Daniel V O'Hara, Jeffrey K Wong, Bruce Cooper, Germaine Wong, Muh Geot Wong, Hicham Ibrahim Cheikh Hassan
No abstract text is available yet for this article.
April 15, 2021: Journal of Nephrology
Masayuki Tanemoto
This lesson presents a midsummer night's cluster of hypernatremia cases. The cluster developed during consecutive very hot and humid summer days, where profuse sweating could have caused water deficit, the leading cause of hypernatremia. However, all the cases did not have any symptoms indicating hypernatremia and had hypochloremia despite the presence of hypernatremia. It turned out that human error caused the cluster. Clinicians need to suspect spurious electrolyte disorders when the supporting clinical symptoms and laboratory data were absent...
April 15, 2021: Journal of Nephrology
Masatoshi Hara, Shigeru Tanaka, Kumiko Torisu, Yuta Matsukuma, Akihiro Tsuchimoto, Masanori Tokumoto, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono
BACKGROUND: A growing body of evidence has shown that non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). Non-invasive fibrosis assessments of NAFLD such as Fibrosis-4 (FIB-4) index and NAFLD fibrosis score (NFS) have been developed to substitute liver biopsy. Little is known about the association between FIB-4 index or NFS and the components of CKD. METHODS: In the present cross-sectional study, we assessed of 3640 Japanese CKD patients...
April 15, 2021: Clinical and Experimental Nephrology
Samuel Wacrenier, Jérémie Riou, Pierre Jourdain, Fanny Guibert, Nicolas Henry, Assia Djema, Jean-Philippe Coindre, Romain Crochette, Maud Cousin, Anne Croue, Jean-François Subra, Giorgina Piccoli, Jean-François Augusto, Benoit Brilland
BACKGROUND: Lymphopenia is commonly observed in autoimmune diseases, where it has been associated with disease activity or prognosis. However, in ANCA-associated vasculitis (AAV) only few, small-scale studies have been targeted to this issue. Research has not yet focused on AAV with renal involvement (AAV-RI) patients. Thus, the aim of this study was to analyze the association between lymphocyte counts and outcomes in a large cohort of AAV-RI patients. METHODS: We used the Maine-Anjou AAV registry that retrospectively gathers data on consecutive patients affected by AAV in four French Nephrology Centers, recorded since January 2000...
April 15, 2021: Nephrology, Dialysis, Transplantation
Lorenzo Signorini, Gianluigi Zaza, Giovanni Gambaro
No abstract text is available yet for this article.
April 14, 2021: Nephrology, Dialysis, Transplantation
Ram Jagannathan, Kanya Rajagopalan, Julien Hogan, Allyson Hart, Kenneth A Newell, Stephen O Pastan, Rachel E Patzer
Background: Two coding risk variants in the Apo L1 gene ( APOL1 ) underlie most of the excess risk for kidney diseases in recent African ancestry patients. Strength and consistency of the relationship between APOL1 high-risk genotypes and the risk of chronic kidney diseases (CKD) and end-stage renal disease (ESRD) are not uniform. Objective: To conduct a systematic review and meta-analysis of prospective studies assessing the association of APOL1 genotypes and the risk of developing CKD, ESRD, and CKD to ESRD in adults...
2021: International Journal of Nephrology and Renovascular Disease
Kelly A Hyndman, Matthew D Griffin
No abstract text is available yet for this article.
April 14, 2021: Journal of the American Society of Nephrology: JASN
Barry I Freedman, Wylie Burke, Jasmin Divers, Lucy Eberhard, Crystal A Gadegbeku, Rasheed Gbadegesin, Michael E Hall, Tiffany Jones-Smith, Richard Knight, Jeffrey B Kopp, Csaba P Kovesdy, Keith C Norris, Opeyemi A Olabisi, Glenda V Roberts, John R Sedor, Erika Blacksher
BACKGROUND: APOL1 variants contribute to the markedly higher incidence of ESKD in Blacks compared with Whites. Genetic testing for these variants in patients with African ancestry who have nephropathy is uncommon, and no specific treatment or management protocol for APOL1 -associated nephropathy currently exists. METHODS: A multidisciplinary, racially diverse group of 14 experts and patient advocates participated in a Delphi consensus process to establish practical guidance for clinicians caring for patients who may have APOL1 -associated nephropathy...
April 14, 2021: Journal of the American Society of Nephrology: JASN
David Wojciechowski, Alexander Wiseman
The long-term management of maintenance immunosuppression in kidney transplant recipients remains complex. The vast majority of patients are treated with the calcineurin inhibitor tacrolimus as the primary agent in combination with mycophenolate, with or without corticosteroids. A tacrolimus trough target 5-8 ng/ml seems to be optimal for rejection prophylaxis, but long-term tacrolimus-related side effects and nephrotoxicity support the ongoing evaluation of noncalcineurin inhibitor-based regimens. Current alternatives include belatacept or mammalian target of rapamycin inhibitors...
April 14, 2021: Clinical Journal of the American Society of Nephrology: CJASN
Andrea Gibbons, Janet Bayfield, Marco Cinnirella, Heather Draper, Rachel J Johnson, Gabriel C Oniscu, Rommel Ravanan, Charles Tomson, Paul Roderick, Wendy Metcalfe, John L R Forsythe, Christopher Dudley, Christopher J E Watson, J Andrew Bradley, Clare Bradley
OBJECTIVE: To examine quality of life (QoL) and other patient-reported outcome measures (PROMs) in kidney transplant recipients and those awaiting transplantation. DESIGN: Longitudinal cohort questionnaire surveys and qualitative semi-structured interviews using thematic analysis with a pragmatic approach. SETTING: Completion of generic and disease-specific PROMs at two time points, and telephone interviews with participants UK-wide. PARTICIPANTS: 101 incident deceased-donor (DD) and 94 incident living-donor (LD) kidney transplant recipients, together with 165 patients on the waiting list (WL) from 18 UK centres recruited to the Access to Transplantation and Transplant Outcome Measures (ATTOM) programme completed PROMs at recruitment (November 2011 to March 2013) and 1 year follow-up...
