Giuseppe Schepisi, Vincenza Conteduca, Chiara Casadei, Giorgia Gurioli, Lorena Rossi, Valentina Gallà, Maria Concetta Cursano, Nicole Brighi, Cristian Lolli, Cecilia Menna, Alberto Farolfi, Salvatore Luca Burgio, Amelia Altavilla, Giovanni Martinelli, Ugo De Giorgi
Currently, renal cell carcinoma is characterized by encouraging benefits from immunotherapy that have led to significant results in treatment outcome. The approval of nivolumab primarily as second-line monotherapy and, more recently, the approval of new combination therapies as first-line treatment have confirmed the importance of immunotherapy in this type of tumor. In this context, the chimeric antigen receptor (CAR)-T represents a further step forward in the field of immunotherapy. Initially tested on hematological malignancies, this new therapeutic approach is also becoming a topic of great interest for solid tumors...
2020: Frontiers in Oncology
Artsiom Klimko, Georgiana A Toma, Nona Bejinariu, Silviu-Mihai Secareanu, Iuliana Andreiana
We report a patient with IgM-predominant type I cryoglobulinemia (CG), who presented to our nephrology department with acute kidney injury. He was previously diagnosed with sensorimotor neuropathy, which was in remission with maintenance dose of corticosteroids. Upon admission, there were ulcerated, necrotic cutaneous lesions localized to the inner aspect of the thighs bilaterally. Further workup revealed a mucosa-associated lymphoid tissue lymphoma, causing type I CG. Screening tests for hepatitis viruses were negative at this time...
September 14, 2020: Curēus
Tyler J Ryan, Alik Farber, Thomas W Cheng, Stephen J Raulli, Kristiana Sather, Quinten G Dicken, Scott R Levin, Yixin Zhang, Jeffrey J Siracuse
OBJECTIVE: Arteriovenous (AV) access is the preferred hemodialysis (HD) modality to avoid complications associated with tunneled dialysis catheters (TDCs). Despite efforts to create timely AV access, many patients still initiate HD through TDCs. Our goal was to determine patient factors associated with having TDCs present at initial AV access creation and how this impacts survival. METHODS: We performed a single-center, retrospective review of all patients undergoing initial AVF creations between 2014 and 2019...
October 14, 2020: Journal of Vascular Surgery
Pınar Yılmazbaş, Gökçe Velioğlu Haşlak, Hasan Dursun
Hypertension (HTN) and obesity prevalences are rising in childhood and it is important to evaluate associations of these situations. The objective of this study is to investigate the relationship between HTN and body fat ratios (BFR) in children. This cross-sectional study was conducted among 134 participants who were directed to pediatric nephrology outpatient clinic with the prediagnosis of primary HTN. Weight, height, body fat ratio, blood pressure, and ambulatory blood pressure monitor (ABPM) was carried out for all the participants...
October 15, 2020: Journal of Human Hypertension
Alexander J Kula, Michael J G Somers
No abstract text is available yet for this article.
October 15, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Michael R Rudnick, Rachel Hilburg
No abstract text is available yet for this article.
October 15, 2020: American Journal of Nephrology
Priya Pais, Tom D Blydt-Hansen, John A Michael Raj, Luca Dello Strologo, Arpana Iyengar
After 2 decades as a low-cost transplant centre in India, our rates of kidney transplantation are low compared to the burden of end-stage kidney disease (ESKD). We performed this study to identify possible barriers inhibiting paediatric kidney transplant and to assess the outcomes of paediatric ESKD. A retrospective chart review of ESKD patients (2013 - 2018) at a tertiary paediatric nephrology centre was conducted. Medical/non-medical barriers to transplant were noted. Patient outcomes were classified as "continued treatment," "lost to follow-up (LTFU)" or "died...
October 15, 2020: Pediatric Transplantation
Giorgina Barbara Piccoli
No abstract text is available yet for this article.
