keyword
https://read.qxmd.com/read/34331637/ten-year-experience-of-an-outpatient-clinic-for-ckd-5-patients-with-multidisciplinary-team-and-educational-support
#1
Vincenzo Terlizzi, Massimo Sandrini, Valerio Vizzardi, Mattia Tonoli, Annalisa Facchini, Luigi Manili, Letizia Zeni, Giovanni Cancarini
PURPOSE: To analyze the results of an outpatient clinic with a multidisciplinary team and educational support for patients with late-stage CKD (lsCKD), to check its possible effect on their outcomes. METHODS: Longitudinal cohort study on patients followed up in the MaReA (Malattia Renale Avanzata = CKD5) outpatient clinic at ASST Spedali Civili of Brescia from 2005 to 2015 for at least six months. Trajectory of renal function over time has been evaluated only in those patients with at least four estimations of eGFR before referring to MaReA...
July 31, 2021: International Urology and Nephrology
https://read.qxmd.com/read/34331573/kidney-disease-profile-and-encountered-problems-during-follow-up-in-syrian-refugee-children-a-multicenter-retrospective-study
#2
Ayse Balat, Beltinge Demircioglu Kilic, Bagdagul Aksu, Mehtap Akbalik Kara, Mithat Buyukcelik, Ayse Agbas, Fehime Kara Eroglu, Tulin Gungor, Demet Alaygut, Nurdan Yildiz, Funda Bastug, Bahriye Atmis, Engin Melek, Midhat Elmaci, Sebahat Tulpar, Cemile Pehlivanoglu, Serra Surmeli Doven, Elif Comak, Yilmaz Tabel, Atilla Gemici, Berfin Uysal, Gamze Seval Ozzorlar, Nuran Kuçuk, Ali Delibas, Gul Ozcelik, Nilufer Goknar, Ismail Dursun, Pelin Ertan, Ipek Akil Ozunan, Ferah Sonmez
BACKGROUND: Children are one of the most vulnerable groups in conflict zones, especially those with chronic diseases. This study aimed to investigate kidney disease profiles and problems during follow-up in a population of Syrian refugee children residing in Turkey. METHODS: Syrian refugee children aged between 0 and 18 years were included in the study. Demographic data, diagnosis, particular interventions due to nephrological problems, and problems encountered during follow-up were obtained from all participating pediatric nephrology centers...
July 31, 2021: Pediatric Nephrology
https://read.qxmd.com/read/34331385/modifiable-risk-factors-for-chronic-kidney-disease-in-adulthood-seen-among-school-children-in-asaba
#3
O C Ajaegbu, B U Ezeonwu, O D Emeagui, H U Okafor
BACKGROUND: The burden of chronic kidney disease (CKD) is huge especially in developing countries like Nigeria. In Nigeria, treatment modalities for ESRD (renal replacement therapy) are not readily available and, where available, they are not affordable. Consequently, preventive nephrology aimed at early detection and prompt treatment of children with CKD risk factors has become the viable alternative in curbing this rising problem. AIM: To determine the burden of some modifiable risk factors for CKD in adulthood (hypertension, obesity, proteinuria, and microalbuminuria) among primary school children in Asaba and to ascertain if there is any association between the prevalence of such modifiable risk factors and socio-economic status (SES) or school type of the children...
July 29, 2021: West African Journal of Medicine
https://read.qxmd.com/read/34331378/possible-role-of-the-mitochondrial-genome-in-the-pathogenesis-of-autosomal-dominant-polycystic-kidney-disease
#4
REVIEW
Sayanthooran Saravanabavan, Gopala K Rangan
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic renal disease in adults and is due to heterozygous germ-line variants in either PKD1, PKD2 or rarely other genes. It characterized by marked intra-familial disease variability suggesting that other genetic and/or environmental factors are involved in determining the life-time course ADPKD. Recently, research indicates that polycystin-mediated mitochondrial dysfunction and metabolic re-programming contributes to progression of ADPKD...
July 30, 2021: Nephrology
https://read.qxmd.com/read/34331131/severe-kidney-dysfunction-in-a-child-who-presented-with-constipation-questions
#5
Emre Leventoğlu, Bahar Büyükkaragöz, Kibriya Fidan, Serhat Gürocak
No abstract text is available yet for this article.
July 30, 2021: Pediatric Nephrology
https://read.qxmd.com/read/34331130/severe-kidney-dysfunction-in-a-child-who-presented-with-constipation-answers
#6
Emre Leventoğlu, Bahar Büyükkaragöz, Kibriya Fidan, Serhat Gürocak
No abstract text is available yet for this article.
