Hideaki Kuno, Takuya Fujimaru, Nozomi Kadota, Kasumi Konishi, Momoko Sekiguchi, Kimio Watanabe, Yugo Ito, Masahiko Nagahama, Fumika Taki, Toru Hifumi, Norio Otani, Masaaki Nakayama
Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported. Here we report a case of lactic acidosis and euDKA after metformin overdose. A 57-year-old female patient was transferred to our hospital with severe metabolic acidosis and acute kidney injury. She had type 2 diabetes mellitus and was on oral antidiabetic therapy of vildagliptin metformin hydrochloride daily. On the admission day, she had committed suicide by overdosing 50 tablets of vildagliptin metformin hydrochloride, which was equivalent to 25,000 mg of metformin and 2500 mg of vildagliptin...
March 19, 2023: CEN Case Reports
Zsuzsanna Cserép, Ákos Batiz, Andrea Székely
Coronary artery disease is a highly prevalent heart disease and the leading cause of morbidity and mortality in developed countries. During the last decades, numerous studies have focused on the comprehension of the relationship between coronary heart disease and different psychosocial factors. Coronary artery bypass graft surgery is a common treatment for coronary artery disease and is usually associated with improved clinical outcomes. Symptoms of anxiety and unipolar depression are common psychological disorders in patients awaiting coronary artery bypass graft surgery...
March 19, 2023: Orvosi Hetilap
Karen Chow, Darcy Wooten, Sindhuja Annepally, Leah Burke, Rina Edi, Sheldon R Morris
BACKGROUND: Bacterial vaginosis (BV) is one of the most common vaginal dysbiosis in women aged 15-44 years old. METHODS: We administered a cross-sectional, single timepoint survey to women ages 18 years or older and who have had bacterial vaginosis (BV). Women completed an anonymous online survey evaluating the impact of BV on their quality of life, how effective different types of treatments were and the amount of self-diagnosed vs. provider diagnosed BV episodes they had...
March 18, 2023: BMC Women's Health
Amanda Mofina, Jordan Miller, Joan Tranmer, Wenbin Li, Catherine Donnelly
BACKGROUND: Individuals experiencing multimorbidity have more complex healthcare needs, use more healthcare services, and access multiple service providers across the healthcare continuum. They also experience higher rates of functional decline. Rehabilitation therapists are well positioned to address these functional needs; however, little is known about the influence of rehabilitation therapy on patient outcomes, and subsequent unplanned healthcare utilization for people with multimorbidity...
March 18, 2023: BMC Health Services Research
Yi-Chun Li, Keh-Chung Lin, Chia-Ling Chen, Grace Yao, Ya-Ju Chang, Ya-Yun Lee, Chien-Ting Liu, Wen-Shiang Chen
OBJECTIVE: To examine the effects of bilateral robotic priming combined with mirror therapy (R-mirr) versus bilateral robotic priming combined with bilateral arm training (R-bilat), relative to the control approach of bilateral robotic priming combined with movement-oriented training (R-mov) in patients with stroke. DESIGN: A single-blind, preliminary, randomized controlled trial. SETTING: Four outpatient rehabilitation settings. PARTICIPANTS: Outpatients with stroke and mild to moderate motor impairment (N = 63)...
March 16, 2023: Archives of Physical Medicine and Rehabilitation
Leila Khalili, Gholamreza Dehghan, Arezou Fazli, Alireza Khataee
Over the years, layered double hydroxides (LDHs) hold a specific position in biomedicine due to their tunable chemical composition and appropriate structural properties. However, LDHs lack adequate sensitivity for active targeting because of less active surface area and low mechanical strength in physiological conditions. The exploitation of eco-friendly materials, such as chitosan (CS), for surface engineering of LDHs, whose payloads are transferred only under certain conditions, can help develop stimuli-responsive materials owing to high biosafety and unique mechanical strength...
March 5, 2023: Advances in Colloid and Interface Science
T P A Beddows, A Weir, R Agricola, I J R Tak, T M Piscaer, J A N Verhaar, P van Klij
OBJECTIVES: Investigate point prevalence (second half season 2018-2019) and incidence (season 2017-2018 and first half season 2018-2019) of non-time-loss and time-loss hip/groin pain in male field hockey players. Secondary aims were to study associations between: current/previous hip/groin pain and hip muscle strength, patient reported outcome measures (PROM) and hip muscle strength, and previous hip/groin pain and PROMs. Additionally we studied normal values for the PROMs (Hip and Groin Outcome Score (HAGOS))...
