Hideaki Kuno, Takuya Fujimaru, Nozomi Kadota, Kasumi Konishi, Momoko Sekiguchi, Kimio Watanabe, Yugo Ito, Masahiko Nagahama, Fumika Taki, Toru Hifumi, Norio Otani, Masaaki Nakayama
Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported. Here we report a case of lactic acidosis and euDKA after metformin overdose. A 57-year-old female patient was transferred to our hospital with severe metabolic acidosis and acute kidney injury. She had type 2 diabetes mellitus and was on oral antidiabetic therapy of vildagliptin metformin hydrochloride daily. On the admission day, she had committed suicide by overdosing 50 tablets of vildagliptin metformin hydrochloride, which was equivalent to 25,000 mg of metformin and 2500 mg of vildagliptin...
March 19, 2023: CEN Case Reports
Amar Murdeshwar, Sriram Krishnamurthy, Narayanan Parameswaran, Medha Rajappa, Bobbity Deepthi, Sudarsan Krishnasamy, Sachit Ganapathy, Pediredla Karunakar
BACKGROUND: There is paucity of information regarding the etiology and outcomes of Acute Kidney Disease (AKD) in children. METHODS: The objectives of this cohort study were to evaluate the etiology and outcomes of AKD; and analyze predictors of kidney survival (defined as free of CKD 2, 3a, 3b, 4 or 5). Patients aged 1 month to 18 years who developed AKD over a 4-year-period (January 2018-December 2021) were enrolled. Survivors were followed-up at the pediatric nephrology clinic, and screened for residual kidney injury...
March 18, 2023: Clinical and Experimental Nephrology
Laia Sans, Ismael Vallvé, Joan Teixidó, Josep Manel Picas, Jordi Martínez-Roldán, Julio Pascual
BACKGROUND: A huge amount of clinical data is generated daily and it is usually filed in clinical reports as natural language. Data extraction and further analysis requires reading and manual review of each report, which is a time consuming process. With the aim to test folksonomy to quickly obtain and analyze the information contained in media reports we set up this study. METHODS AND OBJECTIVES: We have used folksonomy to quickly obtain and analyze data from 1631 discharge clinical reports from the Nephrology Department of Hospital del Mar, without the need to create a structured database...
March 15, 2023: Nefrología
Serhan Tuğlular, Valerie Luyckx, Raymond Vanholder, Andrej Skoberne, Andrzej Wiecek, İonut Nistor, Ewa Pawlowicz-Szlarska, Rukshana Shroff, Dymtro Ivanov, Kai-Uwe Eckardt, Edita Noruisiene, Daniel Gallego, Olena Loboda, Mehmet S Sever
People living with kidney disease are among the most vulnerable groups at the time of natural or man-made disasters. In addition to their unpredictable course, armed-conflicts impose a major threat given disruption of infrastructure, sanitation, access to food, water, and medical care. The ongoing war in Ukraine has once more demonstrated the importance of preparedness, organization, coordination and solidarity during disasters. People living with kidney disease face serious challenges given their dependence on life-saving treatment, irrespective of whether they remain in the war zone, or are displaced internally or externally...
March 17, 2023: Nephrology, Dialysis, Transplantation
Ebun L Bamgboye, Manjusha Yadla, Guillermo Garcia-Garcia, Vincent Boima, Privilage D Makanda-Charambira, Mignon I McCulloch, Dwomoa Adu
In the absence of malignancy or other severe comorbidity, kidney transplantation offers better survival rates and quality of life than dialysis. Despite this survival advantage, many lower- and upper-middle-income countries do not offer adequate kidney transplant services. This is particularly troubling because end-stage kidney disease often is more common in these countries than in high-income countries and overall is less costly in the life of a patient. We describe the contrasting levels of provision of kidney transplantation in Mexico, India, Nigeria, Ghana, and Zimbabwe, and kidney transplant services for children in Africa...
March 15, 2023: Seminars in Nephrology
Michael Eder, Lisabeth Pimenov, Georg A Böhmig, Barbara Kornek, Lisa Göschl, Gregor Bond, Matthias G Vossen, Winfried F Pickl, Monika Breuer, Irene Görzer, Nicolas Kozakowski, Hermann Laferl, Stefan Winkler
No abstract text is available yet for this article.
March 17, 2023: Journal of Nephrology
Tuba Vural, Vural Taner Yilmaz, Sadi Koksoy, Abdullah Kisaoglu, Deniz Ozel, Ismail Demiryilmaz, Bulent Aydinli, Huseyin Kocak, Gultekin Suleymanlar
PURPOSE: It is known that vitamin D has positive effects on graft functions (reduce fibrosis, suppress excessive inflammatory response, improve graft functions). In our study, it was aimed to evaluate the effects and predictive roles of vitamin D, the expression of vitamin D receptor (VDR) in lymphocytes, monocytes, natural killer cells on chronic rejection and graft functions in kidney transplant patients. METHODS: Seventy one people were included in the study and analyses were made by dividing them into 3 groups...
