Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Md Ariful Islam, Ujala Sehar, Omme Fatema Sultana, Upasana Mukherjee, Malcolm Brownell, Sudhir Kshirsagar, P Hemachandra Reddy
Graceful healthy ageing and extended longevity is the most desired goal for human race. The process of ageing is inevitable and has a profound impact on the gradual deterioration of our physiology and health since it triggers the onset of many chronic conditions like dementia, osteoporosis, diabetes, arthritis, cancer, and cardiovascular disease. However, some people who lived/live more than 100 years called 'Centenarians" and how do they achieve their extended lifespans are not completely understood. Studying these unknown factors of longevity is important not only to establish a longer human lifespan but also to manage and treat people with shortened lifespans suffering from age-related morbidities...
April 22, 2024: Mechanisms of Ageing and Development
#42
JOURNAL ARTICLE
LillyBelle K Deer, Ella-Marie P Hennessey, Jenalee R Doom, Robert J Gallop, M Camille Hoffman, Catherine H Demers, Benjamin L Hankin, Elysia Poggi Davis
BACKGROUND: Prenatal glucocorticoids are one of the most widely proposed prenatal programming mechanisms, yet few studies exist that measure fetal cortisol via neonatal hair. Neonatal hair provides a window into the fetal experience and represents cortisol accumulation in the third trimester of pregnancy. In the current study, we test the links between two types of anxiety over the course of gestation (pregnancy-related anxiety and general anxiety) with neonatal hair cortisol. METHOD: Pregnant individuals (N = 107) and their neonates (59...
April 6, 2024: Psychoneuroendocrinology
#43
JOURNAL ARTICLE
Z Romeo, S Dolfi, M D'Amelio, G Mioni
People constantly process temporal, numerical, and length information in everyday activities and interactions with the environment. However, it is unclear whether quantity perception changes during ageing. Previous studies have provided heterogeneous results, sometimes showing an age-related effect on a particular quantity, and other times reporting no differences between young and elderly samples. However, three dimensions were never compared within the same study. Here, we conducted two experiments with the aim of investigating the processing of duration, numerosity and length in both healthy and pathological ageing...
April 24, 2024: European Journal of Ageing
#44
JOURNAL ARTICLE
Imke Janssen, Lynda H Powell, Sheila A Dugan, Carol A Derby, Howard M Kravitz
BACKGROUND: Cognitive decline may progress for decades before dementia onset. Better cardiovascular health (CVH) has been related to less cognitive decline, but it is unclear whether this begins early, for all racial subgroups, and all domains of cognitive function. The purpose of this study was to determine the impact of CVH on decline in the 2 domains of cognition that decline first in White and Black women at midlife. METHODS AND RESULTS: Subjects were 363 Black and 402 White women, similar in baseline age (mean±SD, 46...
April 24, 2024: Journal of the American Heart Association
#45
JOURNAL ARTICLE
Xiaoyan Xu, Yawen Zheng, Juan Fang, Jiahui Huang, Xudong Yang, Xianghe Zhu, Yanlong Liu, Li Chen, Shaochang Wu
BACKGROUND: The importance of healthy aging is growing in China as it has the largest number of older adults in the world and is one of the fastest-aging countries. This study aimed to examine the predictive value of regular physical exercise in relation to the physical, emotional, and cognitive health among samples of adults aged ≥60 years in China during an 8-year period. METHODS: A total of 10,691 older adults were extracted from two waves of national data from the China Family Panel Studies in 2010 and 2018...
2024: Frontiers in Public Health
#46
JOURNAL ARTICLE
Jun-Xiao Li, Qiong-Qiong Zhong, Tong Zhu, Ya-Li Jin, Jing Pan, Shi-Xiang Yuan, Feng Zhu
It is unclear whether cognitive impairment and the longitudinal change in cognition are associated with the risk of fatal stroke in aging populations. Based on the Guangzhou Biobank Cohort Study data a sum of 26,064 participants at baseline and all deaths caused by stroke in a mean follow-up of 14.3 years (standard deviation = 3.2) were included, and the Cox proportional hazard regression was used in this prospective cohort study. Cognitive impairment was respectively associated with an increased risk of fatal strokes (the adjusted hazard ratio (aHR) = 1...
