Jia-Qi Wang, Ren-Jie Zhang, Lu-Ping Zhou, Chong-Yu Jia, Bo Zhang, Rui Sheng, Shu Fang, Cai-Liang Shen
OBJECTIVE: The aim of this study was to design a novel lumbar cortical bone trajectory (CBT) penetrating the anterior, middle, and posterior vertebral area using imaging; measure the relevant parameters to find theoretical parameters and screw placement possibilities; and investigate the optimal implantation trajectory of the CBT in patients with osteoporosis. METHODS: Three types of CBTs with appropriate lengths were selected to simulate screw placement using Mimics software...
May 24, 2024: Journal of Neurosurgery. Spine
Rie Harboe Nygaard, Esben Stistrup Lauritzen, Tanja Sikjær, Carsten Schriver Højskov, Lars Rejnmark, Holger Jon Møller
A 29-year-old female, born to consanguineous parents, was found with unmeasurable levels of vitamin D (<10 nmol/l) after routine biochemical screening during her first pregnancy. She did not respond to either oral or intramuscular vitamin D supplementation and was an otherwise healthy young woman, with no signs of rickets, osteomalacia, osteoporosis or secondary hyperparathyroidism. Western blot analysis revealed total lack of vitamin D binding protein, and next generation sequencing confirmed a novel, pathogenic homozygote loss-of-function mutation in exon 13 of the group-specific component gene, that encodes the poly A tail for vitamin D binding protein...
May 24, 2024: European Journal of Endocrinology
Bo Tian, Xiaolu Li, Weiyuan Li, Zhizhou Shi, Xu He, Shengyu Wang, Xun Zhu, Na Shi, Yan Li, Ping Wan, Chongtao Zhu
BACKGROUND: Bone formation and homeostasis are greatly dependent on the osteogenic differentiation of human bone marrow stem cells (BMSCs). Therefore, revealing the mechanisms underlying osteogenic differentiation of BMSCs will provide new candidate therapeutic targets for osteoporosis. METHODS: The osteogenic differentiation of BMSCs was measured by analyzing ALP activity and expression levels of osteogenic markers. Cellular Fe and ROS levels and cell viability were applied to evaluate the ferroptosis of BMSCs...
May 22, 2024: Aging
Adam C Eckart, Pragya Sharma Ghimire, James Stavitz
Background: Popular movement-based injury risk screens were shown to lack predictive precision, leading to interest in multifactorial models. Furthermore, there is a lack of research regarding injury risk assessment for those currently or planning to be recreationally active. This study aims to provide injury risk insights by analyzing multifactorial injury risk models and associated clinical measures in the U.S. population. Methods: Data related to injury, inflammatory markers, physical functioning, body composition, physical activity, and other variables from 21,033 respondents were extracted from NHANES...
April 28, 2024: Sports
Karen Laurene Dalla Costa, Letícia Furtado Abreu, Camila Barreto Tolomei, Rachel Gomes Eleutério, Rosanna Basting, Gabriela Balbinot, Fabrício Mezzomo Collares, Pedro Lopes, Nelio Veiga, Gustavo Vicentis Oliveira Fernandes, Daiane Cristina Peruzzo
The aim of this study was to evaluate the effect of local administration of melatonin (MLT) on molecular biomarkers and calvaria bone critical defects in female rats with or without osteoporosis, associated or not with a xenogeneic biomaterial. Forty-eight female rats were randomly divided into two groups: (O) ovariectomized and (S) placebo groups. After 45 days of osteoporosis induction, two critical-size defects (5 mm diameter) were created on the calvaria. The groups were subdivided according to the following treatment: (C) Clot, MLT, MLT associated with Bio-Oss® (MLTBO), and Bio-Oss® (BO)...
May 13, 2024: Journal of Functional Biomaterials
Capucine Jourdain de Muizon, Céline Moriou, Marceau Levasseur, David Touboul, Bogdan I Iorga, Hristo Nedev, Elsa Van Elslande, Pascal Retailleau, Sylvain Petek, Eric Folcher, Arnaud Bianchi, Mireille Thomas, Solène Viallon, Sylvie Peyroche, Sarah Nahle, Marthe Rousseau, Ali Al-Mourabit
As a result of screening a panel of marine organisms to identify lead molecules for the stimulation of endochondral bone formation, the calcareous sponge Pericharax heteroraphis was identified to exhibit significant activity during endochondral differentiation. On further molecular networking analysis, dereplication and chemical fractionation yielded the known clathridine A-related metabolites 3-6 and the homodimeric complex (clathridine A)2 Zn2+ ( 9 ), together with the new unstable heterodimeric complex (clathridine A-clathridimine)Zn2+ ( 10 )...