March 17, 2023: International Urology and Nephrology
Kevin Gilhaus, Claudia Cepok, David Kamm, Beate Surmann, Pavel I Nedvetsky, Jana Emich, Alina Sundukova, Katharina Saatkamp, Harald Nüsse, Jürgen Klingauf, Dirk O Wennmann, Britta George, Michael P Krahn, Hermann-Joseph Pavenstädt, Beate A Vollenbröker
BACKGROUND: The highly conserved Hippo pathway, which regulates organ growth and cell proliferation by inhibiting transcriptional co-factors YAP/TAZ, plays a special role in podocytes, where activation of the pathway leads to apoptosis. The Ajuba family proteins (Ajuba, LIMD1 and WTIP) can bind and inactivate LATS1/2, two of the Hippo pathway key kinases. WTIP furthermore connects the slit diaphragm (SD), the specialized cell-cell junction between podocytes, with the actin cytoskeleton...
March 16, 2023: Journal of the American Society of Nephrology: JASN
Deniz Karakaya, Tülin Güngör, Evrim Kargın Çakıcı, Fatma Yazılıtaş, Evra Çelikkaya, Sait Can Yücebaş, Mehmet Bülbül
BACKGROUND: Acute post-streptococcal glomerulonephritis (APSGN) is an immune-mediated inflammatory respsonse in the kidneys caused by nephritogenic strains of group A β-hemolytic streptococcus (GAS). The present study aimed to present a large patient cohort of APSGN patients to determine the factors that can be used for predicting the prognosis and progression to rapidly progressive glomerulonephritis (RPGN). METHODS: The study included 153 children with APSGN that were seen between January 2010 and January 2022...
March 16, 2023: Pediatric Nephrology
Giuseppina Spartà, Karine Hadaya, Luc Paunier, Eric Girardin, Ernst Leumann
BACKGROUND: Kidney transplantation in children in 1970 was considered by many to be unethical, as long-term survival was minimal. It was therefore risky at the time to offer transplantation to a child. CASE DIAGNOSIS/TREATMENT: A 6-year-old boy with kidney failure due to haemolytic uraemic syndrome received 4 months of intermittent peritoneal dialysis followed by 6 months of haemodialysis until at 6 years and 10 months, he underwent bilateral nephrectomy and received a kidney transplant from a deceased 18-year-old donor...
March 16, 2023: Pediatric Nephrology
Satoshi Kimura, Kazuyoshi Shimizu, Tatsuo Iwasaki, Tomoyuki Kanazawa, Takashi Morimatsu, Takeru Hatano, Hiroshi Morimatsu
BACKGROUND: The present retrospective study was carried out to determine the incidence of unrecognized cardiac surgery-associated acute kidney injury (CSA-AKI) due to infrequency of serum creatinine (SCr) measurements in pediatric cardiac patients and to assess the association between unrecognized CSA-AKI and clinical outcomes. METHODS: This study was a single-center, retrospective study of pediatric patients who underwent cardiac surgery. Patients were diagnosed with CSA-AKI based on SCr measurements, and unrecognized CSA-AKI was defined under the assumptions that there had been only one or two SCr measurements within 48 h after surgery: CSA-AKI unrecognized by one SCr measurement (AKI-URone), CSA-AKI unrecognized by two SCr measurements (AKI-URtwo), and CSA-AKI recognized by one and two SCr measurements (AKI-R)...
March 16, 2023: Pediatric Nephrology
Elke De Bruyne, Lore Willem, Koen Van Hoeck, Sarah Reynaert, Sylvie Vankerckhove, Brigitte Adams, Stéphanie Leroi, Laure Collard, Aline Michaux, Nathalie Godefroid, Djalila Mekahli, Noël Knops, Sunny Eloot, Ann Raes, Johan Vande Walle, Eline Van Hoecke, Evelien Snauwaert, Elena Levtchenko
BACKGROUND: This cross-sectional study investigated quality of life (QoL) and illness-related parental stress in children with kidney diseases by (1) comparing mean levels of these two variables between several kidney disease categories; (2) exploring correlations between QoL and parental stress; and (3) describing which disease category reports lowest QoL and highest parental stress. METHODS: We included 295 patients with a kidney disease (0-18 years) and their parents, followed at 6 reference centers for pediatric nephrology...
March 16, 2023: Pediatric Nephrology
Peter Nourse, Mignon McCulloch, Ashton Coetzee, Tim Bunchman, Stefano Picca, Jody Rusch, Andre Brooks, Hilton Heydenrych, Brenda Morrow
BACKGROUND: Our previously demonstrated continuous flow peritoneal dialysis (CFPD) technique in children with acute kidney injury (AKI), although effective, was manpower heavy and expensive due to the high-volume pumps required. The aim of this study was to develop and test a novel gravity-driven CFPD technique in children using readily available, inexpensive equipment and to compare this technique to conventional PD. METHODS: After development and initial in vitro testing, a randomised crossover clinical trial was conducted in 15 children with AKI requiring dialysis...
