Ruiheng Zhang, Li Dong, Xuefei Fu, Lin Hua, Wenda Zhou, Heyan Li, Haotian Wu, Chuyao Yu, Yitong Li, Xuhan Shi, Yangjie Ou, Bing Zhang, Bin Wang, Zhiqiang Ma, Yuan Luo, Meng Yang, Xiangang Chang, Zhaohui Wang, Wenbin Wei
PURPOSE: Retinal and optic nerve diseases have become the primary cause of irreversible vision loss and blindness. However, there is still a lack of thorough evaluation regarding their prevalence in China. METHODS: This artificial intelligence-based national screening study applied a previously developed deep learning algorithm, named the Retinal Artificial Intelligence Diagnosis System (RAIDS). De-identified personal medical records from January 2019 to December 2021 were extracted from 65 examination centers in 19 provinces of China...
April 2, 2024: Translational Vision Science & Technology
Toby M Maher
IMPORTANCE: Interstitial lung disease (ILD) consists of a group of pulmonary disorders characterized by inflammation and/or fibrosis of the lung parenchyma associated with progressive dyspnea that frequently results in end-stage respiratory failure. In the US, ILD affects approximately 650 000 people and causes approximately 25 000 to 30 000 deaths per year. OBSERVATIONS: The most common forms of ILD are idiopathic pulmonary fibrosis (IPF), which accounts for approximately one-third of all cases of ILD, hypersensitivity pneumonitis, accounting for 15% of ILD cases, and connective tissue disease (CTD), accounting for 25% of ILD cases...
April 22, 2024: JAMA
Kristin N Henning, Rebba D Omer, Janet M de Jesus, Kristen Giombi, Jessi Silverman, Elle Neal, Tanya Agurs-Collins, Alison G M Brown, Charlotte Pratt, Sung Sug Sarah Yoon, Funke Ajenikoko, Erin Iturriaga
Every year, hundreds of thousands of youth across the country enter the juvenile legal system. A significantly disproportionate number of them are youth of color. While youth arrests have declined over the past several decades, racial disparities have increased and persist at every stage of the system. Many youth of color enter the juvenile legal system with a history of trauma and stress that compromises their health and well-being. Arrest, prosecution, and incarceration exacerbate these poor health outcomes...
April 22, 2024: Journal of Racial and Ethnic Health Disparities
Xiaoxu Li, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Zhou, Jun Yin, Fabo Shan, Chengzhong Yang, Li Jiao, Dewei Chen, Jian Huang
Li, Xiaoxu, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Zhou, Jun Yin, Fabo Shan, Chengzhong Yang, Li Jiao, Dewei Chen, and Jian Huang. Hypoxia-induced myocardial hypertrophy companies with apoptosis enhancement and p38-MAPK pathway activation. High Alt Med Biol. 00:00-00, 2024. Background: Right ventricular function and remodeling are closely associated with symptom severity and patient survival in hypoxic pulmonary hypertension. However, the detailed molecular mechanisms underlying hypoxia-induced myocardial hypertrophy remain unclear...
April 21, 2024: High Altitude Medicine & Biology
Toshiro Ogata, Terufumi Sakai, Sho Shibata, Hiroki Kanno, Hiroyuki Nakane, Takeshi Aoyagi, Kazuhiro Koikawa, Yoshihiko Sadakari, Gentaro Hirokata, Masahiko Taniguchi
BACKGROUND: Spontaneous clearance of chronic hepatitis C virus (HCV) is rare in adults. A T-lymphocyte response is thought to be involved in HCV-RNA clearance. Splenectomy reportedly has a beneficial effect on T cell immune function in patients with cirrhosis. To the best of our knowledge, the present report is the first to describe spontaneous clearance of serum HCV-RNA within 1 year after splenectomy in a patient with cirrhosis. CASE PRESENTATION: A 55-year-old man with HCV cirrhosis was transferred to our institution with advanced pancytopenia, splenomegaly, and gastric varices...
April 22, 2024: Surgical Case Reports
Ashly C Westrick, Peiyao Zhu, Christopher R Friese, Kenneth M Langa, Lindsay C Kobayashi
PURPOSE: Cardiovascular risk factors (CVRFs) are associated with increased risk for cognitive impairment and decline in the general population, but less is known about how CVRFs might influence cognitive aging among older cancer survivors. We aimed to determine how CVRFs prior to a cancer diagnosis affect post-cancer diagnosis memory aging, compared to cancer-free adults, and by race/ethnicity. METHODS: Incident cancer diagnoses and memory (immediate and delayed recall) were assessed biennially in the US Health and Retirement Study (N = 5,736, 1998-2018)...
