Rizky Andhika, Afiatin Makmun, Yovita Hartantri, Indra Wijaya, Ian Huang
Diagnosis of COVID-19 in end-stage kidney disease (ESKD) patients on hemodialysis is challenging,  as the symptoms are often atypical. Herein, we reported a confimed case of COVID-19 in a patient on maintenance hemodialysis. A 38-year-old man with ESKD on regular hemodialysis initially presented with progressive shortness of breath and dry cough, without fever. He had lymphopenia, and chest X-ray suggested pulmonary edema with cardiomegaly and suspected bilateral bronchopneumonia. The patient clinically improved after 7 days of hospitalization, and was subsequently discharged from hospital...
January 16, 2021: CEN Case Reports
Pokkrong Limwannata, Bancha Satirapoj, Samitti Chotsriluecha, Paramat Thimachai, Ouppatham Supasyndh
BACKGROUND: Malnutrition is highly prevalent and a consequence of inflammation and related comorbidities among patients on maintenance hemodialysis. Oral nutritional supplementation (ONS) is recommended for malnourished patients with kidney failure. The study aimed to evaluate renal-specific oral nutrition (ONCE dialyze) supplement on nutritional status in patients on hemodialysis. METHODS: Patients were randomized into 3 groups; treatment groups received 370 kcal/day of ONCE Dialyze (N = 26) or 370 kcal/day of NEPRO (N = 30) for 30 days...
January 16, 2021: International Urology and Nephrology
Soichiro Yoshida, Taro Takahara, Yuki Arita, Kazuma Toda, Ichiro Yamada, Hajime Tanaka, Minato Yokoyama, Yoh Matsuoka, Ryoichi Yoshimura, Yasuhisa Fujii
PURPOSE: To evaluate the clinical characteristics of genuine- and induced-oligometastatic castration-resistant prostate cancer (OM-CRPC) and assess the therapeutic effect of progressive-site directed therapy (PSDT). METHODS: We performed a retrospective analysis of 45 patients with OM-CRPC. Whole-body diffusion-weighted MRI (WB-DWI) was used to diagnose oligo-progressive disease. Based on the clinical and radiological findings, the OM-CRPCs were classified as genuine or induced...
January 16, 2021: International Urology and Nephrology
Feng-You Kuo, Wei-Chun Huang, Pei-Ling Tang, Chin-Chang Cheng, Cheng-Hung Chiang, Hsiao-Chin Lin, Tzu-Jung Chuang, Shue-Ren Wann, Guang-Yuan Mar, Chun-Peng Liu, Juei-Tang Cheng, Ming-Chang Wu
BACKGROUND: Use of statin has been associated with reduced risk of cardiovascular diseases events and mortality. However, in patients with end-stage renal disease (ESRD), the protective effects of statin are controversial. To evaluate the impact of chronic statin use on clinical outcomes of patients with acute myocardial infarction (AMI) with ESRD. METHODS: We enrolled 8056 patients with ESRD who were initially diagnosed and admitted for first AMI from Taiwan's National Health Insurance Research Database...
January 15, 2021: Postgraduate Medical Journal
Venkatesh K Ariyamuthu, Bekir Tanriover
No abstract text is available yet for this article.
January 15, 2021: Clinical Journal of the American Society of Nephrology: CJASN
Su-Hsin Chang, Massini Merzkani, Krista L Lentine, Mei Wang, David A Axelrod, Siddiq Anwar, Mark A Schnitzler, Jason Wellen, William C Chapman, Tarek Alhamad
BACKGROUND AND OBJECTIVES: Kidneys from hepatitis C virus (HCV) viremic donors have become more commonly accepted for transplant, especially after effective direct-acting antiviral therapy became available in 2014. We examined the contemporary trend of kidney discard from donors with HCV seropositivity and viremia. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from the Organ Procurement and Transplantation Network were used to identify deceased donor kidneys recovered for transplant...
January 15, 2021: Clinical Journal of the American Society of Nephrology: CJASN
Mahmud Islam, Yasin Ozturk, Yener Koc
PURPOSE: Patients on maintenance hemodialysis are vulnerable to viral infections like COVID-19 because of the low chance of obedience and complying with rules besides the need for transfer to distant dialysis facilities. We investigated the impact and clinical effect of treatment of COVID-19 in dialysis patients. METHODS: We included patients on maintenance hemodialysis at different healthcare facilities in Zonguldak city. With the diagnosis of the first infected HD case, all other patients who shared the same session were screened...
