keyword
https://read.qxmd.com/read/38535014/ultrasound-during-advanced-life-support-help-or-harm
#41
JOURNAL ARTICLE
Adrian Goudie, Michael Blaivas, Rudolf Horn, Wan-Ching Lien, Guido Michels, Daniel Wastl, Christoph Frank Dietrich
Ultrasound is used in cardiopulmonary resuscitation (CPR) and advanced life support (ALS). However, there is divergence between the recommendations of many emergency and critical care societies who support its use and the recommendations of many international resuscitation organizations who either recommend against its use or recommend it only in limited circumstances. Ultrasound offers potential benefits of detecting reversable causes of cardiac arrest, allowing specific interventions. However, it also risks interfering with ALS protocols and increasing unhelpful interventions...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38535009/cardiac-magnetic-resonance-imaging-based-ischemic-injury-pattern-in-patients-with-acute-myocardial-infarction-sensu-left-ventricular-global-systolic-function
#42
JOURNAL ARTICLE
Lyudmila Salyamova, Valentin Oleynikov, Natalia Donetskaya, Alexander Vdovkin, Angelina Chernova, Irina Avdeeva
The purpose of the study was to identify factors characterizing a decrease in LV global systolic function in patients with ST-segment elevation myocardial infarction (STEMI) after revascularization using cardiac magnetic resonance imaging (MRI)-based ischemic injury pattern and laboratory parameters sensu left ventricular global systolic function. A total of 109 STEMI patients were examined. The patients underwent contrast-enhanced cardiac MRI with a 1.5 Tesla GE SIGNA Voyager (GE HealthCare, Chicago, IL, USA) on the 7th-10th days from the onset of the disease...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38534881/primary-bone-lymphoma-of-the-scapula
#43
Josip Lovaković, Inga Mandac Smoljanović, Andro Matković, Tomislav Smoljanović
Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. The presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring fingers. The 45-year-old man underwent several radiological and neurological assessments of the palm, elbow, and neck before radiographs revealed a tumor of the left shoulder. Once diffuse large B-cell lymphoma was confirmed, immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and methylprednisolone (R-CHOP) started...
February 28, 2024: Hematology Reports
https://read.qxmd.com/read/38534766/low-salt-diet-regulates-the-metabolic-and-signal-transduction-genomic-fabrics-and-remodels-the-cardiac-normal-and-chronic-pathological-pathways
#44
JOURNAL ARTICLE
Dumitru A Iacobas, Haile Allen, Sanda Iacobas
Low-salt diet (LSD) is a constant recommendation to hypertensive patients, but the genomic mechanisms through which it improves cardiac pathophysiology are still not fully understood. Our publicly accessible transcriptomic dataset of the left ventricle myocardium of adult male mice subjected to prolonged LSD or normal diet was analyzed from the perspective of the Genomic Fabric Paradigm. We found that LSD shifted the metabolic priorities by increasing the transcription control for fatty acids biosynthesis while decreasing it for steroid hormone biosynthesis...
March 12, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#45
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534740/covid-19-associated-cardiovascular-disease-risks-prevention-and-management-heart-at-risk-due-to-covid-19
#46
REVIEW
Andrew Kemerley, Abhishek Gupta, Mahesh Thirunavukkarasu, Monica Maloney, Sean Burgwardt, Nilanjana Maulik
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and the resulting COVID-19 pandemic have had devastating and lasting impact on the global population. Although the main target of the disease is the respiratory tract, clinical outcomes, and research have also shown significant effects of infection on other organ systems. Of interest in this review is the effect of the virus on the cardiovascular system. Complications, including hyperinflammatory syndrome, myocarditis, and cardiac failure, have been documented in the context of COVID-19 infection...
February 29, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534614/hydrogels-for-cardio-and-vascular-tissue-repair-and-regeneration
#47
REVIEW
Ilenia Motta, Michelina Soccio, Giulia Guidotti, Nadia Lotti, Gianandrea Pasquinelli
Cardiovascular disease (CVD), the leading cause of death globally, affects the heart and arteries with a variety of clinical manifestations, the most dramatic of which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), and intracranial aneurysm (IA) rupture. In MI, necrosis of the myocardium, scar formation, and loss of cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, the arteries that are structurally and functionally connected to the cardiac tissue can undergo pathological dilation, i...