March 8, 2023: Physical Therapy in Sport
Dulal Musib, Aarti Upadhyay, Maynak Pal, Md Kausar Raza, Indranil Saha, Amit Kunwar, Mithun Roy
We report the synthesis and characterization of red-light activable gold nanoparticle functionalized with biotinylated copper(II) complex of general molecular formula, [Cu(L3 )(L6 )]-AuNPs ([email protected]), where L3  = N-(3-((E)-3,5-di-tert-butyl-2-hydroxybenzylideneamino)-4-hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, L6  = 5-(1,2-dithiolan-3-yl)-N-(1,10-phenanthrolin-5-yl)pentanamide, which was explored for their photophysical, theoretical and photo-cytotoxic potentials...
March 11, 2023: Journal of Inorganic Biochemistry
Ludovica Verde, Stefania Lucà, Simona Cernea, Cem Sulu, Volkan Demirhan Yumuk, Trond Geir Jenssen, Silvia Savastano, Gerardo Sarno, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
PURPOSE OF REVIEW: The purpose of this review is to summarize the current evidence on the role of obesity in the development and progression of chronic kidney disease and the current evidence on nutritional, pharmacological, and surgical strategies for the management of individuals with obesity and chronic kidney disease. RECENT FINDINGS: Obesity can hurt the kidney via direct pathways, through the production of pro-inflammatory adipocytokines, and indirectly due to systemic complications of obesity, including type 2 diabetes mellitus and hypertension...
March 18, 2023: Current Obesity Reports
Bilal Katipoglu, Sultan Keskin Demircan, Mehmet Ilkin Naharci
BACKGROUND: The Drug Burden Index (DBI) is a validated tool for assessing the dose-dependent cumulative exposure to sedative and anticholinergic medications. However, the increased risk of delirium superimposed dementia (DSD) with high DBI levels has not yet been investigated. AIM: This study aimed to examine the potential association between DBI scores and delirium in community-dwelling older adults with dementia. METHOD: A total of 1105 participants with cognitive impairment underwent a comprehensive geriatric assessment...
March 18, 2023: International Journal of Clinical Pharmacy
Zarfasheen Zia, Huma Riaz, Iqra Imtiaz
This study was conducted to determine the effect of early physical therapy intervention on symptoms of post-operative ileus after abdominal hysterectomy. This randomised control trial was carried out at the Railway General Hospital, Rawalpindi, Pakistan, from February 2021 to July 2021. Participants were randomly allocated to experimental (n=21) and control (n=21) groups using sealed envelope method. The experimental group received an enhanced physiotherapy rehabilitation plan of care consisting of patient education, breathing exercises, early mobilisation, connective tissue manipulation, and transcutaneous electrical nerve stimulation, while the control group only performed ambulation...
March 2023: JPMA. the Journal of the Pakistan Medical Association
Chaoqiong Ma, Xiaofeng Yang, Chih-Wei Chang, Ruirui Liu, Duncan Bohannon, Liyong Lin, Tian Liu, Sibo Tian, Jun Zhou
BACKGROUND: Ultra-high dose rate (FLASH) proton planning with only transmission beams (TBs) has limitations in normal tissue sparing. The single-energy spread-out Bragg peaks (SESOBPs) of the FLASH dose rate have been demonstrated feasible for proton FLASH planning. PURPOSE: To investigate the feasibility of combining TBs and SESOBPs for proton FLASH treatment. METHODS: A hybrid inverse optimization method was developed to combine the TBs and SESOBPs (TB-SESOBP) for FLASH planning...
March 17, 2023: Medical Physics
Sidsel Lombardo, Gunvor Hilde, Milada Cvancarova Småstuen, Margreth Grotle
BACKGROUND: Patients with chronic low back pain (LBP) and lumbar disc degeneration are recommended to try out nonsurgical treatment options before surgery. There is need for good nonsurgical alternatives that can be adapted to the patient's needs and level of function. The aim of this pilot trial was to test study feasibility of a future full randomized controlled trial (RCT) evaluating the feasibility and benefit of the physiotherapy-based Godelieve Denys-Struyf (GDS) muscle and articulation chain treatment for patients with chronic LBP and lumbar disc degeneration referred to surgical assessment in a hospital outpatient clinic...
