Tiffany R Glynn, Noelle A Mendez, Deborah L Jones, Sannisha K Dale, Adam W Carrico, Daniel J Feaster, Allan E Rodriguez, Steven A Safren
Individuals living with HIV report disproportionately high levels of trauma exposure and PTSD symptoms, both which have been associated with suboptimal ART adherence. Often conflated, the question arises as to which construct is driving subsequent HIV self-care behavior. Given the HIV disparities among Black and Hispanic/Latinx individuals, and that Miami is a geographic region with a high racial/ethnic minority make up and a unique socioeconomic environment, it is important to explore factors related to HIV outcomes in Miami to mitigate its uncontrolled epidemic...
October 24, 2020: Journal of Behavioral Medicine
Livio Azzoni, David Metzger, Luis J Montaner
The original version of this article unfortunately contained mistakes.
October 24, 2020: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
Henna Budhwani, Gabriel Robles, Tyrel J Starks, Karen Kolmodin MacDonell, Veronica Dinaj, Sylvie Naar
Considering the lack of validated stigma reduction interventions for youth living with HIV (YLWH), we evaluated effects of the Healthy Choices intervention on HIV-related stigma among YLWH. We analyzed data from the Adolescent Medicine Trials Network protocol 129, multi-site randomized controlled trial, applying latent growth curve modeling with two linear slopes estimating changes in Berger's Stigma Scale pre-intervention, 16, 28, and 52 weeks post-intervention, as well as the trajectory of stigma scores over the follow-up period (N = 183)...
October 24, 2020: AIDS and Behavior
Bilkisu Z Iliyasu, Taiwo G Amole, Hadiza S Galadanci, Shahida S Abdullahi, Zubairu Iliyasu, Muktar Hassan Aliyu
BACKGROUND: Clinical students are at increased risk of exposure to blood-borne pathogens. However, little has been documented about their exposure to blood and body fluids and their knowledge of post-exposure prophylaxis (PEP) in high-HIV burden settings, such as Nigeria. OBJECTIVE: To determine the prevalence and predictors of BBF exposure and knowledge about PEP among medical and allied health students in northern Nigeria. METHODS: In a cross-sectional study, 273 clinical students were asked to complete structured questionnaires...
October 2020: International Journal of Occupational and Environmental Medicine
Gwendolyn J McGinnis, Matthew S Ning, Memory Bvochora-Nsingo, Sebathu Chiyapo, Dawn Balang, Tlotlo Ralefala, Alexander Lin, Nicola M Zetola, Surbhi Grover
OBJECTIVES/HYPOTHESIS: Head and neck cancer (HNC) is the fifth most common malignancy in sub-Saharan Africa, a region with hyperendemic human immunodeficiency virus (HIV)-infection. HIV patients have higher rates of HNC, yet the effect of HIV-infection on oncologic outcomes and treatment toxicity is poorly characterized. STUDY DESIGN: Prospective observational cohort study. METHODS: HNC patients attending a government-funded oncology clinic in Botswana were prospectively enrolled in an observational cohort registry from 2015 to 2019...
October 24, 2020: Laryngoscope
Donald J Brambilla, Michael P Busch, Simone A Glynn, Steven H Kleinman
BACKGROUND: The standard approach to estimating HIV incidence in repeat blood donors includes only donors who made two or more donations in an estimation interval. In China and some other countries, large proportions of repeat donors donate only once in a 1- or 2-year interval. The standard approach may not represent risk among all repeat donors in these areas. Two approaches to including all repeat donors in the incidence estimate were evaluated in a simulation study. STUDY DESIGN AND METHODS: Under one approach, a donor infected at the first donation contributes a partial case to incidence that equals the proportion of time since the preceding donation that is in the estimation interval...
October 24, 2020: Transfusion
Marwa Adel Afify, Iman Gamal Ghareeb Ahmed, Theeb Ayedh Alkahtani, Raed Ibrahim Altulayhi, Amjad Saud Mhrb Alrowili, Sherief Ghozy, May Bin-Jumah, Mohamed M Abdel-Daim
This research aims to study the safety and efficacy of doravirine in the treatment of HIV-1 (human immunodeficiency virus) patients. We conducted an electronic search in eight databases for the inclusion of eligible studies. We have only included randomized controlled trials (RCTs) that study the safety and efficacy of doravirine in the treatment of HIV-1 adult patients. Six papers were included in this meta-analysis. For network (direct and indirect) estimates, the doravirine 100 mg treatment strategy found to have the highest efficacy (P score = 0...