July 30, 2021: Pediatric Nephrology
https://read.qxmd.com/read/34330770/early-postoperative-basal-insulin-therapy-versus-standard-of-care-for-the-prevention-of-diabetes-mellitus-after-kidney-transplantation-a-multicenter-randomized-trial
#7
Elisabeth Schwaiger, Simon Krenn, Amelie Kurnikowski, Leon Bergfeld, María José Pérez-Sáez, Alexander Frey, David Topitz, Michael Bergmann, Sebastian Hödlmoser, Friederike Bachmann, Fabian Halleck, Susanne Kron, Hildegard Hafner-Giessauf, Kathrin Eller, Alexander R Rosenkranz, Marta Crespo, Anna Faura, Andrea Tura, Peter X K Song, Friedrich K Port, Julio Pascual, Klemens Budde, Robin Ristl, Johannes Werzowa, Manfred Hecking
BACKGROUND: Post-transplantation diabetes mellitus (PTDM) might be preventable. METHODS: This open-label, multicenter randomized trial compared 133 kidney transplant recipients given intermediate-acting insulin isophane for postoperative afternoon glucose ≥140 mg/dl with 130 patients given short-acting insulin for fasting glucose ≥200 mg/dl (control). The primary end point was PTDM (antidiabetic treatment or oral glucose tolerance test-derived 2 hour glucose ≥200 mg/dl) at month 12 post-transplant...
August 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34330769/phase-separation-of-magi2-mediated-complex-underlies-formation-of-slit-diaphragm-complex-in-glomerular-filtration-barrier
#8
Haijiao Zhang, Lin Lin, Jianping Liu, Lifeng Pan, Zhijie Lin, Mingjie Zhang, Jiong Zhang, Ying Cao, Jinwei Zhu, Rongguang Zhang
BACKGROUND: Slit diaphragm is a specialized adhesion junction between the opposing podocytes, establishing the final filtration barrier to urinary protein loss. At the cytoplasmic insertion site of each slit diaphragm there is an electron-dense and protein-rich cellular compartment that is essential for slit diaphragm integrity and signal transduction. Mutations in genes that encode components of this membrane-less compartment have been associated with glomerular diseases. However, the molecular mechanism governing formation of compartmentalized slit diaphragm assembly remains elusive...
August 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34330768/prevention-of-post-transplantation-diabetes-small-steps-big-opportunities
#9
EDITORIAL
Adnan Sharif
No abstract text is available yet for this article.
August 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34330767/novel-insights-into-mechanisms-of-intestinal-phosphate-absorption-in-patients-with-chronic-kidney-disease
#10
EDITORIAL
Kittrawee Kritmetapak, Rajiv Kumar
No abstract text is available yet for this article.
August 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34330731/atypical-haemolytic-uraemic-syndrome-a-case-of-rare-genetic-mutation
#11
Geminiganesan Sangeetha, Jaippreetha Jayaraj, Swathi Ganesan, Sreeapoorva Puttagunta
Complement-mediated kidney disease has been an evolving area in the field of nephrology. Atypical haemolytic uraemic syndrome (aHUS) is a rare thrombotic microangiopathy that affects multiple organs, particularly kidneys. The disease is characterised by a triad of haemolytic anaemia, thrombocytopenia and acute kidney injury (AKI). aHUS is most commonly caused by dysregulation of alternative complement pathway. In contrast to shiga toxin-associated haemolytic uraemic syndrome, diarrheal prodrome is usually absent in children with aHUS...
July 30, 2021: BMJ Case Reports
https://read.qxmd.com/read/34330690/vacuolar-denatured-cast-the-unknown-element-in-the-urinary-sediment
#12
Carlos Martínez-Figueroa, Karen Cortés-Sarabia, Hilda Guadalupe Catalán-Nájera, Micaela Martínez-Alarcón, Enrique Alejandro Molina-Avilés
No abstract text is available yet for this article.
July 27, 2021: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://read.qxmd.com/read/34330689/measurement-of-galactosyl-deficient-iga1-by-the-monoclonal-antibody-km55-contributes-to-predicting-patients-with-iga-nephropathy-with-high-risk-of-long-term-progression
#13
Luis Martín-Penagos, Gema Fernández-Fresnedo, Adalberto Benito-Hernández, Jaime Mazón, Marina de Cos, María Victoria Oviedo, David San Segundo, Marcos López-Hoyos, Javier Gómez-Román, Juan Carlos Ruiz, Emilio Rodrigo
BACKGROUND AND OBJECTIVE: About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years of evolution. Various tools have been developed in recent years designed to predict which of the patients will had poorer outcomes. The value of circulating galactosyl-deficient IgA1 (Gd-IgA1) has been related to a worse evolution of IgAN in several studies. There are also some publications that relate higher APRIL values with a worse evolution. Recently, a new method has been developed that allows measuring the value of circulating Gd-IgA1 in a simpler way than those previously available...
