Kimiaki Takagi, Masashi Mizuno, Kota Kawase, Kenichi Minoshima, Masayoshi Yamaha, Masanobu Horie
BACKGROUND: Outcomes of patients with end-stage renal disease at urgent dialysis initiation are varied, but evidence of their long-term prognosis is limited. We aimed to characterize patients undergoing urgent dialysis initiation and analyse its effect on survival outcome. METHODS: We retrospectively identified 208 patients who began haemodialysis from 1 January 2012 to 31 December 2018 at our hospital. In this observational case-control study, the case group comprised patients starting urgent dialysis, and the control group comprised patients starting planned dialysis...
August 7, 2020: Clinical and Experimental Nephrology
Farah Anum Jameel, Abdul Mannan Junejo, Qurat Ul Ain Khan, Sudeep Date, Ahmad Faraz, Syed Hasan Mustafa Rizvi, Fatima Ahmad, Muhammad Tahir
Introduction Chronic kidney disease (CKD) carries a significant association with cardiac diseases, which suggests a minor reduction in the glomerular filtration rate (GFR) can act as an independent risk factor for causing cardiovascular abnormalities. Patients of CKD having cardiovascular disease (CVD) had three to thirty times higher risk of mortality as compared to the general population. In addition, mortality among cardiovascular patients has been found to be twofold higher in CKD stage 2 patients and three-fold higher in patients with stage 3 CKD, when collated to patients with normal renal function...
July 2, 2020: Curēus
Takaya Ozeki, Shoichi Maruyama, Michio Nagata, Akira Shimizu, Hitoshi Sugiyama, Hiroshi Sato, Hitoshi Yokoyama
BACKGROUND: The Japan Renal Biopsy Registry (J-RBR), the first nation-wide registry of renal biopsies in Japan, was established in 2007, and expanded to include non-biopsy cases as the Japan Kidney Disease Registry (J-KDR) in 2009. The J-RBR/J-KDR is one of the biggest registries for kidney diseases. It has revealed the prevalence and distribution of kidney diseases in Japan. This registry system was meant to be revised after 10 years. METHODS: In 2017, the Committees of the Japanese Society of Nephrology started a project for the revision of the J-RBR/J-KDR...
August 6, 2020: Clinical and Experimental Nephrology
Keith D Brown, Catherine Campbell, Glenda V Roberts
Research in the field of nephrology continues to improve our understanding of the mechanisms that promote and drive kidney disease, including how human genetic variation might affect disease predisposition and progression. One of the goals of these research efforts is to inform and enable the implementation of precision medicine, whereby patient management is tailored to the individual according to the mechanisms underlying their disease to increase the chances of therapeutic success. To achieve this goal, we need a clearer understanding of the molecular pathways that underlie the many different causes of kidney failure...
August 5, 2020: Nature Reviews. Nephrology
Tetiana V Budnik, Tetiana B Bevzenko
OBJECTIVE: The aim: To study the prevalence of ABR among children with UTI over the past 10 years, with an assessment of the sensitivity of E. Coli to common antibiotics in dynamics. PATIENTS AND METHODS: Materials and methods: The study involved 1,044 children with UTI aged from 1 month to 18 years. Examination of patients and interpretation of the results was performed in accordance with the provisions of the Declaration of Helsinki of Human Rights. According to the design, the study included 3 comparison groups: Group 1 - children of the 2009 follow-up year (n = 337), Group 2 - of 2014 (n = 328) and Group 3 - of 2019 (n = 379)...
2020: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Kevin John Fowler
No abstract text is available yet for this article.
August 5, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Dhwanil Patel, Tiffany Truong, Nikhil Shah, Gates B Colbert, Beje Thomas, Juan Carlos Q Velez, Edgar V Lerma, Swapnil Hiremath
Coronavirus disease-2019 (COVID-19) has caused a pandemic that has affected millions of people worldwide. COVID-19 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and is spread by close contact and by respiratory droplets. It has also impacted different aspects of caring for people with kidney disease, including those with acute kidney injury (AKI), chronic kidney disease (CKD), those requiring kidney replacement therapy (KRT), and those with a kidney transplant. All of these patients are considered high risk...