January 15, 2021: International Urology and Nephrology
Bonita Falkner, Empar Lurbe
No abstract text is available yet for this article.
January 15, 2021: Pediatric Nephrology
Olga Laszczyńska, Milton Severo, Ana Azevedo
AIM: With the use of a joint model (JM) we investigated how different definitions of baseline serum creatinine (SCr) would affect the association between an acute increase in inpatients' SCr and 30-day mortality and whether this effect depends on premorbid SCr trajectory. METHODS: This was a retrospective study including adult patients admitted to a tertiary acute-care hospital in Porto, Portugal, between January 1, 2013, and December 31, 2015, who had at least two preadmission ambulatory and two inpatients SCr measurements...
December 2020: Nephrology
Kenan Turgutalp, Savas Ozturk, Mustafa Arici, Necmi Eren, Numan Gorgulu, Mahmut Islam, Sami Uzun, Tamer Sakaci, Zeki Aydin, Erkan Sengul, Bulent Demirelli, Yavuz Ayar, Mehmet Riza Altiparmak, Savas Sipahi, Ilay Berke Mentes, Tuba Elif Ozler, Ebru Gok Oguz, Bulent Huddam, Ender Hur, Rumeyza Kazancioglu, Ozkan Gungor, Bulent Tokgoz, Halil Zeki Tonbul, Alaattin Yildiz, Siren Sezer, Ali Riza Odabas, Kenan Ates
BACKGROUND: Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinants of mortality in a large group of MHD patients hospitalized for COVID-19. METHODS: This multicenter, retrospective, observational study collected data from 47 nephrology clinics in Turkey. Baseline clinical, laboratory and radiological characteristics, and COVID-19 treatments during hospitalization, need for intensive care and mechanical ventilation were recorded...
January 14, 2021: BMC Nephrology
Pirunthan Perampalam, Haider M Hassan, Grace E Lilly, Daniel T Passos, Joseph Torchia, Patti K Kiser, Andrea Bozovic, Vathany Kulasingam, Frederick A Dick
DREAM is a transcriptional repressor complex that regulates cell proliferation and its loss causes neonatal lethality in mice. To investigate DREAM function in adult mice, we utilized an assembly defective p107 protein and conditional deletion of its redundant family member p130. In the absence of DREAM assembly, mice displayed shortened survival characterized by systemic amyloidosis, but no evidence of excessive cellular proliferation. Amyloid deposits were found in the heart, liver, spleen, and kidneys, but not the brain or bone marrow...
January 14, 2021: Journal of Clinical Investigation
Eriene-Heidi Sidhom, Choah Kim, Maria Kost-Alimova, May Theng Ting, Keith Keller, Julian Avila-Pacheco, Andrew Jb Watts, Katherine A Vernon, Jamie L Marshall, Estefanía Reyes-Bricio, Matthew Racette, Nicolas Wieder, Giulio Kleiner, Elizabeth J Grinkevich, Fei Chen, Astrid Weins, Clary B Clish, Jillian L Shaw, Catarina M Quinzii, Anna Greka
Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss of podocytes, essential cells of the kidney filter. Curiously, neighboring tubular epithelial cells are spared early in disease, despite higher mitochondrial content. We sought to illuminate non-canonical, cell-specific roles for CoQ, independent of the electron transport chain (ETC). Here we demonstrate that CoQ depletion caused by Pdss2 enzyme deficiency in podocytes results in perturbations in polyunsaturated fatty acid (PUFA) metabolism and the Braf/Mapk pathway, rather than ETC dysfunction...
January 14, 2021: Journal of Clinical Investigation
Patrick Saudan, Sophie De Seigneux, Fadi Haidar
Impact of gliflozines in the treatment of non-diabetic nephropathies and cardiac failure has lately been demonstrated. Tolvaptan has now been recognized in Switzerland as a treatment of hyponatremia. In hemodialysis, some progress has been made in the management of dysfunctional arterio-venous fistulas. A glimmer of hope in the treatment of uremic pruritus? Conservative management of a stable coronary heart disease is also advocated in patients with end-stage kidney disease. Therapy with immune cells may either minimize or remove the need for immunosuppression in renal transplant patients...
