keyword
https://read.qxmd.com/read/36441499/renal-biopsy-diagnosis-of-igg4-related-kidney-disease-with-minor-hematuria-and-mild-renal-dysfunction-lessons-for-the-clinical-nephrologist
#1
JOURNAL ARTICLE
Yu Soma, Miku Kato, Gaku Shimura, Manabu Kamio, Maki Iida
No abstract text is available yet for this article.
November 28, 2022: Journal of Nephrology
https://read.qxmd.com/read/36441498/thoracic-kidney-a-mass-in-the-chest
#2
JOURNAL ARTICLE
Daphne J Theodorou, Stavroula J Theodorou, Lampros K Bourantas, Thomas Tzimas
No abstract text is available yet for this article.
November 28, 2022: Journal of Nephrology
https://read.qxmd.com/read/36441433/effect-of-pioglitazone-on-serum-fgf23-levels-among-patients-with-diabetic-kidney-disease-a-randomized-controlled-trial
#3
JOURNAL ARTICLE
Wutipong Triwatana, Bancha Satirapoj, Ouppatham Supasyndh, Naowanit Nata
AIM: Elevated fibroblast growth factor-23 (FGF23) is an established marker of cardiovascular disease among patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD). Recently, circulating FGF23 positively correlated with insulin resistance level among patients with CKD. Pioglitazone improves insulin sensitivity and it may have potential for treating CKD-related FGF23 overactivity. METHODS: A randomized, open-label, controlled trial was performed among patients with T2DM and CKD...
November 28, 2022: International Urology and Nephrology
https://read.qxmd.com/read/36441281/what-to-do-with-kidney-length-and-volumes-in-large-individuals
#4
EDITORIAL
Guido Filler, Laura Torres-Canchala, Ajay P Sharma, Maria E Díaz González de Ferris, Jaime M Restrepo
No abstract text is available yet for this article.
November 28, 2022: Pediatric Nephrology
https://read.qxmd.com/read/36441018/trends-in-the-incidence-of-kidney-replacement-therapy-comparisons-of-era-usrds-and-japan-registries
#5
JOURNAL ARTICLE
Kunihiro Yamagata
No abstract text is available yet for this article.
November 28, 2022: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36441014/the-new-guidelines-of-the-european-association-of-urology-on-urolithiasis-the-urology-nephrology-intersection
#6
JOURNAL ARTICLE
Giovanni Gambaro, Lazaros Tzelves, Andreas Skolarikos, Mehmet Kanbay, Alberto Ortiz, Mario Cozzolino
No abstract text is available yet for this article.
November 28, 2022: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36441012/clinical-and-genetic-characteristics-of-dent-s-disease-type-1-in-europe
#7
JOURNAL ARTICLE
Carla Burballa, Gerard Cantero-Recasens, Larisa Prikhodina, Francesca Lugani, Karlpeter Schlingmann, Petr V Ananin, Martine Besouw, Detlef Bockenhauer, Leire Madariaga, Aurelia Bertholet-Thomas, Francesca Taroni, Mattia Parolin, Peter Conlon, Dorella Delprete, Dominique Chauveau, Linda Koster-Kamphuis, Marc Fila, Andrea Pasini, Isabel Castro, Giacomo Colussi, Marta Gil, Barian Mohidin, Tanja Wlodkowski, Franz Schaefer, Gema Ariceta
BACKGROUND: Dent's disease type 1 (DD1) is a rare X-linked nephropathy caused by CLCN5 mutations, characterized by proximal tubule dysfunction, including low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrolithiasis-nephrocalcinosis, progressive chronic kidney disease (CKD) and kidney failure (KF). Current management is symptomatic and does not prevent disease progression. Here we describe the contemporary DD1 picture across Europe to highlight its unmet needs. METHODS: A physician-based anonymous international e-survey supported by several European Nephrology Networks/Societies was conducted...