July 25, 2020: Disease-a-month: DM
Carole Ayav, Cécile Couchoud, Bénédicte Sautenet, Thierry Lobbedez, Florence Sens, Olivier Moranne
In France, the method of financing is mainly based on the quantity of care produced. The fixed-rate financing of patients with chronic kidney disease at stage IV or V introduces the notion of payment to quality. Part of the quality assessment will focus on the patients' feelings about their care. The objective of this paper is to assess these indicators used in nephrology, markers in their own right of the quality of care. The patients reported outcomes measures considering the impact of illness or care and the Patient Reported Experience Measures considering their perception of their experience with the health care system or care pathway, are broader than quality of life...
August 1, 2020: Néphrologie & Thérapeutique
Hilary R Teaford, Andrew D Rule, Kristin C Mara, Kianoush B Kashani, John C Lieske, Diana J Schreier, Patrick M Wieruszewski, Erin F Barreto
OBJECTIVE: To characterize the use of cystatin C (cysC) across and within hospitals. PATIENTS AND METHODS: This 2-part study first evaluated access to cysC testing across 129 hospitals in the state of Minnesota, using a telephone-based survey. Second, granular data from a single center (Mayo Clinic) with on-site, rapid-turnaround testing (<1 day) and automated estimated glomerular filtration rate (eGFR) reporting was used to describe temporal patterns. The characteristics of hospitals that offered cysC testing and of patients who underwent rapid cysC testing at Mayo Clinic between January 1, 2011, and March 31, 2018, were described...
August 2020: Mayo Clinic Proceedings
Dick de Zeeuw
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will have to change the current strategies in drug discovery, clinical trials and clinical practice. Target finding and the search for new interventions has to change to include more individual mechanistic approaches. Drugs will be selected on basis of finding the "individual" mechanism of renal function loss by looking at renal tissue biopsies or new biomarkers in urine or plasma...
August 4, 2020: Journal of Nephrology
Giuseppe Gatta
Questo documento è stato tradotto dall'inglese a nome dell'ERBP (European Renal Best Practice), un organo ufficiale dell'ERA-EDTA (European Renal Association - European Dialysis and Transplant Association), e si basa su una pubblicazione ufficiale edita su Nephrology, Dialysis and Transplantation (NDT). ERBP si assume la piena responsabilità solo per la versione completa delle linee guida in originale e in lingua inglese pubblicate su NDT: Gallieni M, Hollenbeck M, Inston N, et al. Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults...
August 3, 2020: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Victor Ea Boom, Laura T van der Kamp, Arjan D van Zuilen, Wendela L De Ranitz, Willem Jan Bos, Wilbert T Jellema, Kwok Wai Mui, Alexander F Later, Monique Prinssen, Karin Kaasjager
INTRODUCTION: eConsultation in nephrology is an innovative way for general practitioners (GPs) to consult a nephrologist. Studies have shown that questions from GPs can be answered and intended referrals can be avoided by eConsultation. However, follow-up data are lacking. The primary aim of this study was therefore to assess whether patients for whom a referral to the outpatient clinic of a medical specialist was avoided in the short term were not then referred for the same problem within one year after the eConsultation...
August 3, 2020: Journal of Telemedicine and Telecare
Wei Gao, Tong-Wen Ou, Xin Cui, Jiang-Tao Wu, Bo Cui
BACKGROUND: Retroperitoneal fibrosis is an exceptionally rare disease characterized by proliferation of fibrous tissue and inflammation in the retroperitoneum. It features many symptoms in the kidneys and in other organs and usually leads to ureteral obstruction. CASE SUMMARY: Here we present 9 consecutive cases of idiopathic retroperitoneal fibrosis (IRPF) in patients who presented to the Department of Nephrology or Department of Rheumatology, Xuanwu Hospital, Capital Medical University, Beijing, China, between January 2012 and June 2017 with ureteral obstruction due to external compression of the ureter that led to hydronephrosis and kidney dysfunction...
July 6, 2020: World Journal of Clinical Cases
Alice Sabatino, Claudia D'Alessandro, Giuseppe Regolisti, Francesca di Mario, Giuseppe Guglielmi, Alberto Bazzocchi, Enrico Fiaccadori
Muscle wasting is a frequent finding in patients with chronic kidney disease (CKD), especially in those with end-stage kidney disease (ESKD) on chronic dialysis. Muscle wasting in CKD is a main feature of malnutrition, and results principally from a vast array of metabolic derangements typical of the syndrome, that converge in determining reduced protein synthesis and accelerated protein catabolism. In this clinical setting, muscle wasting is also frequently associated with disability, frailty, infections, depression, worsened quality of life and increased mortality...
