Rowan S Hardy, Hannah Botfield, Keira Markey, James L Mitchell, Zerin Alimajstorovic, Connar S J Westgate, Michael Sagmeister, Rebecca J Fairclough, Ryan S Ottridge, Andreas Yiangou, Karl-Heinz H Storbeck, Angela E Taylor, Lorna C Gilligan, Wiebke Arlt, Paul M Stewart, Jeremy W Tomlinson, Susan P Mollan, Gareth G Lavery, Alexandra J Sinclair
BACKGROUND: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines pre-receptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, leading to the development of selective 11β-HSD1 inhibitors. We examined the impact of the reversible competitive 11β-HSD1 inhibitor, AZD4017, on the metabolic profile in an overweight female cohort with idiopathic intracranial hypertension...
October 24, 2020: Journal of Clinical Endocrinology and Metabolism
Muriel Girard, Claire Douillard, Dominique Debray, Florence Lacaille, Manuel Schiff, Sandrine Vuillaumier-Barrot, Thierry Dupré, Monique Fabre, Lena Damaj, Alice Kuster, Stéphanie Torre, Karine Mention, Valérie McLin, Dries Dobbelaere, Delphine Borgel, Eric Bauchard, Nathalie Seta, Arnaud Bruneel, Pascale De Lonlay
BACKGROUND: Mannose Phosphate Isomerase MPI-CDG (formerly CDG-1b) is a potentially fatal inherited metabolic disease which is readily treatable with oral D-mannose. We retrospectively reviewed long-term outcomes of patients with MPI-CDG, all but one of whom were treated with D-mannose. METHODS: Clinical, biological and histological data were reviewed at diagnosis and on D-mannose treatment. RESULTS: Nine patients were diagnosed with MPI-CDG at a median age of 3 months...
July 17, 2020: Journal of Inherited Metabolic Disease
Nadia Pristaj, Sahrai Saeed, Helga Midtbø, Hilde Halland, Knut Matre, Eva Gerdts
INTRODUCTION: Sex-difference in types of cardiac organ damage has been reported in subjects with increased body mass index (BMI). However less is known about sex-differences in left ventricular (LV) myocardial function assessed by global longitudinal strain (GLS) in these subjects. METHODS: 493 subjects (mean age 47 ± 9 years, 61% women) with BMI > 27.0 kg/m2 and without known cardiac disease underwent 24-hour (24h) ambulatory blood pressure (BP) recording, body composition analysis, carotid-femoral pulse wave velocity (PWV) measurement and echocardiography...
October 24, 2020: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
Naoki Kashihara, Yoshimitsu Yamasaki, Takeshi Osonoi, Hiromasa Harada, Yugo Shibagaki, June Zhao, Hyosung Kim, Toshitaka Yajima, Nobuaki Sarai
BACKGROUND: Hyperkalemia is associated with many chronic diseases and renin-angiotensin-aldosterone system inhibitor therapy. Sodium zirconium cyclosilicate (SZC), an oral, highly selective cation-exchanger, is approved for the treatment of hyperkalemia. METHODS: This phase 3, multicenter, open-label, single-arm, flexible-dose study assessed the safety and efficacy of SZC in Japanese patients with hyperkalemia during a correction phase of up to 3 days and long-term (1 year) maintenance phase (NCT03172702)...
October 24, 2020: Clinical and Experimental Nephrology
L R Kolesnikova, M A Darenskaya, L I Kolesnikova, L A Grebenkina, L I Korytov, Yu K Batoroev, E I Belinskaya, I M Mikhalevich, S I Kolesnikov
We performed comparative analysis of hemodynamic in the periodontal microcirculatory bed in adolescents with arterial hypertension (AH) and morphological changes in the periodontal tissues of in hypertensive ISIAH rats of comparable biological age. In the periodontal tissues of adolescents with hypertension, the blood flow velocity and index of peripheral resistance increased, while pulse pressure decreased. In ISIAH rats, the mean area of periodontal and pulp vessels increased and the area of the connective tissue decreased...
October 24, 2020: Bulletin of Experimental Biology and Medicine
Brittney L Blevins, Harry V Vinters, Seth Love, Donna M Wilcock, Lea T Grinberg, Julie A Schneider, Rajesh N Kalaria, Yuriko Katsumata, Brian T Gold, Danny J J Wang, Samantha J Ma, Lincoln M P Shade, David W Fardo, Anika M S Hartz, Gregory A Jicha, Karin B Nelson, Shino D Magaki, Frederick A Schmitt, Merilee A Teylan, Eseosa T Ighodaro, Panhavuth Phe, Erin L Abner, Matthew D Cykowski, Linda J Van Eldik, Peter T Nelson
Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Here, we describe aspects of the unique architecture of brain arterioles, histomorphologic features of B-ASC, relevant neuroimaging findings, epidemiology and association with aging, established genetic risk factors, and the co-occurrence of B-ASC with other neuropathologic conditions such as Alzheimer's disease and limbic-predominant age-related TDP-43 encephalopathy (LATE)...
