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JOURNAL ARTICLE
Ashlyn Burns, Jyotsna Gutta, Harold Kooreman, Miranda Spitznagle, Valerie A Yeager
BACKGROUND: Tobacco screening interventions have demonstrated effectiveness at improving population health, yet many people who want to quit using tobacco lack access to professional assistance. One way to address this gap is to train members of the clinical team as tobacco treatment specialists (TTSs). PURPOSE: The purpose of this study was to understand how TTSs have been used across a variety of health care organizations implementing health systems change for tobacco treatment and examine the sustainability of TTSs as a health systems change innovation for tobacco cessation...
August 9, 2023: Health Care Management Review
#22
JOURNAL ARTICLE
Abhishek Agnihotri, Shuji Mitsuhashi, Ian Holmes, Faisal Kamal, Austin L Chiang, David E Loren, Thomas E Kowalski, Alexander Schlachterman, Anand R Kumar
BACKGROUND AND AIMS: Mucosal closure adds time but reduces complications associated with endoscopic submucosal dissection (ESD). We aim to assess the closure time, technical success and cost effectiveness between a novel through-the-scope helix tack suture system (TTSS) and the over-the-scope suturing system (OTSS). METHODS: In this single center, prospective, randomized trial, all patients having ESD with anticipated closure were randomized 1:1 to TTSS (study group) or OTSS (control group...
August 1, 2023: Gastrointestinal Endoscopy
#23
JOURNAL ARTICLE
Xinjie Zhao, Shiwen Xu, Jingrui Li, Hailin Yang, Li Tian, Fan Song, Wanzhi Cai, Zhonglong Lin, Hu Li
Although mitochondrial gene rearrangement has been observed in many insect lineages, little is known about how it affects mitochondrial gene transcription. To address this question, we first constructed a quantitative transcription map for Aphidius gifuensis , a species of parasitoid wasp known to have a highly rearranged mitochondrial genome (mitogenome) and two potential control regions (CRs). Based on this transcription map, we assessed the models of the mitochondrial transcription and post-transcription cleavage...
June 2023: Heliyon
#24
JOURNAL ARTICLE
Lisa Carter-Bawa, Chris Kotsen, Elizabeth Schofield, Joelle Fathi, Victoria Frederico, Leah E Walsh, Christine Sheffer, Jamie S Ostroff
OBJECTIVES: Less than 5% of eligible U.S. individuals undergo lung cancer screening (LCS). A significant barrier is lack of awareness; more effective outreach and education strategies are needed to achieve greater population LCS uptake. Tobacco Treatment Specialists (TTSs) are an untapped resource to assist and understanding TTS knowledge and perspectives about LCS and readiness and capacity to assist is a critical first step. METHODS: A sequential explanatory mixed-methods study design was conducted to understand LCS knowledge, attitudes, beliefs, and practices of TTSs...
June 29, 2023: Patient Education and Counseling
#25
JOURNAL ARTICLE
Jinsong Shi, Shuangyong Yan, Wenjing Li, Xiurong Yang, Zhongqiu Cui, Junling Li, Guangsheng Li, Yuejiao Li, Yanping Hu, Shan Gao
Chloroplast and mitochondrial DNA (cpDNA and mtDNA) are apart from nuclear DNA (nuDNA) in a eukaryotic cell. The transcription system of chloroplasts differs from those of mitochondria and eukaryotes. In contrast to nuDNA and animal mtDNA, the transcription of cpDNA is still not well understood, primarily due to the unresolved identification of transcription initiation sites (TISs) and transcription termination sites (TTSs) on the genome scale. In the present study, we characterized the transcription of chloroplast (cp) genes with greater accuracy and comprehensive information using PacBio full-length transcriptome data from Arabidopsis thaliana ...
