Richard Imrich, Andrea Zatkova, Olga Lukacova, Jana Sedlakova, Elizabeth Zanova, Miroslav Vlcek, Adela Penesova, Zofia Radikova, Andrea Havranova, Lakshminarayan Ranganath
Alkaptonuria (AKU, OMIM, No. 203500) is a rare, slow-progressing, irreversible, multisystemic disease resulting from a deficiency of the homogentisate 1,2-dioxygenase enzyme, which leads to the accumulation of homogentisic acid (HGA) and subsequent deposition as pigment in connective tissues called ochronosis. As a result, severe arthropathy of large joints and spondyloarthropathy with frequent fractures, ligament ruptures, and osteoporosis develops in AKU patients. Since 2020, the first-time treatment with nitisinone has become available in the European Union...
January 1, 2023: Endocrine Regulations
Elsa Nunes, Eugenia Gallardo, Sara Morgado-Nunes, José Fonseca-Moutinho
Previous studies using immunoassays for steroid measurements have focused on the association between steroid hormone levels and bone mineral density (BMD) in postmenopausal women, obtaining contradictory results. This study aimed to assess this association using a highly sensitive bioanalytical method. A total of 68 postmenopausal women, aged 65-89 years, were enrolled in a cross-sectional study. Measurements of the BMD of the hip and lumbar spine were performed using dual energy X-ray absorptiometry, and serum hormone levels were quantified by gas chromatography and tandem mass spectrometry...
March 25, 2023: Scientific Reports
Rikke Viggers, Jakob Starup-Linde, Peter Vestergaard
OBJECTIVE: Subjects with diabetes mellitus have an increased risk of fractures. We aimed to identify discrepancies in the first type of major osteoporotic fracture (MOF) and anti-osteoporotic therapy between subjects with type 2 diabetes (T2D) and subjects without diabetes. Methods and research design. We conducted a retrospective national cohort study by access to all discharge diagnoses (ICD-10 system) and redeemed drug prescriptions (ATC classification system). We included all subjects alive and Danish citizens in 2010 and identified subjects with T2D diagnosed after the age of 50 between 1998 and 2018...
March 23, 2023: Bone
Sara N Levintow, Carrie M Nielson, Rohini K Hernandez, Alexander Breskin, David Pritchard, Timothy L Lash, Kenneth J Rothman, David Gilbertson, Paul Muntner, Cathy Critchlow, M Alan Brookhart, Brian D Bradbury
This narrative review describes the application of negative control outcome (NCO) methods to assess potential bias due to unmeasured or mismeasured confounders in non-randomized comparisons of drug effectiveness and safety. An NCO is assumed to have no causal relationship with a treatment under study while subject to the same confounding structure as the treatment and outcome of interest; an association between treatment and NCO then reflects the potential for uncontrolled confounding between treatment and outcome...
March 25, 2023: Pharmacoepidemiology and Drug Safety
Zhiyuan Yan, Qiansong He
Non-coding RNAs, including long-chain non-coding RNA (lncRNA) and micro-RNA (miRNA), have been implicated in osteoporosis (OP) progression by regulating osteoblast-dependent bone metabolism. Herein, we investigated whether LINC01234, miR-513a-5p, and AOX1 regulate osteogenic differentiation and proliferation of human bone marrow mesenchymal stem cells (hMSCs). The expression of LINC01234, miR-513a-5p, and AOX1 was monitored using RT-qPCR or western blotting. Cell proliferation was assessed using a CCK8 assay...
March 24, 2023: Molecular Biotechnology
Kai Zhao, Dong Han, Si-Rui He, Long-Yan Wu, Wu-Yang Liu, Zhao-Ming Zhong
Bone marrow endothelial cells (BMECs) play a crucial role in the maintenance of bone homeostasis. The decline in BMECs is associated with abnormal bone development and loss. At present, the mechanism of age-related oxidative stress enhancement in BMEC dysfunction remains unclear. Our experiment explored injury caused by oxidative stress enhancement in BMECs both in vivo and in vitro. The BMECs, indicators of oxidative stress, bone mass, and apoptosis-related proteins were analyzed in different age groups...
March 17, 2023: Biochemical and Biophysical Research Communications
Natalia Konstantelos, Andrea M Burden, Angela M Cheung, Sandra Kim, Paul Grootendorst, Suzanne M Cadarette
We identified inconsistency in fracture definitions in a prior review of studies that utilized claims data. Here, we aimed to compare fracture rates estimated using thirteen hip and seven radius/ulna fracture definitions. Our primary analysis compared results in a cohort of 120,363 older adults treated with oral bisphosphonates for ≥3 years. The most inclusive definition (hip: inpatient or emergency diagnosis; radius/ulna: inpatient, emergency, or outpatient diagnosis) served as a referent to compare the number and proportion of fractures captured...
