Alice M Sheridan
No abstract text is available yet for this article.
April 17, 2024: Clinical Journal of the American Society of Nephrology: CJASN
Helena I Kurniawan, Kelly O'Malley, Renée Santana, Jeff Kowaleski, Lara M Skarf
Guidelines are lacking for patients with calciphylaxis on renal replacement therapy, often leading to difficulty optimally treating these patients. A 60-year-old male veteran receiving hemodialysis presented with calciphylaxis of the left lower extremity and intractable pain. His condition was complicated by chronic back pain, long-term opioid therapy, and psychological trauma history. He was ultimately transferred to a calciphylaxis treatment center but was unable to tolerate further treatments due to sepsis and hemodynamic instability...
April 17, 2024: Journal of Palliative Medicine
Himani Goswami, Harda Shah, Kinnari Vala, Shahenaz Kapadia, Bharat Tiwari, Anshuman Saha
BACKGROUND: Chronic kidney disease (CKD) leads to reduced muscle mass and strength in children resulting in a decrease in functional capacity. The objectives of this cross-sectional observational study were to evaluate and compare the functional capacity and muscle strength in children with CKD stage I - V (group A), on dialysis (stage VD) (group B), and kidney transplant recipients (KTR) (group C) in Indian children. MATERIALS AND METHODS: 60 children, 20 each in groups A, B, and C were enrolled...
April 17, 2024: Clinical Nephrology
Ying-Chun Ma, Yang Xie, Limin Liao
BACKGROUND: Previous studies have indicated that creatinine (Cr)-based glomerular filtration rate (GFR) estimating equations - including the new Chronic Kidney Disease Epidemiology creatinine (CKD-EPIcr ) equation without race and the estimated glomerular filtration rate (eGFR) equation developed for the Chinese population - displayed suboptimal performance in patients with neurogenic lower urinary tract dysfunction (NLUTD), which limited their clinical application for detecting changes in GFR levels in all cohorts...
April 17, 2024: Clinical Nephrology
Jaime Yoke May Chan, Farida Islahudin, Nurul Ain Mohd Tahir, Mohd Makmor-Bakry, Clare Hui Hong Tan
Background Metabolic acidosis in chronic kidney disease (CKD) patients has lately gained attention due to the growing evidence of its treatment benefits. This study aims to provide baseline data on the prevalence, risk factors, and current management of metabolic acidosis among the pre-dialysis adult Malaysian CKD population. Methodology This multicenter cross-sectional retrospective study involved pre-dialysis CKD patients above 18 years old on regular nephrology clinic follow-up at three Malaysian government hospitals with nephrology subspecialty...
March 2024: Curēus
Omosomi Enilama, Cynthia MacDonald, Pearl Thompson, Umair Khan, Selina Allu, Mary Beaucage, Kevin Yau, Matthew J Oliver, Michelle A Hladunewich, Adeera Levin
BACKGROUND: People living with chronic kidney disease (CKD) face an increased risk of severe outcomes such as hospitalization or death from COVID-19. COVID-19 vaccination is a vital approach to mitigate the risk and severity of infection in patients with CKD. Limited information exists regarding the factors that shape COVID-19 vaccine uptake, including health information-seeking behavior and perceptions, within the CKD population. OBJECTIVE: The objectives were to describe among CKD patients, (1) health information-seeking behavior on COVID-19, (2) their capacity to comprehend and trust COVID-19 information from different sources, and (3) their perceptions concerning COVID-19 infection and vaccination...
2024: Canadian Journal of Kidney Health and Disease
Omer Zaidi, Fen Du, Zhaoli Tang, Sandipan Bhattacharjee, Kristin Pareja
BACKGROUND: Immunoglobulin type A (IgA) nephropathy is the most common primary glomerulonephritis (GN) worldwide with higher rates in East and Pacific Asia compared to North America and Europe. Despite high reported prevalence of IgAN in these countries, the overall disease prevalence across Asia is not available. Treatment patterns of IgAN patients across Asian countries have also not been summarized. The aim of this study was to review and summarize evidence on IgA nephropathy prevalence, treatment patterns, and humanistic and economic burden in mainland China, Taiwan, South Korea, Japan, and Australia...