April 30, 2024: Heliyon
#47
JOURNAL ARTICLE
Hannah Baumeister, Jacob W Vogel, Philip S Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M Gellersen, Renat Yakupov, Matthias C Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka D Freiesleben, Lukas Preis, Luisa-Sophie Schneider, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Ina R Vogt, Claudia Bartels, Björn H Schott, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Doreen Goerss, Matthias H Munk, Stefan Hetzer, Peter Dechent, Michael Ewers, Klaus Scheffler, Anika Wuestefeld, Olof Strandberg, Danielle van Westen, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Annika Spottke, Christoph Laske, Stefan Teipel, Robert Perneczky, Katharina Buerger, Anja Schneider, Josef Priller, Oliver Peters, Alfredo Ramirez, Jens Wiltfang, Michael T Heneka, Michael Wagner, Emrah Düzel, Frank Jessen, Oskar Hansson, David Berron
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± SD age = 70...
April 24, 2024: Brain
#48
Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen, Zongze Zhang
No abstract text is available yet for this article.
April 23, 2024: Molecular Brain
#49
JOURNAL ARTICLE
Yuan Chen
BACKGROUND: Sensory impairment in older adults is associated with cognitive decline, elevated depressive symptoms, and low levels of life satisfaction. However, these relationships are usually investigated separately and in pairs. This study examined these relationships comprehensively, for the first time. METHODS: The analysis included 5,658 community-dwelling older adults from the China Health and Retirement Longitudinal Study (aged 50 to 108 years, 52.1% male) who completed the Jorm Informant Questionnaire Cognitive Decline in the Elderly and the Center for Epidemiological Studies-Depression-short form...
April 23, 2024: BMC Public Health
#50
REVIEW
Teerachai Amnuaylojaroen, Nichapa Parasin
The effects of PM2.5 on human health fluctuate greatly among various age groups, influenced by a range of physiological and immunological reactions. This paper compares the pathogenesis of the disease caused by PM2.5 in people of different ages, focusing on how children, adults, and the elderly are each susceptible to it because of differences in their bodies. Regarding children, exposure to PM2.5 is linked to many negative consequences. These factors consist of inflammation, oxidative stress, and respiratory problems, which might worsen pre-existing conditions and potentially cause neurotoxicity and developmental issues...
March 31, 2024: Epigenomes
#51
Yong Jiang, Perianen Ramasawmy, Andrea Antal
INTRODUCTION: With aging, dual task (DT) ability declines and is more cognitively demanding than single tasks. Rapidly declining DT performance is regarded as a predictor of neurodegenerative disease. Task training and non-invasive transcranial electrical stimulation (tES) are methods applied to optimize the DT ability of the elderly. METHODS: A systematic search was carried out in the PUBMED, TDCS (transcranial direct current stimulation) databases, as well as Web of Science, and a qualitative analysis was conducted in 56 included studies...
2024: Frontiers in Aging Neuroscience
#52
REVIEW
Walter A Rocca, Kejal Kantarci, Stephanie S Faubion
OBJECTIVE: The effects on the brain of hormone therapy after the onset of menopause remain uncertain. The effects may be beneficial, neutral, or harmful. We provide a conceptual review of the evidence. METHODS: We 1) provide a brief history of the evidence, 2) discuss some of the interpretations of the evidence, 3) discuss the importance of age at menopause, type of menopause, and presence of vasomotor symptoms, and 4) provide some clinical recommendations. RESULTS: The evidence and the beliefs about hormone therapy and dementia have changed over the last 30 years or more...
April 17, 2024: Maturitas
#53
JOURNAL ARTICLE
Jahred M Liddie, Carolina L Z Vieira, Brent A Coull, David Sparrow, Petros Koutrakis, Marc G Weisskopf
BACKGROUND: Studies show that changes in solar and geomagnetic activity (SGA) influence melatonin secretion and the autonomic nervous system. We evaluated associations between solar and geomagnetic activity and cognitive function in the Normative Aging Study from 1992 to 2013. METHODS: We used logistic and linear generalized estimating equations and regressions to evaluate the associations between moving averages of sunspot number (SSN) and Kp index (a measure of geomagnetic activity) and a binary measure for Mini-Mental State Examination (MMSE) scores (≤25 or > 25) and six other cognitive tests as continuous measures, combined into one global composite score and considered separately...
