keyword
https://read.qxmd.com/read/38396580/poisoning-by-nerium-oleander-l-in-franconia-geese
#1
Nicola Pugliese, Antonella Tinelli, Giuseppe Crescenzo, Maria Nieddu, Elena Baralla, Antonella Schiavone, Nicola Zizzo, Rossella Samarelli, Filomena Dessì, Elena Circella, Claudia Zizzadoro, Medhat S Saleh, Antonio Camarda
This study describes the acute poisoning of four 3-month-old Franconia geese ( Anser anser ) by oleander plants ( Nerium oleander ). After the accidental ingestion of oleander clippings, the geese exhibited a rapid onset of severe symptoms, leading to mortality within 15-90 min. Necropsy revealed cardiac and renal lesions. Specifically, interstitial edema, red blood cell infiltration, and myofibril loss were observed in the cardiac muscle, and tubular epithelial degeneration, interstitial edema, and hemorrhages were evident in the kidneys...
February 14, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38205498/asymptomatic-presentation-of-yellow-oleander-poisoning-in-a-57-year-old-saudi-woman-a-case-report
#2
Halah R AlMuhaidib, Noof Alabdulwahab, Shaikhah Al-Otaibi, Rima Aldakheel, Dunya Alfaraj
Yellow oleander ( Thevetia peruviana ), known for its cardiac glycosides, can cause severe poisoning with varied clinical manifestations, primarily affecting the cardiovascular system. We present a unique case of a 57-year-old Saudi woman with a history of type 2 diabetes, dyslipidemia, and previous meningioma excision who ingested 3.4 grams of yellow oleander fruit, mistaking it for an edible fruit. Remarkably, she remained asymptomatic with no gastrointestinal, neurological, or cardiovascular symptoms. Examination and investigations, including electrocardiograms and laboratory tests, showed no abnormalities...
December 2023: Curēus
https://read.qxmd.com/read/38146758/a-suicide-attempt-by-ingestion-of-oleander-leaves-and-treatment-with-digoxin-specific-fab-antibody-fragments
#3
Tanja Kovačević, Branka Polić, Tatjana Ćatipović Ardalić, Davor Petrović, Luka Stričević, Maja Rogulj, Joško Markić
Natural cardiac glycosides have positive inotropic heart effects but at high, toxic doses they can cause life-threatening cardiac arrhythmias. Here we present the first Croatian case of a 16-year-old girl who attempted suicide by eating dried oleander leaves, which contain natural cardiac glycosides, and her treatment with a specific antidote. The girl presented with an oedema of the uvula indicating local toxicity, severe bradycardia, first-degree atrioventricular block, drowsiness, and vomiting. Having taken her medical history, we started treatment with atropine, intravenous infusion of dextrose-saline solution and gastroprotection, but it was not successful...
December 1, 2023: Arhiv za Higijenu Rada i Toksikologiju
https://read.qxmd.com/read/38133853/accidental-fatal-poisoning-in-a-child-due-to-ingestion-of-nerium-oleander-leaf
#4
JOURNAL ARTICLE
Sathish Ayyappan, Ashok N, Pampa Ch Toi
Nerium oleander is an ornamental plant that belongs to the family Apocynaceae. It contains a cardiac glycoside named oleandrin, which is present in all parts of the oleander plant. Suicidal and medication-related deaths due to Nerium oleander poisoning are not uncommon. However, accidental deaths due to oleander leaf ingestion are most commonly encountered. We are reporting a case of an accidental ingestion of Nerium oleander leaf in a child by mistaking it for a guava leaf. The child presented to the casualty with vomiting, poor sensorium, hypotension, and shock...
December 22, 2023: Forensic Science, Medicine, and Pathology
https://read.qxmd.com/read/37885923/laurel-but-hardy-unintended-poisoning-a-case-report-of-oleander-misidentification-as-bay-laurel
#5
Giovanni Mantelli, Massimo Carollo, Lorenzo Losso, Ilaria Costantini, Elia Morando, Matilde Bacchion, Mauro Pizzuto, Letizia Spagnuolo, Giorgio Ricci
INTRODUCTION: Nerium oleander is a toxic plant containing cardiac glycosides throughout all its parts, thereby posing severe health risks upon ingestion. The clinical manifestations of oleander poisoning closely resemble those of digoxin toxicity, encompassing a spectrum of gastrointestinal symptoms, neuropsychiatric disorders, and cardiac disturbances. This scientific case report describes a case of accidental intoxication resulting from the consumption of an oleander leaves infusion misidentified as bay laurel leaves...
