Rong Yan, Yue Xia, Kangxi Zhou, Jun Liu, Yueyue Sun, Chunyan He, Xinxin Ge, Mengnan Yang, Chenglin Sun, Liuxia Yuan, Shujun Li, Biao Yang, Fanbi Meng, Lijuan Cao, Changgeng Ruan, Kesheng Dai
Glycoprotein (GP) Ib, the ligand-binding subunit of platelet GPIb-IX complex, interacts with von Willebrand factor (VWF) exposed at the injured vessel wall, initiating platelet adhesion, activation, hemostasis, and thrombus formation. The cytoplasmic tail of GPIb interacts with 14-3-3, regulate ng the VWF-GPIb-elicited signal transduction and VWF binding function of GPIb. However, we unexpectedly found that the GPIb-14-3-3 association, beyond VWF-dependent function, is essential for general platelet activation...
May 3, 2024: Blood Advances