Rubén Fernández-Rodríguez, Celia Álvarez-Bueno, Asunción Ferri-Morales, Ana Torres-Costoso, Diana P Pozuelo-Carrascosa, Vicente Martínez-Vizcaíno
BACKGROUND: Falls are the leading cause of injury-related deaths in older adults. Physical exercise is a suitable strategy to reduce the risk of falls, but there is little research on the effectiveness of specific exercise modalities. OBJECTIVES: To estimate the effectiveness of Pilates compared to habitual or non-exercise on physical performance and the risk of falls in older adults. DATA SOURCES: Five databases were searched through April 15, 2021...
June 7, 2021: Physiotherapy
Jeff Houck, Daniel Kang, Tyler Cuddeford
BACKGROUND: Understanding how symptoms influence patient judgements of their health informs providers where to direct care. Patient reported physical outcomes (physical function, pain interference) and self-efficacy of symptom management (SEsm)) predict a patient's health state (i.e. patient acceptable symptom state (PASS)). However, it's unclear if therapist should consider a psychological outcome like SEsm separately or combine this outcome with other physical outcomes for clinical decisions...
July 5, 2021: Musculoskeletal Science & Practice
Gozde Unal, Jaiti K Swami, Carliza Canela, Samantha L Cohen, Niranjan Khadka, Mohammad Rad, Baron Short, Miklos Argyelan, Harold A Sackeim, Marom Bikson
BACKGROUND: Improvements in electroconvulsive therapy (ECT) outcomes have followed refinement in device electrical output and electrode montage. The physical properties of the ECT stimulus, together with those of the patient's head, determine the impedances measured by the device and govern current delivery to the brain and ECT outcomes. OBJECTIVE: However, the precise relations among physical properties of the stimulus, patient head anatomy, and patient-specific impedance to the passage of current are long-standing questions in ECT research and practice...
July 28, 2021: Brain Stimulation
Linda Brent, Elaine A Lissner, Michelle A Kutzler
This case study reports on the use of hormone therapy to treat a dog with a range of physical and behavioral signs that began after gonadectomy. A male mixed breed dog neutered at 7 months of age presented at 1 year with health issues impacting quality of life. Reduced mobility, limping, rapid weight gain, and fear of unfamiliar people were treated over the next three years with trials of pain medication, joint supplements, thyroxine, antidepressant, and significant diet restrictions. Frequent carprofen administration and daily joint supplements reduced limping, but mobility was still poor...
July 28, 2021: Topics in Companion Animal Medicine
Boqian Wang, Antony R Warden, Xianting Ding
Designing optimal combinatorial drug therapies is challenging, because the drug interactions depend not only on the drugs involved, but also on their doses. With recent advances, combinatorial drug therapy is closer than ever to clinical application. Herein, we summarize approaches and advances over the past decade for identifying and optimizing drug combination therapies, with innovations across research fields, covering physical laboratory platforms for combination screening to computational models and algorithms designed for synergism prediction and optimization...
July 28, 2021: Drug Discovery Today
Diana Rafael, Maria Mercè Roca Melendres, Fernanda Andrade, Sara Montero, Francesc Martinez-Trucharte, Francesc Martinez-Trucharte, Mireia Vilar-Hernandez, Esteban Francisco Durán-Lara, Simó Schwartz, Ibane Abasolo
Despite the enormous efforts done by the scientific community in the last decades, advanced cancer is still considered an incurable disease. New formulations are continuously under investigation to improve drugs therapeutic index, i.e., increase chemotherapeutic efficacy and reduce adverse effects. In this context, hydrogels-based systems for drug local sustained/controlled release have been proposed to reduce off-target effects caused by the repeated administration of systemic/oral anticancer drugs and improve their therapeutic effectiveness...
July 28, 2021: International Journal of Pharmaceutics
Daniel L Riddle, David F Hamilton, Levent Dumenci, David J Beard
Physical therapy is routinely delivered to patients after discharge from the hospital following knee arthroplasty (KA). Posthospitalization physical therapy is thought to be beneficial, particularly for those patients most at risk for poor outcome, the subgroup with persistent function-limiting pain despite an apparently successful surgery. Research teams have undertaken 3 large-scale multicenter Phase III randomized clinical trials designed specifically for patients at risk for poor outcome following KA. All 3 trials screened for poor outcome risk using different methods and investigated different physical therapist interventions delivered in different ways...
