Hesham R El-Seedi, Shaden A M Khalifa, Eman A Taher, Mohamed A Farag, Aamer Saeed, Mohamed Gamal, Mohamed-Elamir F Hegazy, Diaa Youssef, Syed G Musharraf, Muaaz M Alajlani, Jianbo Xiao, Thomas Efferth
Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na+ /K+ -ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation...
December 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society