April 22, 2024: Journal of Cancer Survivorship: Research and Practice
Adam Serafin, Wojciech Kosmala, Thomas H Marwick
PURPOSE OF REVIEW: Speckle-tracking echocardiography (STE) can assess myocardial motion in non-LV chambers-including assessment of left atrial (LA) and right ventricular (RV) strain. This review seeks to highlight the diagnostic, prognostic, and clinical significance of these parameters in heart failure, atrial fibrillation (AF), diastolic dysfunction, pulmonary hypertension (PH), tricuspid regurgitation, and heart transplant recipients. RECENT FINDINGS: Impaired LA strain reflects worse LV diastolic function in individuals with and without HF, and this is associated with decreased exercise capacity...
April 22, 2024: Current Cardiology Reports
Frédéric Legrand, Justina Motiejunaite, Florence Arnoult, Alexandre Lahens, Nahid Tabibzadeh, Tiphaine Robert-Mercier, François Rouzet, Natalia Alencar De Pinho, François Vrtovsnik, Martin Flamant, Emmanuelle Vidal-Petiot
OBJECTIVES: Optimal blood pressure (BP) control is key to prevent cardiovascular complications in patients with chronic kidney disease (CKD). We described the prevalence and factors associated with masked hypertension in CKD. METHODS: We analyzed 1113 ambulatory 24-h BP monitoring (ABPM) records of 632 patients referred for kidney function evaluation. Masked hypertension was defined as office BP less than 140/90 mmHg but daytime BP at least 135/85 mmHg or nighttime BP at least 120/70 mmHg...
February 12, 2024: Journal of Hypertension
Thomas Keiser, Sarah Katz, Shannon M Robson, Jody L Greaney, Sean Healy, Susan K Malone, Vahid Farrahi, Freda Patterson
The purpose of this review is to synthesize results from studies examining the association between time-of-day for eating, exercise, and sleep with blood pressure (BP) in adults with elevated BP or hypertension. Six databases were searched for relevant publications from which 789 were identified. Ten studies met inclusion criteria. Four studies examined time-of-day for eating, five examined time-of-day for exercise, and one examined time-of-day for sleep and their associations with BP. Results suggested that later time-of-day for eating (n = 2/4) and later sleep mid-point (n = 1/1) were significantly related to higher BP in multivariable models, whereas morning (n = 3/5) and evening (n = 4/5) exercise were associated with significantly lower BP...
April 3, 2024: Journal of Hypertension
Paolo Palatini, Anastasios Kollias, Francesca Saladini, Roland Asmar, Grzegorz Bilo, Konstantinos G Kyriakoulis, Gianfranco Parati, George S Stergiou, Guido Grassi, Reinhold Kreutz, Giuseppe Mancia, Jens Jordan, Italo Biaggioni, Alejandro de la Sierra
Recent evidence suggests that an exaggerated blood pressure (BP) response to standing (ERTS) is associated with an increased risk of adverse outcomes, both in young and old individuals. In addition, ERTS has been shown to be an independent predictor of masked hypertension. In the vast majority of studies reporting on the prognostic value of orthostatic hypertension (OHT), the definition was based only on systolic office BP measurements. This consensus statement provides recommendations on the assessment and management of individuals with ERTS and/or OHT...
March 4, 2024: Journal of Hypertension
Getu Gamo Sagaro, Marzio Di Canio, Gopi Battineni, Giovanna Ricci, Francesco Amenta
BACKGROUND: Seafarers are at increased risk of diabetes due to their lifestyle and working conditions on board ships. There is, however, limited evidence regarding the magnitude of diabetes and its risk factors. In this study, we aimed to assess the prevalence of self-reported diabetes among seafarers on board ships and identify risk factors associated with it. MATERIALS AND METHODS: A cross-sectional epidemiological survey was conducted among seafarers aboard ships between November and December 2022...
2024: International Maritime Health
Fosca Quarti Trevano, Sara Vera Bernal, Rita Facchetti, Cesare Cuspidi, Giuseppe Mancia, Guido Grassi
OBJECTIVES: Heterogeneous are the results of the published studies aimed at determining the long-term effects of habitual coffee consumption on blood pressure (BP). Specifically, no data are available on the longitudinal association between habitual coffee consumption and office, home and 24 h BP profile and variability. METHODS: In 1408 subjects recruited in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study, followed for a 10 year follow-up period and classified as coffee consumers and nonconsumers (self-reporting), we prospectically investigated the association between habitual coffee consumption and office, home and 24-h ambulatory BP; 24-h BP variability; and development of a new hypertensive state...
February 29, 2024: Journal of Hypertension
Jing Miao, Charat Thongprayoon, Tibor Fülöp, Wisit Cheungpasitporn
No abstract text is available yet for this article.