October 24, 2020: Environmental Science and Pollution Research International
Anqun Chen, Jin Xu, Han Lai, Vivette D D'Agati, Tian-Jun Guan, Shawn Badal, John Liles, John C He, Kyung Lee
BACKGROUND: Chronic kidney disease (CKD) is a common cause of morbidity and mortality in human immunodeficiency virus (HIV)-positive individuals. Among the HIV-related kidney diseases, HIV-associated nephropathy (HIVAN) is a rapidly progressive renal disease characterized by collapsing focal glomerulosclerosis (GS), microcystic tubular dilation, interstitial inflammation and fibrosis. Although the incidence of end-stage renal disease due to HIVAN has dramatically decreased with the widespread use of antiretroviral therapy, the prevalence of CKD continues to increase in HIV-positive individuals...
October 23, 2020: Nephrology, Dialysis, Transplantation
Patrick D W Kiely, Mark E Lloyd
Ankle arthritis is a useful clinical signpost to differential diagnosis in rheumatic disease. Biomechanical features and differences in cartilage physiology compared with the knee may confer protection of the ankle joint from factors predisposing to certain arthritides. The prevalence of ankle OA is low, and usually secondary to trauma. Primary OA of the ankle should be investigated for underlying causes, especially haemochromatosis. New presentations of inflammatory mono/oligo arthritis involving the ankle are more likely due to undifferentiated arthritis or spondyloarthritis than RA, and gout over CPPD...
October 24, 2020: Rheumatology
Maximo O Brito, Caitlin M Dugdale, Michelle Collins-Ogle, Jessica Snowden, David A Wheeler
ID/HIV physicians and other healthcare professionals advocate within the healthcare system to ensure adults and children receive effective treatment. These advocacy skills can be used to inform domestic and global infectious diseases policies to improve healthcare systems and public health. ID/HIV physicians have a unique frontline perspective to share with federal policymakers regarding how programs and policies benefit patients and public health. Providing this input is critical to the enactment of legislation that will maximize the response to infectious diseases...
October 24, 2020: Journal of the Pediatric Infectious Diseases Society
Stuart Gilmour, Liping Peng, Jinghua Li, Shinichi Oka, Junko Tanuma
HIV prevalence in Japan continues to increase among men who have sex with men (MSM). We built a mathematical model to describe the HIV epidemic, including acute infection and pre-exposure prophylaxis (PrEP), and projected the model to 2050. We compared current testing and treatment policies, a scenario where Japan achieves UNAIDS 90-90-90 targets, three PrEP scenarios defined by different coverage levels of 25%, 50%, and 75% among the 20% of MSM with the highest risk behavior, and combinations of these scenarios...
October 23, 2020: Scientific Reports
Arman A Bashirova, Mathias Viard, Vivek Naranbhai, Alba Grifoni, Wilfredo Garcia-Beltran, Marjan Akdag, Yuko Yuki, Xiaojiang Gao, Colm O'hUigin, Malini Raghavan, Steven Wolinsky, Jay H Bream, Priya Duggal, Jeremy Martinson, Nelson L Michael, Gregory D Kirk, Susan P Buchbinder, David Haas, James J Goedert, Steven G Deeks, Jacques Fellay, Bruce Walker, Philip Goulder, Peter Cresswell, Tim Elliott, Alessandro Sette, Jonathan Carlson, Mary Carrington
Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and African Americans ( n = 97), which revealed a broad continuum of values. Ex vivo examination of cytotoxic T cell responses to the entire HIV-1 proteome from infected subjects indicates that tapasin-dependent allotypes present a more limited set of distinct peptides than do tapasin-independent allotypes, data supported by computational predictions...
October 23, 2020: Proceedings of the National Academy of Sciences of the United States of America
(no author information available yet)
No abstract text is available yet for this article.
October 23, 2020: Journal of Neuroscience
Simon Wigley, Joseph L Dieleman, Tara Templin, John Everett Mumford, Thomas J Bollyky
OBJECTIVE: To assess the relation between autocratisation-substantial decreases in democratic traits (free and fair elections, freedom of civil and political association, and freedom of expression)-and countries' population health outcomes and progress toward universal health coverage (UHC). DESIGN: Synthetic control analysis. SETTING AND COUNTRY SELECTION: Global sample of countries for all years from 1989 to 2019, split into two categories: 17 treatment countries that started autocratising during 2000 to 2010, and 119 control countries that never autocratised from 1989 to 2019...
