Skin cancer, family medicine

Ali Kashkooe, Frough Afsari Sardari, Mahkameh Moradi Mehrabadi, Mohammad M Zarshenas
BACKGROUND: Adiantum capillus-veneris L. (Family: Pteridaceae) is a well-known safe medicinal herb used in traditional and modern medicine due to its beneficial pharmacological properties. Current study aimed to compile a review on phytochemicals, pharmacological properties and toxicological effects of this plant. METHODS: An incisive search was conducted through electronic scientific databases including PubMed, Scopus, ScienceDirect, and Cochrane Library using keyword 'Adiantum capillus-veneris'...
March 16, 2020: Current Drug Discovery Technologies
Caroline A Nelson, Lourdes Maria Pérez-Chada, Andrew Creadore, Sara Jiayang Li, Kelly Lo, Priya Manjaly, Ashley Bahareh Pournamdari, Elizabeth Tkachenko, John S Barbieri, Justin M Ko, Alka V Menon, Rebecca Ivy Hartman, Arash Mostaghimi
Importance: The use of artificial intelligence (AI) is expanding throughout the field of medicine. In dermatology, researchers are evaluating the potential for direct-to-patient and clinician decision-support AI tools to classify skin lesions. Although AI is poised to change how patients engage in health care, patient perspectives remain poorly understood. Objective: To explore how patients conceptualize AI and perceive the use of AI for skin cancer screening. Design, Setting, and Participants: A qualitative study using a grounded theory approach to semistructured interview analysis was conducted in general dermatology clinics at the Brigham and Women's Hospital and melanoma clinics at the Dana-Farber Cancer Institute...
March 11, 2020: JAMA Dermatology
Meng-Ting Zuo, Zi-Yuan Wang, Kun Yang, Yu-Juan Li, Chong-Ying Huang, Yan-Chun Liu, Hui Yu, Xue-Jiao Zhao, Zhao-Ying Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Herbal medicine contains hundreds of natural products, and studying their absorption, metabolism, distribution, and elimination presents great challenges. Gelsemium elegans (G. elegans) is a flowering plants in the Loganiaceae family. The plant is known to be toxic and has been used for many years as a traditional Chinese herbal medicine for the treatment of rheumatoid arthritis, neuropathic pain, spasticity, skin ulcers and cancer. It was also used as veterinary drugs for deworming, promoting animal growth, and pesticides...
January 24, 2020: Journal of Ethnopharmacology
Roque Spinelli, Laura Andrea Barrero Guevara, Javier Alejandro López, Carolina Muñoz Camargo, Helena Groot de Restrepo, Alvaro Sebastián Siano
The use of preparations derived from frog skins for curative purposes antedates research history and is perpetuated in current medicine. The skins of anuran's (frogs and toads) are a rich source of compounds with a great importance in the search of antibiotics, analgesics, immunomodulators, enzymatic inhibitors and antitumoral agents applying to human health. Nowadays, cancer is the second most common cause of mortality with more than 8.2 million of deaths worldwide per year. Acute monocytic leukemia is the subtype M5 of acute myeloid leukemia (AML) a cancer type with reduced survival rates in patients...
January 23, 2020: Toxicon: Official Journal of the International Society on Toxinology
Bharat Singh, Ram A Sharma
Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India. In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species...
December 15, 2019: Phytotherapy Research: PTR
Kenneth J Helmandollar, Nathan C Lorei, Barak C Clement, Kara R Hoverson, Nicholas F Logemann
INTRODUCTION: Compared to their civilian counterparts, military personnel can have more exposure to sunlight and, as recent studies have shown, do have an increased incidence of melanoma. Given the inherent challenges service members may face in getting appropriate care whether because of operational tempo, deployments, and/or austere locations, many are initially diagnosed by specialties other than dermatology. In this study, we sought to determine if patients within the military health system were receiving appropriate follow-up management after biopsies by non-dermatologists led to the diagnosis of melanoma by pathology...
