Ofer Kobo, Dmitry Abramov, Marat Fudim, Garima Sharma, Vijay Bang, Ashish Deshpande, Rishi K Wadhera, Mamas A Mamas
AIMS: Although cardiovascular (CV) mortality increased during the COVID-19 pandemic, little is known about how these patterns varied across key subgroups, include age, sex, and race and ethnicity, as well as by specific cause of CV death. METHODS AND RESULTS: The Centers for Disease Control WONDER database was used to evaluate trends in age-adjusted CV mortality between 1999 and 2020 among US adults aged 18 and older. Overall, there was a 4.6% excess CV mortality in 2020 compared to 2019, which represents an absolute excess of 62 802 deaths...
November 28, 2022: European Heart Journal. Quality of Care & Clinical Outcomes
Jonathan Toutain, Selim Fares, Isabelle Cochereau, Mohamed Ali Gargouri, Chérif Titah
PURPOSE: To describe a patient with hypertensive herpetic uveitis complicated by arterial retinal occlusions and a decompression retinopathy revealing a sickle cell trait. STUDY DESIGN: Case report. RESULTS: A 24-year-old African man presented with a hypertensive herpetic keratouveitis. A brutal lowering of the intraocular pressure (IOP) by systemic acetazolamide resulted in a ocular decompression retinopathy and multiple arterial occlusions involving the macular and the mid-periphery retina...
November 28, 2022: Ocular Immunology and Inflammation
Erum Mubashir Shariff, Fahd Ali Al Khmais, Saima Nazish, Noman Ishaque, Aishah Ibrahim Al Bakr, Reem S AlOmar, Danah Aljaafari, Mohammad AlShurem, Azra Zafar, Rizwana Shahid, Sari AlSuhaibani, Saeed Al-Jubran, Nehad M Soltan, Abdulaziz Mohammad Al-Sharydah, Majed Alabdali
Objective: Wake-up stroke (WUS) comprises a significant proportion of ischemic strokes. However, due to unclear onset, these patients are often not considered for reperfusion therapy. The objective of this study was to investigate the clinical and imaging differences between WUS patients and those with clear-onset stroke, documenting any sex, age, or risk factor predilection for WUS. Methods: This prospective observational cohort study used an ongoing stroke registry to identify patients with acute ischemic stroke admitted to a hospital in Saudi Arabia within 5 days of symptom onset from April 2018 to March 2020...
November 24, 2022: Primary Care Companion to CNS Disorders
Łukasz Obrycki, Jędrzej Sarnecki, Michał Pac, Tadeusz Dereziński, Weronika Lewandowska, Janusz Feber, Mieczysław Litwin
BACKGROUND: Primary hypertension may lead to early vascular ageing. We aimed to evaluate differences between expected vascular age based on pulse wave velocity (PWV)/carotid intima-media thickness (cIMT) and actual chronological age (CHA) in adolescents with primary hypertension. METHODS: Three hundred and fifty-two children (median age of 15.5 years) with office hypertension and 64 normotensive healthy children of the same age underwent anthropometry, office and ambulatory blood pressure (BP), left ventricular mass index, cIMT, PWV, pulse wave analysis and biochemistry measurements...
November 3, 2022: Journal of Hypertension
Ayinalem Alemu, Zebenay Workneh Bitew, Getachew Seid, Getu Diriba, Emebet Gashu, Nega Berhe, Solomon H Mariam, Balako Gumi
BACKGROUND: The emergence of COVID-19 overwhelmed tuberculosis (TB) prevention and control, resulting in a decrease in TB detection rate and an increase in TB deaths. Furthermore, the temporary immunosuppressive effects, lung inflammation, and the corticosteroids used to treat COVID-19, may play a direct role in immunosuppression, leading to reactivation of either previous infection or latent TB or the development of new TB. Thus, the aim of this study was to review TB incidence in individuals who recovered from COVID-19...
2022: PloS One
Angela Isabel Del Rio, Ilais Moreno Velásquez, Reina Roa, Roger Montenegro Mendoza, Jorge Motta, Hedley K Quintana
BACKGROUND: Recent estimates of hypertension in Panama remain unknown. We aim to describe the variation in prevalence and unawareness of hypertension in two Panamanian provinces using two different cross-sectional population-based studies and to investigate risk factors associated with hypertension unawareness. METHODS: Data were derived from a sub-national study conducted in the provinces of Panama and Colon (PREFREC-2010 [2,733 participants]) and from a nationally representative study (ENSPA-2019), in which we restricted our analyses to the same provinces (4,653 participants)...