April 16, 2024: BMC Nephrology
Xiaoyu Chen, Yingchun Hu, Lei Peng, Hongmei Wu, Jiangwen Ren, Guanjian Liu, Li Cao, Ming Yang, Qiukui Hao
Multidimensional health function impairments are common in older patients with chronic kidney disease (CKD). The purpose of this study was to explore whether the risk or severity of geriatric syndrome increased with a decline in renal function. This survey was conducted for CKD patients aged  ≥ 60 years and hospitalized at West China Hospital of Sichuan University (Center of Gerontology and Geriatrics, Nephrology, and Endocrinology) and Chengdu Kangfu Kidney Disease Hospital from September 01, 2013 to June 30, 2014...
April 16, 2024: Scientific Reports
Alicia Paessler, Colin Forman, Kishore Minhas, Premal Amrishkumar Patel, James Carmichael, Luke Smith, Fayyad Jaradat, Sergio Assia-Zamora, Zainab Arslan, Francis Calder, Samiran Ray, Nicos Kessaris, Jelena Stojanovic
BACKGROUND: 3D printing has been used in different medical contexts, although it is underutilised in paediatrics. We present the first use of 3D printing in the management of three paediatric patients with complex renovascular disease. METHODS: Patient-specific 3D models were produced from conventional 2D imaging and manufactured using 3D polyjet printing technology. All three patients had different underlying pathologies, but all underwent multiple endovascular interventions (renal artery balloon angioplasty) prior to 3D printing and subsequent vascular surgery...
April 16, 2024: Archives of Disease in Childhood
Luke C Wilson, Jacob Ward, Daniel F B Wright, Suetonia C Green, Sophie L Stocker, Tracey L Putt, John B W Schollum, Robert J Walker
Gout affects 15%-30% of individuals with advanced kidney disease. Allopurinol which is rapidly and extensively metabolised to an active metabolite, oxypurinol, is the most commonly prescribed urate-lowering therapy. Oxypurinol is almost entirely eliminated by the kidneys (>95%) and has an elimination half-life of 18-30 h in those with normal kidney function. However, oxypurinol pharmacokinetics are poorly understood in individuals with kidney failure on peritoneal dialysis. This study characterised the elimination of oxypurinol and urate in people with gout receiving peritoneal dialysis...
April 16, 2024: Nephrology
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2024: Journal of the American Society of Nephrology: JASN
Jiayi Yang, Hongjie Zhuang, Jinhua Li, Ana B Nunez-Nescolarde, Ning Luo, Huiting Chen, Andy Li, Xinli Qu, Qing Wang, Jinjin Fan, Xiaoyan Bai, Zhiming Ye, Bing Gu, Yue Meng, Xingyuan Zhang, Di Wu, Youyang Sia, Xiaoyun Jiang, Wei Chen, Alexander N Combes, David J Nikolic-Paterson, Xueqing Yu
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregulation of a secreted micropeptide, C4orf48 (Cf48), in mouse diabetic nephropathy. Cf48 RNA and protein levels were upregulated in tubular epithelial cells in human and experimental CKD. Serum Cf48 levels were increased in human CKD and correlated with loss of kidney function, increasing CKD stage, and the degree of active interstitial fibrosis...
April 16, 2024: Journal of Clinical Investigation
Lange Guo, Yukui Nan, Lizhong Yao
PURPOSE: Elevated blood lipids are considered a risk factor for atherosclerosis, which can lead to erectile dysfunction. This study aimed to explore the relationship between the atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli's risk index-I (CRI-I), Castelli's risk index-II (CRI-II), and erectile dysfunction. METHODS: Based on the National Health and Nutrition Examination Survey (NHANES) data from 2001-2004, multivariable-adjusted logistic regression models were used to evaluate the association between AIP, AC, CRI-I, and CRI-II with ED...
April 16, 2024: International Urology and Nephrology
Maurizio Bossola, Barbara Picconi
Chronic kidney disease (CKD) patients have an increased risk for cognitive impairment compared to the general population. The risk is much higher in CKD patients who progress to end-stage kidney disease (ESKD) and require hemodialysis or peritoneal dialysis. Multiple factors may contribute to cognitive impairment in CKD patients and in patients on chronic dialysis. However, the observation that, after kidney transplantation, there is an improvement in several cognitive performance markers and that some structural and functional brain abnormalities may improve suggests that cognitive deficits in patients on dialysis may be at least partially reversible...