October 23, 2020: BMJ: British Medical Journal
N A Mohd Salleh, Pauline Voon, Mohammad Karamouzian, M-J Milloy, Lindsey Richardson
BACKGROUND: The beneficial links between engagement in methadone maintenance therapy (MMT) and HIV treatment outcomes have been extensively described. Nevertheless, people who use drugs (PWUD) continue to experience suboptimal HIV treatment outcomes. In this systematic review, we sought to identify components of MMT service provision that are associated with improvements in HIV care outcomes across the HIV care cascade. METHODS: We searched for peer-reviewed studies in online databases...
October 11, 2020: Drug and Alcohol Dependence
Pradeep B Bhosale, Rishabh Jaiswal, Shaligram Purohit, Shreekar M Arte
BACKGROUND: The role of total hip arthroplasty (THA) in healed tuberculosis (TB) of the hip has been reported with success in the past. However, the role and success of THA in active TB of the hip has remained controversial. METHODS: We retrospectively evaluated prospective study of 52 THAs done for active TB of the hip in 51 patients. The protocol includes 3-6 months of effective preoperative and 9-18 months postoperative anti-TB therapy. All THAs were performed by the same surgeon (author 1)...
October 1, 2020: Journal of Arthroplasty
Mengyuan Li, Zhilan Zhang, Wenxiu Cao, Yijing Liu, Beibei Du, Canping Chen, Qian Liu, Md Nazim Uddin, Shanmei Jiang, Cai Chen, Yue Zhang, Xiaosheng Wang
The COVID-19 virus has infected more than 38 million people and resulted in more than one million deaths worldwide as of October 14, 2020. By using the logistic regression model, we identified novel critical factors associated with COVID19 cases, death, and case fatality rates in 154 countries and in the 50 U.S. states. Among numerous factors associated with COVID-19 risk, economic inequality enhanced the risk of COVID-19 transmission. The per capita hospital beds correlated negatively with COVID-19 deaths...
October 13, 2020: Science of the Total Environment
P F Blatyta, S Kelly, T T Goncalez, A B Carneiro-Proietti, T Salomon, C Miranda, E Sabino, L Preiss, C Maximo, P Loureiro, B Custer, C de Almeida-Neto
BACKGROUND: A low prevalence of HIV in sickle cell disease (SCD) patients has been reported in the literature though mechanisms for this are not understood. METHODS: HIV risk behaviors were compared between SCD cases and non-SCD controls using a self-administered audio computer-assisted self-interview. SCD cases were recruited from a multi-center SCD cohort established in Brazil; controls were recruited from SCD social contacts. Categorical variables were analyzed using Chi-Square or Fisher exact test...
October 23, 2020: BMC Public Health
Ivan Marbaniang, Shashikala Sangle, Smita Nimkar, Kanta Zarekar, Sonali Salvi, Amol Chavan, Amita Gupta, Nishi Suryavanshi, Vidya Mave
INTRODUCTION: Globally, India has the third largest population of people living with HIV (PLHIV) and the second highest number of COVID-19 cases. Anxiety is associated with antiretroviral therapy (ART) nonadherence. It is crucial to understand the burden of anxiety and its sources among Asian Indian PLHIV during the COVID pandemic, but data are limited. METHODS: During the first month of government mandated lockdown, we administered an anxiety assessment via telephone among PLHIV registered for care at a publicly funded antiretroviral therapy (ART) center in Pune, India...
October 23, 2020: BMC Public Health
Robin Schaefer, Ranjeeta Thomas, Laura Robertson, Jeffrey W Eaton, Phyllis Mushati, Constance Nyamukapa, Katharina Hauck, Simon Gregson
BACKGROUND: Benefits of cash transfers (CTs) for HIV prevention have been demonstrated largely in purposively designed trials, commonly focusing on young women. It is less clear if CT interventions not designed for HIV prevention can have HIV-specific effects, including adverse effects. The cluster-randomised Manicaland Cash Transfer Trial (2010-11) evaluated effects of CTs on children's (2-17 years) development in eastern Zimbabwe. We evaluated whether this CT intervention with no HIV-specific objectives had unintended HIV prevention spillover effects (externalities)...
October 23, 2020: BMC Public Health
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