October 9, 2020: Journal of Nephrology
A Jose, A J Binu, K E Cherian, N Kapoor, H S Asha, T V Paul
Objective: Vitamin D deficiency is widely prevalent worldwide. This has led to a significant surge in referrals for vitamin D assessment in recent years. The cost-effectiveness and rationalization of this practice is uncertain. This study aimed to evaluate the referral pattern for vitamin D testing from a tertiary center in southern India. Materials and Methods: This was a cross-sectional study done over a period of one year (2017). A total of 95,750 individuals, referred for vitamin D screening were included in this study...
October 7, 2020: Journal of Postgraduate Medicine
Nathan Chang, Karley Mariano, Lakshmi Ganesan, Holly Cooper, Kevin Kuo
BACKGROUND: Disorders of water and sodium balance can occur after brain injury. Prolonged polyuria resulting from central diabetes insipidus and cerebral salt wasting complicated by gradient washout and a type of secondary nephrogenic diabetes insipidus, however, has not been described previously, to the best of our knowledge. We report an unusual case of an infant with glioblastoma who, after tumor resection, was treated for concurrent central diabetes insipidus and cerebral salt wasting complicated by secondary nephrogenic diabetes insipidus...
October 10, 2020: Journal of Medical Case Reports
Mario Prieto-Velasco, María Dolores Del Pino Y Pino, Juan Manuel Buades Fuster, Lourdes Craver Hospital, Ramón Pons Prades, Juan Carlos Ruiz San Millán, Mercedes Salgueira Lazo, Patricia de Sequera Ortiz, Nicanor Vega Díaz
BACKGROUND AND OBJECTIVE: Recently, the Advanced Chronic Kidney Disease Units (UERCA, in Spanish) have been developed in Spain to offer a better quality of life to patients with advanced chronic kidney disease (ACKD), improving their survival and reducing morbidity in this phase of the disease. Nowadays, there is not much evidence in the Spanish and international literature regarding the structure and how to achieve these objectives in the UERCA. From the ERCA working group of the Spanish Society of Nephrology (SEN), this project is promoted to improve care for ERCA patients through the definition of quality standards for the operation of the UERCA...
October 5, 2020: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Markus M Rinschen, Julio Saez-Rodriguez
Kidney research is entering an era of 'big data' and molecular omics data can provide comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics, proteomics and metabolomics generate data that relate more directly to the pathological symptoms and clinical parameters observed in patients. Owing to its complexity, the proteome still holds many secrets, but has great potential for the identification of drug targets. Proteomics can provide information about protein synthesis, modification and degradation, as well as insight into the physical interactions between proteins, and between proteins and other biomolecules...
October 7, 2020: Nature Reviews. Nephrology
(no author information available yet)
No abstract text is available yet for this article.
October 7, 2020: Nature Reviews. Nephrology
Giacomo Mori, Gaetano Alfano, Francesco Fontana, Riccardo Magistroni
In March 2020, a 74-year-old man affected by end-stage renal disease and on peritoneal dialysis was referred to an emergency room in Modena, Northern Italy, due to fever and respiratory symptoms. After ruling out COVID-19 infection, a diagnosis of chronic obstructive pulmonary disease exacerbation was confirmed and he was thus transferred to the nephrology division. Physical examination and blood tests revealed a positive fluid balance and insufficient correction of the uraemic syndrome, although peritoneal dialysis prescription was maximised...
October 7, 2020: BMJ Case Reports
Hao Mei, Niuniu Wu, Xiao Huang, Zheng Cui, Jingya Xu, Xiawen Yang, Fang Zeng, Kaiping Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Silkworm faeces are the dry faeces of the insect Bombyx mori (Linnaeus) and have historically been used in traditional Chinese medicine to treat blood deficiency and rheumatic pain. Silkworm faeces extract (SFE) is derived from silkworm faeces. AIM OF THE STUDY: Clinical observations of patients in the Department of Nephrology have shown that SFE effectively improves renal anaemia. However, the molecular mechanism remains unclear...
