Daniela Benzano, Felipe Ornell, Jaqueline Bohrer Schuch, Flavio Pechansky, Anne Orgler Sordi, Lisia von Diemen, Felix Henrique Paim Kessler
The COVID-19 pandemic is a public health emergency. Individuals with substance use disorder have a higher risk of infection and may suffer from more severe forms of the disease. Our goal is to investigate the prevalence of risk factors for COVID-19 severity in individuals with different substance use and explore whether specific types of substance are potentially associated with more clinical risk factors which could increase morbimortality in this population. The sample included 821 men hospitalized at an inpatient Addiction unit (305 alcohol users, 233 cocaine/crack users, and 283 multiusers)...
March 31, 2021: Psychiatry Research
Hiroyuki Tanaka, Tatsuhiko Wada, Katsuhiro Ohyama Ohyama, Toshihiro Ishii
PURPOSE: Data on immune reconstitution inflammatory syndrome (IRIS), despite being a widely recognized complication of antiretroviral therapy, remain limited. The objective of the present study was to evaluate the time-to-onset and factors affecting clinical outcomes of IRIS in people living with HIV (PLWH) using data from the Japanese Adverse Drug Event Report (JADER) database. METHODS: Data of PLWH who developed IRIS as an adverse event were extracted from the JADER database...
2021: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Serge Tonen-Wolyec, Roland Marini Djang'eing'a, Salomon Batina-Agasa, Charles Kayembe Tshilumba, Jérémie Muwonga Masidi, Marie-Pierre Hayette, Laurent Bélec
BACKGROUND: The burden of HIV, HBV, and HCV infections remains disproportionately high in sub-Saharan Africa, with high rates of co-infections. Multiplex rapid diagnostic tests for HIV, HBV and HCV serological testing with high analytical performances may improve the "cascade of screening" and quite possibly the linkage-to-care with reduced cost. Based on our previous field experience of HIV self-testing, we herein aimed at evaluating the practicability and acceptability of a prototype finger-stick whole-blood Triplex HIV/HCV/HBsAg self-test as a simultaneous serological screening tool for HIV, HBV, and HCV in the Democratic Republic of the Congo (DRC)...
2021: PloS One
Elodie Curlier, Laurence Fagour, Cécile Herrmann-Storck, Adrien Staelen, Ingrid Vingadassalom, Sébastien Breurec, Sylvie Abel, Sandrine Pierre-François, Janick Jean-Marie, Cédric Laouénan, Raymond Césaire, Bruno Hoen, André Cabié
BACKGROUND: In 2014, a first outbreak of chikungunya hit the Caribbean area where chikungunya virus (CHIKV) had never circulated before. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional study to measure the seroprevalence of CHIKV immediately after the end of the 2014 outbreak in HIV-infected people followed up in two clinical cohorts at the University hospitals of Guadeloupe and Martinique. Study patients were identified during the first months of 2015 and randomly selected to match the age and sex distribution of the general population in the two islands...
April 9, 2021: PLoS Neglected Tropical Diseases
Amiera Fatin Azman, Suet Lin Chia, Zamberi Sekawi, Khatijah Yusoff, Saila Ismail
Human respiratory syncytial virus (RSV) is one of the major causes of childhood acute lower respiratory tract infection worldwide. Autophagy is an intracellular pathway involved in nutrient recycling. Recently, autophagy has been reported to play a role in regulating host cytokine response to several viruses, including vesicular stomatitis virus and human immunodeficiency virus. Previous in vivo studies using mouse model has shown that inhibition of autophagy reduces RSV-induced cytokine production. However, the role of autophagy in modulating RSV-induced cytokine response in human cells has not been reported...
April 9, 2021: Viral Immunology
Gundolf Schuettfort, Alfonso Cabello, Aoife G Cotter, Philipp D E Leuw, Miguel Górgolas, Lisa Hamzah, Eva Herrmann, Gerrit Kann, Pavel Khaykin, Alvaro Mena, Christoph Stephan, Annette E Haberl
The choice of an optimal antiretroviral therapy (ART) in naive patients presenting late for initial therapy with advanced HIV infection, that is, with a CD4 cell count <200/μL and/or an AIDS-defining disease (late presenters, LPs), is still a challenge, even for HIV specialists. At present, there is little information on the decision process and selection criteria that physicians must take into account when choosing the presumably optimal initial ART for LPs. This study analyzes reasons for the individual choice of first-line ART in HIV LPs...
