Angeliki Spathopoulou, Gabriella A Sauerwein, Valentin Marteau, Martina Podlesnic, Theresa Lindlbauer, Tobias Kipura, Madlen Hotze, Elisa Gabassi, Katharina Kruszewski, Marja Koskuvi, János M Réthelyi, Ágota Apáti, Luciano Conti, Manching Ku, Therese Koal, Udo Müller, Radu A Talmazan, Ilkka Ojansuu, Olli Vaurio, Markku Lähteenvuo, Šárka Lehtonen, Jerome Mertens, Marcel Kwiatkowski, Katharina Günther, Jari Tiihonen, Jari Koistinaho, Zlatko Trajanoski, Frank Edenhofer
Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder remains elusive although it is hypothesized to be associated with the aberrant response to neurotransmitters, such as dopamine and glutamate. Therefore, investigating the link between dysregulated metabolites and distorted neurodevelopment holds promise to offer valuable insights into the underlying mechanism of this complex disorder. In this study, we aimed to explore a presumed correlation between the transcriptome and the metabolome in a SCZ model based on patient-derived induced pluripotent stem cells (iPSCs)...
April 29, 2024: Molecular Psychiatry