March 14, 2023: Pharmacy (Basel, Switzerland)
Ronnie Sebro, Mahmoud Elmahdy
PURPOSE: To predict whether a patient has osteoporosis/osteopenia using the attenuation of trabecular bone obtained from knee computed tomography (CT) scans. METHODS: Retrospective analysis of 273 patients who underwent contemporaneous knee CT scans and dual-energy X-ray absorptiometry (DXA) within 1 year. Volumetric segmentation of the trabecular bone of the distal femur, proximal tibia, patella, and proximal fibula was performed to obtain the bone CT attenuation...
March 24, 2023: Canadian Association of Radiologists Journal
Wei Lu, Zhaowei Teng, Jiayu Chen, Rongmao Shi, Tiannan Zou, Ming Gao, Weichao Li, Zhi Peng, Long Wang, Yonghui Zhao, Sheng Lu
PURPOSE: The objective of this study was to analyze the clinical characteristics and the therapeutic effects of treatment at our spinal center in OVCF patients associated with referred pain. The underlying goals were to deepen the understanding of referred pain caused by OVCFs, improve the currently low early diagnosis rate of OVCFs, and improve the effectiveness of treatment. METHODS: The patients who had referred pain from OVCFs and met the inclusion criteria were retrospectively analyzed...
2023: Journal of Pain Research
Sílvia Santos Monteiro, Tiago da Silva Santos, Liliana Fonseca, Jorge Dores
BACKGROUND: Fragility fractures are increasingly recognized as a complication of type 2 diabetes mellitus (T2DM). The FRAX-Port® is a calculation tool that assesses the 10-year risk of either major and hip fracture, integrating several clinical risk factors, including T2DM. We aimed to evaluate the fracture risk in adults with T2DM and determine the rate of patients at high risk for fracture under anti-osteoporotic therapy. METHODS: We developed a cross-sectional study, including a convenience sample of adults with T2DM, followed in our tertiary center between 2019 and 2022...
February 2023: Curēus
Chengqiang Zhou, Yifeng Liao, Han Chen, Yunqing Wang
PURPOSE: To explore the optimal volume fraction percentage (VF%) and influencing factors of bone cement distribution in percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCF) using digital techniques. PATIENTS AND METHODS: From January 2019 to February 2021, 150 patients with 0VCF who underwent PVP surgery in our hospital were analyzed. Based on postoperative X-ray and CT, the spatial distribution score of the intravertebral cement was calculated and the patients were divided into two groups: 0-7 were divided into group A; 8-10 were divided into group B...
March 23, 2023: Journal of Orthopaedic Surgery and Research
Omar Osman, Susan Manzi, Mary Chester Wasko, Barbara A Clark
BACKGROUND: Nephrolithiasis as a feature of rheumatologic diseases is under recognized. Understanding presenting features, diagnostic testing is crucial to proper management. CASE PRESENTATION: A 32 year old woman with a history of recurrent complicated nephrolithiasis presented to a rheumatologist for a several month history of fatigue, dry eyes, dry mouth, arthralgias. She had a positive double-stranded DNA, positive SSA and SSB antibodies. She was diagnosed with Systemic Lupus erythematosus (SLE) and Sjogren's syndrome and was started on mycophenalate mofetil...
March 23, 2023: BMC Urology
Solmaz Dastmanesh, Masoud Karimi, Leila Ghahremani, Mozhgan Seif, Elahe Zare
BACKGROUND: Osteoporosis, as the most common metabolic disease and the leading cause of death among older people, affects more than 200 million women throughout the world. This study aimed to evaluate the effect of a health communication campaign on knowledge, attitude, and practice of older women towards prevention and control of osteoporosis. METHODS: In this multi-stage mixed methods study, 30 days' health communication campaign for prevention of osteoporosis was conducted on 60- 75-year-old women, in rural areas of Fasa, Iran...
March 23, 2023: BMC Women's Health
Elnaz Olyaei, Mohammad Mohammadzadeh, Parisa Azimi
BACKGROUND: Vertebroplasty is a minimally invasive outpatient procedure to stabilize compression fractures in the spine. This procedure involves injecting bone cement into the vertebrae that have been cracked or broken, typically due to osteoporosis. The cement hardens inside the bones, providing stability to the fractures and supporting the spine. Additionally, radioactive bone cement and brachytherapy sources have been utilized to suppress tumor growth in the vertebral body. OBJECTIVE: We present a novel brachytherapy technique for treating vertebral body metastases using a liquid form of radioactive sources, Phosphorus-32 and Lutetium-177, separately mixed with bone cement and injected into vertebral body bone prostheses...