April 2021: AIDS Patient Care and STDs
Pimwarat Nanthaprut, Natthaporn Manojai, Pongthorn Chanlearn, Natnita Mattawanon, Phisanu Chiawkhun, Nontiya Homkham, Patrinee Traisathit
Human immunodeficiency virus (HIV) infection is still a major cause of death in Thais and new cases of infection are still emerging among the key population comprising men who have sex with men (MSM), sex workers and their clients, and transgender women (TGW) and people who inject drugs. The objective of this study was to compare the incidence of HIV infection between MSM and TGW who were tested at stand-alone and mobile HIV voluntary counseling and testing (VCT) centers and to identify factors associated with HIV-positive individuals from the two services...
April 2021: AIDS Patient Care and STDs
Chun-Yuan Lee, Pei-Hua Wu, Tun-Chieh Chen, Po-Liang Lu
Chemsex drug use (CDU) is a frequent, yet neglected issue in the era of treat-all policy. We evaluated the temporal pattern of CDU, factors associated with CDU, and drug-drug interactions (DDIs) between chemsex drugs and initial antiretroviral therapy (ART) by surveying 621 Taiwanese individuals (mean age: 29.7 years; 99.2% men; 92.9% men who have sex with men) diagnosed with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) from 2015 to 2020 [2015 to 2016 (period 1), 2017 to 2018 (period 2), and 2019 to 2020 (period 3)]...
April 2021: AIDS Patient Care and STDs
Dirk A Davis, Gustavo Angeles, Luz McNaughton-Reyes, Derrick D Matthews, Kathryn E Muessig, Sanny Northbrook, Clare Barrington
Gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by mental health problems and human immunodeficiency virus (HIV). Health navigation has the potential to improve both HIV and mental health outcomes; however, few studies have measured the impact of navigation on mental health among people living with HIV. We analyzed longitudinal data from a sociobehavioral survey and navigation monitoring system with GBMSM living with HIV in Guatemala ( n  = 346) that participated in a 12-month differentiated care intervention...
April 2021: AIDS Patient Care and STDs
Emily Murphy, Jean Keller, Cynthia Argani, Lorraine Milio, Anna Powell, Jeanne Sheffield, Allison Agwu, Jean Anderson
Adolescents (13-24 years of age) account for more than one-fifth of new HIV diagnoses yearly, and the United States has one of the highest rates of adolescent pregnancy among high resource countries. However, there is limited information on the characteristics and outcomes of adolescents living with HIV (ALWHIV) during pregnancy and differences with pregnancy in adults living with HIV. We performed a retrospective cohort study to compare demographic characteristics, HIV viral suppression, and pregnancy outcomes in adolescents ( n  = 90) as compared with adults ( n  = 250) in an urban HIV pregnancy clinic from 2003 to 2015...
April 2021: AIDS Patient Care and STDs
Marc Germain, Yves Grégoire, Brian S Custer, Mindy Goldman, Marjorie Bravo, Hany Kamel, Katy Davison, Stephen Field, Katja van den Hurk, Thijs J W van de Laar, David O Irving, Ann Jones, Giancarlo Liumbruno, Sarah Morley, Sheila F O'Brien, Josiane Pillonel, Christine Torsvik Steinsvåg, Minoko Takanashi, Nelson Hirokazu Tsuno, Miguel Angel Vesga Carasa, Silvano Wendel, Ralph R Vassallo, Pierre Tiberghien
BACKGROUND AND OBJECTIVES: Efficiency in mitigating HIV transmission risk by transfusion may vary internationally. We compared HIV prevalence and incidence in blood donors across different jurisdictions in relation to those rates in the general population and differences in deferral practices. MATERIALS AND METHODS: Data from 2007 to 2016 were collected in Australia, Brazil (São Paulo), Canada, England, France, Italy, Ireland, Japan, the Netherlands, New Zealand, Norway, Spain (Basque Country), USA (Vitalant) and Wales...
April 9, 2021: Vox Sanguinis
Lisa Hightow-Weidman, Joaquin Carcano, Seul Ki Choi, Lynne Sampson, Clare Barrington
Despite the disproportionate burden of HIV among Latinxs, there is a paucity of culturally appropriate interventions that have shown efficacy at increasing their engagement and retention in HIV care. We describe the development and implementation of Enlaces, a six-session, individual-level intervention, guided by the transnational framework, to improve HIV care outcomes for newly diagnosed and out-of-care Mexican men and transgender women (TW). Descriptive statistics summarizing baseline data and implementation outcomes are provided...
April 9, 2021: Journal of Immigrant and Minority Health
Sunita Chaudhary, Anroop B Nair, Jigar Shah, Bapi Gorain, Shery Jacob, Hiral Shah, Vimal Patel
Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral drug, possesses solubility issues. The current research was aimed to improve the solubility of the DTG and thereby enhance its efficacy using the solid dispersion technique. In due course, the miscibility study of the drug was performed with different polymers, where Poloxamer 407 (P407) was found suitable to move forward. The solid dispersion of DTG and P407 was formulated using solvent evaporation technique with a 1:1 proportion of drug and polymer, where the solid-state characterization was performed using differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray diffraction...
