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JOURNAL ARTICLE
Camille Ng, Angela Penney, Rojin Sharaflari, Akash Pathak, John H Howard Iii, Kuang-Yu Jen
Kidney complications can occur due to infective endocarditis, one of which is glomerulonephritis. Most often, an immune complex or complement-mediated glomerulonephritis is seen on kidney biopsy. In a minor subset of cases, pauci-immune glomerulonephritis may be present. Most often, such patients will demonstrate the presence of antineutrophil cytoplasmic antibodies (ANCA) on serologic testing. A growing number of cases of ANCA-associated glomerulonephritis due to Bartonella endocarditis have been reported...
2024: Case Reports in Nephrology
#2
JOURNAL ARTICLE
Tinika A Montgomery, Hari R Nair, Manali Phadke, Erin Morhardt, Adam Ludvigson, Piruz Motamedinia, Dinesh Singh, Neera K Dahl
RATIONALE & OBJECTIVE: We evaluated the metabolic differences between pure and impure uric acid stone formers in this retrospective study of uric acid kidney stone formers diagnosed between 1996 and 2021. STUDY DESIGN: Demographics and medical history were compared by χ2 tests. Twenty-four-hour urine chemistries were compared using logistic regressions while controlling for demographics and comorbid conditions. SETTING & PARTICIPANTS: Patients from Yale Urology and Nephrology Clinics with a documented kidney stone analysis containing uric acid were included...
September 2024: Kidney medicine
#3
REVIEW
Quan Yao Ho, Joanna Hester, Fadi Issa
Regulatory cell therapies, including regulatory T cells and mesenchymal stromal cells, have shown promise in early clinical trials for reducing immunosuppression burden in transplantation. While regulatory cell therapies may also offer potential for treating autoimmune kidney diseases, data remains sparse, limited mainly to preclinical studies. This review synthesises current literature on the application of regulatory cell therapies in these fields, highlighting the safety and efficacy shown in existing clinical trials...
September 16, 2024: Pediatric Nephrology
#4
REVIEW
Jitendra Meena, Parnika Nangla, Sanjay Ojha, Aditi Sinha, Pankaj Hari, Arvind Bagga
BACKGROUND: Crescentic glomerulonephritis, if not managed promptly, is associated with unsatisfactory outcomes. There are limited studies reporting the outcomes of crescentic glomerulonephritis in children. OBJECTIVES: This systematic review is aimed at synthesizing the data on etiology, clinical profile, and outcomes of crescentic glomerulonephritis in children. DATA SOURCES: We performed a literature search using PubMed, Embase, and Web of Science from inception to January 2024 without language or geographic restrictions...
September 16, 2024: Pediatric Nephrology
#5
JOURNAL ARTICLE
Menka Yadav, Trishla Jadon, Geetika Singh, Kshetrimayum Ghanapriya Devi, Monica Chandan, Priyanka Khandelwal, Jitendra Meena, Thenral S Geetha, Mohammed Faruq, Pankaj Hari, Aditi Sinha, Arvind Bagga
BACKGROUND: Next-generation sequencing has enabled non-invasive diagnosis of type IV collagen disease in clinical settings other than the typical presentation of Alport syndrome (AS). METHODS: We reviewed the clinical and histological records of children diagnosed with Alport syndrome based on next-generation sequencing. Variants on clinical exome sequencing were categorized using ACMG 2015 criteria. RESULTS: During 2015-2023, we found 43 patients (34 boys) with 39 variants in COL4A5 (n = 27), COL4A4 (n = 7), and COL4A3 (n = 5)...