March 16, 2023: Pediatric Nephrology
Tomonori Kimura, Hidekazu Ikeuchi, Mitsuaki Yoshino, Ryuichi Sakate, Shoichi Maruyama, Ichiei Narita, Keiju Hiromura
BACKGROUND: Kidney involvement frequently occurs in systemic lupus erythematosus (SLE), and its clinical manifestations are complicated. We profiled kidney involvement in SLE patients using deep learning based on data from the National Database of Designated Incurable Diseases of Japan. METHODS: We analyzed the cross-sectional data of 1655 patients with SLE whose Personal Clinical Records were newly registered between 2015 and 2017. We trained an artificial neural network using clinical data, and the extracted characteristics were evaluated using an autoencoder...
March 16, 2023: Clinical and Experimental Nephrology
Christian Combe, Sébastien Rubin
No abstract text is available yet for this article.
March 16, 2023: Nephrology, Dialysis, Transplantation
Yan Ma, Yuqian Ren, Di Hui, Lihua Zhang, Chengfeng Jiao, Honglang Xie
BACKGROUND: HbA1c variability may be related to risk of poor prognoses in chronic kidney disease patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate whether HbA1c variability is associated with rapid renal function decline and the related risk factors in type 2 diabetic nephropathy (DN). MATERIALS AND METHODS: An observational analysis was performed on 387 DN patients who were diagnosed by kidney biopsy from January 2006 through January 2016 at the Department of Nephrology, Jinling Hospital Affiliated to Nanjing University...
March 17, 2023: Clinical Nephrology
Dipal M Patel, Nicolas Page, Neera K Dahl
In an era of increased accessibility to genetic testing, nephrologists may be able to better understand pathophysiologic mechanisms by which their patients develop specific conditions. In this study, we describe clinical and genetic findings of two patients with kidney cysts, who were found to have variants in HOGA1 , a mitochondrial 4-hydroxy-2-oxoglutarate aldolase enzyme associated with primary hyperoxaluria type 3 and the development of oxalate-containing kidney stones. We describe possible mechanisms by which mutations in this enzyme could result in the kidney cyst formation seen in our two patients...
March 17, 2023: Clinical Nephrology
Patrycja Kucharczyk, Giuseppe Albano, Christine Deisl, Tin Manh Ho, Matteo Bargagli, Manuel Anderegg, Stephan Wueest, Daniel Konrad, Daniel G Fuster
BACKGROUND: Thiazide diuretics are associated with glucose intolerance and new onset diabetes mellitus. Previous studies demonstrated that thiazides attenuate insulin secretion, but the molecular mechanisms remain elusive. We hypothesized that thiazides attenuate insulin secretion via one of the known molecular thiazide targets in β-cells. METHODS: We performed static insulin secretion experiments with islets of wild-type, NCC (SLC12A3), and NDCBE (SLC4A8) knock-out (KO) mice and with murine Min6 cells with individual knock-down of carbonic anhydrase (CA) isoforms to identify the molecular target of thiazides in β-cells...
March 17, 2023: Journal of the American Society of Nephrology: JASN
Pantelis Sarafidis, Rajiv Agarwal, Bertram Pitt, Christoph Wanner, Gerasimos Filippatos, John Boletis, Katherine R Tuttle, Luis M Ruilope, Peter Rossing, Robert Toto, Stefan D Anker, Zhi-Hong Liu, Amer Joseph, Christiane Ahlers, Meike Brinker, Robert Lawatscheck, George Bakris
Background Patients with stage 4 chronic kidney disease (CKD) and type 2 diabetes have limited treatment options to reduce their persistent cardiovascular and kidney risk. In FIDELITY, a prespecified pooled analysis of FIDELIO-DKD and FIGARO-DKD, finerenone improved heart-kidney outcomes in participants with CKD and type 2 diabetes. Methods This FIDELITY subgroup analysis investigated the effects of finerenone in participants with stage 4 CKD (estimated glomerular filtration rate [eGFR] <30 ml/min/1.73 m2)...
March 17, 2023: Clinical Journal of the American Society of Nephrology: CJASN
Amir Kazory
Compared to women with normal kidney function, women with end-stage kidney disease (ESKD) are much less likely to become pregnant, but more likely to have a complicated pregnancy. While renal transplantation remains the best option for women who desire to have a child, pregnancy on dialysis should be considered an option for those who may not receive a transplant during their reproductive years. Many physicians do not encounter a pregnant patient with ESKD during their nephrology training, and may not feel prepared to provide care for such patients in a busy practice...
March 16, 2023: Hemodialysis International
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