January 13, 2021: Revue Médicale Suisse
Joseph Lunyera, Robert M Clare, Karen Chiswell, Julia J Scialla, Patrick H Pun, Kevin L Thomas, Monique A Starks, Clarissa J Diamantidis
BACKGROUND: Undergoing percutaneous coronary intervention (PCI) is a risk factor for AKI development, but few studies have quantified racial differences in AKI incidence after this procedure. METHODS: We examined the association of self-reported race (Black, White, or other) and baseline eGFR with AKI incidence among patients who underwent PCI at Duke University Medical Center between January 1, 2003, and December 31, 2013. We defined AKI as a 0.3 mg/dl absolute increase in serum creatinine within 48 hours, or ≥1...
December 18, 2020: Journal of the American Society of Nephrology: JASN
Konstantin Doberer, Michael Duerr, Philip F Halloran, Farsad Eskandary, Klemens Budde, Heinz Regele, Jeff Reeve, Anita Borski, Nicolas Kozakowski, Roman Reindl-Schwaighofer, Johannes Waiser, Nils Lachmann, Sabine Schranz, Christa Firbas, Jakob Mühlbacher, Georg Gelbenegger, Thomas Perkmann, Markus Wahrmann, Alexander Kainz, Robin Ristl, Fabian Halleck, Gregor Bond, Edward Chong, Bernd Jilma, Georg A Böhmig
BACKGROUND: Late antibody-mediated rejection (ABMR) is a leading cause of transplant failure. Blocking IL-6 has been proposed as a promising therapeutic strategy. METHODS: We performed a phase 2 randomized pilot trial to evaluate the safety (primary endpoint) and efficacy (secondary endpoint analysis) of the anti-IL-6 antibody clazakizumab in late ABMR. The trial included 20 kidney transplant recipients with donor-specific, antibody-positive ABMR ≥365 days post-transplantation...
December 18, 2020: Journal of the American Society of Nephrology: JASN
Hua Sun, Chandra Perez-Gill, Johannes S Schlöndorff, Balajikarthick Subramanian, Martin R Pollak
BACKGROUND: FSGS caused by mutations in INF2 is characterized by a podocytopathy with mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a formin-type actin nucleator, research has focused on its actin-regulating function, providing an important but incomplete insight into how these mutations lead to podocytopathy. A yeast two-hybridization screen identified the interaction between INF2 and the dynein transport complex, suggesting a newly recognized role of INF2 in regulating dynein-mediated vesicular trafficking in podocytes...
December 22, 2020: Journal of the American Society of Nephrology: JASN
Teerawat Thanachayanont, Methee Chanpitakkul, Jukkapong Hengtrakulvenit, Podjanee Watcharakanon, Watcharapong Wisansak, Teerapong Tancharoensukjit, Phosri Kaewsringam, Vinai Leesmidt, Krit Pongpirul, Salyaveth Lekagul, Kriang Tungsanga
AIM: We conducted a prospective cohort study to evaluate the effectiveness of an integrated care model on delaying chronic kidney disease (CKD) progression in routine clinical practice in rural primary care setting. METHODS: After enrollment, patients with stage 3-4 CKD patients from 5 district hospitals in a northern province of Thailand (400 kilometers from Bangkok) received integrated care comprising hospital multidisciplinary care and home visits by community care teams...
January 13, 2021: Nephrology
Flaviu Tosa, Roxana Manaila, Alina Elec, Tudor Moisoiu, Liviu Ghervan, Florin Elec
As coronavirus disease 2019 (COVID-19) caused by the novel virus SARS-CoV-2 is expanding worldwide, kidney involvement seems to be part of the spectrum of its effects. Moreover, the prognosis of the disease seems to be worse in immunocompromised patients when compared to the general population, with 4-5 times higher mortality rates. However, the overall impact on long-term function of the kidney graft is unknown. We report on a case of a 46-year-old kidney transplant recipient who was successfully treated for severe COVID-19 pneumonia...
September 2020: Case Reports in Nephrology and Dialysis
Daniel Cukor, Dawn P Edwards
No abstract text is available yet for this article.
January 13, 2021: Clinical Journal of the American Society of Nephrology: CJASN
Alan M Weinstein, Paul L Kimmel
No abstract text is available yet for this article.
January 13, 2021: Clinical Journal of the American Society of Nephrology: CJASN
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