Rafael Barrera Salgueiro, Anaysa Paola Bolin, Sandra Andreotti, Ayumi Cristina Medeiros Komino, Érica de Sousa, Flaviane de Fatima Silva, André Ricardo Gomes de Proença, Rogério Antonio Laurato Sertié, Alice Cristina Rodrigues, Fabio Bessa Lima
The most common form of hypercortisolism is iatrogenic Cushing's syndrome. Lipodystrophy and metabolic disorders can result from the use of exogenous glucocorticoids (GC). Adipocytes play an important role in the production of circulating exosomal microRNAs, and knockdown of Dicer promotes lipodystrophy. The aim of this study is to investigate the effect of GCs on epididymal fat and to assess their influence on circulating microRNAs associated with fat turnover. The data indicate that despite the reduction in adipocyte volume due to increased lipolysis and apoptosis, there is no difference in tissue mass, suggesting that epididymal fat pad, related to animal size, is not affected by GC treatment...
April 23, 2024: Molecular and Cellular Endocrinology