September 16, 2024: Pediatric Nephrology
#6
JOURNAL ARTICLE
Zi Wang, Xiaoying Ma, Shaomei Li, Huaying Pei, Jinghong Zhao, Ying Zhang, Zibo Xiong, Yumei Liao, Ying Li, Qiongzhen Lin, Wenbo Hu, Yulin Li, Zhaoxia Zheng, Liping Duan, Gang Fu, Shanshan Guo, Beiru Zhang, Rui Yu, Li Hao, Guiling Liu, Zhanzheng Zhao, Jing Xiao, Yulan Shen, Yong Zhang, Xuanyi Du, Tianrong Ji, Caili Wang, Lirong Deng, Yingli Yue, Shanshan Chen, Zhigang Ma, Yingping Li, Li Zuo, Huiping Zhao, Xianchao Zhang, Xuejian Wang, Yirong Liu, Xinying Gao, Xiaoli Chen, Hongyi Li, Shutong Du, Cui Zhao, Zhonggao Xu, Li Zhang, Hongyu Chen, Li Li, Lihua Wang, Yan Yan, Yingchun Ma, Yuanyuan Wei, Jingwei Zhou, Yan Li, Fuyun Sun, Jie Dong
BACKGROUND: Hypokalemia has been associated with an increased risk of peritoneal dialysis (PD)-associated peritonitis. However, hypokalemia is commonly associated with malnutrition, inflammation, and severe coexisting comorbidities, which thus are suspected of being potential confounders. This study was aimed at testing whether hypokalemia was independently associated with the occurrence and prognosis of PD-associated peritonitis. METHODS: A national-level dataset from the Peritoneal Dialysis Telemedicine-assisted Platform Cohort (PDTAP) Study was used to explore the independent association of serum potassium with PD-associated peritonitis...
September 15, 2024: Journal of Nephrology
#7
JOURNAL ARTICLE
Kaitlin J Mayne, Rebecca J Sardell, Natalie Staplin, Parminder K Judge, Doreen Zhu, Emily Sammons, David Z I Cherney, Jennifer B Green, Adeera Levin, Roberto Pontremoli, Sibylle J Hauske, Jonathan Emberson, David Preiss, Martin J Landray, Colin Baigent, Christoph Wanner, Richard Haynes, William G Herrington
BACKGROUND AND HYPOTHESIS: Hyperuricaemia and gout are common in chronic kidney disease (CKD). We aimed to assess the effects of sodium-glucose co-transporter-2 (SGLT2) inhibition on uric acid (urate) and gout in patients with CKD. METHODS: The EMPA-KIDNEY trial randomised 6609 patients with CKD (estimated glomerular filtration rate [eGFR] ≥20 and <90 mL/min/1.73m2) to receive either empagliflozin 10 mg daily or matching placebo over a median of two years follow-up...
September 14, 2024: Nephrology, Dialysis, Transplantation
#8
JOURNAL ARTICLE
Sepideh Mahboobi, Rebecca Mollard, Navdeep Tangri, Nicole Askin, Thomas Ferguson, Tahmina Rahman, Rasheda Rabbani, Ahmed M Abou-Setta, Dylan Mackay
BACKGROUND AND HYPOTHESIS: Metabolic acidosis is a common complication of kidney disease and can result in further disease progression. Alkali therapy has been used to treat metabolic acidosis for decades. However, some concerns have been raised regarding its safety and long-term tolerability. Existing data suggest that dietary interventions can be beneficial in the management of chronic kidney disease (CKD). This systematic review and meta-analysis aims to summarize findings from studies comparing dietary interventions with placebo/usual care/no treatment in the management of metabolic acidosis in outpatient adults with CKD...
September 14, 2024: Nephrology, Dialysis, Transplantation
#9
JOURNAL ARTICLE
Shusu Liu, Peiyu Lu, Bixia Yang, Yan Yang, Hua Zhou, Min Yang
BACKGROUND: Although the patient survival rate for many malignancies has been improved with immune checkpoint inhibitors (ICIs), some patients experience various immune-related adverse events (irAEs). IrAEs impact several organ systems, including the kidney. With anti-programmed cell death protein 1 (PD-1) therapy (pembrolizumab), kidney-related adverse events occur relatively rarely compared with other irAEs. However, the occurrence of AKI usually leads to anti-PD-1 therapy interruption or discontinuation...
