osteotomy plus tubercle osteotomy in a follow-up study. Materials and Methods: This is a prospective census cross-sectional study conducted on 146 patients with the history of genu varus undergone high tibial open-wedge osteotomy and tubercle osteotomy since 2011...
2020: Advanced Biomedical Research
Cheuk Yin Li, Kenneth Jordan Ng Cheong Chung, Omar M E Ali, Nicholas D H Chung, Cheuk Heng Li
Adverse knee pain occurs in 10-34% of all total knee replacements (TKR), and 20% of TKR patients experience more pain post-operatively than pre-operatively. Knee pain is amongst the top five reasons for knee replacement revision in the United Kingdom. The number of TKRs is predicted to continue increasing due to the ageing population.A narrative literature review was performed on the different causes of pain following TKR. A database search on Scopus, PubMed, and Google Scholar was conducted to look for articles related to TKR, pain, and cause...
September 2020: EFORT Open Reviews
Cooper Dean, Ivan Davis, David Alvarez
Proximal tibiofibular joint (PTFJ) pathology is an uncommon but perhaps underappreciated cause of lateral knee pain. While imaging guided therapeutic injections for diagnosis and management of joint related symptoms are now commonplace and numerous techniques for accessing most joints in the body have been documented, a technique for fluoroscopically guided injection of the PTFJ has not been yet described in the literature. We present a case of an adult patient who presented with lateral knee pain refractory to conservative management who opted for a fluoroscopically-guided therapeutic injection of her PTFJ...
December 2020: Radiology Case Reports
Matheus Silva Norberto, Tarine Botta de Arruda, Marcelo Papoti
Neuromuscular fatigue evaluation is widely performed on different muscles through the conventional protocol using maximum voluntary contraction (MVC) with electrical stimuli in the analyzed muscle. In an attempt to use this protocol on elbow extensor musculature, previous studies and pilot studies showed co-contraction effects from antagonist musculature during muscular stimulations. The aim of this study was to propose a new neuromuscular fatigue protocol evaluation on elbow extensor musculature. Twenty participants preformed exercises to induce central (CenFat) and peripheral fatigue (PerFat)...
2020: Frontiers in Physiology
Riccardo D'Ambrosi, Alessio Biazzo, Francesco Masia, Vincenzo Izzo, Norberto Confalonieri, Nicola Ursino, Francesco Verde
No abstract text is available yet for this article.
October 13, 2020: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
Yutaro Yamamoto, Yoshio Nagai, Shin Kawanabe, Yoshiaki Hishida, Koji Hiraki, Masakatsu Sone, Yasushi Tanaka
Type 2 diabetes is associated with sarcopenia. Resistance training and appropriate nutritional therapy are reported to be effective for muscle strength and mass. This study aimed to evaluate the effect of resistance training using elastic bands at home combined with a leucine-rich amino acid supplement on muscle strength, physical function, and muscle mass in elderly type 2 diabetes. We conducted a 48-week prospective single-center randomized controlled trial in 60 patients who were randomly allocated to one of three groups: control (C), resistance exercise (R), and resistance exercise plus supplement (RL)...
October 17, 2020: Endocrine Journal
Celeste Dix, David Logerstedt, Amelia Arundale, Lynn Snyder-Mackler
OBJECTIVES: Knee injury prevention programs (IPPs) reduce knee and anterior cruciate ligament (ACL) injury rates in female athletes, however, implementation of IPPs is low. The purpose of this study was to identify barriers to implementation of IPPs among collegiate women's soccer coaches. DESIGN: Cross-sectional survey. METHODS: A custom survey based on the RE-AIM (reach, effectiveness, adoption, implementation, maintenance) framework and existing literature was sent to 151 out of 153 women's National Collegiate Athletic Association (NCAA) soccer coaches in the NCAA's Eastern Region...
September 29, 2020: Journal of Science and Medicine in Sport
Sami Giryes, Daniella Militianu, Alexandra Balbir-Gurman
No abstract text is available yet for this article.
October 2020: Israel Medical Association Journal: IMAJ
Syed Shahzad Hasan, Wendy Sunter, Nadia Ahmed, Dalia Dawoud, Syed Tabish Razi Zaidi
Background Increasing evidence for the use of the aspirin in patients undergoing an orthopaedic surgery for venous thromboembolism prophylaxis has led to a change in the national guidelines substituting anticoagulants with aspirin. Little is known about the impact of such substitution on real-world outcomes from clinical practice. Objective The study was designed to examine clinical outcomes associated with the use of aspirin and apixaban. Setting Two large-scale general hospitals in West Yorkshire region of England...