April 16, 2024: Journal of Nephrology
Hans-Jörg Busch, Sebastian Wolfrum, Guido Michels, Matthias Baumgärtel, Klaus-Friedrich Bodmann, Michael Buerke, Volker Burst, Philipp Enghard, Georg Ertl, Wolf Andreas Fach, Frank Hanses, Hans Jürgen Heppner, Carsten Hermes, Uwe Janssens, Stefan John, Christian Jung, Christian Karagiannidis, Michael Kiehl, Stefan Kluge, Alexander Koch, Matthias Kochanek, Peter Korsten, Philipp M Lepper, Martin Merkel, Ursula Müller-Werdan, Martin Neukirchen, Alexander Pfeil, Reimer Riessen, Wolfgang Rottbauer, Sebastian Schellong, Alexandra Scherg, Daniel Sedding, Katrin Singler, Marcus Thieme, Christian Trautwein, Carsten Willam, Karl Werdan
In Germany, physicians qualify for emergency medicine by combining a specialty medical training-e.g. internal medicine-with advanced training in emergency medicine according to the statutes of the State Chambers of Physicians largely based upon the Guideline Regulations on Specialty Training of the German Medical Association. Internal medicine and their associated subspecialities represent an important column of emergency medicine. For the internal medicine aspects of emergency medicine, this curriculum presents an overview of knowledge, skills (competence levels I-III) as well as behaviours and attitudes allowing for the best treatment of patients...
April 16, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Clara Schott, Samantha Colaiacovo, Cadence Baker, Matthew A Weir, Dervla M Connaughton
RATIONALE: Alport Syndrome (AS) is a progressive genetic condition characterized by chronic kidney disease (CKD), hearing loss, and eye abnormalities. It is caused by mutations in the genes COL4A3, COL4A4 , and COL4A5 . Heterozygous mutations in COL4A4 and COL4A3 cause autosomal dominant Alport Syndrome (ADAS), and a spectrum of phenotypes ranging from asymptomatic hematuria to CKD, with variable extra-renal features. In the past, heterozygous mutations in these genes were thought to be benign, however recent studies show that about 30% of patients can progress to CKD, and 15% can progress to end stage kidney disease (ESKD)...
2024: Canadian Journal of Kidney Health and Disease
Robert A Fletcher, William G Herrington, Rajiv Agarwal, Kaitlin J Mayne, Clare Arnott, Meg J Jardine, Kenneth W Mahaffey, Vlado Perkovic, Natalie Staplin, David C Wheeler, Glenn M Chertow, Hiddo J L Heerspink, Brendon L Neuen
No abstract text is available yet for this article.
April 16, 2024: Clinical Journal of the American Society of Nephrology: CJASN
Yun-Kai Yeh, Kuan-Hung Lin, Wayne Huey-Herng Sheu, Su-Huey Lo, Yen-Po Yeh, Chien-Ning Huang, Chii-Min Hwu, Chieh-Hsiang Lu
BACKGROUND: We tried to identify the risk factor associate with early chronic kidney disease (CKD) in recently diagnosed type 2 diabetes mellitus patients by utilizing real-world data from Taiwan Diabetes Registry. MATERIALS AND METHODS: Patients with type 2 diabetes mellitus recently diagnosed within 1 year. We divided the study participants into control group and early CKD group. Early CKD was defined as either CKD stage G1 with albuminuria, CKD stage G2 with albuminuria, or CKD stage G3a regardless of albuminuria (Urine-albumin to creatinine ratio (UACR) ≥ 3 mg/mmol)...
April 15, 2024: BMC Nephrology
Safaa Mohammed, Eltayeb AbdAlla, Amal Elhag, Abdelmoniem El-Mardi
BACKGROUND: Renal artery variations are clinically significant due to their implications for surgical procedures and renal function. However, data on these variations in Sudanese populations are limited. This study aimed to determine the prevalence and characteristics of renal artery variations in a Sudanese population. METHODS: A cross-sectional retrospective study was conducted in Khartoum state from October 2017 to October 2020. A total of 400 Sudanese participants who underwent abdominal CT scans were included...
April 15, 2024: BMC Nephrology
Ruoyu Tong, Zhengmao Luo, Xianyang Zhong, Liming Fan, Huangwen Lai, Meng Shen, Yuanhang Huang
This case report presents a detailed analysis of a 31-year-old male patient who presented with a complex array of clinical symptoms, including proteinuria, hematuria, edema, and kidney insufficiency. Despite undergoing multiple tests, the results for anti-glomerular basement membrane antibodies yielded negative findings. Subsequently, kidney biopsy pathology revealed a distinct diagnosis of atypical anti-glomerular basement membrane (anti-GBM) disease with membrane hyperplasia. Treatment was initiated with a comprehensive approach involving high doses of corticosteroids therapy and cyclophosphamide (CTX)...
April 15, 2024: BMC Nephrology
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