March 13, 2024: Gels
https://read.qxmd.com/read/38534567/wearable-12-lead-ecg-acquisition-using-a-novel-deep-learning-approach-from-frank-or-easi-leads-with-clinical-validation
#48
JOURNAL ARTICLE
Fan Fu, Dacheng Zhong, Jiamin Liu, Tianxiang Xu, Qin Shen, Wei Wang, Songsheng Zhu, Jianqing Li
The 12-lead electrocardiogram (ECG) is crucial in assessing patient decisions. However, portable ECG devices capable of acquiring a complete 12-lead ECG are scarce. For the first time, a deep learning-based method is proposed to reconstruct the 12-lead ECG from Frank leads (VX , VY , and VZ ) or EASI leads (VES , VAS , and VAI ). The innovative ECG reconstruction network called M2Eformer is composed of a 2D-ECGblock and a ProbDecoder module. The 2D-ECGblock module adaptively segments EASI leads into multi-periods based on frequency energy, transforming the 1D time series into a 2D tensor representing within-cycle and between-cycle variations...
March 21, 2024: Bioengineering
https://read.qxmd.com/read/38534511/emerging-trends-in-magnetic-resonance-fingerprinting-for-quantitative-biomedical-imaging-applications-a-review
#49
REVIEW
Anmol Monga, Dilbag Singh, Hector L de Moura, Xiaoxia Zhang, Marcelo V W Zibetti, Ravinder R Regatte
Magnetic resonance imaging (MRI) stands as a vital medical imaging technique, renowned for its ability to offer high-resolution images of the human body with remarkable soft-tissue contrast. This enables healthcare professionals to gain valuable insights into various aspects of the human body, including morphology, structural integrity, and physiological processes. Quantitative imaging provides compositional measurements of the human body, but, currently, either it takes a long scan time or is limited to low spatial resolutions...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534508/contractile-and-genetic-characterization-of-cardiac-constructs-engineered-from-human-induced-pluripotent-stem-cells-modeling-of-tuberous-sclerosis-complex-and-the-effects-of-rapamycin
#50
JOURNAL ARTICLE
Veniamin Y Sidorov, Tatiana N Sidorova, Philip C Samson, Ronald S Reiserer, Clayton M Britt, M Diana Neely, Kevin C Ess, John P Wikswo
The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype-genotype relationships and tissue response to pharmacological manipulation. Mutations in the TSC1 and TSC2 genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534485/reliable-off-resonance-correction-in-high-field-cardiac-mri-using-autonomous-cardiac-b-0-segmentation-with-dual-modality-deep-neural-networks
#51
JOURNAL ARTICLE
Xinqi Li, Yuheng Huang, Archana Malagi, Chia-Chi Yang, Ghazal Yoosefian, Li-Ting Huang, Eric Tang, Chang Gao, Fei Han, Xiaoming Bi, Min-Chi Ku, Hsin-Jung Yang, Hui Han
B0 field inhomogeneity is a long-lasting issue for Cardiac MRI (CMR) in high-field (3T and above) scanners. The inhomogeneous B0 fields can lead to corrupted image quality, prolonged scan time, and false diagnosis. B0 shimming is the most straightforward way to improve the B0 homogeneity. However, today's standard cardiac shimming protocol requires manual selection of a shim volume, which often falsely includes regions with large B0 deviation (e.g., liver, fat, and chest wall). The flawed shim field compromises the reliability of high-field CMR protocols, which significantly reduces the scan efficiency and hinders its wider clinical adoption...
