Costas Tsioufis, Kyriakos Dimitriadis, Dimitrios Tousoulis
No abstract text is available yet for this article.
May 22, 2020: Hellenic Journal of Cardiology: HJC
Ezzouhra El Maaiden, Youssef El Kharrassi, Nagib A S Qarah, Abdel Khalid Essamadi, Khadija Moustaid, Boubker Nasser
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this review: This review article documents and critically assesses, for the first time; up to date categorized information about botanical traits, distribution, traditional uses, phytochemistry, pharmacological and toxicological effects of Ziziphus species...
May 22, 2020: Journal of Ethnopharmacology
Mao-Zhong Yao, Xiao-Yue Ge, Ting Liu, Ning Huang, Hong Liu, Yu Chen, Zheng Zhang, Chang-Ping Hu
AIM: Proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) are regarded as the primary factors resulting in pulmonary arterial remodeling in pulmonary hypertension (PH). Myeloid ecotropic viral integration site 1 (MEIS1) has been positioned as a negative cardiomyocyte cell cycle regulator and regulates proliferation of multiple kinds of cancer cells. Whether MESI1 is involved in the proliferation and migration of PASMCs deserves to be identified. MAIN METHODS: Sprague Dawley rats were exposed to hypoxia condition (10% O2 ) for 4 weeks to induce PH and primary rat PASMCs were cultured in hypoxia condition (3% O2 ) for 48 h to induce proliferation and migration...
May 22, 2020: Life Sciences
KaviyarasiRenu, Pureti Lakshmi Prasanna, V G Abilash
Human coronaviruses, especially COVID-19, is an emerging pandemic infectious disease with high morbidity and mortality. Coronaviruses are associated with comorbidities, along with the symptoms of it. SARS-CoV-2 is one of the highly pathogenic coronaviruses that causes a high death rate compared to the SARS-CoV and MERS. In this review, we focused on the mechanism of coronavirus with comorbidities and impairment in multi-organ function. The main dysfunction upon coronavirus infection is damage to alveolar and acute respiratory failure...
May 22, 2020: Life Sciences
Arvind Sehgal, Barbara T Alexander, Janna L Morrison, Andrew M South
No abstract text is available yet for this article.
May 22, 2020: Journal of Pediatrics
Kanran Wang, Jinbo Hu, Jun Yang, Ying Song, Peter J Fuller, Hikaru Hashimura, Wenwen He, Zhengping Feng, Qingfeng Cheng, Zhipeng Du, Zhihong Wang, Linqiang Ma, Shumin Yang, Qifu Li
CONTEXT: The Endocrine Society Guidelines for the diagnosis of primary aldosteronism (PA) suggest that confirmatory tests (CFT) are not required when the following criteria are met: plasma aldosterone concentration (PAC) is >20ng/dl, plasma renin is below detection levels and hypokalemia is present. The evidence for the applicability of the guideline criteria is limited. OBJECTIVE: To develop and validate optimized criteria for sparing CFT in the diagnosis of PA...
May 25, 2020: Journal of Clinical Endocrinology and Metabolism
Nima Etminan, Arnd Dörfler, Helmuth Steinmetz
BACKGROUND: About 2 million adults in Germany harbor an unruptured intracranial aneurysm (IA). Rupture can lead to a life-threatening subarachnoid hemorrhage. If an IA is detected incidentally in cranial imaging, it must be decided how to proceed. METHODS: This review includes key publications that were identified by a selective search in the PubMed database using the search term "unruptured intracranial aneurysms," which was performed in July 2019, and based on information obtained from the German Federal Statistical Office on the frequency of the hospital discharge diagnosis "cerebral aneurysm," excluding the diagnosis "subarachnoid hemorrhage," in Germany from 2005 to 2017...
April 3, 2020: Deutsches Ärzteblatt International
Jenifer M Brown, Mohammed Siddiqui, David A Calhoun, Robert M Carey, Paul N Hopkins, Gordon H Williams, Anand Vaidya
BACKGROUND: Primary aldosteronism is a nonsuppressible renin-independent aldosterone production that causes hypertension and cardiovascular disease. OBJECTIVE: To characterize the prevalence of nonsuppressible renin-independent aldosterone production, as well as biochemically overt primary aldosteronism, in relation to blood pressure. DESIGN: Cross-sectional study. SETTING: 4 U.S. academic medical centers. PARTICIPANTS: Participants with normotension ( n  = 289), stage 1 hypertension ( n  = 115), stage 2 hypertension ( n  = 203), and resistant hypertension ( n  = 408)...