November 28, 2022: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36439984/urinary-extracellular-vesicles-signature-for-diagnosis-of-kidney-disease
#8
JOURNAL ARTICLE
Keiichi Takizawa, Koji Ueda, Masahiro Sekiguchi, Eiji Nakano, Tatsuya Nishimura, Yuko Kajiho, Shoichiro Kanda, Kenichiro Miura, Motoshi Hattori, Junya Hashimoto, Yuko Hamasaki, Masataka Hisano, Tae Omori, Takayuki Okamoto, Hirotsugu Kitayama, Naoya Fujita, Hiromi Kuramochi, Takanori Ichiki, Akira Oka, Yutaka Harita
Congenital disorders characterized by the quantitative and qualitative reduction in the number of functional nephrons are the primary cause of chronic kidney disease (CKD) in children. We aimed to describe the alteration of urinary extracellular vesicles (uEVs) associated with decreased renal function during childhood. By nanoparticle tracking analysis and quantitative proteomics, we identified differentially expressed proteins in uEVs in bilateral renal hypoplasia, which is characterized by a congenitally reduced number of nephrons...
November 18, 2022: IScience
https://read.qxmd.com/read/36438439/enhance-access-to-kidney-transplantation-and-living-kidney-donation-enakt-lkd-statistical-analysis-plan-of-a-registry-based-cluster-randomized-clinical-trial
#9
JOURNAL ARTICLE
Stephanie N Dixon, Kyla L Naylor, Seychelle Yohanna, Susan McKenzie, Dmitri Belenko, Peter G Blake, Candice Coghlan, Rebecca Cooper, Lori Elliott, Leah Getchell, Vincent Ki, Istvan Mucsi, Gihad Nesrallah, Rachel E Patzer, Justin Presseau, Marian Reich, Jessica M Sontrop, Darin Treleaven, Amy D Waterman, Jeffrey Zaltzman, Amit X Garg
BACKGROUND: Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) is a quality improvement intervention designed to enhance access to kidney transplantation and living kidney donation. We conducted a cluster-randomized clinical trial to evaluate the effect of the intervention versus usual care on completing key steps toward receiving a kidney transplant. OBJECTIVE: To prespecify the statistical analysis plan for the EnAKT LKD trial. DESIGN: The EnAKT LKD trial is a pragmatic, 2-arm, parallel-group, registry-based, open-label, cluster-randomized, superiority, clinical trial...
2022: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/36438438/validation-of-the-smh-equations-for-the-estimation-of-the-total-body-water-volume-in-hemodialysis-patients
#10
JOURNAL ARTICLE
Nazanin Noori, Arti Sharma Parpia, Ron Wald, Marc B Goldstein
BACKGROUND: Online dialysis clearance monitors typically provide an accurate value for Kt. A value for V (total body water [TBW]) is required to calculate Kt/V, the measure of the adequacy of the delivered dialysis in hemodialysis (HD) patients. Using bioimpedance spectroscopy (BIS), we previously developed 2 sex-specific equations for the estimation of the TBW, which we have chosen to name the St Michael's Hospital (SMH) equations. OBJECTIVE: The objective of this study was to validate the SMH equations in a second distinct population of patients...
2022: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/36435934/correction-to-effect-of-dapagliflozin-on-the-initial-estimated-glomerular-filtration-rate-dip-in-chronic-kidney-disease-patients-without-diabetes-mellitus
#11
Ryo Shibata, Kensei Taguchi, Yusuke Kaida, Kei Fukami
No abstract text is available yet for this article.
November 26, 2022: Clinical and Experimental Nephrology
https://read.qxmd.com/read/36435684/does-gender-affirming-hormone-therapy-increase-the-risk-of-kidney-disease
#12
REVIEW
Han E Eckenrode, J Caroline Carwie, Lisa M Curtis
Kidney health and manifestation of disease in transgender men, women, and nonbinary individuals are not well understood. Transgender individuals commonly receive gender-affirming hormone therapy (GAHT) to align their outward appearance with their gender. Recent attention to the differences in fundamental kidney parameters has identified that transgender individuals may manifest levels of these biomarkers differently than their cisgender counterparts. Improving understanding of the differences in biomarkers and in the development of kidney disease is essential to providing appropriate kidney care to this vulnerable population...