2022: PloS One
Senait Tadesse, Ariaya Hymete, Marya Lieberman, Seifu Hagos Gebreyesus, Ayenew Ashenef
BACKGROUND: Iodine is one of the crucial micronutrients needed by the human body, and is vitally important during pregnancy. This study aimed to determine the relationship between the iodine status of pregnant women and their knowledge, and practices regarding iodized salt. All participants were enrolled in the Butajira nutrition, mental health and pregnancy (BUNMAP) cohort, Butajira, Ethiopia in February-May, 2019. METHODS: In this cross-sectional study, 152 pregnant women without hypertension or known thyroid disease before or during pregnancy were randomly selected from the BUNMAP mother to child cohort (n = 832)...
2022: PloS One
Long Xue, Mengyun Sui, YunZhen He, Hongzheng Li, Xiaohua Ying
BACKGROUND: The prevention and control of hypertension should be an effective way to reduce deaths and it has been a high priority in China. In 2013, the Chinese government increased the subsidy standard for the National Essential Public Health Services Package (NEPHSP) from RMB 15 to RMB 30 per person, which was expected to cover 70 million hypertensions. This study explored the influence of increasing NEPHSP subsidy on outpatient and inpatient expenditure among patients with hypertension...
2022: PloS One
Laila Aboulatta, Payam Peymani, Christine Vaccaro, Christine Leong, Kaarina Kowalec, Joseph Delaney, Jamie Falk, Silvia Alessi-Severini, Basma Aloud, Sherif Eltonsy
BACKGROUND: The COVID-19 pandemic has led the Canadian provincial governments to take unprecedented measures, including restrictions to healthcare services and pharmacists. Limited evidence exists on changes in prescription trends in Canada during the pandemic period. OBJECTIVES: To examine the trend of prescription medications' utilization before and during COVID-19, among incident and prevalent users in the general population. We examined 18 major classes of medications...
2022: PloS One
Ki-Jin Ryu, Min Sun Kim, Ji Yoon Lee, Seunghyun Nam, Hye Gyeong Jeong, Tak Kim, Hyuntae Park
IMPORTANCE: The association of tamoxifen use with the risk of uterine diseases, such as endometrial cancer, in premenopausal women with breast cancer remains controversial. However, many studies have reported an increased risk of uterine disease among postmenopausal tamoxifen users. OBJECTIVE: To investigate the association of tamoxifen use with the risk of endometrial cancer and other uterine diseases in premenopausal women with breast cancer. DESIGN, SETTING, AND PARTICIPANTS: A nationwide, population-based, retrospective longitudinal cohort study with an 18-year study period was conducted using data obtained from the Korean National Health Insurance Service...
November 1, 2022: JAMA Network Open
Yu Soma, Miku Kato, Gaku Shimura, Manabu Kamio, Maki Iida
No abstract text is available yet for this article.
November 28, 2022: Journal of Nephrology
Daphne J Theodorou, Stavroula J Theodorou, Lampros K Bourantas, Thomas Tzimas
No abstract text is available yet for this article.
November 28, 2022: Journal of Nephrology
Nasser Sakran, Kim Soifer, Keren Hod, Shiri Sherf-Dagan, Sharon Soued, Yafit Kessler, Dana Adelson, Reut Biton, J N Buchwald, David Goitein, Asnat Raziel
BACKGROUND: Long-term laparoscopic sleeve gastrectomy (LSG) outcomes in patients with obesity are scarce. We aimed to examine the outcomes and subjective experience of patients who underwent primary LSG with long-term follow-up. METHODS: The study is a retrospective observational analysis of patients who underwent primary LSG in a single center with 5-15 years of follow-up. Patients' hospital chart data supplemented by a detailed follow-up online questionnaire and telephone interview were evaluated...
November 28, 2022: Obesity Surgery
Michela Ponzio, Maria Cristina Monti, Giulia Mallucci, Paola Borrelli, Sara Fusco, Andrea Tacchino, Giampaolo Brichetto, Livio Tronconi, Cristina Montomoli, Roberto Bergamaschi
BACKGROUND: Comorbid conditions are common in people with multiple sclerosis (pwMS). They can delay diagnosis and negatively impact the disease course, progression of disability, therapeutic management, and adherence to treatment. OBJECTIVE: To quantify the economic impact of comorbidity in multiple sclerosis (MS), based on cost-of-illness estimates made using a bottom-up approach. METHODS: A retrospective study was carried out in two northern Italian areas...
