Celeste Manfredi, Antonio Franco, Francesco Ditonno, Raman Mathur, Giorgio Franco, Riccardo Lombardo, Giorgio I Russo, Sabrina DE Cillis, Cristian Fiori, Davide Arcaniolo, Alessandro Antonelli, Riccardo Autorino, Marco DE Sio, Cosimo DE Nunzio
INTRODUCTION: Patients' treatment preferences (PTP) depend on the complex interaction of numerous patient- and treatment-related factors; their assessment can guide therapy and promote compliance of patients with erectile dysfunction (ED). We aimed to systematically describe the literature evaluating the treatment preferences of patients with ED, published in the last 25 years. EVIDENCE ACQUISITION: A comprehensive bibliographic search of multiple databases was conducted in June, 2023...
February 2024: Minerva urology and nephrology
Beatriz T Constantinou, Bianca C Benedicto, Breno C Porto, Mikhael Belkovsky, Carlo C Passerotti, Everson L Artifon, Jose P Otoch, Jose A da Cruz
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is considered the gold standard treatment for kidney stones greater than 20 mm. However, retrograde intrarenal surgery (RIRS) may achieve the same stone-free rate with repeated procedures, and potentially fewer complications. This study aimed to compare the efficacy and safety of PCNL and two-staged RIRS. EVIDENCE ACQUISITION: We conducted a systematic search in PubMed, Embase, Scopus, Cochrane, and Web of Science for studies comparing PCNL and RIRS for kidney stones greater than 20mm...
February 2024: Minerva urology and nephrology
Alessandro Volpe, Umberto Capitanio, Mario Falsaperla, Gianluca Giannarini, Carlotta Palumbo, Alessandro Antonelli, Andrea Minervini, Vincenzo Ficarra
INTRODUCTION: Partial nephrectomy (PN) aims to remove renal tumors while preserving renal function without affecting oncological and perioperative surgical outcomes. Aim of this paper is to summarize the current evidence on PN and to provide evidence-based recommendations on indications, surgical technique, perioperative management and postoperative surveillance of PN for renal tumors in the Italian clinical and health care system context. EVIDENCE ACQUISITION: This review is the result of an interactive peer-reviewing process of the recent literature on PN for renal tumors carried out by an expert panel composed of members of the Italian Society of Urology (SIU) Renal Cell Carcinoma Working Group...
February 2024: Minerva urology and nephrology
Maria C Sighinolfi, Bernardo Rocco, Stefano Terzoni, Alessandro Morandi, Margarita Afonina, Simone Assumma, Tommaso Calcagnile, Filippo Turri, Mattia Sangalli, Enrico Panio, Luca Sarchi, Angelica Grasso, Paolo Dell'orto, Efrem Pozzi, Augusto Ramondo, Emanuela Santangelo, Michele Petix, Giorgia Gaia
No abstract text is available yet for this article.
February 2024: Minerva urology and nephrology
Giovanni F M Strippoli, Suetonia C Green
Fewer than half of patients treated with hemodialysis survive 5 years. Multiple therapeutics are used to address the complications of advanced chronic kidney disease but most have not been found to improve clinical outcomes. Clinical trials of treatment innovations for chronic kidney diseases and dialysis care have been suboptimal in number and quality. Recent trials are changing this trend. Practice and policy change when new evidence emerges remains frequently impeded by resource and organizational constraints and accordingly, clinical practice guidelines are updated years or decades after definitive evidence is produced...
February 2024: Clinical Kidney Journal
Massimo Nardone, Vikas S Sridhar, Kevin Yau, Ayodele Odutayo, David Z I Cherney
Volume overload represents a hallmark clinical feature linked to the development and progression of heart failure (HF). Alleviating signs and symptoms of volume overload represents a foundational HF treatment target that is achieved using loop diuretics in the acute and chronic setting. Recent work has provided evidence to support guideline-directed medical therapies, such as sodium glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor (MR) antagonists, as important adjunct diuretics that may act synergistically when used with background loop diuretics in people with chronic HF...
February 29, 2024: Nephrology, Dialysis, Transplantation
Bowen Zhu, Fang Li, Weidong Zhang, Shuan Zhao, Nana Song, Shi Jin, Ziyan Shen, Yufei Lu, Yang Li, Hong Liu
INTRODUCTION: Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population. MATERIALS AND METHODS: The study included 4180 individuals aged 45-85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015...
December 2024: Renal Failure
Biff F Palmer, Deborah J Clegg
Hyperkalemia is a common electrolyte disturbance in both inpatient and outpatient clinical practice. The severity and associated risk depends on the underlying cause and rate of K+ increase. Acute hyperkalemia requires immediate attention due to potentially life-threatening manifestations resulting from the rapid rise in plasma K+ concentration. Treatment is initially focused on stabilizing the cardiac membrane, followed by maneuvers to shift K+ into the cell, and ultimately initiating strategies to decrease total body K+ content...
February 29, 2024: Nephrology, Dialysis, Transplantation
Katherine R Tuttle
No abstract text is available yet for this article.
February 29, 2024: Nephrology, Dialysis, Transplantation
Adrián R Murillo-de-Ozores, Lihe Chen
No abstract text is available yet for this article.
March 1, 2024: Journal of the American Society of Nephrology: JASN
Eugenia Maria Alodia Hartono, Felicia Fransisca Saputra, Angeline Asti Shiela Permata, Jeanne Gabrielle Wibowo
PURPOSE: Intradialytic hypertension affects 5-15% of hemodialysis patients, yet relevant studies are relatively scarce. It is also associated with higher interdialytic blood pressure. Beta-blockers can be preferred as antihypertensive drugs due to their superior blood pressure control, decreased risk of cardiovascular events, improved endothelial cell function, and decreased noradrenaline levels. Through this study, beta-blocker antihypertensive effects in intra- and interdialytic hypertension were analyzed...