July 27, 2021: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://read.qxmd.com/read/34330368/a-call-for-an-ethics-and-governance-action-plan-to-harness-the-power-of-artificial-intelligence-and-digitalization-in-nephrology
#14
REVIEW
Calvin Wai-Loon Ho, Karel Caals
Digitalization in nephrology has progressed in a manner that is disparate and siloed, even though learning (under a broader Learning Health System initiative) has been manifested in all the main areas of clinical application. Most applications based on artificial intelligence/machine learning (AI/ML) are still in the initial developmental stages and are yet to be adequately validated and shown to contribute to positive patient outcomes. There is also no consistent or comprehensive digitalization plan, and insufficient data are a limiting factor across all of these areas...
May 2021: Seminars in Nephrology
https://read.qxmd.com/read/34330367/ethics-in-research-relevance-for-nephrology
#15
REVIEW
Ariadne A Nichol, Erisa S Mwaka, Valerie A Luyckx
Research is crucial to progress in nephrology. It is important that studies are conducted rigorously from the scientific perspective, as well as in adherence to ethical standards. Traditional clinical research places a high value on individual research subject autonomy. Research questions often include the clinical effectiveness of new interventions studied under highly controlled conditions. Such research has brought the promise of new game-changers in nephrology, such as the sodium-glucose cotransporter 2 inhibitors...
May 2021: Seminars in Nephrology
https://read.qxmd.com/read/34330366/ethical-duties-of-nephrologists-when-patients-are-nonadherent-to-treatment
#16
REVIEW
Jordan A Parsons, Dominic M Taylor, Fergus J Caskey, Jonathan Ives
When providing care, nephrologists are subject to various ethical duties. Beyond the Hippocratic notion of doing no harm, nephrologists also have duties to respect their patients' autonomy and dignity, to meet their patients' care goals in the least invasive way, to act impartially, and, ultimately, to do what is (clinically) beneficial for their patients. Juggling these often-conflicting duties can be challenging at the best of times, but can prove especially difficult when patients are not fully adherent to treatment...
May 2021: Seminars in Nephrology
https://read.qxmd.com/read/34330365/moral-distress-and-moral-injury-in-nephrology-during-the-covid-19-pandemic
#17
REVIEW
Kathryn Ducharlet, Mayuri Trivedi, Samantha L Gelfand, Hui Liew, Lawrence P McMahon, Gloria Ashuntantang, Frank Brennan, Mark Brown, Dominique E Martin
Across the world, challenges for clinicians providing health care during the coronavirus disease 2019 (COVID-19) pandemic are highly prevalent and have been widely reported. Perspectives of provider groups have conveyed wide-ranging experiences of adversity, distress, and resilience. In understanding and responding to the emotional and psychological implications of the pandemic for renal clinicians, it is vital to recognize that many experiences also have been ethically challenging. The COVID-19 pandemic has prompted rapid and extensive transformation of health care systems and widely impacted care provision, heightening the risk of barriers to fulfillment of ethical duties...
May 2021: Seminars in Nephrology
https://read.qxmd.com/read/34330364/in-defense-of-patient-autonomy-in-kidney-failure-care-when-treatment-choices-are-limited
#18
REVIEW
Dominique E Martin, Elmi Muller
Respect for patient autonomy is a primary ethical obligation of health care providers. In kidney health care, clinical practice recommendations commonly include strategies to promote shared decision making with patients and their families about treatment options to promote patient autonomy and improve patient outcomes. However, for many people with kidney failure, treatment options may be unavailable or inaccessible. In these circumstances some clinicians may act paternalistically and withhold information from patients because of a fear of causing harm or because clinicians believe that patient autonomy is not a relevant consideration...
May 2021: Seminars in Nephrology
https://read.qxmd.com/read/34330363/priority-setting-as-an-ethical-imperative-in-managing-global-dialysis-access-and-improving-kidney-care
#19
REVIEW
Valerie A Luyckx, M Rafique Moosa
Priority-setting dilemmas arise when trade-offs must be made regarding the kinds of services that should be provided and to whom, thereby withholding other services from individuals or groups that could benefit from them. Currently, it is practically impossible for lower-income countries to provide dialysis for all patients with kidney failure; however, the fundamental premise of the human right to health, while acknowledging the current resource constraints, is the progressive realization of access to care for all...
May 2021: Seminars in Nephrology
https://read.qxmd.com/read/34330362/what-role-can-the-right-to-health-play-in-advancing-equity-in-kidney-care
#20
REVIEW
Diya Uberoi, Lisa Forman
Kidney disease, whether acute or chronic, is an important health concern for more than 750 million people worldwide. Although its magnitude has been better studied within developed countries, evidence increasingly suggests similar scales of impact in developing and underdeveloped countries. On a shared planet where limited resources and high costs keep life-saving care out of reach for the poor and other structurally disadvantaged populations, addressing health concerns on such a large scale requires a governing basis in the recognition of the universal right to health...
May 2021: Seminars in Nephrology
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