April 25, 2024: Marine Drugs
Luca Pio Stoppino, Stefano Piscone, Sara Saccone, Saul Alberto Ciccarelli, Luca Marinelli, Paola Milillo, Crescenzio Gallo, Luca Macarini, Roberta Vinci
This study aimed to demonstrate the potential role of dual-energy CT in assessing bone mineral density (BMD) using hydroxyapatite-fat material pairing in postmenopausal women. A retrospective study was conducted on 51 postmenopausal female patients who underwent DXA and DECT examinations for other clinical reasons. DECT images were acquired with spectral imaging using a 256-slice system. These images were processed and visualized using a HAP-fat material pair. Statistical analysis was performed using the Bland-Altman method to assess the agreement between DXA and DECT HAP-fat measurements...
April 27, 2024: Journal of Imaging
Luca Rinaudo, Sofia Cuttone, Carmelo Messina, Veronica Magni, Davide Capra, Luca Maria Sconfienza, Francesco Sardanelli, Fabio Massimo Ulivieri
Bone Strain Index (BSI), based on dual-energy X-ray absorptiometry (DXA), is a densitometric index of bone strength of the femur and lumbar spine. Higher BSI values indicate a higher strain applied to bone, predisposing to higher fracture risk. This retrospective, multicentric study on Italian women reports the BSI normative age-specific reference curves. A cohort of Caucasian Italian women aged 20 to 90 years was selected from three different clinical centres. Bone mineral density (BMD) and BSI measurements were obtained for the lumbar spine vertebrae (L1-L4) and for the femur (neck, trochanter and intertrochanter) using Hologic densitometers scans...
May 18, 2024: Diagnostics
Keisuke Seki, Maki Nagasaki, Tona Yoshino, Mayuko Yano, Aki Kawamoto, Osamu Shimizu
Osteoporosis is often detected late and becomes severe because of a lack of subjective symptoms. Digital panoramic radiography (DPR) has been reported to be useful for osteoporosis screening based on the morphological classification of the mandibular inferior cortex. The purpose of this study was to evaluate the sensitivity and specificity of the mandibular cortical index (MCI) in the diagnosis of osteoporosis in a group of patients who were and were not using antiosteoporosis medication (AOM). Three hundred and fifty female patients aged 40 years or older who had DPR imaging performed during a 6-year period from December 2015 to February 2022 met the selection criteria...
May 13, 2024: Diagnostics
Jihan Wang, Mengju Xue, Ya Hu, Jingwen Li, Zhenzhen Li, Yangyang Wang
Osteoporosis (OP), a prevalent skeletal disorder characterized by compromised bone strength and increased susceptibility to fractures, poses a significant public health concern. This review aims to provide a comprehensive analysis of the current state of research in the field, focusing on the application of proteomic techniques to elucidate diagnostic markers and therapeutic targets for OP. The integration of cutting-edge proteomic technologies has enabled the identification and quantification of proteins associated with bone metabolism, leading to a deeper understanding of the molecular mechanisms underlying OP...
May 4, 2024: Biomolecules
Juanjuan Han, Cuijing Wang, Haolin Yang, Jiayi Luo, Xiaoyi Zhang, Xin-An Zhang
Musculoskeletal diseases (MSDs), including osteoarthritis (OA), osteosarcoma (OS), multiple myeloma (MM), intervertebral disc degeneration (IDD), osteoporosis (OP), and rheumatoid arthritis (RA), present noteworthy obstacles associated with pain, disability, and impaired quality of life on a global scale. In recent years, it has become increasingly apparent that N6-methyladenosine (m6A) is a key regulator in the expression of genes in a multitude of biological processes. m6A is composed of 0.1-0.4% adenylate residues, especially at the beginning of 3'-UTR near the translation stop codon...
April 24, 2024: Biomolecules
E V Biryukova, M V Shinkin, S V Podachina, I Y Feidorov, O M Mikheeva, L A Zvenigorodskaya, N A Malkina, D A Synkova
Disorders of the mineral balance often determine the symptoms, the severity of the course and the prognosis of many diseases. Primary hyperparathyroidism (PHPT) is a common endocrine disease caused by increased secretion of parathyroid hormone as a result of primary damage to the parathyroid glands. Diagnosis of PHPT is often difficult. Clinical signs of PHPT appear months or years after the onset of the disease, however, the presence of hypercalcemia serves as an early indication of the disease of the thyroid gland...