March 1, 2024: International Urology and Nephrology
Ellen F Carney
No abstract text is available yet for this article.
February 29, 2024: Nature Reviews. Nephrology
Yu Kong, Qian Hui Guo, Le Zhou, Liu He, Yong Zeng, Xin Du, Jian Zeng Dong, Chao Jiang, Ji Guang Wang, Chang Sheng Ma
INTRODUCTION: Mild cognitive impairment (MCI) is an important intervenable stage for the prevention of dementia. Hypertension is associated with impaired cognition, and when combined with MCI, it may lead to a poor prognosis. Digital computerised cognitive training (CCT) has recently become a potential instrument for improving cognition, but evidence for its efficacy remains limited. This study aims to evaluate the efficacy of a digital adaptive CCT intervention in older patients with hypertension and MCI...
February 29, 2024: BMJ Open
Xiaofan Hu, Jing Xu, Wei Wang, Lili Liu, Yuanmeng Jing, Chenni Gao, Xialian Yu, Yi Li, Li Lin, Jun Tong, Qinjie Weng, Xiaoxia Pan, Wen Zhang, Hong Ren, Guisen Li, Krzysztof Kiryluk, Nan Chen, Jingyuan Xie
INTRODUCTION: The aim of this study was to test whether a combined risk score based on genetic risk and serology can improve the prediction of kidney failure in PLA2R-associated primary membranous nephropathy. METHODS: We performed a retrospective analysis of 519 biopsy-proven PLA2R-associated primary membranous nephropathy patients with baseline eGFR ≥ 25ml/min/1.73m2. The combined risk score was calculated by combining the genetic risk score with PLA2R ELISA antibody titers...
February 29, 2024: Clinical Journal of the American Society of Nephrology: CJASN
Joseph Stavas, Arnold L Silva, Thomas D Wooldridge, Ahmed Aqeel, Theodore Saad, Rachita Prakash, George Bakris
INTRODUCTION: Autologous cell-based therapies (CBT) to treat Chronic Kidney Disease (CKD) with diabetes are novel and can potentially preserve renal function and decelerate disease progression. CBT dosing schedules are in early development and may benefit from individual bilateral organ dosing and kidney-dependent function to improve efficacy and durability. The objective of this open-label, phase 2 randomized controlled trial (RCT) is to evaluate participants' response to rilparencel (Renal Autologous Cell Therapy-REACT®) following bilateral percutaneous kidney injections into the kidney cortex with a prescribed dosing schedule versus re-dosing based on biomarker triggers...
February 29, 2024: American Journal of Nephrology
Érica Cristina Vieira, Milena Soriano Marcolino, Antônio Carlos Martins Guedes, Mônica Maria Moreira Delgado Maciel, Wandilza Fátima Dos Santos, Luciana Consoli Fernandes Pimentel, Paulo Rodrigues Gomes, Anita Bressan, Kátia de Paula Farah, Marcelo Grossi Araújo
BACKGROUND: The prevalence of chronic kidney disease (CKD) has increased in the recent decades, along with the number of patients in the terminal stages of this disease, requiring transplantation. Some skin disorders are more frequent in patients with CKD and in renal transplant recipients (RTR). OBJECTIVES: To evaluate the frequency of skin diseases in RTR and patients with CKD receiving conservative treatment. DESIGN AND SETTING: This observational cross-sectional study recruited consecutive patients with CKD and RTR from a nephrology clinic at a teaching hospital in Brazil between 2015 and 2020...
2024: São Paulo Medical Journal
Yoichi Iwafuchi, Tetsuo Morioka, Yuko Oyama, Ichiei Narita
We describe a case of full-house nephropathy without any underlying disease, including systemic lupus erythematosus. A 40-year-old woman was referred to our hospital with mild proteinuria and microscopic hematuria. The patient was diagnosed with immune complex-mediated glomerulonephritis with a predominant mesangioproliferative pattern based on renal histopathological results using full-house immunofluorescence staining. She showed no clinical criteria for the diagnosis of systemic lupus erythematosus, except for kidney disorders, and tested negative for antinuclear antibodies throughout her clinical course...
February 29, 2024: CEN Case Reports
Christoph Schwarz, Gregor Lindner, Martin Windpessl, Maarten Knechtelsdorfer, Marcus D Saemann
Hyponatremia is a disorder of water homeostasis. Water balance is maintained by the collaboration of renal function and cerebral structures, which regulate thirst mechanisms and secretion of the antidiuretic hormone. Measurement of serum-osmolality, urine osmolality and urine-sodium concentration help to diagnose the different reasons for hyponatremia. Hyponatremia induces cerebral edema and might lead to severe neurological symptoms, which need acute therapy. Also, mild forms of hyponatremia should be treated causally, or at least symptomatically...
February 2024: Wiener Klinische Wochenschrift
Wei Zuo, Xinfei Li, Zihao Tao, Zhihua Li, Kunlin Yang, Qi Tang, Hongjian Zhu, Peng Zhang, Bing Wang, Yaming Gu, Yingzhi Diao, Liqun Zhou, Xuesong Li
No abstract text is available yet for this article.
February 29, 2024: Minerva urology and nephrology
Nisha Bansal, Daniel Weiner, Mark Sarnak
No abstract text is available yet for this article.
February 6, 2024: Journal of the American Society of Nephrology: JASN
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