October 3, 2020: Journal of Ethnopharmacology
Marcus G Bastos, Ana Luisa Vieira, Marcelo Mazza do Nascimento, Elvino Barros, José Muniz Pazeli, Gianna Mastroianni Kirsztajn
INTRODUCTION: Point-of-care ultrasonography (US) (POCUS) has been used in several specialties, particularly in medical emergency. Despite the confirmation of its numerous benefits, the use of POCUS is still timid in nephrology. In the present study, we aim to investigate the use of POCUS by Brazilian nephrologists. METHODS: A survey carried out among the members of the Brazilian Society of Nephrology, through institutional e-mail, using the SurveyMonkey platform...
October 5, 2020: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Marlies Ostermann, Alexander Zarbock, Stuart Goldstein, Kianoush Kashani, Etienne Macedo, Raghavan Murugan, Max Bell, Lui Forni, Louis Guzzi, Michael Joannidis, Sandra L Kane-Gill, Mathieu Legrand, Ravindra Mehta, Patrick T Murray, Peter Pickkers, Mario Plebani, John Prowle, Zaccaria Ricci, Thomas Rimmelé, Mitchell Rosner, Andrew D Shaw, John A Kellum, Claudio Ronco
Importance: In the last decade, new biomarkers for acute kidney injury (AKI) have been identified and studied in clinical trials. Guidance is needed regarding how best to incorporate them into clinical practice. Objective: To develop recommendations on AKI biomarkers based on existing data and expert consensus for practicing clinicians and researchers. Evidence Review: At the 23rd Acute Disease Quality Initiative meeting, a meeting of 23 international experts in critical care, nephrology, and related specialties, the panel focused on 4 broad areas, as follows: (1) AKI risk assessment; (2) AKI prediction and prevention; (3) AKI diagnosis, etiology, and management; and (4) AKI progression and kidney recovery...
October 1, 2020: JAMA Network Open
Alexander Wiseman, Enver Akalin, Darshana Dadania, Angelo DeMattos, Mona Doshi, John Friedewald, Christina Klein, Nicolae Leca, Kim Nicoll, Todd Pesavento, Luke Preczewski, Millie Samaniego, Neeraj Singh, Roy Bloom
The management of a kidney transplant program has evolved significantly in the last decades to become a highly specialized, multidisciplinary standard of care for end stage kidney disease. Transplant center job descriptions have similarly morphed with increasing responsibilities to address a more complex patient mix, increasing medical and surgical therapeutic options, and increasing regulatory burden in the face of an ever-increasing organ shortage. Within this evolution, the role of the Kidney Transplant Medical Director (KTMD) has expanded beyond the basic requirements described in the United Network for Organ Sharing bylaws...
October 5, 2020: American Journal of Transplantation
Marco Cappa, Mohamad Maghnie, Vincenza Carbone, Laura Chioma, Carmela Errichiello, Claudia Giavoli, Mario Giordano, Laura Guazzarotti, Antonella Klain, Giovanni Montini, Luisa Murer, Maria Parpagnoli, Carmine Pecoraro, Sabino Pesce, Enrico Verrina
Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of these guidelines has never been tested. Aims: The objective of this study was to establish the level of adherence to international guidelines based on the 2006 consensus and the 2019 criteria that lead to the initiation of growth hormone treatment by both pediatric endocrinologists and pediatric nephrologists...
2020: Frontiers in Endocrinology
William P Martin, James White, Francisco J López-Hernández, Neil G Docherty, Carel W le Roux
Obesity is a major factor in contemporary clinical practice in nephrology. Obesity accelerates the progression of both diabetic and non-diabetic chronic kidney disease and, in renal transplantation, both recipient and donor obesity increase the risk of allograft complications. Obesity is thus a major driver of renal disease progression and a barrier to deceased and living donor kidney transplantation. Large observational studies have highlighted that metabolic surgery reduces the incidence of albuminuria, slows chronic kidney disease progression, and reduces the incidence of end-stage kidney disease over extended follow-up in people with and without type 2 diabetes...
2020: Frontiers in Endocrinology
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