Mary E Norton, Cora Macpherson, Zachary Demko, Melissa Egbert, Fergal Malone, Ronald J Wapner, Ashley S Roman, Asma Khalil, Revital Faro, Rajeevi Madankumar, Noel Strong, Sina Haeri, Robert Silver, Nidhi Vohra, Jon Hyett, Kimberly Martin, Matthew Rabinowitz, Bo Jacobsson, Pe'er Dar
BACKGROUND: The clinical implications of non-reportable cfDNA screening results are uncertain, but this may reflect poor placental implantation in some cases and be associated with adverse obstetrical and perinatal outcomes. OBJECTIVE: To assess the outcomes of pregnancies with non-reportable cell-free DNA (cfDNA) screening in a cohort of patients with complete genetic and obstetric outcomes. STUDY DESIGN: This was a prespecified secondary analysis of a multicenter prospective observational study of prenatal cfDNA screening for fetal aneuploidy and 22q11...
March 23, 2023: American Journal of Obstetrics and Gynecology