December 2023: Toxicology Reports
https://read.qxmd.com/read/37808385/a-study-of-socio-clinical-biochemical-and-electrocardiographic-changes-of-yellow-oleander-seed-poisoning-in-india
#6
JOURNAL ARTICLE
Murugan Subramani, Mudali Anbarasan, Shanmugam Deepalatha, Lakshmi Narayanan Muthumani, Mallu Azmeera Mahesh
Yellow oleander ( Thevetia peruviana ), which belongs to the Apocyanaceae family, is a common shrub seen throughout the tropics. All parts of the plant contain high concentrations of cardiac glycosides, which are toxic to cardiac muscle and the autonomic nervous system. The main objective of this study was to socio-clinical, biochemical and electrocardiographic changes of yellow oleander seed poisoning. This prospective observational study was conducted over a period of 6 months (March 2022 to September 2022)...
2023: Bioinformation
https://read.qxmd.com/read/37753820/fatal-poisoning-due-to-ingestion-of-boiled-oleander-leaf-extract
#7
Hirozumi Okuda, Hidetada Fukushima, Tomoaki Nakatsukasa, Koji Yamamoto, Asuka Kaizaki-Mitsumoto, Satoshi Numazawa, Yoshito Kamijo
Nerium oleander is an ornamental evergreen shrub belonging to the family Apocynaceae. The Apocynaceae family includes the attractive evergreen shrub known as oleander. The cardiotoxic glycoside, oleandrin, is present in all portions of the common oleander plant. Oleander consumption can result in deadly situations accidentally or as a suicide attempt. After consuming kettle-boiled oleander leaf extract as part of a suicide attempt, an 80-year-old man was discovered comatose in his home and taken to our emergency room...
September 27, 2023: Journal of Forensic Sciences
https://read.qxmd.com/read/37721023/2023-american-heart-association-focused-update-on-the-management-of-patients-with-cardiac-arrest-or-life-threatening-toxicity-due-to-poisoning-an-update-to-the-american-heart-association-guidelines-for-cardiopulmonary-resuscitation-and-emergency-cardiovascular
#8
REVIEW
Eric J Lavonas, Peter D Akpunonu, Ann M Arens, Kavita M Babu, Dazhe Cao, Robert S Hoffman, Christopher O Hoyte, Maryann E Mazer-Amirshahi, Andrew Stolbach, Maude St-Onge, Trevonne M Thompson, George Sam Wang, Amber V Hoover, Ian R Drennan
In this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on structured evidence reviews, guidelines are provided for the treatment of critical poisoning from benzodiazepines, β-adrenergic receptor antagonists (also known as β-blockers), L-type calcium channel antagonists (commonly called calcium channel blockers), cocaine, cyanide, digoxin and related cardiac glycosides, local anesthetics, methemoglobinemia, opioids, organophosphates and carbamates, sodium channel antagonists (also called sodium channel blockers), and sympathomimetics...
October 17, 2023: Circulation
https://read.qxmd.com/read/37554479/persistent-cardioactive-glycosides-intoxication-related-to-gastric-phytobezoar-of-oleander-leaves
#9
JOURNAL ARTICLE
Michel Pescia, Marco Conti, Romina Contratto
UNLABELLED: Nerium oleander is a plant containing cardiac glycosides, and intoxication with its leaves is a medical emergency. We report the case of a 73-year-old man who took a decoction of oleander leaves for a reckless purpose. Upon arrival in the emergency room, he presented an altered state of consciousness, drooling and vomiting. He was bradycardic with intermittent third-degree atrioventricular block and typical downsloping ST-segment depression related to glycosides toxicity. Despite initial treatment with atropine, isoprenaline and repeated bolus of digoxin-specific antibody (Fab) fragments, symptoms were persistent 12 hours after admission...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/37521578/of-mixed-vegetables-and-cardiac-arrhythmias-digitalis-purpurea-confused-with-borago-officinalis-a-case-series-of-accidental-digitoxin-intoxications
#10
Federica Iraci, Christian Herdeg, Martin Holzwarth, Maximilian Andreas Storz
UNLABELLED: We present the case series of two women aged 35 and 60 years who presented to our emergency department with severe vomiting, nausea, and malaise. Their symptoms started approximately 2 h after the ingestion of home-made mixed vegetables with freshly picked vegetables and leaves from the patients' garden, of which one was supposed to be borage. An electrocardiogram revealed diffuse ST-segment depression with down-up sloping in both patients. We supposed an accidental confusion of wild borage ( Borago officinalis ) with foxglove ( Digitalis purpurea )...
