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October 19, 2020: Journal of Veterinary Internal Medicine
Adam S Himebauch, Wai Wong, Yan Wang, Francis X McGowan, Robert A Berg, Christopher E Mascio, Todd J Kilbaugh, Kimberly Y Lin, Samuel B Goldfarb, Steven M Kawut, Laura Mercer-Rosa, Nadir Yehya
The importance of preoperative cardiac function in pediatric lung transplantation is unknown. We hypothesized that worse preoperative right ventricular (RV) systolic and worse left ventricular (LV) diastolic function would be associated with a higher risk of primary graft dysfunction grade 3 (PGD 3) between 48 and 72 hours. We performed a single center, retrospective pilot study of children (<18 years) who had echocardiograms <1 year prior to lung transplantation between 2006 and 2019. Conventional and strain echocardiography parameters were measured, and PGD was graded...
October 19, 2020: Pediatric Transplantation
David M Patrick, Justin P Van Beusecum, Annet Kirabo
Hypertension remains the most important modifiable risk factor for the development of cardiovascular disease. While it is clear that inflammation plays a pivotal role in the development and maintenance of hypertension, several novel discoveries have been made within the past decade that have advanced the field and have provided new mechanistic insights. First, recent studies have identified a central role of sodium-induced immune cell activation in the pathogenesis of hypertension by altering the gut microbiome and formation of products of lipid oxidation known as isolevuglandins...
October 13, 2020: Current Opinion in Physiology
Edith H Svensson, Kasim Abul-Kasim, Gunnar Engström, Martin Söderholm
Introduction: While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. Patients and methods: Incidence of intracerebral haemorrhage was studied among 28,416 individuals from the population-based Malmö Diet and Cancer cohort. Intracerebral haemorrhage cases were ascertained using the Swedish Hospital Discharge Register and the Stroke Register of Malmö, validated by review of hospital records and images, and classified by location by a neuroradiologist...
September 2020: European Stroke Journal
Ryuichi Kawamoto, Daisuke Ninomiya, Taichi Akase, Kikuchi Asuka, Teru Kumagi
Background: The risk associated with serum uric acid (SUA) levels when within the normal range is unknown. This study aims to examine whether SUA within the normal range is a predictor of hypertension. Methods: The subjects comprised 704 men aged 71 ± 9 (mean ± standard deviation) years and 946 women aged 70 ± 8 years recruited for a survey at the community based annual medical check-up. The main outcome was the presence of hypertension (antihypertensive medication and/or having SBP ≥140 mmHg and/or DBP ≥90 mmHg)...
2020: Clinical Hypertension
Ahmed Gharib Khamis, Mbazi Senkoro, Akwilina Wendelin Mwanri, Katharina Kreppel, Sayoki Godfrey Mfinanga, Bassirou Bonfoh, Gideon Kwesigabo
Background: Hypertension is among the growing non-communicable diseases (NCDs) in developing countries and the leading cause of death worldwide. Pastoral areas have been identified to be at a higher risk of diseases due to challenges in their daily food production, livelihoods or mobility. Unfortunately, the prevalence of hypertension and the risk factors particularly affecting rural and pastoral populations are not fully understood, making intervention efforts challenging. The aim of this study was to determine the prevalence of hypertension and identify the risk factors among adults living in Monduli district in Tanzania...
2020: Archives of Public Health, Archives Belges de Santé Publique
Tanya N Turan, James F Meschia, Marc I Chimowitz, Ana Roldan, Todd LeMatty, Sothear Luke, Linda Breathitt, Robin Eiland, Jon Foley, Thomas G Brott
INTRODUCTION: The COVID-19 pandemic has presented challenges to managing vascular risk factors with in-person follow-up of patients with asymptomatic carotid stenosis enrolled in the CREST2 trial. CREST2 is comparing intensive medical management alone versus intensive medical management plus revascularization with endarterectomy or stenting. We performed a study to evaluate the feasibility of a home-based program for testing blood pressure (BP) and low-density lipoprotein (LDL) in CREST2...
September 30, 2020: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Jason A Bennie, Katrien De Cocker, Mitch J Duncan
OBJECTIVES: Evidence demonstrates that physical activity is favorably associated with indicators of sleep health. However, population-based studies rarely examine the relationship between different physical activity modalities (ie, aerobic exercise vs muscle-strengthening exercise) with components of sleep health. METHODS: Cross-sectional analyses were conducted on the US 2017 Behavioral Risk Factor Surveillance System. Validated items assessed self-reported moderate-to-vigorous-intensity aerobic physical activity (MVPA), muscle-strengthening exercise (MSE), sleep duration, difficulties and disorders...