October 18, 2020: International Journal of Clinical Pharmacy
Masanori Watanabe, T Mark Campbell, Katherine Reilly, Hans K Uhthoff, Odette Laneuville, Guy Trudel
BACKGROUND: Joint immobility results in deleterious changes such as capsule shortening, bone loss and articular cartilage damage. Immobilization of rat knees in flexion for 32 weeks resulted in the distinctive feature of well-established replacement of articular cartilage by bone. Determining the time of onset of bone replacement following is critical for the prevention of this likely irreversible complication of joint immobilization. OBJECTIVES: To determine the onset and progression of bone replacement in the anterior tibial articular cartilage following knee immobilization in flexion...
October 15, 2020: Bone
Lucian C Warth, Evan R Deckard, R Michael Meneghini
INTRODUCTION: It is accepted dogma in total knee arthroplasty (TKA) that resecting the posterior cruciate ligament (PCL) increases the flexion-space by approximately 4mm. Unfortunately, this doctrine is based on historical studies of limited size with variable technique. The aim of this study was to determine the effect of PCL-resection on in vivo tibiofemoral joint space dimensions in a cohort of modern TKAs. METHODS: Tibiofemoral joint space measurements were made during 129 standardized TKAs by two arthroplasty surgeons...
September 28, 2020: Journal of Arthroplasty
Kieran J Bennett, Stuart C Millar, Francois Fraysse, John B Arnold, Gerald J Atkins, L Bogdan Solomon, Saulo Martelli, Dominic Thewlis
BACKGROUND: The goal of postoperative tibial plateau fracture (TPF) management is to ensure surgical fixation is maintained while returning patients to normal function as soon as possible, allowing patients to resume their normal activities of daily living. The aim of this study was to investigate longitudinal changes in lower limb joint kinematics following TPF and determine how these kinematics relate to self-reported function. METHODS: Patients presenting with a TPF were recruited (n = 18) and undertook gait analysis at six postoperative time points (two weeks, six weeks, three months, six months, one and two years)...
October 10, 2020: Gait & Posture
Djordje Brujic, Karyn E Chappell, Mihailo Ristic
In tissues containing significant amounts of organised collagen, such as tendons, ligaments, menisci and articular cartilage, MR imaging exhibits a strong signal intensity variation caused by the angle between the collagen fibres and the magnetic field. By obtaining scans at different field orientations it is possible to determine the unknown fibre orientations and to deduce the underlying tissue microstructure. Our previous work demonstrated how this method can detect ligament injuries and maturity-related changes in collagen fibre structures...
October 9, 2020: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Nicola Walsh, Louise Jones, Sonia Phillips, Rachel Thomas, Lang'o Odondi, Shea Palmer, Fiona Cramp, Jon Pollock, Mike Hurley
BACKGROUND: Chronic musculoskeletal pain including osteoarthritis (OA) can significantly limit the functional independence of individuals. The spine and hip and knee are predominantly affected; management guidelines for each recommend exercise and education to support self-management. OBJECTIVES: This study investigated the effectiveness of a generic exercise and self-management intervention for people over-50 with hip/knee OA and/or lower back pain compared to continued GP management...
October 10, 2020: Musculoskeletal Science & Practice
Young-Woo Chung, Hong-Yeol Yang, Sung-Ju Kang, Eun-Kyoo Song, Jong-Keun Seon
BACKGROUND: Cartilage repair performed as a single-stage procedure is an important advancement in the treatment of full-thickness cartilage injury and has potential for widespread clinical use. PURPOSE: To investigate the short-term outcomes and cartilage regeneration after implantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in patients who received high tibial osteotomy (HTO) for symptomatic medial knee osteoarthritis...
October 17, 2020: International Orthopaedics
M Bernard, E Pappas, A Georgoulis, A Haschemi, S Scheffler, R Becker
INTRODUCTION: Numerous studies have focused on the anteroposterior stability after anterior cruciate ligament (ACL) reconstruction, with less emphasis on rotational stability. It has been hypothesized that bone patella tendon bone (BTB) autograft for ACL reconstruction restores knee rotation closely to normal due to its comparable fiber orientation to the native ACL. MATERIALS AND METHODS: Twenty patients with unilateral ACL rupture and an uninjured contralateral knee were included in this study...
October 17, 2020: Archives of Orthopaedic and Trauma Surgery
Kyun-Ho Shin, Ki-Mo Jang, Seung-Beom Han
PURPOSE: This study aimed to compare the reliability of two gap assessment methods (component and bone surface gap measurement vs. planned gap balance) and identify the contributors to component gaps other than planned gaps. METHODS: The prospectively collected data for 122 consecutive primary total knee arthroplasties (TKAs; 114 patients). After femoral planning for gap balancing, the medial and lateral planned gaps were calculated (planned gap). The established medial extension and flexion gaps (MEG and MFG, respectively) and lateral extension and flexion gaps (LEG and LFG, respectively) were measured with and without the TKA components (bone surface and component gaps) at 0° and 90° flexion...
October 17, 2020: Knee Surgery, Sports Traumatology, Arthroscopy
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