Ting Cheng, Yao-Chen Zhang, Ke-Yi Fan, Jing-Xi Hu, Qian Wang, Qi Wang, Liu Liu, He-Yi Zhang, Yao-Pu Hou, Xiao-Feng Li, Sheng-Xiao Zhang
INTRODUCTION: The mechanistic target of rapamycin (mTOR) regulates bone homeostasis, a crucial factor in osteoporosis (OP) development. However, most research is based on observational studies, and the causality remains uncertain. Therefore, we analyzed two samples of mendelian randomization (MR) to determine whether there is a causal relationship between mTOR-dependent circulating proteins and OP. METHODS: Mendelian weighting (weighted median [WM], inverse variance weighting [IVW], and MR-Egger regression) were applied to analyze the causality between bone phenotypes (bone mineral density [BMD] in forearm, femoral neck, lumbar spine, and heel) and mTOR-dependent circulating proteins (RP-S6K, 4EBP, EIF-4E, EIF-4A, and EIF-4G)...
September 20, 2023: Advances in Therapy