María-Constanza Trillos-Chacón, Juan A Castillo-M, Ingrid Tolosa-Guzman, Andrés Felipe Sánchez Medina, Silvia Marcela Ballesteros
Carpal Tunnel Syndrome (CTS) is one of the most frequently occurring musculoskeletal disorders of the upper limbs. Strategies for preventing CTS in the workplace include interventions such as ergonomics, education, exercise, physical therapy, and occupational health. The purpose of this study was to provide a general overview based on the review of scientific literature regarding strategies used for preventing CTS in working populations. From September to October 2018, the MEDLINE, PUBMED, EMBASE and SCOPUS (1990 to December 2017) databases were searched for evidence...
January 13, 2021: Applied Ergonomics
Yesid Villota-Narvaez, Diego A Garzon-Alvarado, Angelica M Ramirez-Martinez
Physical activity produces a change in skeletal-muscle size by activating synthesis or degradation of protein, which are outcomes of stimulating the IGF1-AKT signaling pathway. In this work, we propose a mathematical model that predicts the variation in muscle size under different activity conditions. The IGF1-AKT pathway was modeled using its 4 main molecules as variables in a dynamical system. We checked the stability of the system; we defined exercise training as a function of intensity, duration, and frequency; and we tested the model under four scenarios: first, we considered the daily low-intensity activity that should not promote atrophy nor hypertrophy (steady state); second, we simulated the effects of physical therapy in spinal cord injury patients (atrophy); third, we simulated exercise training in healthy subjects (hypertrophy); and fourth, we considered the effects of suspending a training program in healthy subjects (recovery after hypertrophy)...
January 13, 2021: Bio Systems
Luigi Preziosi, Giuseppe Toscani, Mattia Zanella
The mathematical modeling of tumor growth has a long history, and has been mathematically formulated in several different ways. Here we tackle the problem in the case of a continuous distribution using mathematical tools from statistical physics. To this extent, we introduce a novel kinetic model of growth which highlights the role of microscopic transitions in determining a variety of equilibrium distributions. At variance with other approaches, the mesoscopic description in terms of elementary interactions allows to design precise microscopic feedback control therapies, able to influence the natural tumor growth and to mitigate the risk factors involved in big sized tumors...
January 13, 2021: Journal of Theoretical Biology
Mitra Ramezani, Parisa Taheri, Saeed Khosrawi
OBJECTIVE: To compare two different protocols (ESWT, oral medications, and an exercise program with the control group ) for the treatment of CLBP, we designed this study. DESIGN: All the patients were randomly allocated to two intervention and control groups. Simple complete randomization was used for the allocation of the patients using the table of random numbers. SETTING: In this study, 32 patients with CLBP were referred to Isfahan University Hospitals randomly divided into intervention and control groups...
January 13, 2021: Archives of Physical Medicine and Rehabilitation
Diane L Damiano, Egmar Longo, Ana Carolina deCampos, Hans Forssberg, Alexandra Rauch
OBJECTIVE: World Health Organization's (WHO) Rehabilitation 2030 initiative is developing a set of evidence-based interventions selected from clinical practice guidelines for Universal Health Coverage. As an initial step, WHO Rehabilitation Programme and Cochrane Rehabilitation convened global content experts to conduct systematic reviews of clinical practice guidelines for 20 chronic health conditions, including cerebral palsy. DATA SOURCES: Six scientific databases (Pubmed, EMBASE, Scopus, Web of Science, PEDro, CINAHL), Google Scholar, guideline databases and professional society websites were searched...
January 13, 2021: Archives of Physical Medicine and Rehabilitation
Shira Peleg Hasson, Barliz Waissengrin, Eliya Shachar, Marah Hodruj, Rochelle Fayngor, Mirika Brezis, Alla Nikolaevski-Berlin, Sharon Pelles, Tamar Safra, Ravit Geva, Ido Wolf
INTRODUCTION: The use of telemedicine in oncology practice is rapidly expanding and is considered safe and cost effective. However, the implications of telemedicine on patient-physician interaction, patients' satisfaction and absence of personal touch have not been studied to date. Following the spread of COVID-19, telemedicine services were rapidly incorporated at the oncology division of Tel Aviv Medical Center (TLVMC). We aimed to evaluate patients' perspectives and preferences regarding telemedicine and assess whether this virtual communication platform affects the patient-physician relationship...
January 16, 2021: Oncologist
Hua Xu, Guanzhong Gong, Yong Yin, Tonghai Liu
PURPOSE: To investigate the effect of breathing motion on dose distribution for hepatocellular carcinoma (HCC) patients using four-dimensional (4D) CT and deformable registration. METHODS: Fifty HCC patients who were going to receive radiotherapy were enrolled in this study. All patients had been treated with transarterial chemoembolization beforehand. Three-dimensional (3D) and 4D CT scans in free breathing were acquired sequentially. Volumetric modulated arc therapy (VMAT) was planned on the 3D CT images and maximum intensity projection (MIP) images...