April 22, 2024: Journal of Clinical Hypertension
Gülsüm Özkan, Şükrü Ulusoy, Rahmi Yılmaz, Serpil Müge Değer, Ülver Derici, Turgay Arınsoy, Yunus Erdem
No consensus has emerged among different guidelines concerning how many blood pressure (BP) measurements should be performed at office visits in the diagnosis of hypertension. The purpose of this study was to examine the compatibility of various multiple average office BP measurements and 24-h BP monitoring (ABPM) in patients followed up in the posthoc analysis of the Cappadocia hypertension cohort. A total 1158 office BP measurements by 207 patients were examined. The results were then classified as G1 (average of the 1st and 2nd BP), G2 (average of the 2nd and 3rd ), G3 (average of the 2nd , 3rd , and 4th ), G4 (average of the 2nd, 3rd, 4th , and 5th ), and G5 (average of all five measurements)...
April 22, 2024: Journal of Clinical Hypertension
Aditya Bhonsale, Jianhui Zhu, Floyd Thoma, Steve Koscumb, Krishna Kancharla, Andrew Voigt, Jared Magnani, N A Estes, Samir Saba, Oscar Marroquin, Suresh Mulukutla, Sandeep Jain
BACKGROUND: The risk factor (RF) burden, clinical course, and long-term outcome among patients with atrial fibrillation (AF) aged <65 years is unclear. METHODS: Adult (n=67 221; mean age, 72.4±12.3 years; and 45% female) patients with AF evaluated at the University of Pittsburgh Medical Center between January 2010 and December 2019 were studied. Hospital system-wide electronic health records and administrative data were utilized to ascertain RFs, comorbidities, and subsequent hospitalization and cardiac interventions...
April 22, 2024: Circulation. Arrhythmia and Electrophysiology
Alyssa B Kalustian, Richard C Tang, Michiaki Imamura
Background: Aortopulmonary window (APW) is a rare anomaly with variable morphology and associated cardiac anomalies. We evaluated impact of patient and operative factors on mid-term outcomes following APW repair. Methods: Twenty-nine patients underwent surgical APW repair at our institution from 1996 to 2022. Eight (28%) had simple APW, accompanied by only atrial septal defect or patent ductus arteriosus; 21 (72%) had complex APW with additional cardiovascular lesions, including nine with interrupted aortic arch...
April 22, 2024: World Journal for Pediatric & Congenital Heart Surgery
Ziqing Yan, Teng Yang, Xinxuan Li, Zipeng Jiang, Wankun Jia, Jin Zhou, Hui Fang
Renovascular hypertension (RVHT) is characterized by renal artery stenosis and overactivated renin-angiotensin system (RAS). Apelin, known for its negative modulation of RAS, has protective effects against cardiovascular diseases. The role and mechanisms of the primary active form of apelin, Apelin-13, in RVHT are unclear. In this study, male Sprague-Dawley rats were divided into control, 2K1C model, and 2K1C with apelin-13 treatment groups. Renin expression was analyzed using immunohistochemistry and molecular techniques...
April 22, 2024: American Journal of Physiology. Cell Physiology
Jyotirmayee Lenka, Raymond Foley, Mark Metersky, Adrian Salmon
INTRODUCTION: Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemodynamics but whether it contributes to development of clinical pulmonary hypertension (PH) is unclear. AREAS COVERED: In this review we 1) highlight previous studies looking into the possible bidirectional association of OSA and PH, focusing on those that explore clinical prognostic implications, 2) explore potential pathophysiology, 3) discuss the new metrics in OSA, 4) describe endo-phenotyping of OSA, 5) recommend possible risk assessment and screening pathways...
April 22, 2024: Expert Review of Respiratory Medicine
Krishna Revanna Gopagondanahalli, Abdul Alim Abdul Haium, Shrenik Jitendrakumar Vora, Sreekanthan Sundararaghavan, Wei Di Ng, Tze Liang Jonathan Choo, Wai Lin Ang, Nur Qaiyimah Binte Mohamad Taib, Nishanthi Han Ying Wijedasa, Victor Samuel Rajadurai, Kee Thai Yeo, Teng Hong Tan
OBJECTIVES: To evaluate serial tissue Doppler cardiac imaging (TDI) in the evolution of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) among extremely preterm infants. DESIGN: Prospective observational study. SETTING: Single-center, tertiary-level neonatal intensive care unit. PATIENTS: Infant born <28 weeks gestation. MAIN OUTCOME MEASURES: Utility of TDI in the early diagnosis and prediction of BPD-PH and optimal timing for screening of BPD-PH...
2024: Frontiers in Pediatrics
Amal H Mohamed, Ebtihal Eltyeb, Badria Said, Raga Eltayeb, Abdullah Algaissi, Didier Hober, Abdulaziz H Alhazmi
BACKGROUND: COVID-19 and malaria cause significant morbidity and mortality globally. Co-infection of these diseases can worsen their impact on public health. This review aims to synthesize literature on the clinical outcomes of COVID-19 and malaria co-infection to develop effective prevention and treatment strategies. METHODS: A comprehensive literature search was conducted using MeSH terms and keywords from the start of the COVID-19 pandemic to January 2023. The review included original articles on COVID-19 and malaria co-infection, evaluating their methodological quality and certainty of evidence...
2024: PeerJ
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