Howard Y Park, Stephen D Zoller, Vishal Hegde, William Sheppard, Zachary Burke, Gideon Blumstein, Christopher Hamad, Marina Sprague, John Hoang, Ryan Smith, Francisco Romero Pastrana, Julie Czupryna, Lloyd S Miller, Marina López-Álvarez, Mafalda Bispo, Marleen van Oosten, Jan Maarten van Dijl, Kevin P Francis, Nicholas M Bernthal
Implant-associated infections are challenging to diagnose and treat. Fluorescent probes have been heralded as a technologic advancement that can improve our ability to non-invasively identify infecting organisms, as well as guide the inexact procedure of surgical debridement. This study's purpose was to compare two fluorescent probes for their ability to localize Staphylococcus aureus biofilm infections on spinal implants utilizing noninvasive optical imaging, then assessing the broader applicability of the more successful probe in other infection animal models...
January 15, 2021: Scientific Reports