January 15, 2021: Journal of Applied Clinical Medical Physics
Er-Jung Hsueh, El-Wui Loh, Joyce Jui-An Lin, Ka-Wai Tam
BACKGROUND: Complications of breast cancer treatment can cause physical and psychosocial distress in patients. Yoga demonstrates substantial potential as a supportive therapy for patients with breast cancer. Our aim is to conduct a meta-analysis of randomized controlled trials to evaluate the effectiveness of yoga in enhancing the quality of life (QoL) of patients with breast cancer. METHODS: We searched for studies published before March 2020 in the PubMed, Embase, and Cochrane Library databases...
January 15, 2021: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Jon T Giles, Alexis Ogdie, Juan J Gomez Reino, Philip Helliwell, Rebecca Germino, Lori Stockert, Pamela Young, Wael Joseph, Rajiv Mundayat, Daniela Graham, Christopher Ritchlin
OBJECTIVES: This post-hoc analysis explored the impact of body mass index (BMI) on tofacitinib efficacy/safety in patients with active psoriatic arthritis (PsA). METHODS: Data were pooled from two phase 3 studies (NCT01877668; NCT01882439). Analyses included patients randomised to tofacitinib 5/10 mg twio times a day or placebo, stratified by baseline BMI: <25 kg/m2 , ≥25-<30 kg/m2 , ≥30-<35 kg/m2 or ≥35 kg/m2 . Endpoints (month 3): American College of Rheumatology (ACR20/50/70), Health Assessment Questionnaire-Disability Index (HAQ-DI) and Psoriasis Area and Severity Index (PASI) 75 response rates; dactylitis/enthesitis resolution rates; changes from baseline Short Form-36 Health Survey version 2 (SF-36v2) Physical/Mental Component Summary (PCS) scores and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) total score...
January 2021: RMD Open
Vibeke Strand, Philip J Mease, Ervant J Maksabedian Hernandez, Bradley S Stolshek, Lyrica X H Liu, David H Collier, Gregory Kricorian, Joseph F Merola
OBJECTIVES: We examined patient-reported outcomes (PROs) in The Study of Etanercept And Methotrexate in Patients with Psoriatic Arthritis (PsA); a 48-week, phase 3, randomised controlled trial that compared outcomes with methotrexate (MTX) monotherapy, etanercept monotherapy, and MTX+ etanercept in patients with PsA. METHODS: Efficacy endpoints included: mean changes from baseline and proportion of patients who reported improvements≥minimal clinically important difference (MCID) at week 24 in treatment groups for Health Assessment Questionnaire-Disability Index, Patient Global Assessment (PtGA), Patient Global Assessment of Joint Pain (PtGAJP) and Medical Outcomes Study Short Form-36 Questionnaire (SF-36) Physical Component Summary (PCS), and Mental Component Summary, and eight domain scores...
January 2021: RMD Open
Alejandra Méndez Romero, Wilco Schillemans, Rob van Os, Friederike Koppe, Cornelis J Haasbeek, Ellen M Hendriksen, Karin Muller, Heleen M Ceha, Pètra M Braam, Onne Reerink, Martijn P M Intven, Ines Joye, Edwin P M Jansen, Henrike Westerveld, Merel S Koedijk, Ben J M Heijmen, Jeroen Buijsen
PURPOSE: Although various studies have reported that stereotactic body radiation therapy (SBRT) for liver metastases has high local control rates and relatively low toxicity, most series included a small number of patients. We aimed to validate these outcomes in a large multi-institution patient cohort treated in accordance with a common protocol. METHODS AND MATERIALS: A shared web-based registry of patients with liver metastases treated with SBRT was developed by 13 centers (12 in the Netherlands and 1 in Belgium)...
December 29, 2020: International Journal of Radiation Oncology, Biology, Physics
Irene Lambrinoudaki, Stavroula A Paschou, Mary Ann Lumsden, Stephanie Faubion, Evangelos Makrakis, Sophia Kalantaridou, Nick Panay
Premature ovarian insufficiency (POI) refers to the loss of ovarian activity before the age of 40 years, which leads to hypoestrogenism and amenorrhoea. The diagnosis of POI in a young woman has potentially life-changing physical and emotional consequences for both the patient and her family. Therefore, it is very important that the diagnosis is correct and that it is made in a timely manner. Unfortunately, the diagnosis and therefore the effective treatment of POI are often delayed, which underlines the need for education of the broad medical community on the issue...