November 23, 2022: Seminars in Nephrology
https://read.qxmd.com/read/36435683/where-are-they-now-spatial-and-molecular-diversity-of-tissue-resident-macrophages-in-the-kidney
#13
REVIEW
Matthew D Cheung, Anupam Agarwal, James F George
Kidney resident macrophages (KRMs) are involved in homeostasis, phagocytosis, defense against infectious agents, response to insults, inflammation, and tissue repair. They also play critical roles in the pathogenesis and recovery from many kidney diseases such as acute kidney injury. KRMs historically have been studied as one homogenous population, but the wide-ranging roles and phenotypes observed suggest that there is greater heterogeneity than previously understood. Advancements in RNA sequencing technologies (single-cell RNA sequencing and spatial transcriptomics) have identified specific subsets of KRMs that are molecularly, functionally, and spatially distinct with dynamic changes after kidney injury...
November 23, 2022: Seminars in Nephrology
https://read.qxmd.com/read/36435682/covid-19-and-the-kidney-recent-advances-and-controversies
#14
REVIEW
Steven Menez, Chirag R Parikh
Kidney involvement is common in coronavirus disease-2019 (COVID-19), and our understanding of the effects of COVID-19 on short- and long-term kidney outcomes has evolved over the course of the pandemic. Initial key questions centered on the spectrum and degree of acute kidney injury (AKI) in patients hospitalized with severe COVID-19. Investigators worldwide have explored the association between COVID-19-associated AKI and short-term outcomes, including inpatient mortality and disease severity. Even as treatments evolved, vaccinations were developed, and newer viral variants arose, subsets of patients were identified as at continued high risk for major adverse kidney outcomes...
October 19, 2022: Seminars in Nephrology
https://read.qxmd.com/read/36434544/a-comparison-of-the-utility-of-the-urine-dipstick-and-urine-protein-to-creatinine-ratio-for-predicting-microalbuminuria-in-patients-with-non-diabetic-lifestyle-related-diseases-a-comparison-with-diabetes
#15
JOURNAL ARTICLE
Makoto Ogi, Takuya Seto, Yoshinori Wakabayashi
BACKGROUND: The utility of dipstick proteinuria for predicting microalbuminuria in non-diabetic lifestyle-related diseases compared with the urine protein-to-creatinine ratio (uPCR) and the effect of dipstick proteinuria on the cut-off value (CO) and accuracy of uPCR are unclear. METHODS: The subjects included Japanese patients ≥ 18 years old with lifestyle-related diseases who had an estimated glomerular filtration rate of ≥ 15 ml/min/1...
November 24, 2022: BMC Nephrology
https://read.qxmd.com/read/36434513/albuminuria-testing-and-nephrology-care-among-insured-us-adults-with-chronic-kidney-disease-a-missed-opportunity
#16
JOURNAL ARTICLE
Chi D Chu, Neil R Powe, Michael G Shlipak, Rebecca Scherzer, Sri Lekha Tummalapalli, Michelle M Estrella, Delphine S Tuot
BACKGROUND: In chronic kidney disease (CKD), assessment of both estimated glomerular filtration rate (eGFR) and albuminuria are necessary for stratifying risk and determining the need for nephrology referral. The Kidney Disease: Improving Global Outcomes clinical practice guidelines for CKD recommend nephrology referral for eGFR < 30 ml/min/1.73m2 or for urinary albumin/creatinine ratio ≥ 300 mg/g. METHODS: Using a national claims database of US patients covered by commercial insurance or Medicare Advantage, we identified patients with CKD who were actively followed in primary care...