October 24, 2020: Acta Neuropathologica
Cianci Rosario, Simeoni Mariadelina, Zingaretti Viviana, Bagordo Domenico, Barbano Biagio, Granatelli Antonino, Gigante Antonietta, Lai Silvia
No abstract text is available yet for this article.
October 24, 2020: QJM: Monthly Journal of the Association of Physicians
Xuanshuo Liu, Shuli Man, Chen Luo, Yu Liu, Yan Liu, Changxiao Liu, Wenyuan Gao
Shunaoxin pills (SNX) have been used to treat cerebrovascular diseases in China since 2005. Hypertension is a major risk factor for cerebrovascular disease. This study aimed to explore the synergistic antihypertensive effect of SNX and nifedipine and whether SNX could alleviate nifedipine-induced renal lipotoxicity. During administration, systolic blood pressure was measured weekly. After 5 weeks administration, we examined pathological changes of kidney, renal function, the lipid metabolism index, and adipogenesis genes expression in the kidney tissues, and explored its underlying mechanism...
October 24, 2020: Environmental Toxicology
Ingrid Vernemmen, Lisse Vera, Glenn Van Steenkiste, Gunther van Loon, Annelies Decloedt
BACKGROUND: Echocardiographic reference intervals for Friesian horses are poorly described. OBJECTIVES: To obtain reference intervals for echocardiographic measurements in Friesians and compare these with Warmbloods. ANIMALS: One hundred healthy adult Friesians and 100 healthy adult Warmblood horses. METHODS: Cross-sectional study. Two-dimensional and M-mode echocardiographic images were obtained. Echocardiographic measurements, including size, area, and volumetric measurements of left atrium, left and right ventricle, aorta, and pulmonary artery, were performed...
October 24, 2020: Journal of Veterinary Internal Medicine
Habib Khoury, Nikhil Bellamkonda, Peyman Benharash, Jivianne T Lee, Marilene B Wang, Jeffrey D Suh
OBJECTIVES: To characterize the incidence, causes, risk factors, and costs of 30-day readmission after inpatient functional endoscopic sinus surgery (FESS) for patients with chronic rhinosinusitis. STUDY DESIGN: Retrospective cohort study. METHODS: The Nationwide Readmissions Database was used to characterize readmission after inpatient sinus surgery for chronic rhinosinusitis from 2015 to 2017. International Classification of Disease codes were used to identify the patient population, which included 5,644 patients...
October 24, 2020: Laryngoscope
El-Sayed Ibrahim, Mohamed Abdel-Samiee, Mohamed I Youssef, Helmy El-Shazly, Abd-ElAleem A El-Gendy, Ayman Ahmed Sakr, Doaa Elwazzan, Mervat Ragab Nassar, Amr Aly Elshormilisy, Ahmad Madkour, Mostafa Kamal, Yasmine M Amrousy, Sally Waheed Elkhadry, Eman Abdelsameea
Oral Direct-acting antivirals (DAAs) are safe, highly effective altering disease burden and prognosis in hepatitis C patients. Sustained virologic response (SVR) is achieved nowadays in more than 90 percent of the treated patients and related to the improvements in functions of the liver, fibrosis plus survival. Furthermore, portal hypertension is thought to be improved with achievement of virological response, parallel to the improvements in hepatic inflammation and fibrosis.We aimed assess the recurrence rate of esophageal varices by long term follow up in patients treated with different DAAs regimens who had achieved SVR...
October 23, 2020: Journal of Viral Hepatitis
Danijela Karanovic, Nevena Mihailovic-Stanojevic, Zoran Miloradovic, Milan Ivanov, Una-Jovana Vajic, Jelica Grujic-Milanovic, Jasmina Markovic-Lipkovski, Dragana Dekanski, Djurdjica Jovovic
Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p...
October 23, 2020: Phytotherapy Research: PTR
Zeeshan Hussain, Mingxi Yu, Amy Wozniak, Daniel Kim, Nicholas Krepostman, Max Liebo, Eugenia Raichlin, Alain Heroux, Cara Joyce, Haseeb Ilias-Basha
PURPOSE: Smoking is a major public health issue and its effect on cardiovascular outcomes is well-established. This study evaluates the impact of donor smoking on heart transplant (HT) outcomes. METHODS: HT recipients between January 1, 2005 and December 31, 2016, with known donor smoking status were queried from the International Society of Heart and Lung Transplantation (ISHLT) registry. The primary outcome was all-cause mortality, and secondary endpoints were graft failure, acute rejection and cardiac allograft vasculopathy...