April 9, 2021: AAPS PharmSciTech
Bisola O Ojikutu, Kenneth Mayer
No abstract text is available yet for this article.
April 1, 2021: JAMA Network Open
Louisa Gilbert, Dawn Goddard-Eckrich, Mingway Chang, Timothy Hunt, Elwin Wu, Karen Johnson, Stanley Richards, Sharun Goodwin, Richard Tibbetts, Lisa R Metsch, Nabila El-Bassel
Importance: Concentrated epidemics of HIV and sexually transmitted infections (STIs) have persisted among Black women in community supervision programs (CSPs) in the United States. Accumulating research has highlighted the effectiveness of culturally tailored HIV/STI interventions for Black women; however, there is a dearth of such interventions for the large number of Black women in CSPs. Objective: To determine the effectiveness of a 5-session culturally tailored group-based intervention (Empowering African-American Women on the Road to Health [E-WORTH]) with individualized computerized modules and streamlined HIV testing in reducing STIs and condomless sex vs a 1-session streamlined HIV testing control condition...
April 1, 2021: JAMA Network Open
Jinfeng Cai, Hongbo Gao, Jiacong Zhao, Shujing Hu, Xinyu Liang, Yanyan Yang, Zhunaglin Dai, Zhongsi Hong, Kai Deng
The major barrier to curing HIV-1 infection is a small pool of latently infected cells that harbor replication-competent viruses, which are widely considered the origin of viral rebound when ART is interrupted. The difficulty of distinguishing latently infected cells from the vast majority of uninfected cells has represented a significant bottleneck precluding comprehensive understandings of HIV-1 latency. Here we reported and validated a newly-designed dual fluorescent reporter virus, DFV-B, infection with which in primary CD4+ T cells can directly label latently infected cells and generate a latency model that was highly physiological relevant...
April 9, 2021: ELife
Andrija Jovic, Hristina Kocic, Giovanni Damiani, Danijela Popovic, Natasa Vidovic, Tatjana Radevic, Zorana Zlatanovic, Dejan Popovic, Danica Tiodorovic
Dear editor, Condylomata accuminatum (CA) is a human papillomavirus (HPV) related sexually transmitted infection (STI), clinically characterized by solitary or even clustered dark red or pink lesions solely affecting the anogenital area (1). CA involving the extragenital, non-mucosal skin has been sporadically reported (2-4). Diagnosis of CA is usually straightforward when the lesions are located on the anogenital area. However, involvement of extragenital skin may pose a diagnostic challenge. Herein, we report a rare case of giant linear extragenital CA without coexisting genital lesions, diagnosed with a synergic intervention of dermatoscopy and clinics...
December 2020: Acta Dermatovenerologica Croatica: ADC
Georgia Kyriakou, Efthymia Gialeli, Eleftheria Vryzaki, Stauros Balasis, Sophia Georgiou
A 45-year-old HIV-negative Caucasian man with no reported past medical history was referred to our Department with a large (7 cm in diameter) oozing nodule on the occipital region of the scalp with spontaneous periodical bloody or purulent discharge. The lesion had appeared over a period of six months, had an irregular color, non-specific dermoscopic features, and resembled squamous cell carcinoma. The physical examination revealed three more atypical melanocytic lesions (on the abdomen, back, and buccal mucosa), and multiple swollen occipital, postauricular, as well as superficial and deep cervical lymph nodes...
December 2020: Acta Dermatovenerologica Croatica: ADC
Martyna Sławińska, Maria Hlebowicz, Ewa Iżycka-Świeszewska, Monika Sikorska, Małgorzata Sokołowska-Wojdyło, Tomasz Smiatacz, Marta Gesing, Roman J Nowicki, Michał Sobjanek
Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. We examined a 40-year-old patient who had been diagnosed with acquired immunodeficiency syndrome (AIDS) two months earlier...
December 2020: Acta Dermatovenerologica Croatica: ADC
Natalie A Blackburn, Willa Dong, Megan Threats, Megan Barry, Sara LeGrand, Lisa B Hightow-Weidman, Karina Soni, Deren V Pulley, Jose A Bauermeister, Kate Muessig
BACKGROUND: Mobile health platforms can facilitate social support and address HIV (human immunodeficiency virus) stigma but pose challenges for intervention design and participant engagement. Giddens's structuration theory, that individuals are shaped by-and shape-their communities through rules and resources that give them power to operate within these environments, provides a useful analytic framework for exploring these dynamic intervention spaces. METHOD: Data were drawn from an online randomized controlled trial intervention (HealthMpowerment) for young Black men who have sex with men to reduce condomless anal intercourse...
April 9, 2021: Health Education & Behavior
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