November 28, 2022: Neurological Sciences
Nareena Imam, Sathyaprasad Burjonrappa
PURPOSE: Radical nephrectomy is the gold standard in Wilms tumor (WT) treatment and is combined with adjuvant treatment in early stage disease or performed after neo adjuvant therapy in advanced disease. With the development of novel adjuvant and neoadjuvant therapeutic strategies, there is increasing interest in organ preserving procedures in several adult malignancies. Potential long-term complications of living with a single kidney include hyperfiltration syndrome, hypertension, and fluid retention...
November 28, 2022: Pediatric Surgery International
Jasmin Honkamäki, Pinja Ilmarinen, Hanna Hisinger-Mölkänen, Leena E Tuomisto, Heidi Andersén, Heini Huhtala, Anssi Sovijärvi, Ari Lindqvist, Helena Backman, Bright I Nwaru, Eva Rönmark, Lauri Lehtimäki, Paula Pallasaho, Päivi Piirilä, Hannu Kankaanranta
BACKGROUND: Chronic nonrespiratory diseases are seemingly more prevalent in subjects with than without asthma, and asthma seems to differentiate by age of onset. However, studies with comparison of nonrespiratory diseases in subjects with and without asthma, considering asthma age of onset, are scarce. OBJECTIVE: To compare the quantity and type of chronic nonrespiratory diseases in adults with and without asthma considering age at asthma diagnosis. METHODS: In 2016, a FinEsS questionnaire was sent to 16,000 20- to 69-year-old adults randomly selected in Helsinki and Western Finland populations...
November 2, 2022: Journal of Allergy and Clinical Immunology in Practice
Olivia M T Davies, Ashley T Ng, Jennifer Tran, Shoshana Blumenthal, Lisa M Arkin, Amy J Nopper, Catherine E Cottrell, Maria Garzon, Dawn H Siegel, Ilona J Frieden, Beth A Drolet
BACKGROUND AND OBJECTIVES: Cutaneous capillary malformations (CMs) describe a group of vascular birthmarks with heterogeneous presentations. CMs may present as an isolated finding or with other associations, including glaucoma and leptomeningeal angiomatosis (i.e., Sturge-Weber syndrome) or pigmentary birthmarks (i.e., phakomatosis pigmentovascularis). The use of targeted genetic sequencing has revealed that postzygotic somatic variations in GNAQ and GNA11 at codon 183 are associated with CMs...
November 2022: Pediatric Dermatology
Subodha Waiddyanatha, Anjana Silva, Kosala Weerakoon, Sisira Siribaddana, Geoffrey K Isbister
BACKGROUND: There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. METHODS: Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013-October 2014), reviewed after 4 years, and 168 patients in group II with a snakebite (May 2017-August 2018), reviewed after one year, with serum creatinine (estimated glomerular filtration rate [eGFR]) and urinary albumin to creatinine ratio (ACR)...
November 28, 2022: Clinical Toxicology
Nicole L Wolter, Iris Z Jaffe
As growing evidence implicates extra-renal mineralocorticoid receptor (MR) in cardiovascular disease (CVD), recent studies have defined both cell- and sex-specific roles. MR is expressed in vascular smooth muscle (SMC) and endothelial cells (EC). This review integrates published data from the past five years to identify novel roles for vascular MR in CVD, with a focus on understanding sex differences. Four areas are reviewed in which there is recently expanded understanding of the cell type- or sex-specific role of MR in: (1) obesity-induced microvascular endothelial dysfunction, (2) vascular inflammation in atherosclerosis, (3) pulmonary hypertension and (4) chronic-kidney disease (CKD)-related CVD...
November 28, 2022: American Journal of Physiology. Cell Physiology
Lingfeng Qin, Bo Jiang, Krisztina Zsebo, Henricus J Duckers, Michael Simons, Pei-Yu Chen
Pulmonary arterial hypertension (PAH) is a progressive life-threatening disease, primarily affecting small pulmonary arterioles of the lung. Currently, there is no cure for PAH. It is important to discover new compounds that can be used to treat PAH. The mouse hypoxia-induced PAH model is a widely used model for PAH research. This model recapitulates human clinical manifestations of PAH Group 3 disease and is an important research tool to evaluate the effectiveness of new experimental therapies for PAH. Research using this model often requires the administration of compounds in mice...
November 11, 2022: Journal of Visualized Experiments: JoVE
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.