October 23, 2020: Clinical Transplantation
Gabrielle T Tse, Aviva S Frydman, Marie F O'Shea, Greg J Fitt, David L Weintrob, Michael A Murphy, Gavin C Fabinyi, Kristian J Bulluss, Mark J Cook, Samuel F Berkovic
OBJECTIVE: To investigate the etiology and longitudinal clinical, neuropsychological, psychosocial, and surgical outcome profile of patients with medication refractory epilepsy and temporal encephaloceles with a view to highlight diagnostic clues and management strategies. METHODS: The comprehensive epilepsy program databases at two surgical epilepsy centers from January 2000 to October 2018 were reviewed for this observational study, to identify patients with encephaloceles causing temporal lobe epilepsy (TLE) and treated with surgical resection...
October 23, 2020: Epilepsia
Richard T Spence, Dhruvin H Hirpara, Sachin Doshi, Fayez A Quereshy, Sami A Chadi
IMPORTANCE: Failure to rescue (FTR), or death after major complications, has emerged as a marker of hospital-level quality of care. OBJECTIVE: To evaluate the predictive performance of the ACS-NSQIP modified frailty index (mFI) in determining FTR following an anastomotic leak (AL) after a colectomy for colorectal cancer. DESIGN: Retrospective cohort study. SETTING: Multicenter interrogation of the 2012-2016 American College of Surgeons (ACS) colectomy procedure targeted National Surgical Quality Improvement Program (NSQIP) database...
October 23, 2020: Annals of Surgical Oncology
Jonathan G Stine, Christopher Soriano, Ian Schreibman, Gloriany Rivas, Breianna Hummer, Esther Yoo, Kathryn Schmitz, Christopher Sciamanna
BACKGROUND: Lifestyle changes, including physical activity, are the cornerstones of the treatment of nonalcoholic fatty liver disease (NAFLD). For unclear reasons, most NAFLD patients do not achieve the recommended amount of weekly activity. AIMS: Our aim was to measure perceived barriers to physical activity and enablers to exercise intervention. METHODS: Consecutive subjects aged 18-70 with NAFLD were prospectively enrolled. An exercise motivation questionnaire was administered to assess current behaviors and perceived barriers...
October 23, 2020: Digestive Diseases and Sciences
Takeo Nakada, Suguru Shirai, Yuko Oya, Yusuke Takahashi, Noriaki Sakakura, Takashi Ohtsuka, Hiroaki Kuroda
BACKGROUND: We aimed to analyze the feasibility and risk factors associated with early mobilization (EM) within 4 h after thoracoscopic lobectomy and segmentectomy. METHODS: This study retrospectively evaluated 214 consecutive patients who underwent thoracoscopic anatomical pulmonary resection using our EM protocol between October 2017 and February 2019. We compared the correlations of the patients' characteristics including the total number of drugs and perioperative parameters such as air leak, and orthostatic hypotension (OH) between the EM (E group) and failed EM (F group) groups...
October 23, 2020: World Journal of Surgery
Zhida Chen, Chunying Wu, Yuting Liu, Haonan Li, Yeyan Zhu, Cailing Huang, Huangbo Lin, Qiao Qiao, Mengming Huang, Qing Zhu, Lei Wang
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
October 23, 2020: Cell Death & Disease
John M Dennis, Bilal A Mateen, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer
OBJECTIVE: To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting. RESEARCH DESIGN AND METHODS: This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or intensive care unit (ICU) between 1 March 2020 and 27 July 2020. Cox proportional hazards models were used to estimate 30-day in-hospital all-cause mortality associated with type 2 diabetes, with adjustment for age, sex, ethnicity, obesity, and other major comorbidities (chronic respiratory disease, asthma, chronic heart disease, hypertension, immunosuppression, chronic neurological disease, chronic renal disease, and chronic liver disease)...
October 23, 2020: Diabetes Care
Samantha C Huo, Ryan C Gibbons, Thomas G Costantino
BACKGROUND: Emergency physicians are frequently required to identify and triage patients with increased intracranial pressure (ICP). Idiopathic intracranial hypertension (IIH) is a possible cause that must be considered. Its prognosis depends on prompt recognition and treatment, and progression of the disease can lead to permanent vision loss and considerable morbidity. Point-of-care ultrasound can rapidly identify elevated ICP. Measurements of the optic nerve sheath diameter (ONSD) and optic disc elevation (ODE) can act as surrogates for ICP...
October 20, 2020: Journal of Emergency Medicine
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