December 28, 2023: Terapevticheskiĭ Arkhiv
Jeremy A Dubin, Sandeep S Bains, Ruben Monarrez, Christopher Salib, Daniel Hameed, James Nace, Michael Mont, Gregory Golladay, Ronald E Delanois
INTRODUCTION: Minimizing the burden of periprosthetic fractures (PFF) following total joint arthroplasty (TJA) with regard to morbidity and mortality remains an outcome of interest. Patient and surgical risk factors, including osteoporosis and fixation type, have not truly been optimized in patients undergoing TJA as a means to reduce the risk of PFF. As such, we examined: (1) What percentage of patients who underwent THA and total knee arthroplasty (TKA) met the criteria for osteoporosis screening? (2) How did the 5-year rate of PFF and fragility fracture differ in the high-risk and low-risk groups for osteoporosis between the cemented and cementless cohorts? (3) What percentage of the aforementioned patients received a dual x-ray absorptiometry (DEXA) scan before THA or TKA? METHODS: We queried an all-payer, national database from April 1, 2016 to December 31, 2021, to identify high-risk and low-risk patients who underwent TJA with a cementless or cemented fixation...
October 2024: Journal of Orthopaedics
Dorina-Gabriela Condurache, Stefania D'Angelo, Ahmed M Salih, Liliana Szabo, Celeste McCracken, Adil Mahmood, Elizabeth M Curtis, Andre Altmann, Steffen E Petersen, Nicholas C Harvey, Zahra Raisi-Estabragh
This study examined the association of estimated heel bone mineral density (eBMD, derived from quantitative ultrasound) with: (1) prevalent and incident cardiovascular diseases (CVDs: ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), non-ischemic cardiomyopathy (NICM), arrhythmia), (2) mortality (all-cause, CVD, IHD), and (3) cardiovascular magnetic resonance (CMR) measures of left ventricular and atrial structure and function and aortic distensibility, in the UK Biobank. Clinical outcomes were ascertained using health record linkage over 12...
June 2024: JBMR Plus
Mazen AbuQamar, Mohammed I Tabash, Adnan Aish, Abd-Rabo Abu Hasheesh, Fulla Sharaf
BACKGROUND: Improving water supply quality could be essential for disease prevention strategy that promotes human health. The study aims to investigate the relationship between drinking water quality and the occurrence of osteoporosis in Gaza Strip. METHODS: A case-control study design was used, and a multistage sampling method was employed at the main orthopedic clinic. Participants included 200 individuals diagnosed with osteoporosis and 200 without osteoporosis...
September 2023: Ethiopian Journal of Health Sciences
Yunyan Zhang, Tong-Chuan He, Hongmei Zhang
Periodontitis is a chronic inflammatory disease caused by plaque biofilm which shares risk factors with systemic chronic diseases such as diabetes, cardiovascular disease, and osteoporosis. Many studies have found increased prevalence and rate of progression of periodontal disease in children with common metabolic disorders. Although the causal relationship and specific mechanism between them has not been determined yet. The aim of this paper is to progress on the impact of metabolic disorders on periodontal health in children and the underlying mechanisms, which provides new evidences for the prevention and intervention of metabolic disorders and periodontitis in children...
March 2024: Pediatr Discov
Soon Hye Yang, Neha Mittal, Amanda L Bell, Christian E Bell
Objective: The objective of the study is to highlight the role and safety of romosozumab in patients at high risk of fractures in primary care. Data Sources: A systemic database search of PubMed/MEDLINE,, and Cochrane Library was conducted for articles with keywords romosozumab, osteoporosis, and safety between inception and July 2022. Study Selection and Data Extraction: Phase 3 trials in patients with osteoporosis were included. Data results from these trials were utilized for assessment...
June 2024: Journal of Pharmacy Technology: JPT: Official Publication of the Association of Pharmacy Technicians
Emily R Quarato, Noah A Salama, Laura M Calvi
PURPOSE OF THE REVIEW: In this review, we discuss the most recent scientific advances on the reciprocal regulatory interactions between the skeletal and hematopoietic stem cell niche, focusing on immunomodulation and its interplay with the cell's mitochondrial function, and how this impacts osteoimmune health during aging and disease. RECENT FINDINGS: Osteoimmunology investigates interactions between cells that make up the skeletal stem cell niche and immune system...
May 23, 2024: Current Osteoporosis Reports
Frederick M Azar
No abstract text is available yet for this article.
July 2024: Orthopedic Clinics of North America
Daniel Gelvez, Katherine Dong, Nathan Redlich, Jestin Williams, Amit Bhandutia, Berje Shamassian
This article reviews the appropriate assessment and management of osteoporotic compression fractures and discusses the implications of osteoporosis on initial patient evaluation, medical optimization for surgery, selection of instrumentation, and surgical technique. Adverse outcomes associated with osteoporosis are discussed. Failure to appropriately evaluate, optimize, and treat spine patients with osteoporotic bone can lead to disastrous complications. Weakened bone can lead to implant failure through cage subsidence and screw pullout, as well as, peri-implant fractures, failure of deformity correction, and proximal kyphosis...
July 2024: Orthopedic Clinics of North America
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