October 15, 2020: Sleep Health
Layton Lamsam, Hriday P Bhambhvani, Ajith Thomas, John K Ratliff, Justin M Moore
Migraine headache is a common condition with an estimated lifetime prevalence of greater than 20%. While it is a well-established risk factor for cardiovascular disease and ischemic stroke, its association with subarachnoid hemorrhage is largely unexplored. We sought to compare the incidence of aneurysmal subarachnoid hemorrhage in a cohort of migraine patients with a cohort of patients with tension headache. A cohort comparison study utilizing the MarketScan insurance claims database compared patients diagnosed with migraine who were undergoing treatment with abortive or prophylactic pharmacotherapy (treatment cohort) and patients diagnosed with tension headache who had never been diagnosed with a migraine and who were naïve to migraine pharmacotherapy (control cohort)...
September 2020: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yang Gao, Zhiguang Ping, Xiaoting Pei, Yaning Cai, Junyi Wang
OBJECTIVE: To study the status of chronic disease multimorbidity of middle-aged and elderly people over 45 years old in China, and to analyze the influencing factors. METHODS: Using the data of the"China Health and Nutrition Survey(CHNS)", this survey has been carried out in 10 rounds nationwide since 1989. Multi-stage cluster random sampling was used to investigate rural and urban areas in 9 provinces and cities in China. In this study, the general socio-demographic characteristics, disease history, living habits and other information in the 2009 database were used to analyze the subjects who were collected blood samples...
September 2020: Wei Sheng Yan Jiu, Journal of Hygiene Research
Solam Lee, Hunju Lee, Hye Sim Kim, Sang Baek Koh
OBJECTIVES: This study was conducted to determine the incidence and risk factors of myocardial infarction (MI) and stroke in farmers compared to the general population and to establish 5-year prediction models. METHODS: The farmer cohort and the control cohort were generated using the customized database of the National Health Insurance Service of Korea database and the National Sample Cohort, respectively. The participants were followed from the day of the index general health examination until the events of MI, stroke, or death (up to 5 years)...
September 2020: Journal of Preventive Medicine and Public Health
Ivana Mikolasevic, Viktor Domislovic, Tajana Filipec Kanizaj, Delfa Radic-Kristo, Zeljko Krznaric, Tamara Milovanovic, Toni Juric, Mia Klapan, Nadija Skenderevic, Bozena Delija, Tajana Stevanovic, Ana Mijic, Andjela Lukic, Davor Stimac
AIM: our aim was to explore the association between life habits and the controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) as the surrogate markers of liver steatosis and fibrosis in a large cohort of nonalcoholic fatty liver disease (NAFLD) patients. METHODS: In this prospective, cross-sectional study we had analyzed 1998 patients with diagnosed NAFLD. Sleeping duration was categorized in three groups: short (S) (<6h), moderate (M) (6-8h) and long (L) (>8h) sleep duration...
October 18, 2020: International Journal of Clinical Practice
Andrew C McKinnon, Ariana Stickel, Lee Ryan
Prior research investigating associations between hypertension, obesity, and apolipoprotein (APOE) genotype status with memory performance among older adults has yielded inconsistent results. This may reflect, in part, a lack of first accounting for the effects these variables have on structural brain changes, that in turn contribute to age-related memory impairment. The current study sought to clarify the relationships between these factors via path modeling. We hypothesized that higher body mass index (BMI), hypertension, and being an APOE-ε4 allele carrier would predict poorer memory scores, with much of these effects accounted for by indirect effects operating via differences in the integrity of temporal stem white matter...
October 18, 2020: Journal of Neuroscience Research
Piotr Kuczera, Dorota Ciaston-Mogilska, Barbara Oslizlo, Anna Hycki, Andrzej Wiecek, Marcin Adamczak
BACKGROUND: Metabolic acidosis (MA) is one of the most common consequences of CKD. MA is also a risk factor of CKD progression and increased mortality in these patients. AIM: The aim of this retrospective, cross-sectional study was to assess the prevalence of MA in different stages of CKD and renal replacement therapy (RRT) modalities - haemodialysis (HD) and peritoneal dialysis (PD). Additionally, the relationship between the prevalence of MA and aetiology of kidney disease was analysed...