September 14, 2024: BMC Nephrology
#10
JOURNAL ARTICLE
John Aurora, Theresa Zheng, Julieta Rossi Fortunati, Feyza Erenler
OBJECTIVES: This case report highlights an overlooked cause of hyperglycemia and risk of polypharmacy in a patient with end-stage renal disease (ESRD). CASE SUMMARY: A 75-year-old non-English speaking male with T2DM, hypertension, coronary artery disease status post percutaneous coronary intervention, and ESRD secondary to IgG Kappa nephropathy on nightly peritoneal dialysis reported a loss of appetite, decrease in weight, and an increase in symptoms of depression...
September 12, 2024: Journal of the American Pharmacists Association: JAPhA
#11
JOURNAL ARTICLE
Yifei Wu, Xiao Xu, Quan Wenxiang, Jie Dong
BACKGROUND: Carrying out dialysis at home brings non-medical factors, including social support, or caretaker relationship, and internal features relevant to personality into the forefront. In this study, we aimed to explore the relationship between coping strategies of patients undergoing continuous ambulatory peritoneal dialysis (CAPD) and health outcomes. METHODS: Our post-hoc analysis was based on one previous randomized controlled trial that enrolled 150 incident patients who started CAPD from December 2010 to June 2016...
September 14, 2024: Journal of Nephrology
#12
JOURNAL ARTICLE
Nikola Zagorec, Ivica Horvatić, Dino Kasumović, Besa Osmani, Slavica Sović, Jagoda Nikić, Matija Horaček, Petar Šenjug, Krešimir Galešić, Danica Galešić Ljubanović
Background: C4d deposits are present in a substantial proportion of patients with IgA nephropathy (IgAN), indicating the activation of the lectin pathway (LP) of the complement system. It seems that patients with activated LP have worse renal prognosis. The aim of this study was to investigate the prevalence and prognostic significance of C4d in our cohort of patients with primary IgA nephropathy (pIgAN). Methods: Patients with pIgAN were recruited from a hospital register of kidney biopsies of the Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb...
September 9, 2024: Journal of Clinical Medicine
#13
JOURNAL ARTICLE
María Valdenebro, Jose Portoles, María Luisa Serrano Salazar, Ana Muñoz Sánchez, Ines Alameda-Aguado, Leyre Martín Rodriguez, Felipe Zalamea-Jarrin, Paula López-Sánchez
Introduction : Acute kidney injury (AKI) significantly disrupts vital renal functions and is a common and serious condition in intensive care units (ICUs). AKI leads to extended hospital stays, increases mortality rates, and often necessitates nephrology consultations. Continuous renal replacement therapy (CRRT) plays a central role in managing AKI, requiring a multidisciplinary approach involving nephrologists, intensivists, and anesthesiologists. This study examines the clinical profile and progression of AKI in ICU patients requiring CRRT, with a focus on CRRT indications and modalities...
August 27, 2024: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
Kathryn S Corbett, Danica H Chang, Victoria J Riehl-Tonn, Sofia B Ahmed, Neha Rao, Fareed Kamar, Sandra M Dumanski
Up to 80% of women living with chronic kidney disease (CKD) experience sexual dysfunction, though its link with sexual activity and sexual satisfaction is not well understood. Among older women with CKD treated with hemodialysis, the majority report sexual inactivity, though few describe sexual difficulty and most report high sexual satisfaction. Whether this applies to reproductive-aged females living with CKD is yet unknown. This study aimed to assess the sexual activity, function, and satisfaction of reproductive-aged females living with CKD...
August 30, 2024: Healthcare (Basel, Switzerland)
#15
JOURNAL ARTICLE
Alice L Kennard, Suzanne Rainsford, Kelly L Hamilton, Nicholas J Glasgow, Kate L Pumpa, Angela M Douglas, Girish S Talaulikar
BACKGROUND: Understanding the patient perspective of frailty is critical to offering holistic patient-centred care. Rehabilitation strategies for patients with advanced chronic kidney disease (CKD) and frailty are limited in their ability to overcome patient-perceived barriers to participation, resulting in high rates of drop-out and non-adherence. The aim of this study was to explore patient perspectives and preferences regarding experiences with rehabilitation to inform a CKD/Frailty rehabilitation model...