January 2023: RNA Biology
#26
JOURNAL ARTICLE
Diana Hernández-Oaxaca, Karen Claro, Marco A Rogel, Mónica Rosenblueth, Julio Martinez-Romero, Esperanza Martinez-Romero
Inga vera and Lysiloma tree legumes form nodules with Bradyrhizobium spp. from the japonicum group that represent novel genomospecies, for which we describe here using genome data, symbiovars lysilomae, lysilomaefficiens and ingae. Genes encoding Type three secretion system (TTSS) that could affect host specificity were found in ingae but not in lysilomae nor in lysilomaefficiens symbiovars and uptake hydrogenase hup genes (that affect nitrogen fixation) were observed in bradyrhizobia from the symbiovars ingae and lysilomaefficiens...
May 11, 2023: Systematic and Applied Microbiology
#27
RANDOMIZED CONTROLLED TRIAL
Barbara Morera Maiquez, Caitlin Smith, Katherine Dyke, Chia-Ping Chou, Belinda Kasbia, Ciara McCready, Hannah Wright, Jessica K Jackson, Isabel Farr, Erika Badinger, Georgina M Jackson, Stephen R Jackson
Tourette syndrome (TS) and chronic tic disorder (CTD) are neurological disorders of childhood onset characterized by the occurrence of tics; repetitive, purposeless, movements or vocalizations of short duration which can occur many times throughout a day. Currently, effective treatment for tic disorders is an area of considerable unmet clinical need. We aimed to evaluate the efficacy of a home-administered neuromodulation treatment for tics involving the delivery of rhythmic pulse trains of median nerve stimulation (MNS) delivered via a wearable 'watch-like' device worn at the wrist...
September 2023: Journal of Neuropsychology
#28
JOURNAL ARTICLE
Xumeng Zhang, Yong Li, Chenyu Zhu, Fada Li, Zhiyuan Liu, Xiujin Li, Xu Shen, Zhongping Wu, Mengsi Fu, Danning Xu, Yunbo Tian, Yunmao Huang
Skeletal muscle development from embryonic stages to hatching is critical for poultry muscle growth, during which DNA methylation plays a vital role. However, it is not yet clear how DNA methylation affects early embryonic muscle development between goose breeds of different body size. In this study, whole genome bisulfite sequencing (WGBS) was conducted on leg muscle tissue from Wuzong (WZE) and Shitou (STE) geese on embryonic day 15 (E15), E23, and post-hatch day 1. It was found that at E23, the embryonic leg muscle development of STE was more intense than that of WZE...
April 13, 2023: International Journal of Molecular Sciences
#29
JOURNAL ARTICLE
Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer, Gunnar Hedlund
BACKGROUND: Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrier to effective treatment is the lack of a durable long-term response. Tumor-targeted superantigen (TTS) therapy may overcome this barrier to enhance therapeutic efficacy. TTS proteins, such as the clinical-stage molecule naptumomab estafenatox (NAP), increase tumor recognition and killing by both coating tumor cells with bacterial-derived superantigens (SAgs) and selectively expanding T-cell lineages that can recognize them...
March 26, 2023: Journal of Translational Medicine
#30
JOURNAL ARTICLE
Danse Bi, Linda Y Zhang, Mohammad Alqaisieh, Apurva Shrigiriwar, Jad Farha, Tala Mahmoud, Karl Akiki, Antonio Almario Jose, Sardar M Shah-Khan, Stuart R Gordon, Jeffrey M Adler, Mark Radetic, Peter V Draganov, Yakira N David, Brianna Shinn, Zahraa Mohammed, Alexander Schlachterman, Sofia Yuen, Ahmad Al-Taee, Namn Yunseok, Roberto Trasolini, Michael Bejjani, Bachir Ghandour, Hemchand Ramberan, Andrew Canakis, Saowanee Ngamruengphong, Andrew C Storm, Shailendra Singh, Heiko Pohl, Juan Carlos Bucobo, Jonathan M Buscaglia, Lionel S D'Souza, Bashar Qumseya, Nikhil A Kumta, Anand Kumar, Gregory B Haber, Aihara Hiroyuki, Mandeep Sawhney, Raymond Kim, Tyler M Berzin, Mouen A Khashab
BACKGROUND AND AIMS: Large colon polyps removed by endoscopic mucosal resection (EMR) can be complicated by delayed bleeding. Prophylactic defect clip closure can reduce post-EMR bleeding. Larger defects can be challenging to close using through-the-scope clips (TTSCs) and proximal defects are difficult to reach using over-the-scope techniques. A novel, through-the-scope suture (TTSS) device allows direct closure of mucosal defects without scope withdrawal. We aim to evaluate the rate of delayed bleeding following the closure of large colon polyp EMR sites with TTSS...