March 17, 2023: Pilot and Feasibility Studies
Yan Liu, Xiao-Na Xiang, Qian Wang, Hong-Chen He
BACKGROUND: Platelet-rich plasma (PRP) contains various growth factors and inflammatory regulators, which can effectively reduce inflammation in joints and promote tissue repair. Multiple studies have proved its effectiveness in the treatment of knee osteoarthritis (KOA). Low-intensity focused ultrasound (LIFU) and transcutaneous electrical nerve stimulation (TENS) are non-invasive and safe physical therapy methods for KOA. This study is the first to propose the treatment of KOA with physical stimulation after PRP treatment, and to observe the clinical efficacy of the treatment method...
March 17, 2023: Trials
Kati Räsänen, Kati Markula-Patjas, Saija Kantanen, Kalle Sipilä, Timo A Lakka, Pekka Arikoski, Eija Piippo-Savolainen
BACKGROUND: In recent years, biologic drug therapies have altered the course of juvenile idiopathic arthritis (JIA) possibly also improving the patients' physical fitness. However, studies measuring both cardiorespiratory and muscular fitness in children with JIA are sparse and have failed to show consistent results. Our aim was to assess both cardiorespiratory and neuromuscular fitness and contributing factors in children and adolescents with JIA in the era of biologic drug therapies...
March 17, 2023: Pediatric Rheumatology Online Journal
Jarson Pedro da Costa Pereira, José Reginaldo Alves de Queiroz Júnior, Luís César de Medeiros, Gleyce Kelly Araújo Bezerra, Isabella Valois Pedrosa Porto, Poliana Coelho Cabral, Marcella Campos Lima da Luz, Cláudia Porto Sabino Pinho, Rocio Ayala Romero
BACKGROUND: There are few studies that assess the relationship between nutritional status and quality of life in individuals with Parkinson's disease, despite the well-established negative impact of sarcopenia and dynapenia on functional capacity and quality of life. These conditions impair protein-muscular status and are prevalent in individuals with Parkinson's disease. This study aimed to examine the relationship between nutritional status, including body composition, functional capacity, and diagnosis of sarcopenia and dynapenia, and quality-of-life perception in individuals with Parkinson's disease...
March 17, 2023: Nutritional Neuroscience
Darya A Poletaeva, Raisa A Kotelnikova, Irina I Faingold, Olga A Kraevaya, Pavel A Troshin, Alexander I Kotelnikov
Water-soluble fullerene derivatives are good candidates for various biological applications such as anticancer or antimicrobial therapy, cytoprotection, enzyme inhibition, and many others. Their toxicity, both in tissue culture and in vivo, is a critical characteristic for the development and restriction of these applications. The effects of six water-soluble cationic and anionic polysubstituted fullerene derivatives on cytochrome c oxidase activity in rat brain mitochondria and the possibility of cytochrome c binding were studied...
March 18, 2023: Journal of Biological Physics
Meghan K Chambers, Matthew Thomas, Maximilian J Brimmer, James Butcher, Kim Griswold
INTRODUCTION: Integrated mental and physical health care has the potential to improve health outcomes. A behavioral health organization established a reverse integration program site using a co-located model to provide primary care services to patients receiving behavioral health services. We ask whether this model of co-located care was effective in improving a range of physical health outcomes for clients. This program was funded with a grant from the Substance Abuse and Mental Health Services Administration Primary and Behavioral Health Care Integration...
March 16, 2023: Families, Systems & Health: the Journal of Collaborative Family Healthcare
Jie Hu, Yongsheng Zheng, Zhijie Wen, Hudie Fu, Xuedan Yang, Xuexin Ye, Shengpeng Zhu, Li Kang, Xiaojun Li, Xinzhou Yang, Yan Hu
The aim of this study was to construct a bifunctional liposome with hepatic-targeting capacity by modifying with a targerting ligand and an intracellular tumor reduction response functional group to deliver drugs precisely to focal liver tissues and release them in large quantities in hepatocellular carcinoma cells. This could improve drug efficacy and reduce toxic side effects at the same time. First, the bifunctional ligand for lipsome was successfully obtained by chemically synthesizing it from the hepatic-targeting glycyrrhetinic acid (GA) molecule, cystamine, and the membrane component cholesterol...
March 15, 2023: Chemistry and Physics of Lipids
Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Youn Kim, Hee-Sun Kim
Parkinson's disease (PD) belongs to an α-synucleinopathy and manifests motor dysfunction attributed to nigrostriatal dopaminergic degeneration. In clinical practice, the beneficial role of physical therapy such as motor skill learning training has been recognized in PD-linked motor defects. Nevertheless, the disease-modifying effects of motor skill learning training on PD-related pathology remain unclear. Here, we investigated the disease-modifying effects of rotarod walking exercise (RWE), a modality of motor skill learning training, in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD...
March 15, 2023: Neurochemistry International
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