May 26, 2020: Annals of Internal Medicine
C U Becker, C L Sartório, C Campos-Carraro, R Siqueira, R Colombo, A Zimmer, A Belló-Klein
The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session, at 60% of VO2 max. Right ventricular (RV) pressures were measured, heart and gastrocnemius were removed for morphometric/biochemical analysis. Lipid peroxidation (LPO), H2 O2 , GSH/GSSG, and activity/expression of antioxidant enzymes were evaluated...
May 25, 2020: Archives of Physiology and Biochemistry
Kevin Ning Zhou, Kuo-Tzu Sung, Chih-Hsuan Yen, Cheng-Huang Su, Ping-Ying Lee, Ta-Chuan Hung, Wen-Hung Huang, Shih-Chieh Chien, Jui-Peng Tsai, Chun-Ho Yun, Shun-Chuan Chang, Hung-I Yeh, Chung-Lieh Hung
AIMS: We aimed to investigate the functional alterations, diagnostic utilization, and prognostic implication of carotid arterial deformations in subjects with cardiovascular risk factors and heart failure (HF) with preserved ejection fraction (HFpEF). METHODS AND RESULTS: Among 251 prospectively participants (mean age 66.0 ± 9.8 years, 65.7% female) in a single centre between December 2011 and September 2014, carotid artery deformations including circumferential strain (CCS)/strain rate and radial strain were analysed by two-dimensional speckle tracking...
May 25, 2020: ESC Heart Failure
Amanda T Sawyer, Jo Wheeler, Pamela Jennelle, Julie Pepe, Patricia Stearnes Robinson
The purpose of this randomized controlled trial was to examine the effects of a motivational interviewing intervention to improve whole-person lifestyle and reduce cardiovascular disease risk profile. A sample of 111 adults with type 2 diabetes and/or hypertension was recruited from a primary care physician practice. The intervention was facilitated by a program specialist trained in motivational interviewing. Outcomes included body mass index, cholesterol, hemoglobin A1c, blood pressure, waist circumference, wellness scores, and substance use...
January 2020: Journal of Primary Care & Community Health
Qiuxiang Yang, Ling Xie, Wei Zhang, Lin Zhao, HuaJun Wu, Jie Jiang, Jili Zou, Jianguang Liu, Jun Wu, Yonggang Chen, Jinhu Wu
WHAT IS KNOWN AND OBJECTIVE: Since the December 2019 discovery of several cases of coronavirus disease 2019 (COVID-19) in Wuhan, China, the infection has spread worldwide. Our aim is to report on the clinical characteristics, treatments and prognoses of COVID-19. METHODS: This was a retrospective, single-centre, case series of 136 patients who were diagnosed with COVID-19 at Wuhan Third Hospital in Wuhan, China, between 28 January 2020 and 12 February 2020. The clinical characteristics, laboratory tests, treatment features and prognoses were summarized...
May 25, 2020: Journal of Clinical Pharmacy and Therapeutics
Robert J Ng, Sol Bae
No abstract text is available yet for this article.
May 24, 2020: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Dimitri Renard, Giovanni Castelnovo, Ioana Ion, Jean Sebastien Guillamo, Eric Thouvenot
Simultaneous multiple intracerebral hemorrhage (SMICH) is defined as ICH in two or more discrete noncontiguous acute intraparenchymal locations on initial CT. About 5% of ICH patients present with SMICH. ICH/SMICH etiology is classically divided into disorders of primary or secondary origin. About half of primary SMICH cases are caused by cerebral amyloid angiopathy or hypertensive arteriopathy. In this review, we will discuss the radiological features associated with the different causes of primary and secondary ICH and SMICH...