March 6, 2023: Gastrointestinal Endoscopy
#31
JOURNAL ARTICLE
Arunkumar Krishnan, Sardar M Shah-Khan, Yousaf Hadi, Neel Patel, Shyam Thakkar, Shailendra Singh
BACKGROUND : Multiple devices are available for tissue approximation. A new through-the-scope suturing (TTSS) device has recently been introduced; however, data on its scope of use and clinical effectiveness are limited. We aimed to assess the clinical course and effectiveness of this TTSS device. METHODS : A retrospective review was performed for consecutive patients who underwent TTSS application. Primary outcomes were technical and clinical success, and secondary outcomes included adverse events and long-term clinical success...
March 13, 2023: Endoscopy
#32
JOURNAL ARTICLE
Sarah Féray, Clarisse Blayau, Hicham Masmoudi, Samuel Haddad, Christophe Quesnel, Jalal Assouad, Muriel Fartoukh
BACKGROUND: The development of titanium claw plates has made rib osteosynthesis easy to achieve and led to a renewed interest for this surgery. We report the management of patients referred to the intensive care unit (ICU) of a referral center for surgical rib fracture fixation (SRFF) after chest trauma. METHODS: We performed a retrospective observational cohort study describing the patients' characteristics and analyzing the determinants of postoperative complications...
January 18, 2023: Journal of Cardiothoracic Surgery
#33
JOURNAL ARTICLE
Chris Hollis, Charlotte L Hall, Kareem Khan, Rebecca Jones, Louise Marston, Marie Le Novere, Rachael Hunter, Per Andrén, Sophie D Bennett, Beverley J Brown, Liam R Chamberlain, E Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin McKenzie, Charlotte Sanderson, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy
BACKGROUND: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 and 18 months after treatment initiation. METHODS: ORBIT (online remote behavioural intervention for tics) was a two-arm (1:1 ratio), superiority, single-blind, multicentre randomised controlled trial comparing online ERP for tics with online psychoeducation...
January 17, 2023: Journal of Child Psychology and Psychiatry, and Allied Disciplines
#34
JOURNAL ARTICLE
Boaz Munga, Adan Guyo Shibia, Eldah Onsomu
The government of Kenya introduced the Excisable Goods Management System (EGMS) in November 2013, which is a form of Track and Trace Systems (TTSs) for excisable goods, including cigarettes and cigars. This study appraised the EGMS with a focus on its impact on cigarette and cigars excise tax revenue and possibly control of related illicit trade in Kenya. Illicit trade in cigarettes and cigars pose significant health risks owing to increased access to tobacco products, besides contributing to loss of government revenues...
December 29, 2022: Preventive Medicine
#35
JOURNAL ARTICLE
Hamza Tahir, Abdul Basit, Hafsa Tariq, Zulquernain Haider, Asim Ullah, Zafar Hayat, Shafiq Ur Rehman
The poultry industry in developing countries still faces a significant threat from fowl typhoid, a disease caused by Salmonella Gallinarum that has been well contained in more economically developed countries. In addition to the virulence exhibited by large virulence plasmid (85 kb), Salmonella Pathogenicity Island 2 in S . Gallinarum plays a key role in mediating disease through its type III secretion systems (TTSS). The TTSS secrete effector protein across the Salmonella containing vacuoles and mediate the internalization of bacteria by modulating vesicular passage...