October 28, 2019: Military Medicine
Fenglian Wu, Jun Zhu, Guoliang Li, Jiaxin Wang, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Qingfu Zhang
Siberian ginseng , perennial herb belongs to Araliaceae family used in traditional medicines to treat hypertension, thrombus, inflammation and cancer. In the present study, we biosynthesized goldnanoparticles using Siberian ginseng aqeous extract in a cost effective manner. The synthesized Siberian ginseng gold nanoparticle (SG-GNPs) were characterized using UV-Vis spec, HR-TEM, XRD, FTIR, SAED analysis. UV-Vis spectroscopic analysis showed a surface Plasmon resonance peak at 538 nm which does not reduce till 30 days of incubation...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Luis Liu Pérez, Benjamin Bashline
Primary care physicians play an important role in skin cancer prevention. Counseling on modifiable risk factors and sun-avoidance strategies, particularly for patients with a personal or family history of skin cancer, should be part of preventive medicine. Patients should be educated about selection and application of sunscreen. The American Academy of Dermatology recommends use of water-resistant, broad-spectrum sunscreens with a sun protection factor of 30 or higher. Patients also should be educated about the evidence against use of tanning beds and the potential roles of diet and dietary supplementation in skin cancer prevention...
June 2019: FP Essentials
Оlena О Оshyvalova, Oleg L Ziukov, Vitaliy G Gurianov
OBJECTIVE: Introduction: Early detection of people at risk of skin cancer will reduce the incidence of disease, lower the cost of health technologies and decrease anxiety level in patients. The aim of the work is to create a prognostic model for identifying people at increased risk of skin cancer development. PATIENTS AND METHODS: Material and methods: We used the results of our previous research on identifying risk factors in patients with actinic keratosis (AK), squamous cell carcinoma in situ (SCCis) and cutaneous squamous cell carcinoma (cSCC), who were under dynamic observation at the State Institution of Science "Research and Practical Centre of Preventive and Clinical Medicine" State Administrative Department (hereinafter SIS) in 2014-2017...
2019: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Feras M Ghazawi, Nebras Alghazawi, Michelle Le, Elena Netchiporouk, Steven J Glassman, Denis Sasseville, Ivan V Litvinov
The applications of disease cluster investigations in medicine have developed rather rapidly in recent decades. Analyzing the epidemiology of non-random aggregation of patients with a particular disease fostered identification of environmental and external exposures as disease triggers and promoters. Observation of patient clusters and their association with nearby exposures, such as Dr. John Snow's astute mapping analysis in the mid-1800's, which revealed proximity of cholera patients in London to a contaminated water pump infected with Vibrio cholerae , have paved the way for the field of epidemiology...
2019: Frontiers in Oncology
Cristiana Tanase, Ionela Daniela Popescu, Ana-Maria Enciu, Ancuta Augustina Gheorghisan-Galateanu, Elena Codrici, Simona Mihai, Lucian Albulescu, Laura Necula, Radu Albulescu
Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF-VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas...
May 2019: Oncology Letters
Anna Lee, Aleksandra Kuczmarska-Haas, Meghan W Macomber, Kaitlin Woo, Chris Freese, Zachary S Morris
Purpose: Complementary and alternative medicines (CAMs) are widely used by patients with cancer. However, little is known about the extent to which these potential remedies are used internationally to treat the most common toxicities of radiation therapy. We report on the results of an international survey that assessed the use of CAMs. Methods and Materials: Surveys were distributed to 1174 practicing radiation oncologists. Questions evaluated the perceptions of CAMs and specific practice patterns for the use of CAM remedies in the treatment of common radiation-induced toxicities (eg, skin, fatigue, nausea, diarrhea, and mucositis/xerostomia)...
January 2019: Advances in Radiation Oncology
Nigatu Tuasha, Beyene Petros, Zemede Asfaw
Background: This systematic review aimed at examining the use patterns of Ethiopian anticancer traditional medicinal plants (MPs) in view of recommending further validation studies. Methods: The information was retrieved from PubMed according to the PRISMA guideline. The electronic library of Addis Ababa University and relevant church-based religious books were also inspected for additional data. Results: From 34 studies meeting specific inclusion/exclusion criteria, 119 anticancer MP species distributed in 98 genera and 57 families were recorded...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Kanika Patel, Vikas Kumar, Amita Verma, Mahfoozur Rahman, Dinesh K Patel
There is a need for the development of liposomes based nanomedicines formulation for better efficacy and safety of the available drugs in the market. Liposomes have various applications in the field of pharmaceutical and medical field for their drug target potential, diagnostic importance and imaging techniques. Natural plant based drugs and their derivatives have been used in the medicine, nutraceuticals, perfumery, cosmetic and beverages industry. More than half of the prescribed drugs in the worldwide are mainly derived from different natural sources...