August 2023: Journal of Cardiology Cases
https://read.qxmd.com/read/36838857/molecular-modes-of-action-of-an-aqueous-nerium-oleander-extract-in-cancer-cells-in-vitro-and-in-vivo
#11
JOURNAL ARTICLE
Luay J Rashan, Nadire Özenver, Joelle C Boulos, Mona Dawood, Wynand P Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin. The phytochemical characterization by nuclear magnetic resonance spectroscopy (NMR) and low- and high-resolution mass spectrometry revealed several monoglycosidic cardenolides as major constituents (adynerin, neritaloside, odoroside A, odoroside H, oleandrin, and vanderoside)...
February 16, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36706925/a-toxic-shrub-turned-therapeutic-the-dichotomy-of-nerium-oleander-bioactivities
#12
REVIEW
Rajat Sharma, Swati Singh, Nisha Tewari, Priyankar Dey
Nerium oleander L. is a medicinal plant, used for the treatment of cancers and hyperglycemia across the world, especially in Indian sub-continent, Turkey, Morocco, and China. Although clinical studies supporting its pharmacological effects remain critically underexplored, accidental and intentional consumption of any part of the plant causes fatal toxicity in animals and humans. While the polyphenolic fraction of oleander leaves has been attributed to its pre-clinical pharmacological activities, the presence of diverse cardiac glycosides (especially oleandrin) causes apoptosis to cancer cells in vitro and results in clinical signs of oleander poisoning...
January 24, 2023: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/36341053/identification-of-antinutritional-antioxidant-and-antimicrobial-activity-of-plants-that-cause-livestock-poisoning-in-bojonegoro-regency-indonesia
#13
JOURNAL ARTICLE
Maria Rosaria Odilia, Dhiya Tajhanun Zahra Astika Putri, Antasiswa Windraningtyas Rosetyadewi, Agustina Dwi Wijayanti, Agung Budiyanto, Arvendi Rachma Jadi, Anggi Muhtar Pratama
Background and Aim: The utilization of cassava leaves and peels, ceara rubber leaves, sweet potato leaves, Chinese Albizia leaves, and lophatheri leaves from Bojonegoro Regency has led to the poisoning of livestock due to antinutritional factors. Nevertheless, the plants are known to have bioactive components and potential antioxidant and antibacterial activity if appropriately processed. This study aimed to determine the antinutritional compounds as well as the antioxidant and antibacterial potential of these plants responsible for livestock poisoning in the Bojonegoro Regency...
September 2022: Veterinary World
https://read.qxmd.com/read/36208203/forage-and-you-shall-find-cardiac-glycoside-poisoning-and-the-danger-of-foraging
#14
JOURNAL ARTICLE
Kevin M Shanahan, Mary A Thomas, Erika N Walker, John W Downs
Amateur foraging, which can be described as the gathering of uncultivated plants for sustenance or recreation, supports many benefits for the forager and the environment; however, it can also present the hazard of unintentional poisoning. Asclepias syriaca, or common milkweed, is a potentially edible plant that also contains cardioactive steroids akin to digoxin. A 38-year-old female amateur forager boiled and sautéed 8-10 milkweed pods before ingesting them. She developed vomiting and heart palpitations within 1 hour and presented to an emergency department 3 hours after ingestion...
October 8, 2022: Military Medicine
https://read.qxmd.com/read/36113683/vasoconstrictor-and-hemodynamic-effects-of-a-methanolic-extract-from-rhinella-marina-toad-poison
#15
JOURNAL ARTICLE
Cintia Vieira Dos Santos, Jacqueline Kerkhoff, Caroline Aparecida Tomazelli, Camilla Ferreira Wenceslau, Adilson Paulo Sinhorin, Domingos de Jesus Rodrigues, Fernando Silva Carneiro, Gisele Facholi Bomfim
Rhinella marina toad is abundant in Brazil. Its poison contains cardiac glycosides called bufadienolides, which are extensively investigated for their bioactivity. Our aim was to characterize the vasoactivity of Rhinella marina poison (RmP) on the aorta of male Wistar rats. For this, the RmP was first collected and processed to obtain an alcoholic extract. To determine cardiovascular effects of RmP, we performed in vivo tests by administering RmP intravenously in doses of 0.1-0.8 mg/kg. Vascular reactivity was also performed through concentration-response curves to RmP (10 ng/mL to 200 μg/mL) in aortic segments with and without endothelium...