April 16, 2024: Environment International
#54
JOURNAL ARTICLE
Ashly C Westrick, Peiyao Zhu, Christopher R Friese, Kenneth M Langa, Lindsay C Kobayashi
PURPOSE: Cardiovascular risk factors (CVRFs) are associated with increased risk for cognitive impairment and decline in the general population, but less is known about how CVRFs might influence cognitive aging among older cancer survivors. We aimed to determine how CVRFs prior to a cancer diagnosis affect post-cancer diagnosis memory aging, compared to cancer-free adults, and by race/ethnicity. METHODS: Incident cancer diagnoses and memory (immediate and delayed recall) were assessed biennially in the US Health and Retirement Study (N = 5,736, 1998-2018)...
April 22, 2024: Journal of Cancer Survivorship: Research and Practice
#55
JOURNAL ARTICLE
Fang Zheng, Marc Dahlmanns, Philipp Kessler, Christian Alzheimer
Activin A, a member of the transforming growth factor β (TGF-β) family, is widely recognized for its neurotrophic and neuroprotective function in the developing and injured brain, respectively. Moreover, in the healthy adult brain, activin A has been shown to tune signal processing at excitatory synapses in a fashion that improves cognitive performance. Because its level in human cerebrospinal fluid rises with age, we wondered whether activin A has a role in mitigating the gradual cognitive decline that healthy individuals experience in late-life...
2024: Frontiers in Aging Neuroscience
#56
Jeremy M Shea, Saul A Villeda
During aging, microglia - the resident macrophages of the brain - exhibit dystrophic phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks of age-related microglia dystrophy have been elucidated, the progression from homeostasis to dysfunction during the aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular and molecular analyses of microglia in the mouse hippocampus across the adult lifespan and in the experimental aging model of heterochronic parabiosis...
April 9, 2024: bioRxiv
#57
JOURNAL ARTICLE
Luisanna Reinoso Medina, Christina A Thrasher, Lauren L Harburger
Several studies report spatial memory decline in old age. However, few studies have examined whether old adults are specifically impaired in allocentric memory tasks (testing for object-to-object spatial location memory). Thus, the present study examined the effects of age on allocentric spatial memory using a novel landmark memory task. Young (18-25 years old) and old (65 years and older) participants watched 10 short videos that displayed 180-degree viewpoints of distinct real-world locations with landmark cues...
April 21, 2024: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
#58
Sebastián Silva, Mónica Rosas, Benjamín Guerra, Marión Muñoz, Atsushi Fujita, Masamune Sakamoto, Naomichi Matsumoto
INTRODUCTION: CAD (MIM*114010) encodes a large multifunctional protein with the enzymatic activity of the first three enzymes initiating and controlling the de novo pyrimidine biosynthesis pathway. Biallelic pathogenic variants in CAD cause the autosomal recessive developmental and epileptic encephalopathy 50 (MIM #616457) or CAD deficiency presenting with epilepsy, status epilepticus (SE), neurological deterioration and anemia with anisopoikilocytosis. Mortality is around 9% of patients, mainly related to the no use of its specific treatment with uridine...
April 18, 2024: Brain & Development
#59
JOURNAL ARTICLE
Mohamed Ali Boujelbane, Khaled Trabelsi, Atef Salem, Achraf Ammar, Jordan M Glenn, Omar Boukhris, Maha M AlRashid, Haitham Jahrami, Hamdi Chtourou
BACKGROUND: Alzheimer's disease and mild cognitive impairment (MCI) progress silently, making early diagnosis challenging, especially in less educated populations. The visual paired comparison (VPC) task, utilizing eye-tracking movement (ETM) technology, offers a promising alternative for early detection of memory decline. OBJECTIVE: This systematic review and meta-analysis evaluated the efficacy of the VPC task, utilizing ETM as a tool for assessing age-related cognitive changes...
April 16, 2024: Journal of Alzheimer's Disease: JAD
#60
JOURNAL ARTICLE
Katrin Wolfova, Barbora Frycova, Dominika Seblova, Sarah Tom, Vegard Fykse Skirbekk, Pavla Brennan Kearns
OBJECTIVES: Previous studies on sex differences in cognitive decline provide inconsistent findings, with many European countries being underrepresented. We determined the association between sex and cognitive decline in a sample of Europeans and explored differences across birth cohorts and regions. METHODS: Participants 50+ years old enrolled in the Survey of Health, Ageing and Retirement in Europe had their cognition measured by tests of immediate recall, delayed recall and verbal fluency biennially up to 17 years of follow-up (median 6, interquartile range 3-9 years)...
April 1, 2024: Age and Ageing
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