September 13, 2024: BMC Nephrology
#16
JOURNAL ARTICLE
Carlos Riveros, Sanjana Ranganathan, Yash B Shah, Emily Huang, Jiaqiong Xu, Enshuo Hsu, Michael Geng, Siqi Hu, Zachary Melchiode, Brian J Miles, Nestor Esnaola, Zachary Klaassen, Angela Jerath, Christopher J D Wallis, Raj Satkunasivam
BACKGROUND: Chronic kidney disease (CKD) is associated with higher incidence of major surgery. No studies have evaluated the association between preoperative kidney function and postoperative outcomes across a wide spectrum of procedures. We aimed to evaluate the association between CKD and 30-day postoperative outcomes across surgical specialties. METHODS: We selected adult patients undergoing surgery across eight specialties. The primary study endpoint was major complications, defined as death, unplanned reoperation, cardiac complication, or stroke within 30 days following surgery...
September 13, 2024: BMC Nephrology
#17
JOURNAL ARTICLE
Ying Deng, JiaHui Lai, LeiLe Tang, ShaoMin Li, XingHua Guo, JianHao Kang, Xun Liu
BACKGROUND: Frailty and its components are proposed to associate with kidney function, but little attention is paid to the significance of changes in their status on rapid loss of kidney function. This study aimed to investigate the association between changes in frailty and its components status with rapid loss of renal function. METHODS: This study used data from China Health and Retirement Longitudinal Study (CHARLS). Frailty status was measured using the Fried frailty phenotype (FP) scale, including five components: slowness, weakness, exhaustion, inactivity, and shrinking...
September 13, 2024: BMC Nephrology
#18
REVIEW
Atlas Khan, Krzysztof Kiryluk
Genome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on the risk of human diseases, including chronic kidney disease, type 2 diabetes, heart diseases and inflammatory disorders, but cumulatively explain a substantial fraction of disease risk, underscoring the complexity and pervasive polygenicity of common disorders. This complexity poses unique challenges to the clinical translation of GWAS findings. Polygenic scores combine small effects of individual GWAS risk variants across the genome to improve personalized risk prediction...
September 13, 2024: Nature Reviews. Nephrology
#19
REVIEW
Giulia Chimenti, Anna Magli, Giulia Spanu, Giulia Santagati, Antioco Fois, Linda Njandjo, Cristina Adriana Popa, Massimo Torreggiani, Giorgina Barbara Piccoli
Contraception, pregnancy and fertility are seldom discussed with women receiving dialysis and the medical staff of dialysis centres. Since the majority of women on dialysis are past childbearing age, these themes are not always given proper consideration and this category of patients may be missing important information. Young women of childbearing age who are on dialysis frequently experience sexual dysfunction and hormonal disorders of the hypothalamic-pituitary-gonadal axis. In addition, dialysis often has a relevant psychological impact and affects the person's social role...
September 13, 2024: Journal of Nephrology
#20
JOURNAL ARTICLE
Pauline Perreard, Sarah Castets, Karine Aouchiche, Delphine Bernoux, Daniele Bruno, Mathilde Cailliez, Stéphanie Clave, Marie-Edith Coste, Cécile De Leusse, Pauline Duvant, Florentine Garaix, Laetitia Gauche, Emeline Marquant, Céline Roman, Bertrand Roquelaure, Caroline Rousset Rouvière, Julia Vergier, Michel Tsimaratos, Julie Berbis, Alexandre Fabre, Rachel Reynaud
OBJECTIVE: The aim of this study was to describe the quality of life (QoL) of children with a chronic illness treated in a tertiary multidisciplinary pediatric department in comparison with the general population. STUDY DESIGN: A cross-sectional study was conducted in the tertiary multidisciplinary (nephrology, hepatogastroenterology, endocrinology, diabetology, transplantation) pediatric department of Timone Hospital in Marseille, France. Patients 8-17 years of age with a chronic disease were included during regular follow-up appointments...
September 12, 2024: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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