August 2020: Quantitative Imaging in Medicine and Surgery
Vincent Javaugue, Léa Dufour-Nourigat, Estelle Desport, Audrey Sibille, Bruno Moulin, Pierre Bataille, Pascal Bindi, Cyril Garrouste, Christophe Mariat, Lionel Karlin, Mathilde Nouvier, Jean-Michel Goujon, Viviane Gnemmi, Jean-Paul Fermand, Guy Touchard, Frank Bridoux
Immunotactoid glomerulopathy is a rare disease defined by glomerular microtubular immunoglobulin deposits. Since management and long-term outcomes remain poorly described, we retrospectively analyzed results of 27 adults from 21 departments of nephrology in France accrued over19 years. Inclusion criteria were presence of glomerular Congo red-negative monotypic immunoglobulin deposits with ultrastructural microtubular organization, without evidence for cryoglobulinemic glomerulonephritis. Baseline manifestations of this cohort included: proteinuria (median 6...
July 30, 2020: Kidney International
Thomas Hays, Emily E Groopman, Ali G Gharavi
In many cases of chronic kidney disease, the cause of disease remains unknown despite a thorough nephrologic workup. Genetic testing has revolutionized many areas of medicine and promises to empower diagnosis and targeted management of such cases of kidney disease of unknown etiology. Recent studies using genetic testing have demonstrated that Mendelian etiologies account for approximately 20% of cases of kidney disease of unknown etiology. Although genetic testing has significant benefits, including tailoring of therapy, informing targeted workup, detecting extrarenal disease, counseling patients and families, and redirecting care, it also has important limitations and risks that must be considered...
April 24, 2020: Kidney International
Kagnur Ramya, Sriram Krishnamurthy, Ramanitharan Manikandan, Palanisamy Sivamurukan, Bikash Kumar Naredi, Pediredla Karunakar
OBJECTIVE: To study the etiological profile and patterns of clinical presentations of urolithiasis (UL) in children. METHODS: This observational study included patients <18 y with UL, who were referred to the pediatric nephrology clinic. Clinical features, family history, consanguinity and estimated glomerular filtration rate (eGFR) at presentation and follow-up were recorded. The children were evaluated using relevant blood and urine investigations. RESULTS: A total of 72 children with UL were evaluated for the study...
August 1, 2020: Indian Journal of Pediatrics
Min Woo Kang, Navdeep Tangri, Yong Chul Kim, Jung Nam An, Jeonghwan Lee, Lilin Li, Yun Kyu Oh, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee
Predicting the risk of end-stage renal disease (ESRD) progression facilitates appropriate nephrology care of patients with chronic kidney disease (CKD). Previously, the kidney failure risk equations (KFREs) were developed and validated in several cohorts. The purpose of this study is to validate the KFREs in a Korean population and to recalibrate the equations. A total of 38,905 adult patients, including 13,244 patients with CKD stages G3-G5, who were referred to nephrology were recruited. Using the original KFREs (4-, 6- and 8-variable equations) and recalibration equations, we predicted the risk of 2- and 5-year ESRD progression...
July 31, 2020: Scientific Reports
Laura Nishi, Craig Langman, Cybele Ghossein
No abstract text is available yet for this article.
November 2019: Kidney medicine
Lubaina Presswala, Susana Hong, Yael Harris, Isabela Romao, Meng Zhang, Kenar D Jhaveri, Vipul Sakhiya, Steven Fishbane
Rationale & Objective: The accuracy of glycated hemoglobin (HbA1c ) level for assessment of glycemic control in patients with chronic kidney disease (CKD) is uncertain. This study assessed the accuracy of HbA1c level using continuous glucose monitoring. Study Design: Diagnostic test study of HbA1c and serum fructosamine. The continuous glucose monitor was worn for 14 days. Glucose was measured every 15 minutes (up to 1,344 measurements). Average glucose concentration was calculated for each patient from the patient's continuous glucose monitor measurements...
September 2019: Kidney medicine
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