October 16, 2020: Kidney & Blood Pressure Research
Ahmed Mohammed Ateia, Ahmed Elbassiouny, Sobhy Hassab El-Nabi, Nagia Aly Fahmy, Mahmoud Haroon Ibrahim, Islam El-Garawani, Khaled Mohammed Geba, Magdy Khalaf
OBJECTIVE: This study aims to investigate the genetic predisposition of haptoglobin (Hp) genotype as a predictor for cerebral vasospasm (CV) after acute subarachnoid hemorrhage (aSAH) in the Egyptian population. This permits CV risk factors stratification of patients with aSAH. Hence, it will guide the treatment plan and intensive monitoring for those patients. PATIENTS AND METHODS: The study was carried out at El Matareya Teaching Hospital, Cairo, Egypt. We studied 50 patients with aSAH who were prospectively recruited and followed up by transcranial Doppler (TCD) examination for 14 days following aneurysmal rupture to early detect hemodynamic changes associated with CV and also the occurrence of delayed cerebral ischemia (DCI) as a secondary outcome...
October 7, 2020: Clinical Neurology and Neurosurgery
Elinor Tan, Jialu Song, Adam M Deane, Mark P Plummer
BACKGROUND: The COVID-19 pandemic has placed unprecedented burden on the delivery of intensive care services worldwide. RESEARCH QUESTION: What is the global point estimate of mortality and risk factors for patients admitted to intensive care units (ICUs) with severe COVID-19? METHODS: In this systematic review and meta-analysis Medline, Embase and the Cochrane library were searched up to 1 August 2020. Pooled prevalence of participant characteristics, clinical features and outcome data were calculated using random effects models...
October 15, 2020: Chest
Pedro Armario, Carlos Brotons, Roberto Elosua, Maria Alonso de Leciñana, Almudena Castro, Albert Clarà, Olga Cortés, Ángel Díaz Rodriguez, María Herranz, Soledad Justo, Carlos Lahoz, Juan Pedro-Botet, Antonio Pérez Pérez, Rafael Santamaria, Ricard Tresserras, Susana Aznar Lain, Miguel Ángel Royo-Bordonada
We present the adaptation for Spain of the updated European Cardiovascular Prevention Guidelines. In this update, greater stress is laid on the population approach, and especially on the promotion of physical activity and healthy diet through dietary, leisure and active transport policies in Spain. To estimate vascular risk, note should be made of the importance of recalibrating the tables used, by adapting them to population shifts in the prevalence of risk factors and incidence of vascular diseases, with particular attention to the role of chronic kidney disease...
October 14, 2020: Hipertensión y Riesgo Vascular
Yongxue Zhang, Qingsheng Lu, Jing Jia, Dekun Xiang, Yanan Xi
OBJECTIVE: Delayed neurological sequelae (DNS) is a devastating consequence following acute carbon monoxide (CO) poisoning. This study aims at exploring the independent predictors of DNS in patients with CO exposure. METHODS: Data of patients with diagnosis of CO poisoning was retrospectively collected and reviewed in 5 regional medical facilities. Patients were classified into the DNS group and non-DNS group according to clinical findings during a follow-up period of 6 months...
July 12, 2020: American Journal of Emergency Medicine
Mariam Nadeem Rana, Sadeer G Al-Kindi
OBJECTIVE: Fibromuscular Dysplasia (FMD) is a rare non-atherosclerotic non-inflammatory vascular disease associated with arterial aneurysms and dissections. The epidemiology of FMD is not well understood. We sought to characterize the epidemiology of FMD utilizing a large aggregated electronic medical record database. METHODS: We used a commercial database (Explorys, IBM Watson), which aggregates data from electronic health records from 26 major integrated healthcare systems in the United States...
October 14, 2020: Heart & Lung: the Journal of Critical Care
A Didier-Laurent, S De Gaalon, S Ferhat, S-D Mihailescu, D Maltete, D Laplaud, R Lefaucheur, E Guegan-Massardier, L Grangeon
BACKGROUND/OBJECTIVE: Occurrence of post-dural puncture headache (PDPH) after diagnostic lumbar puncture (LP) for idiopathic intracranial hypertension (IIH) may seem very unlikely in clinical practice. Nevertheless, it has been suggested by several studies, mainly in sub-group analyses. We aimed to evaluate the prevalence of PDPH in an IIH population and determine any eventual predictive factors of PDPH occurrence. METHODS: We conducted a retrospective multiple-center observational study...
October 14, 2020: Revue Neurologique
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