March 24, 2023: Journal of Cancer Research and Clinical Oncology
Maëlle Baillet, Rémy Morello, Olivier Vittecoq, Chantal Chavoix, Christian Marcelli
UNLABELLED: Risk factors involved in the different osteoporotic fracture locations are not well-known. The results of this study suggest that there is not one typical profile characterising a particular fracture site but that the occurrence of a fracture may result from the combination of different bone, cognitive, and anthropometrics characteristics. PURPOSE: Risk factors involved in the different osteoporotic fracture locations are not well-known. The aim of this study was to identify the differences in bone, cognitive, and anthropometric characteristics between different fracture sites, and to determine whether the site of a fall-related fracture is related to a specific profile...
March 24, 2023: Osteoporosis International
Yiqi Zhang, Long Zhou, Qin Fu, Ziyun Liu
Bone marrow-derived mesenchymal stem cells (BMSCs) are considered promising materials for treating bone diseases such as osteoporosis (OP). This research explored the functions and molecular mechanism of ankyrin repeat domain 1 (ANKRD1) in BMSC osteogenesis. An OP model in mice was established by bilateral ovariectomy. Manipulation of ANKRD1 expression in BMSCs or femurs was achieved by lentivirus infection. Increased ANKRD1 expression was observed in BMSCs during osteogenic induction. Silencing of ANKRD1 impaired the osteogenesis of BMSCs, as shown by the decreased alkaline phosphatase (ALP) activity, osteogenic gene (Runx2, Col1a1, Bglap, and Spp1) expression, and mineralized formation...
March 21, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
Xia Liu, Mingchun Huang, Lijuan Wang, Chen Yang, Mei Zhang, Qin Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Curculigo orchioides Gaertn. (CO), a traditional Chinese herb recorded in Chinese Pharmacopoeia, can nourish kidney yang, strengthen bones, and dispell cold-dampness. Raw CO (rCO) and wine-processed CO (pCO), the main processed products of CO for clinical application, show differences in nourishing kidney yang and ameliorate osteoporosis. However, the difference in efficacy and mechanism of rCO and pCO on bone destruction in rheumatoid arthritis (RA) remain unclear...
March 21, 2023: Journal of Ethnopharmacology
Brandon C Jones, Felix W Wehrli, Nada Kamona, Rajiv S Deshpande, Brian-Tinh Duc Vu, Hee Kwon Song, Hyunyeol Lee, Rasleen Kaur Grewal, Trevor Jackson Chan, Walter R Witschey, Matthew T MacLean, Nicholas J Josselyn, Srikant Kamesh Iyer, Mona Al Mukaddam, Peter J Snyder, Chamith S Rajapakse
BACKGROUND: Assessment of cortical bone porosity and geometry by imaging in vivo can provide useful information about bone quality that is independent of bone mineral density (BMD). Ultrashort echo time (UTE) MRI techniques of measuring cortical bone porosity and geometry have been extensively validated in preclinical studies and have recently been shown to detect impaired bone quality in vivo in patients with osteoporosis. However, these techniques rely on laborious image segmentation, which is clinically impractical...
March 21, 2023: Bone
Ran Duan, Chun-Gu Hong, Meng-Lu Chen, Xin Wang, Zhi-Lin Pang, Hui Xie, Zheng-Zhao Liu
Alzheimer's disease (AD) is a common degenerative disease among the elderly population. In addition to cognitive impairment, AD is often accompanied by behavioral manifestations. However, little attention has been paid to changes in bone metabolism and related mechanisms in patients with AD. We found that AD mice (APPswe/PS1dE9) had reduced bone density, weakened bone strength, and amyloid beta (Aβ) deposition in the bone tissue. It was further found that targeting autophagy receptors Optineurin (OPTN) and Sequestosome 1 (SQSTM1) increased bone density and bone strength in AD mice, promoted the clearance of Aβ in the bone tissue, and maintained bone homeostasis...
March 21, 2023: Chemico-biological Interactions
Jacob Hoffmann, Gordon Preston, James Whaley, Jad G Khalil
Vertebral augmentation has been a well-studied adjunct percutaneous procedure in spine surgery. Cement augmentation has been used in the treatment of compression fractures through kyphoplasties or vertebroplasties. Historically, data have shown no difference between treating compression fractures conservatively versus with percutaneous cement augmentation procedures. Recent literature has shown improvement in patient outcomes and increase in mobility with percutaneous cement augmentation procedures. Cement augmentation has been used in treating patients with spinal column fractures in higher energy trauma...
March 23, 2023: Journal of the American Academy of Orthopaedic Surgeons
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