2019: Recent Patents on Anti-infective Drug Discovery
Marjorie A Bowman, Anne Victoria Neale, Dean A Seehusen
Some aspects of the health of Americans are declining, and family medicine is addressing these ailments. Obesity is one factor, and family physicians provide nutrition counseling. Despite new models such as direct primary care, we have not found an ideal method for providing primary care to everyone in our health system. Not all family physicians report burnout: what is their secret? Scribes: some positives and negatives from one group. Rural America is in need of more family physicians who provide prenatal and natal care, and the proof is in the infant mortality rate...
July 2018: Journal of the American Board of Family Medicine: JABFM
Annadurai Senthilkumar, Noushad Karuvantevida, Luca Rastrelli, Shyam S Kurup, Abdul J Cheruth
Moringa is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, Moringa peregrina is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values. The plant parts are used in folk medicine for many human health care purposes including diabetes, wound healing, disinfectant, fever, constipation, muscle pains, slimness, burns, labor pain, hypertension, malaria, stomach disorder, asthma, skin problems, and to expel a retained placenta...
2018: Frontiers in Pharmacology
Branka Marinović
On a Sunday afternoon almost six months ago, we were deeply moved by the news that our Krešimir is no longer with us. The sad news spread from Sarajevo with the speed only most horrible and saddest news can achieve. And everybody who was reached by these news wondered whether it was possible and whether it was true. Because our professor Kostović left us a day before his 48th birthday. Krešimir Kostović was born on the 16th October 1969 in Zagreb, where he completed primary and secondary education. He enrolled at the University of Zagreb School of Medicine in 1988, and got his medical degree in 1995...
April 2018: Acta Dermatovenerologica Croatica: ADC
Brech Aikman, Andreia de Almeida, Samuel M Meier-Menches, Angela Casini
Aquaporins (AQPs) are membrane proteins allowing permeation of water, glycerol & hydrogen peroxide across biomembranes, and playing an important role in water homeostasis in different organs, exocrine gland secretion, urine concentration, skin moisturization, fat metabolism and neural signal transduction. Notably, a large number of studies showed that AQPs are closely associated with cancer biological functions and expressed in more than 20 human cancer cell types. Furthermore, AQP expression is positively correlated with tumour types, grades, proliferation, migration, angiogenesis, as well as tumour-associated oedema, rendering these membrane channels attractive as both diagnostic and therapeutic targets in cancer...
May 23, 2018: Metallomics: Integrated Biometal Science
Mary Beth Campbell, Wesley C Campbell, James Rogers, Natalie Rogers, Zachary Rogers, Anne Marie van den Hurk, Annie Webb, Talon Webb, Paul Zaslaw
Bloom syndrome (BS) is a rare, autosomal recessive genetic disorder characterized by short stature, a skin rash associated with sun exposure, and an elevated likelihood of developing cancers of essentially all types, beginning at an early age. Cancer is the leading cause of death for persons with BS, and its early onset results in a reported median lifespan of <30 years. With fewer than 300 documented cases since BS was first described in 1954, its rarity has challenged progress in advancing both the care of and the cure for persons with BS...
April 2018: Cold Spring Harbor Molecular Case Studies
Fatima Majeed, Fozia Zahur Malik, Zaheer Ahmed, Asma Afreen, Muhammad Naveed Afzal, Nauman Khalid
During the last few decades, cancer has mushroomed as a major health issue; and almost all drugs used for its therapy are very toxic with lethal side effects. Complementary and alternative medicines gain popularity among health professionals in recent era owing to its preventive mechanism against side effect chemotherapeutic drugs. Efforts are focused by scientists to isolate compounds from medicinal plant that have chemotherapeutic attributes; and ability to neutralize the side effects of chemotherapy. Ginseng is an oriental medicinal recipe from Araliceae family and Panax species...
April 2018: Biomedicine & Pharmacotherapy
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