Aaron W Trammell, C Michael Hart
No abstract text is available yet for this article.
September 22, 2023: American Journal of Respiratory Cell and Molecular Biology
Xinmiao Tao, Lin Liu, Pingnan Ma, Jinxia Hu, Zhu Ming, Keke Dang, Yuntao Zhang, Ying Li
BACKGROUND: Limited studies have shown a protective effect of very long chain saturated fatty acids (VLSFAs) on healthy aging, diabetes, heart failure and risk factors related to cardiovascular disease (CVD), but the role of VLSFAs on mortality risk is unclear. We aimed to investigate the association of serum docosanoic acid (C22:0) and serum lignoceric acid (C24:0) with all-cause and disease-specific mortality and to confirm the effect of VLSFAs on mortality risk in the whole, hyperlipidemia and hypertensive populations...
September 21, 2023: Journal of Clinical Endocrinology and Metabolism
Lucas Lauder, Felix Mahfoud, Michael Böhm
Resistant hypertension (RH) is a severe form of hypertension associated with increased cardiovascular risk. Although true RH affects less than 10% of the patients receiving antihypertensive therapy, the absolute number is high and continues to increase. The workup of these patients requires screening for secondary hypertension and pseudoresistance, including poor adherence to prescribed medicines and the white-coat phenomenon. The treatment of RH consists of lifestyle modifications and pharmacological therapies...
September 22, 2023: Annual Review of Medicine
Sander Groen In 't Woud, Marleen M H J van Gelder, Iris A L M van Rooij, Wout F J Feitz, Nel Roeleveld, Michiel F Schreuder, Loes F M van der Zanden
BACKGROUND: Congenital solitary functioning kidney (CSFK) is an anomaly predisposing to hypertension, albuminuria and chronic kidney disease. Its aetiology is complex and includes genetic and environmental factors. The role of gene-environment interactions (GxE), although relevant for other congenital anomalies, has not yet been investigated. Therefore, we performed a genome-wide GxE analysis with six preselected environmental factors to explore the role of these interactions in the aetiology of CSFK...
September 20, 2023: Nephrology, Dialysis, Transplantation
Subramanyam Polopalli, Achintya Saha, Pakter Niri, Mohit Kumar, Parikshit Das, Dev Vrat Kamboj, Pronobesh Chattopadhyay
Purpose: Currently, corneal blindness is affecting >10 million individuals worldwide, and there is a significant unmet medical need because only 1.5% of transplantation needs are met globally due to a lack of high-quality grafts. In light of this global health disaster, researchers are developing corneal substitutes that can resemble the human cornea in vivo and replace human donor tissue. Thus, this review examines ROCK (Rho-associated coiled-coil containing protein kinases) inhibitors as a potential corneal wound-healing (CWH) therapy by reviewing the existing clinical and nonclinical findings...
September 22, 2023: Journal of Ocular Pharmacology and Therapeutics
Robbie Bourke, Paul Doody, Sergio Pérez, David Moloney, Lewis Lipsitz, Rose Anne Kenny
BACKGROUND: Falls are a common cause of injury, hospitalisation, functional decline, and residential care admission among older adults. Cardiovascular disorders are recognised risk factors for falls. This systematic review assesses the association between cardiovascular disorders and falls in older adults. METHODS: Systematic searches were conducted on MEDLINE and EMBASE, encompassing all literature published prior to 31/12/2022. Included studies addressed persons aged 50 years and older, and assessed the association between cardiovascular disorders and falls or the efficacy of cardiovascular based interventions to reduce falls...
September 20, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Hai-Rong Li, Guan-Liang Chen, Xiao-Li Fang, Xing-Jiu Cai, Rong-Li Xu, Dong-Dong Li, Zhi-Wei Zhang
BACKGROUND: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). In this work, we defined the precise part of circ_0068481 in PASMC proliferation and migration induced by hypoxia. We hypothesized that circ_0068481 enhanced hypoxia-induced PASMC proliferation, invasion and migration through the miR-361-3p/KLF5 pathway. METHODS: Human PASMCs (hPASMCs) were exposed to hypoxic (3% O2) conditions...