February 23, 2024: Bioengineering
https://read.qxmd.com/read/38534473/a-comparison-of-the-impact-of-pharmacological-treatments-on-cardioversion-rate-control-and-mortality-in-data-driven-atrial-fibrillation-phenotypes-in-critical-care
#52
JOURNAL ARTICLE
Alexander Lacki, Antonio Martinez-Millana
Critical care physicians are commonly faced with patients exhibiting atrial fibrillation (AF), a cardiac arrhythmia with multifaceted origins. Recent investigations shed light on the heterogeneity among AF patients by uncovering unique AF phenotypes, characterized by differing treatment strategies and clinical outcomes. In this retrospective study encompassing 9401 AF patients in an intensive care cohort, we sought to identify differences in average treatment effects (ATEs) across different patient groups. We extract data from the MIMIC-III database, use hierarchical agglomerative clustering to identify patients' phenotypes, and assign them to treatment groups based on their initial drug administration during AF episodes...
February 20, 2024: Bioengineering
https://read.qxmd.com/read/38534442/deletion-of-interleukin-1%C3%AE-converting-enzyme-alters-mouse-cardiac-structure-and-function
#53
JOURNAL ARTICLE
Gohar Azhar, Koichiro Nagano, Pankaj Patyal, Xiaomin Zhang, Ambika Verma, Jeanne Y Wei
Interleukin-1β converting enzyme (ICE, caspase-1) is a thiol protease that cleaves the pro-inflammatory cytokine precursors of IL-1β and IL-18 into active forms. Given the association between caspase-1 and cardiovascular pathology, we analyzed the hearts of ICE knockout (ICE KO) mice to test the hypothesis that caspase-1 plays a significant role in cardiac morphology and function. We characterized the histological and functional changes in the hearts of ICE KO mice compared to the Wild type. The cardiomyocytes from the neonatal ICE KO mice showed an impaired response to oxidative stress...
March 7, 2024: Biology
https://read.qxmd.com/read/38534433/the-cardiometabolic-impact-of-rebaudioside-a-exposure-during-the-reproductive-stage
#54
JOURNAL ARTICLE
Isabella Bracchi, Juliana Morais, João Almeida Coelho, Ana Filipa Ferreira, Inês Alves, Cláudia Mendes, Beatriz Correia, Alexandre Gonçalves, João Tiago Guimarães, Inês Falcão Pires, Elisa Keating, Rita Negrão
The consumption of non-sugar sweeteners (NSS) has increased during pregnancy. The European Food Safety Agency suggested that steviol glycosides, such as Rebaudioside A (RebA), the major sweetener component of stevia, are safe for humans up to a dose of 4 mg/kg body weight/day. However, the World Health Organization recommended in 2023 the restraint of using NSS, including stevia, at any life stage, highlighting the need to study NSS safety in early periods of development. We aimed to study the mitochondrial and cardiometabolic effects of long-term RebA consumption during the reproductive stage of the life cycle...
March 2, 2024: Biology
https://read.qxmd.com/read/38534410/feasibility-and-reliability-of-quadriceps-muscle-power-and-optimal-movement-velocity-measurements-in-different-populations-of-subjects
#55
JOURNAL ARTICLE
Tomasz Kostka, Joanna Kostka
This study aimed to assess the feasibility and reliability of quadriceps maximal short-term power (Pmax ) and corresponding optimal movement velocity (υopt -velocity at which the power reaches a maximum value) measurements in different populations of subjects. Five groups of subjects, fifty participants in each group, took part in the study: students; patients of the cardiac rehabilitation program; patients after stroke; older adults; and subjects of different ages who performed repetitive measurements with two different bicycles...
February 22, 2024: Biology
https://read.qxmd.com/read/38534402/transgene-free-cynomolgus-monkey-ipscs-generated-under-chemically-defined-conditions
#56
JOURNAL ARTICLE
Yuliia Tereshchenko, Nesil Esiyok, Enrique Garea-Rodríguez, Daniele Repetto, Rüdiger Behr, Ignacio Rodríguez-Polo
Non-human primates (NHPs) are pivotal animal models for translating novel cell replacement therapies into clinical applications, including validating the safety and efficacy of induced pluripotent stem cell (iPSC)-derived products. Preclinical development and the testing of cell-based therapies ideally comprise xenogeneic (human stem cells into NHPs) and allogenic (NHP stem cells into NHPs) transplantation studies. For the allogeneic approach, it is necessary to generate NHP-iPSCs with generally equivalent quality to the human counterparts that will be used later on in patients...