July 30, 2021: Physical Therapy
Phoebe Simpson, Riikka Holopainen, Robert Schütze, Peter O'Sullivan, Anne Smith, Steven J Linton, Michael Nicholas, Peter Kent
OBJECTIVE: Current guidelines recommend management of musculoskeletal pain conditions from a biopsychosocial approach, however biopsychosocial interventions delivered by physical therapists vary considerably in effectiveness. It is unknown whether the differences are explained by the intervention itself, the training and/or competency of physical therapists delivering the intervention, or fidelity of the intervention. The aim was to investigate and map the training, competency assessments and fidelity checking of individualized biopsychosocial interventions delivered by physical therapists to treat musculoskeletal pain conditions...
July 30, 2021: Physical Therapy
Yana Cristina de Barba, Angela Khetly Lazarotto, Maria Carolina Alves De Martini, Everton Artuso, Eduardo Henrique Szpak Gaievski, André Lazarin Gallin, Dalila Moter Benvegnú
This study is a comparative analysis of the effects of intuitive eating and correlations with quality of life and wellbeing in Yoga practitioners, physical activity practitioners and sedentary individuals. The study involved 204 participants, comprising 66 Yoga practitioners, 74 physical activity practitioners and 64 sedentary individuals, between the ages of 20 and 59, who were resident in Brazil at the time of the study. Quantitative research was conducted through Facebook and the application questionnaires via Google Forms to measure intuitive eating, food consumption, quality of life, stress level, satisfaction with body image and level of mindfulness...
July 31, 2021: Alternative Therapies in Health and Medicine
Pulkit Kumar, Dhaniket Patel
Background: This review is a great route for future researchers on the topic of alternative medicine. The review goes in depth with respect to Ocimum sanctum and its proposed mechanism of action for different types of cancers. Primary Study Objective: The primary objective of the study was to bring traditional therapy back, which can prove to be economically beneficial and may be helpful to many patients with cancer with few to no adverse events. Intervention: Ocimum sanctum (OS), commonly known as Holy Basil or tulsi, is a very important medicinal herb in parts of India and Southeast Asia...
July 31, 2021: Alternative Therapies in Health and Medicine
Alan D Kaye, Sasha Ridgell, E Saunders Alpaugh, Aya Mouhaffel, Aaron J Kaye, Elyse M Cornett, Azam A Chami, Rutvij Shah, Bruce M Dixon, Omar Viswanath, Ivan Urits, Amber N Edinoff, Richard D Urman
Chronic pain is a common source of morbidity in many patient populations worldwide. There are growing concerns about the potential side effects of currently prescribed medications and a continued need for effective treatment. Related to these concerns, peripheral nerve stimulation has been regaining popularity as a potential treatment modality. Peripheral nerve stimulation components include helically coiled electrical leads, which direct an applied current to afferent neurons providing sensory innervation to the painful area...
July 31, 2021: Pain and Therapy
Sriram Yennurajalingam, Karen Basen-Engquist, James M Reuben, Bryan M Fellman, Sanjay Shete, Rama Maddi, Janet L Williams, Rony Dev, David Hui, Eduardo Bruera
PURPOSE: Cancer-related fatigue (CRF) is the most frequent and debilitating symptom in patients with advanced cancer. There are limited effective treatments for CRF. The objective of this prospective longitudinal study was to evaluate the change in CRF at Day 43 after treatment with combination therapy of oral Anamorelin 100 mg daily with physical activity and nutrition counseling. METHODS: In this study, patients with CRF [≤ 34 Functional Assessment of Chronic Illness Therapy-Fatigue subscales(FACIT-F)] received Anamorelin 100 mg orally daily with standardized physical activity and nutrition counseling for 43 days...
July 31, 2021: Supportive Care in Cancer
Feiyang Cai, Shiyi Li, Hui Huang, Javed Iqbal, Canran Wang, Xing Jiang
Immune responses are involved in the pathogenesis of many diseases, including cancer, autoimmune diseases, and chronic inflammation. These responses are attributed to immune cells that produce cytokines, mediate cytotoxicity, and synthesize antibodies. Gold nanoparticles (GNPs) are novel agents that intervene with immune responses because of their unique physical-chemical properties. In particular, GNPs enhance anti-tumour activity during immunotherapy and eliminate excessive inflammation in autoimmune diseases...
July 31, 2021: Journal of Biomedical Materials Research. Part A
Loris Zamai, Marco B L Rocchi
The present work provides arguments for the involvement of anti-vector immunity and of SARS-CoV-2 variants on the efficacy of ChAdOx1 nCoV-19 vaccine. First, it is suggested that anti-vector immunity takes place as homologous vaccination with ChAdOx1 nCoV-19 vaccine is applied and interferes with vaccine efficacy when the interval between prime and booster doses is less than 3 months. Second, longitudinal studies suggest that ChAdOx1 nCoV-19 vaccine provides suboptimal efficacy against SARS-CoV-2 Alpha variant, which appears to have an increased transmissibility among vaccinated people...