May 24, 2020: Acta Neurologica Belgica
Kenneth M Fifer, Katherine Small, Samantha Herrera, Yang Doris Liu, Lauren Peccoralo
The Collaborative Care Model (CoCM), in which social workers, primary care physicians, and a consulting psychiatrist work as a team, is an established approach to the treatment of common mental health conditions in primary care settings. Following implementation of a CoCM depression care program at our hospital-based academic primary care practice, we observed a low rate of retention with the use of problem solving therapy/behavioral activation (PST/BA). Our aim in this study was to evaluate the effectiveness of interpersonal psychotherapy (IPT), an evidence-based, flexible strategy that focuses on the relationship between depression and interpersonal challenges, compared to PST/BA...
May 24, 2020: Psychiatric Quarterly
Yanjiao Lu, Jingjing Guo, Shengnan Zhu, Han Zhang, Qing Zhu, Yanming Li
Previous studies have shown that some specific long non-coding RNAs are dysregulated in vascular walls and abnormally expressed in vascular disease. LncRNA HLA complex group 18 (HCG18) is a member of the HLA complex group, which has been rarely investigated in human diseases. In this study, we aimed to investigate the role of HCG in vascular smooth muscle cells. HCG18 was over-expressed by adenovirus transfection and knocked down in vascular smooth muscle cells by shRNA. Cell proliferation was detected by CCK-8 assays...
May 24, 2020: Human Cell
Liza Das, Anil Bhansali, Rosario Pivonello, Pinaki Dutta, Sanjay Kumar Bhadada, Chirag Kamal Ahuja, Ravimohan Mavuduru, Santosh Kumar, Arunanshu Behera, Uma Nahar Saikia, Sivashanmugam Dhandapani, Rama Walia
PURPOSE: Nelson's syndrome (NS) is regarded as an aggressive complication of total bilateral adrenalectomy (TBA) for Cushing's disease (CD). This challenge may be addressed by using clinical criteria to guide frequency of neuroimaging to enable timely management of NS and also avoid unnecessary frequent imaging. METHODS: All patients (n = 43) with CD subjected to TBA over 35 years at a tertiary care centre were included. NS was defined as a newly appearing or expanding (> 2 mm) pituitary adenoma with or without ACTH levels exceeding 500 pg/ml...
May 25, 2020: Pituitary
Yueqiao Si, Jingyi Liu, Chao Han, Ruijuan Wang, Tong Liu, Lixian Sun
Retinol-binding protein-4 (RBP-4) along with the lipid profile plays crucial roles in Acute coronary syndrome (ACS). The study aimed to investigate the correlation of RBP-4, lipoprotein combine index (LCI), and RBP-4 + LCI with ACS. 163 ACS and 77 non-CAD in patients were consecutively enrolled in this study. The serum level of RBP-4 was measured via enzyme-linked immunosorbent assay. LCI was calculated using the formula: total cholesterol × triglyceride × low-density lipoprotein cholesterol/high-density lipoprotein cholesterol...
May 24, 2020: Heart and Vessels
Jun Haruma, Simon Escalard, Stanislas Smajda, Michel Piotin
Central vein disease (CVD) is a well-known complication of central venous cannulations, indwelling dialysis catheters, and arteriovenous grafts. Brachiocephalic vein (BCV) stenosis or thrombotic occlusion can occur in dialysis patients, and the presence of an ipsilateral arteriovenous fistula can cause cerebral venous hypertension due to retrograde flow in the ipsilateral jugular vein. A 53-year-old man receiving hemodialysis (left brachiocephalic hemodialysis fistula) presented with impaired consciousness and seizures related to status epilepticus due to left temporal multifocal hemorrhages...
May 25, 2020: Neuroradiology
Hirofumi Tomiyama, Kazuki Shiina
The brachial-ankle pulse wave velocity (brachial-ankle PWV), which is measured simply by wrapping pressure cuffs around the four extremities, is a simple marker to assess the stiffness of the medium- to large- sized arteries. The accuracy and reproducibility of its measurement have been confirmed to be acceptable. Risk factors for cardiovascular disease, especially advanced age and high blood pressure, are reported to be associated with an increase of the arterial stiffness. Furthermore, arterial stiffness might be involved in a vicious cycle with the development/progression of hypertension, diabetes mellitus and chronic kidney disease...
May 23, 2020: Journal of Atherosclerosis and Thrombosis
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