April 14, 2021: BMJ Open
Janine Hawkins, Nigel Smeeton, Amanda Busby, David Wellsted, Beth Rider, Julia Jones, Retha Steenkamp, Catherine Stannard, Rachel Gair, Sabine N van der Veer, Claire Corps, Ken Farrington
OBJECTIVES: To examine the relative importance of patient and centre level factors in determining self-reported experience of care in patients with advanced kidney disease treated by maintenance haemodialysis (HD). DESIGN: Analysis of data from a cross sectional national survey; the UK Renal Registry (UKRR) national Kidney patient-reported experience measure (PREM) survey (2018). Centre-level data were obtained from the UKRR report (2018). SETTING: National survey of patients with advanced kidney disease receiving treatment with maintenance HD in UK renal centres in 2018...
April 14, 2021: BMJ Open
Zainab Arslan, Premal Amrishkumar A Patel, Kishore Minhas, Kjell Tullus, Jelena Stojanovic
No abstract text is available yet for this article.
April 14, 2021: Archives of Disease in Childhood
Walter Morale, Concetto Sessa, Ivana Alessandrello, Giorgio Aprile, Dario Galeano, Elisa Giglio, Vincenzo Ficara, Stella Musumeci, Viviana Scollo, Carmelo Zuppardo, Andrea Baglieri, Giovanni Rizza, Pietro Bonomo, Salvatore Modica, Giuseppe Patriarca, Raffaele Elia, Angelo Aliquò, Salvatore Musso
The public emergency caused by Covid-19 has forced health services to reorganize in order to separate positive patients from negative ones. In nephrology, this reorganization involves several levels of assistance concerning hospitalizations, ambulatory care and haemodialysis. Within the Complex Unit of Nephrology in Ragusa, the distribution of nephro-dialytic resources has involved four different hospitals, hence ensuring haemodialysis services for asymptomatic and pauci-symptomatic Covid-19 patients as well as for patients in Covid-Unit, Sub-Intensive Therapy and Intensive Care Unit...
April 14, 2021: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Maria Teresa Sciarrone Alibrandi, Marta Vespa, Giancarlo Joli, Romina Bucci, Elena Brioni, Rodolfo F Rivera
The SARS-CoV-2 (Covid-19) has infected about 124 million people worldwide and the total amount of casualties now sits at a staggering 2.7 million. One enigmatic aspect of this disease is the protean nature of the clinical manifestations, ranging from total absence of symptoms to extremely severe cases with multiorgan failure and death. Chronic Kidney Disease (CKD) has emerged as the primary risk factor in the most severe patients, apart from age. Kidney disease and acute kidney injury have been correlated with a higher risk of death...
April 14, 2021: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Kalie L Tommerdahl, Allison L B Shapiro, Edward J Nehus, Petter Bjornstad
The prevalence of youth-onset diabetes is progressing rapidly worldwide, and poor glycemic control, in combination with prolonged diabetes duration and comorbidities including hypertension, has led to the early development of microvascular complications including diabetic kidney disease, retinopathy, and neuropathy. Pediatric populations with type 1 (T1D) and type 2 (T2D) diabetes are classically underdiagnosed with microvascular complications, and this leads to both undertreatment and insufficient attention to the mitigation of risk factors that could help attenuate further progression of complications and decrease the likelihood for long-term morbidity and mortality...
April 14, 2021: Pediatric Nephrology
Onkar Singh, Partho Mukherjee, M S Sakthivel, Cornerstone Wann, A J P George, Rajesh Gopalakrishnan, Belavendra Antonisamy, Antony Devasia, Santosh Kumar, Nitin S Kekre, J Chandrasingh
OBJECTIVES: Bilateral extracapsular or total orchiectomy (BEO) for prostate cancer is presumed to have psychological consequences after the surgery due to perception of an empty scrotum. Bilateral subcapsular orchiectomy (BSO) was designed to preserve perception of palpable testes. We compared the patients' satisfaction and genital perception following BEO and BSO. MATERIALS AND METHODS: Prostate cancer patients eligible for androgen deprivation therapy who opted for orchiectomy were enrolled in prospective randomized study...
April 13, 2021: International Urology and Nephrology
Yihui Zhai, Xiaoling Ge, Xiaoxiong Liu, Li Xie, Qian Shen, Chengjie Ye, Zhen Shen, Jie Chen, Hong Xu, Xiaobo Zhang
Background: Telemedicine is becoming an emerging innovative supplement to the traditional medical system in China. In the present study, we described the rapid implementation of the telemedicine in pediatrics during the coronavirus disease 2019 (COVID-19) outbreak and explored its value in response to the demand for pediatric medical services during the epidemic. Methods: An Internet-based platform for multidisciplinary online medical consultation was established on February 8, 2020, by a national children's medical center in China...
March 2021: Translational Pediatrics
Vesna Brglez, Barbara Seitz-Polski
No abstract text is available yet for this article.
April 13, 2021: Clinical Journal of the American Society of Nephrology: CJASN
Erin D Michos, Katherine R Tuttle
No abstract text is available yet for this article.
April 13, 2021: Clinical Journal of the American Society of Nephrology: CJASN
Rachel Lennon, Alessia Fornoni
No abstract text is available yet for this article.
April 13, 2021: Clinical Journal of the American Society of Nephrology: CJASN
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