July 31, 2021: British Journal of Pharmacology
Alex Catherine Staines, Niall Broomfield, Laura Pass, Faith Orchard, Jessica Bridges
Research indicates a bidirectional relationship between sleep and anxiety, with findings suggesting anxiety can precede poor sleep and vice versa. Evidence suggests sleep-related thought processes associated with anxiety are involved in the maintenance of insomnia. Previous meta-analyses provide some evidence to suggest cognitive behavioural therapy for insomnia moderately improves anxiety, yet little research has investigated the effect of other sleep interventions on anxiety symptoms. The aim of this meta-analysis was to review whether non-pharmacological sleep interventions have an impact on anxiety symptoms immediately post-intervention...
July 30, 2021: Journal of Sleep Research
Alan D Kaye, Amber N Edinoff, Logan Scoon, Sean Youn, Kyle J Farrell, Aaron J Kaye, Rutvij J Shah, Elyse M Cornett, Azem A Chami, Bruce M Dixon, Michael A Alvarado, Omar Viswanath, Ivan Urits, Aaron K Calodney
Acute and chronic pain are public health issues that clinicians have been battling for years. Opioid medications have been a treatment option for both chronic and acute pain; however, they can cause unwanted complications and are a major contributor to our present opioid epidemic. The sacroiliac (SI) joint is a common cause of both acute and chronic low back pain. It affects about 15-25% of patients with axial low back pain, and up to 40% of patients with ongoing pain following lumbar fusion. Recent advances in the treatment of SI joint pain have led to the development of a wide variety of SI joint fusion devices...
July 30, 2021: Rheumatology and Therapy
Christina Ziebart, Joy MacDermid, Dianne Bryant, Mike Szekeres, Nina Suh
INTRODUCTION: This pilot study will determine the feasibility of recruitment, retention and adherence for the online combined exercise and education programme (Hands-Up) compared with usual care. METHODS AND ANALYSIS: The proposed randomised controlled trial will be a pilot feasibility study with a 1:1 randomisation to the Hands-Up programme or usual physical therapy. The programme setting is an online home exercise and education program. Outcome assessments will take place at the Roth|McFarlane Hand and Upper Limb Clinic in London, Ontario, which is a tertiary care academic centre...
July 30, 2021: BMJ Open
Joshua Tulk, Joshua A Rash, John Thoms, Richard Wassersug, Brian Gonzalez, Sheila N Garland
OBJECTIVES: This paper (1) sought to compare sleep, mood and physical symptom profiles of men with prostate cancer (PCa) who experienced subjective and objective cancer-related cognitive impairment (CRCI) during the first year of treatment and (2) examine if fluctuations in mood and physical symptoms are associated with change in subjective or objective CRCI. METHODS: This prospective observational cohort study examined 24 new patients with PCa receiving androgen deprivation therapy (ADT) and radiation therapy (RT) during the first 12 months of treatment...
July 30, 2021: BMJ Supportive & Palliative Care
Angela Vivanti
BACKGROUND: Completing malnutrition assessments when physically distant has been an immediate challenge during the COVID-19 pandemic. Even during periods of physical distancing, continuing nutrition assessments amongst those without COVID-19 is vital given that high malnutrition prevalence exists in clinical settings. The investigation aim was to assess the reliability of utilising the validated Subjective Global Assessment (SGA) tool, without compared to with physical examination. METHODOLOGY: Original paper-based SGA documentation from a hospital-wide audit was reassessed by a blinded experienced clinician using history alone without reviewing documented physical examination...
August 2021: Clinical Nutrition ESPEN
Jaime A Foushee, Mandy McCaslan Couch, Erika E Tillery, Amber B Giles
BACKGROUND AND PURPOSE: Teaching and learning the spectrum of activity (SOA) of antimicrobial agents can be a challenge in pharmacy education. This study describes the implementation and assessment of a novel tool to aid in the instruction of SOA. Physical manipulatives were used as an active-learning technique to model bacterial pathogens for antimicrobial SOA in an infectious diseases (ID) integrated medication therapy management course. EDUCATIONAL ACTIVITY AND SETTING: Pharmacy students enrolled in two consecutive years of the ID course were provided the opportunity to utilize a set of manipulatives for in-class activities and out-of-class practice...
September 2021: Currents in Pharmacy Teaching & Learning
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