September 20, 2023: American Journal of Hypertension
Hui Jiang, Can Huang, Yu Shi, Chu-Han Wang, Si-Yun Chen, Jun Li, Qian Wang, Meng-Tao Li, Xin-Ping Tian, Xiao-Feng Zeng, Yan Zhao, Jiu-Liang Zhao
OBJECTIVES: Cigarette smoking is an established risk factor for autoimmune diseases. However, whether smoking plays a clear role in thrombotic antiphospholipid syndrome (TAPS) has not been determined. We aimed to investigate the effects of smoking on clinical characteristics and prognosis of TAPS. METHODS: This was a prospective cohort study from 2013 to 2022. During the study period, 297 patients were diagnosed with TAPS, including 82 smokers and 215 non-smokers...
September 20, 2023: Rheumatology
Neil Cockburn, David Flood, Jacqueline A Seiglie, Jennifer Manne-Goehler, Krishna Aryal, Khem Karki, Albertino Damasceno, Rifat Atun, Sebastian Vollmer, Till Bärnighausen, Pascal Geldsetzer, Mary Mayige, Lisa Hirschhorn, Justine Davies
Cardiovascular disease risk factors (CVDRF), in particular diabetes and hypertension, are chronic conditions which carry a substantial disease burden in Low- and Middle-Income Countries. Unlike HIV, they were neglected in the Millenium Development Goals along with the health services required to manage them. To inform the level of health service readiness that could be achieved with increased attention, we compared readiness for CVDRF with that for HIV. Using data from national Service Provision Assessments, we describe facility-reported readiness to provide services for CVDRF and HIV, and derive a facility readiness score of observed essential components to manage them...
2023: PLOS Glob Public Health
Mohammad A Salameh, Andrea G Kattah
No abstract text is available yet for this article.
September 20, 2023: American Journal of Hypertension
Lauren A Eberly, Kaitlyn Shultz, Maricruz Merino, Maria Ynes Brueckner, Ernest Benally, Ada Tennison, Sabor Biggs, Lakotah Hardie, Ye Tian, Ashwin S Nathan, Sameed Ahmed M Khatana, Judy A Shea, Eldrin Lewis, Gene Bukhman, Sonya Shin, Peter W Groeneveld
IMPORTANCE: American Indian and Alaska Native persons face significant health disparities; however, data regarding the burden of cardiovascular disease in the current era is limited. OBJECTIVE: To determine the incidence and prevalence of cardiovascular disease, the burden of comorbid conditions, including cardiovascular disease risk factors, and associated mortality among American Indian and Alaska Native patients with Medicare insurance. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based cohort study conducted from January 2015 to December 2019 using Medicare administrative data...
September 5, 2023: JAMA Network Open
Odayme Quesada
Cardiovascular disease (CVD) remains the leading cause of death for women. Adverse pregnancy outcomes, including hypertensive disorders of pregnancy, gestational diabetes mellitus, preterm delivery, and low birth weight-affecting up to 30% of pregnant women-increase the risk of CVD. Early menarche and polycystic ovary syndrome are implicated. Premature and early menopause and significant vasomotor symptoms are all associated. Including reproductive risk assessment is critical when determining CVD risk and implementing evidence-based prevention strategies...
October 1, 2023: Menopause: the Journal of the North American Menopause Society
Issam S Hamadeh, Jai N Patel, Ryan Jacobs, Hang Zeng, Jiaxian He, Bei Hu, Tamara Kay Moyo, Amy Soni, Steven Park, Ed Copelan, Belinda Avalos, Alicia Hamilton, Nury Steuerwald, Nilanjan Ghosh
PURPOSE: Patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib are at risk of developing cardiovascular side effects (CVSEs). The molecular determinants of CVSEs have not been fully elucidated. We interrogated genetic polymorphisms in the Bruton Tyrosine Kinase (BTK) signaling pathway for their association with ibrutinib-related CVSEs. EXPERIMENTAL DESIGN: We conducted a retrospective/prospective observational pharmacogenetic study of 50 patients with newly diagnosed or relapsed CLL who received ibrutinib at a starting daily dose of 420 mg for at least six months...