March 21, 2024: Cells
https://read.qxmd.com/read/38534327/isolevuglandins-promote-mitochondrial-dysfunction-and-electrophysiologic-abnormalities-in-atrial-cardiomyocytes
#57
JOURNAL ARTICLE
Tuerdi Subati, Zhenjiang Yang, Matthew B Murphy, Joshua M Stark, David Z Trykall, Sean S Davies, Joey V Barnett, Katherine T Murray
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet the cellular and molecular mechanisms underlying the AF substrate remain unclear. Isolevuglandins (IsoLGs) are highly reactive lipid dicarbonyl products that mediate oxidative stress-related injury. In murine hypertension, the lipid dicarbonyl scavenger 2-hydroxybenzylamine (2-HOBA) reduced IsoLGs and AF susceptibility. We hypothesized that IsoLGs mediate detrimental pathophysiologic effects in atrial cardiomyocytes that promote the AF substrate...
March 9, 2024: Cells
https://read.qxmd.com/read/38534320/phosphodiesterases-4b-and-4d-differentially-regulate-camp-signaling-in-calcium-handling-microdomains-of-mouse-hearts
#58
JOURNAL ARTICLE
Axel E Kraft, Nadja I Bork, Hariharan Subramanian, Nikoleta Pavlaki, Antonio V Failla, Bernd Zobiak, Marco Conti, Viacheslav O Nikolaev
The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains. Phosphodiesterase subfamilies 4B and 4D are critically involved in the regulation of cAMP signaling in mammalian cardiomyocytes. Alterations of PDE4 activity in human hearts has been shown to result in arrhythmias and heart failure. Here, we sought to systematically investigate specific roles of PDE4B and PDE4D in the regulation of cAMP dynamics in three distinct subcellular microdomains, one of them located at the caveolin-rich plasma membrane which harbors the L-type calcium channels (LTCCs), as well as at two sarco/endoplasmic reticulum (SR) microdomains centered around SR Ca2+ -ATPase (SERCA2a) and cardiac ryanodine receptor type 2 (RyR2)...
March 8, 2024: Cells
https://read.qxmd.com/read/38534305/autonomic-nervous-system-activity-and-dental-anxiety-in-the-northern-finland-birth-cohort-nfbc1966-population
#59
JOURNAL ARTICLE
Atte Somero, Auli Suominen, Vesa Pohjola, Mika Ogawa, Kirsi Sipilä, Niklas Kakko, Mikko Tulppo, Satu Lahti
Autonomic nervous system (ANS) activity may be associated with dental anxiety; however, no studies exist on the topic. The aim of this study was to assess if ANS activity and dental anxiety are associated. Data were collected as part of a Northern Finland Birth Cohort Study, NFBC1966, at the age of 46 years with eligible data on 1905 participants. Dental anxiety was measured using the Modified Dental Anxiety Scale (MDAS) categorized as follows: 19-25 = high, 10-18 = moderate, 5-9 = no to low dental anxiety...
March 21, 2024: Dentistry Journal
https://read.qxmd.com/read/38534105/association-of-personality-traits-with-the-efficacy-of-stress-management-interventions-for-medical-students-taking-objective-structured-clinical-examinations
#60
JOURNAL ARTICLE
Olivia Le Saux, Brice Canada, Ursula Debarnot, Nour El Houda Haouhache, Jean Jacques Lehot, Marion Binay, Marion Cortet, Thomas Rimmelé, Antoine Duclos, Gilles Rode, Marc Lilot, Sophie Schlatter
PURPOSE: Personality traits are associated with psychophysiological stress, but few studies focus on medical students. This study aimed to better understand the association of personality traits with the efficacy of stress management interventions for medical students. METHOD: A randomized controlled trial was conducted with fourth-year students who took the objective structured clinical examination at Bernard University Lyon 1 in December 2021. Students were randomized in cardiac biofeedback, mindfulness, and control groups...
March 25, 2024: Academic Medicine
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