January 12, 2021: Maturitas
Briyana L M Morrell, Kara A Cecil, Alison M Nichols, Elizabeth S Moore, Jennifer N Carmack, Kathleen E Hetzler, Jane Toon, Jessica Emlich Jochum
Healthcare professions faculty at a private Midwestern university designed an Interprofessional Education (IPE) Week, consisting of 12 different interprofessional learning activities over the span of one week. The purpose of the study was to determine students' perceptions toward interprofessional healthcare, as measured by the Student Perceptions of Interprofessional Clinical Education-Revised (SPICE-R), one week before and one week after the events to determine if the type of learning activity - more passive, didactic-type events or active learning events - impacted outcomes...
January 15, 2021: Journal of Interprofessional Care
Francesca Beretti, Francesca Farnetani, Luca Reggiani Bonetti, Luca Fabbiani, Manuela Zavatti, Antonino Maiorana, Giovanni Pellacani, Tullia Maraldi
BACKGROUND: Melanoma is the leading cause of death due to cutaneous malignancy and its incidence is on the rise. Several signaling pathways, including receptor tyrosine kinases, have a role in the development and progression of melanocytic lesions and malignant melanoma. Among those, the hepatocyte growth factor (HGF)/c-met axis is emerging as a critical player because it can play a role in drug resistance. Indeed, 50% of melanoma patients present BRAF mutations, however, all responders develop resistance to the inhibitors typically within one year of treatment...
January 13, 2021: International Journal of Molecular Sciences
Léa Clusan, Pascale Le Goff, Gilles Flouriot, Farzad Pakdel
Breast cancer (BC) is the most common cancer among women worldwide. More than 70% of BC cases express estrogen receptor alpha (ERα), a central transcription factor that stimulates the proliferation of breast cancer cells, usually in the presence of estrogen. While most cases of ER-positive BC initially respond to antiestrogen therapies, a high percentage of cases develop resistance to treatment over time. The recent discovery of mutated forms of ERα that result in constitutively active forms of the receptor in the metastatic-resistance stage of BC has provided a strong rationale for the development of new antiestrogens...
January 13, 2021: International Journal of Molecular Sciences
Shibnath Ghatak, Vincent C Hascall, Roger R Markwald, Suniti Misra
Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway...
January 13, 2021: International Journal of Molecular Sciences
Anaïs Paris, Nina Tardif, Marie-Dominique Galibert, Sébastien Corre
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been shown to be an essential regulator of a broad spectrum of biological activities required for maintaining the body's vital functions. AhR also plays a critical role in tumorigenesis. Its role in cancer is complex, encompassing both pro- and anti-tumorigenic activities. Its level of expression and activity are specific to each tumor and patient, increasing the difficulty of understanding the activating or inhibiting roles of AhR ligands...
January 13, 2021: International Journal of Molecular Sciences
Bartosz F Grześkowiak, Damian Maziukiewicz, Agata Kozłowska, Ahmet Kertmen, Emerson Coy, Radosław Mrówczyński
The development of multifunctional drug delivery systems combining two or more nanoparticle-mediated therapies for efficient cancer treatment is highly desired. To face this challenge, a photothermally active polydopamine (PDA) nanoparticle-based platform was designed for the loading of chemotherapeutic drug and targeting of cancer cells. PDA spheres were first functionalized with polyamidoamine (PAMAM) dendrimers followed by the conjugation with polyethylene glycol (PEG) moieties and folic acid (FA) targeting ligand...
January 13, 2021: International Journal of Molecular Sciences
Javier Torres-Jiménez, Víctor Albarrán-Fernández, Javier Pozas, María San Román-Gil, Jorge Esteban-Villarrubia, Alfredo Carrato, Adriana Rosero, Enrique Grande, Teresa Alonso-Gordoa, Javier Molina-Cerrillo
Urothelial carcinoma represents one of the most prevalent types of cancer worldwide, and its incidence is expected to grow. Although the treatment of the advanced disease was based on chemotherapy for decades, the developments of different therapies, such as immune checkpoint inhibitors, antibody drug conjugates and tyrosine kinase inhibitors, are revolutionizing the therapeutic landscape of this tumor. This development coincides with the increasing knowledge of the pathogenesis and genetic alterations in urothelial carcinoma, from the non-muscle invasive setting to the metastatic one...
January 13, 2021: International Journal of Molecular Sciences
Radu Pirlog, Andrei Cismaru, Andreea Nutu, Ioana Berindan-Neagoe
Lung cancer is currently the first cause of cancer-related death. The major lung cancer subtype is non-small cell lung cancers (NSCLC), which accounts for approximatively 85% of cases. The major carcinogenic associated with lung cancer is tobacco smoke, which produces long-lasting and progressive damage to the respiratory tract. The progressive and diffuse alterations that occur in the respiratory tract of patients with cancer and premalignant lesions have been described as field cancerization. At the level of tumor cells, adjacent tumor microenvironment (TME) and cancerized field are taking place dynamic interactions through direct cell-to-cell communication or through extracellular vesicles...
January 13, 2021: International Journal of Molecular Sciences
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