November 24, 2022: BMC Prim Care
https://read.qxmd.com/read/36434355/evaluation-of-lung-ultrasound-to-detect-volume-overload-in-children-undergoing-dialysis
#17
JOURNAL ARTICLE
Lindsay Arthur, Parthak Prodhan, Richard Blaszak, Brendan Crawford, Clare C Brown, Jason Arthur
BACKGROUND: Lung ultrasound is a well-established technique to assess extravascular lung water, a proxy for volume status, in the adult population. Despite its utility, the data are limited supporting the use of ultrasound to evaluate fluid volume status among pediatric patients. Our study uses a simplified ultrasound protocol to evaluate changes in extravascular lung water, represented by b-lines, among pediatric patients undergoing hemodialysis. METHODS: This prospective single-center study included children from birth to 18 years of age...
November 24, 2022: Pediatric Nephrology
https://read.qxmd.com/read/36434354/simultaneous-kidney-and-pancreas-transplantation-in-a-patient-with-nail-patella-syndrome-and-insulin-dependent-diabetes
#18
JOURNAL ARTICLE
Peter Sloane, Janel Darcy Hunter, Jen-Jar Lin, Ashton Chen
BACKGROUND: Nail-patella syndrome (NPS) is a rare autosomal dominant disorder caused by a mutation in LIM-homeodomain transcription factor 1-beta (LMX1B) and characterized by nail dystrophy, skeletal changes, glaucoma, and kidney disease with up to 30% of patients progressing to kidney failure. Autoimmune diseases, including thyroid disease, have been reported previously in patients with NPS. CASE-DIAGNOSIS/TREATMENT: We report the case of a pediatric patient with NPS with kidney failure, hypothyroidism, and type 1 diabetes mellitus...
November 24, 2022: Pediatric Nephrology
https://read.qxmd.com/read/36434353/treatment-of-idiopathic-nephrotic-syndrome-at-onset-a-comparison-between-8-and-12-week-regimens-in-everyday-clinical-practice
#19
JOURNAL ARTICLE
Laura Lucchetti, Antonio Gatto, Alessandra Gianviti, Marina Vivarelli, Francesco Emma, Laura Massella
BACKGROUND: Optimal steroid treatment at onset of idiopathic nephrotic syndrome is still debated. The aim of this study was to analyze the clinical outcome at 24 months of follow-up in patients admitted to our unit for the first episode of steroid-sensitive nephrotic syndrome comparing two different steroid regimens. METHODS: We collected data on patients treated from 1992 to 2007 with prednisone according to the International Study on Kidney Diseases in Children 8-week regimen and since 2008 according to the Arbeitsgemeinschaft fur Padiatrische Nephrologie 12-week regimen...
November 24, 2022: Pediatric Nephrology
https://read.qxmd.com/read/36434262/risk-improvement-and-adverse-kidney-outcomes-in-patients-with-chronic-kidney-disease-findings-from-know-ckd
#20
JOURNAL ARTICLE
Hee Byung Koh, Hyung Woo Kim, Chan-Young Jung, Yaeji Lee, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Joongyub Lee, Yeong Hoon Kim, Dong-Wan Chae, Woo Kyung Chung, Kook-Hwan Oh, Seung Hyeok Han
BACKGROUND: Many trials have attempted to slow the progression of chronic kidney disease (CKD) by modifying specific risk factors, but without achieving satisfactory results. We aimed to evaluate the association between the degree of improvement in multiple risk factors and adverse kidney outcomes. METHODS: This was a prospective observational study of 839 patients with CKD G3-G4. The main predictors were the number of improved risk factors between baseline and year one as follows: a decrease in proteinuria, systolic blood pressure, phosphate, and uric acid, and an increase in hemoglobin and bicarbonate from the baseline status to out of the target range...
November 24, 2022: Journal of Nephrology
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