September 14, 2022: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/36082325/-bridelia-ferruginea-benth-an-ethnomedicinal-phytochemical-pharmacological-and-toxicological-review
#16
JOURNAL ARTICLE
Genevieve Naana Yeboah, Frederick William Akuffo Owusu, Mary-Ann Archer, Michael Odoi Kyene, Doris Kumadoh, Frederick Ayertey, Susana Oteng Mintah, Peter Atta-Adjei Junior, Alfred Ampomah Appiah
Ethnopharmacological relevance: Bridelia ferruginea belonging to the family Euphorbiaceae, identified as an important commonly growing shrub, is used in traditional medicine for managing arthritis, dysentery, constipation, chronic diabetes, skin diseases, bladder and intestinal disorders, oral infections, thrush, bites and as an arrow poison antidote. This review aims at providing information on the traditional medicinal uses, pharmacological activities, phytochemistry and toxicity studies of Bridelia ferruginea to bridge the gap between traditional medicinal uses and preclinical studies on B...
August 2022: Heliyon
https://read.qxmd.com/read/36044149/bintaro-cerbera-odollam-and-cerbera-manghas-an-overview-of-its-eco-friendly-use-pharmacology-and-toxicology
#17
REVIEW
Mansi Saxena, Ekta B Jadhav, Mahipal Singh Sankhla, Muskan Singhal, Kapil Parihar, Kumud Kant Awasthi, Garima Awasthi
Bintaro is a tropical mangrove plant often used as a shade tree found in Asia, Australia, Madagascar, and the Islands of the Western Pacific Ocean. The word Bintaro is also often pinned to its closest relative species, the Cerbera odollam. Flower color is one of the distinguishing features between these two species. Human poisoning with the cardiotoxic plant Bintaro is common in Southeast Asia because it bears a fruit that yields a powerful poison that has been used for suicide and homicide, hence it is also called the "Indian suicide tree"...
August 31, 2022: Environmental Science and Pollution Research International
https://read.qxmd.com/read/35839868/life-threatening-pediatric-poisoning-due-to-ingestion-of-bufo-bufo-toad-eggs-a-case-report
#18
Francesco Gambassi, Cecilia Lanzi, Zaccaria Ricci, Pierpaolo Duchini, Manuela L'Erario, Guido Mannaioni, Nicoletta Cini, Alessandro Bonari, Claudia Saffirio, Brunella Occupati
Bufo parotid glands and eggs contain cardiac glycosides also known as bufadienolides. This class of molecules can cause digoxin-like cardiac toxicity, as they can block the sodium potassium-adenosine triphosphatase (Na/K-ATPase) pump. Poisoning with these toxins is rare but carries a high mortality risk. There are only a few cases of toad poisoning that have been reported worldwide, mainly in the southern hemisphere. We will describe the case of a child on the autistic spectrum disorder who developed an acute and severe cardiac bradyarrhythmia soon after being in a mountain creek...
July 12, 2022: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/35735326/-the-possible-poisons-contained-in-the-arrow-that-killed-ferdinand-magellan
#19
JOURNAL ARTICLE
Ricardo Espinoza-González, Juan Pablo Espinoza-González
Ferdinand Magellan's maritime expedition that resulted in the circumnavigation of the Earth and the discovery of the strait that bears his name is among the greatest feats in history. The trip, which took more than three years, was not completed by Magellan, who died on the island of Mactan, Philippines in a scuffle with the locals. As reported in Magellan's voyage journal written by Pigafetta, Magellan died after receiving a poisoned arrow in his right leg. This study reviews the main compounds used by indigenous from the Philippines and Southeast Asian to poison their arrows, their agents, and effects...
November 2021: Revista Médica de Chile
https://read.qxmd.com/read/35144558/suicidal-and-accidental-drug-poisoning-mortality-among-older-adults-and-working-age-individuals-in-spain-between-2000-and-2018
#20
JOURNAL ARTICLE
Daniel Hernández-Calle, Gonzalo Martínez-Alés, Teresa López-Cuadrado
BACKGROUND: Although medication poisoning in older adults is considered an increasingly important, but preventable cause of death, it has received relatively little attention. We explored recent trends and correlates of suicidal and accidental fatal drug poisonings among older and working-age individuals using nationwide data from Spain. METHODS: We identified all 15,353 fatal drug poisonings involving decedents aged ≥15 years in Spain between 2000 and 2018 and divided them by age into older adults (≥65 years) and working-age (15-64 years) individuals...
February 10, 2022: BMC Geriatrics
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