Wanglong Zheng, Rongyun Zhou, Shuangjie Li, Shan He, Jia Luo, Meiqin Zhu, Nanhua Chen, Hongjun Chen, François Meurens, Jianzhong Zhu
The innate immunity DNA sensors have drawn much attention due to their significant importance against the infections with DNA viruses and intracellular bacteria. Among the multiple DNA sensors, IFI16, and cGAS are the two major ones, subjected to extensive studies. However, these two DNA sensors in livestock animals have not been well defined. Here, we studied the porcine IFI16 and cGAS, and their mutual relationship. We found that both enable STING-dependent signaling to downstream IFN upon DNA transfection and HSV-1 infection, and cGAS plays a major role in DNA signaling...
2020: Frontiers in Immunology