September 22, 2023: Clinical Cancer Research
Schena Francesco Paolo, Cox Sharon Natasha
No abstract text is available yet for this article.
September 22, 2023: Journal of Nephrology
Yannan Cao, Jing Sheng, Dongyao Zhang, Li Chen, Ying Jiang, Decui Cheng, Yao Su, Yuexin Yu, Haoyi Jia, Pengyuan He, Li Wang, Xianming Xu
BACKGROUND: Pregnant women with a high triglyceride-glucose (TyG) index during early pregnancy may increase the risk of gestational diabetes mellitus (GDM), and dietary fiber could play an important role in glucose and lipid metabolism. However, no trials have tested the effects of dietary fiber on preventing GDM in women with a high TyG index. This study aims to investigate whether GDM can be prevented by dietary fiber supplementation in women with a TyG index ≥8.5 during early pregnancy (<20 weeks)...
September 22, 2023: Endocrine
Richard M Evans, Martha Gauthier, Margot L Goodkin, Joice T Huang
INTRODUCTION: Sustained-release intraocular implants provide a therapeutic option for open-angle glaucoma (OAG) and ocular hypertension (OHT) patients who are non-compliant with eyedrops. Currently, there are no published patient-reported outcome (PRO) measures that assess treatment satisfaction with intraocular implants. To address this gap, a new PRO instrument, the Allergan Satisfaction with Treatment Experience Questionnaire (ASTEQ), has been developed in accordance with Food and Drug Administration guidance...
September 22, 2023: Ophthalmology and Therapy
Qin-Yu Cai, Zhuo-Hang Li, Bei-Ning Deng, Xin Luo, Xia Lan, Ya Chen, Li-Fang Liang, Chen-Yang Liu, Tai-Hang Liu, Ying-Xiong Wang, Lan Wang
BACKGROUND AND AIMS: Intrahepatic cholestasis of pregnancy (ICP) is a special liver disease during pregnancy, characterized by abnormal bile acid metabolism. However, there is no consensus on how to group women with ICP based on the time of diagnosis worldwide. This study aimed to adopt a new grouping model of women with ICP, and the time from diagnosis to delivery was defined as the monitoring period. METHODS: This retrospective real-world data study was conducted across multiple centers and included 3172 women with ICP...
September 22, 2023: Journal of Hypertension
Faiz A Subzposh, Parikshit S Sharma, Óscar Cano, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Francesco Zanon, Marek Jastrzebski, Jiangang Zou, Mihail G Chelu, Kevin Vernooy, Zachary I Whinnett, Girish M Nair, Manuel Molina-Lerma, Karol Curila, Kenneth A Ellenbogen, Pugazhendhi Vijayaraman
BACKGROUND: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) has been associated with greater clinical improvement in women than men. Recently, left bundle branch area pacing (LBBAP) has been shown to be an alternative form of CRT. OBJECTIVES: The purpose of this study was to investigate sex-specific outcomes for death and heart failure events in a large, international, multicenter, cohort of patients undergoing CRT with BVP or LBBAP. METHODS: In this international study of 1,778 patients (575 female and 1203 male), sex-specific survival analysis was performed to compare the effect of LBBAP-CRT relative to BVP-CRT on the combined endpoint of death or heart failure hospitalization (HFH), and secondary endpoints of HFH only, and death alone...
September 3, 2023: JACC. Clinical Electrophysiology
Soudabeh Kargar
No abstract text is available yet for this article.
September 22, 2023: Journal of Magnetic Resonance Imaging: JMRI
Xinhe Zhou, Jing Xu
INTRODUCTION: Previous studies have shown that the serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) is related to metabolic syndrome. However, no existing study has examined the relationship between UHR and insulin resistance (IR). Therefore, this study aims to explore the association between the UHR and IR in patients with type 2 diabetes mellitus (T2DM). METHODS: Patients with type 2 diabetes mellitus (1,532 males and 1,013 females) were enrolled...
September 22, 2023: Journal of Diabetes Investigation
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