November 24, 2022: Biomedicines
#36
JOURNAL ARTICLE
Kishan M Mohan, Aditi Chopra, Vasudeva Guddattu, Shruti Singh, Kumari Upasana
OBJECTIVES: Dentists are constantly exposed to high-frequency noise at their workplace that increases the risk of occupational noise-induced hearing loss (ONIHL). Even though dentists acknowledge about the noisy dental workplace, hearing protection devices or ear protection devices (EPD) are not commonly used by dentists. No study has yet provided any evidence on how effective EPDs can be in reducing the temporary threshold shift and damage to the outer, middle and inner ears. The aim of this article is to evaluate and compare the changes in the hearing acuity and temporary threshold shift (TTS) in dentists who wear EPDs when compared with those who do not use EPDs...
2022: Journal of International Society of Preventive & Community Dentistry
#37
JOURNAL ARTICLE
Nay Myo Aung, Khine Khine Su, Narisara Chantratita, Chanwit Tribuddharat
Burkholderia pseudomallei, the highly infectious causative organism of melioidosis, was first discovered in Myanmar in 1911. The identification of B. pseudomallei was elucidated in Myanmar because of its genetic relatedness among Burkholderia species. In this study, we identified 2 isolates of Burkholderia cenocepacia, 2 Acinetobacter baumannii complex, and 18 clinical isolates of B. pseudomallei by Vitek 2. These isolates were first screened with a latex agglutination test, which showed positive results in 20 of 22 isolates...
November 30, 2022: Japanese Journal of Infectious Diseases
#38
JOURNAL ARTICLE
Chao Wu, Baifang Zeng, Jiayan Deng, Binwei Qin, Danwei Shen, Xiangyu Wang, Haigang Hu, Li Huang, Xin Liu, Guigang Qiu
OBJECTIVE: Posterior pelvic ring sacroiliac screws are preferred by clinicians for their good biomechanical performance. However, there are few studies on mechanical analysis and intraoperative screw insertion of the dysplastic sacrum and sacroiliac screw. This study investigated the biomechanical performance of oblique sacroiliac screws (OSS) in S1 combined with transiliac-transsacral screws (TTSs) in S2 for pelvic fracture or sacroiliac dislocation with dysplastic sacrum and evaluated the safety of screw placement assisted by the navigation template...
November 24, 2022: Orthopaedic Surgery
#39
JOURNAL ARTICLE
Govend Musa Qader, Khanzad Khudhur Jarjees, Rozhhalat Khudhur Jarjees
Pseudomonas aeruginosa pathogen is opportunistic. Several virulence factors and biofilms can cause its pathogenicity. Furthermore, infections triggered via multidrug-resistant P. aeruginosa among hospitalized patients are a public health concern. The primary antimicrobial agents in treating Gram-negative infection include Meropenem and Imipenem. Moreover, the spread of Carbapenem-resistant P. aeruginosa is a focal concern worldwide. The present research aims to determine the spread of Carbapenem-resistant P...
September 2022: Journal of Medicine and Life
#40
JOURNAL ARTICLE
Jad Farha, Hemchand Ramberan, Hiroyuki Aihara, Linda Y Zhang, Amit Mehta, Camille Hage, Alexander Schlachterman, Anand Kumar, Brianna Shinn, Andrew Canakis, Raymond Eunho Kim, Lionel S D'Souza, Jonathan Buscaglia, Andrew C Storm, Jason Samarasena, Kenneth Chang, Shai Friedland, Peter V Dragonov, Bashar Qumseya, Salmaan Jawaid, Mohamed O Othman, Muhammad Khalid Hasan, Dennis Yang, Mouen A Khashab, Saowanee Ngamruengphong
BACKGROUND: Complete closure of large mucosal defects following colorectal ESD with through-the-scope clips (TTSC) is oftentimes not possible. We aimed to report an early experience of using a novel through-the-scope suturing system (TTSS) for closing large mucosal defects after colorectal ESD. METHODS: We performed a retrospective, multi-center cohort study of consecutive patients who underwent attempted prophylactic defect closure using TTSS after colorectal ESD...
November 2, 2022: Endoscopy
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