Sandra Schlegl, Adrian Meule, Matthias Favreau, Ulrich Voderholzer
OBJECTIVE: The COVID-19 pandemic might pose special challenges to patients with eating disorders (EDs) by interfering with daily routines. The aim of this study was to investigate the impact of the current pandemic on patients with bulimia nervosa (BN). METHODS: Fifty-five former inpatients with BN completed an online survey on psychological consequences of the COVID-19 pandemic as well as on changes in health care utilisation and on the use and helpfulness of different coping strategies...
August 7, 2020: European Eating Disorders Review: the Journal of the Eating Disorders Association
Ali E Ghareeb, Majlinda Lako, David H Steel
Stem cell-derived retinal organoids offer the opportunity to cure retinal degeneration of wide-ranging etiology either through the study of in vitro models or the generation of tissue for transplantation. However, despite much work in animals and several human pilot studies, satisfactory therapies have not been developed. Two major challenges for retinal regenerative medicine are: (a) physical cell-cell interactions, which are critical to graft function, are not formed, and (b) the host environment does not provide suitable queues for development...
August 7, 2020: Stem Cells Translational Medicine
César Fernández-de-Las-Peñas, José L Arias-Buría, Joshua A Cleland, Juan A Pareja, Gustavo Plaza-Manzano, Ricardo Ortega-Santiago
OBJECTIVE: No study has investigated the effects longer than 1-year of manual therapy in carpal tunnel syndrome (CTS). The purpose of this study was to investigate the effects of manual therapy versus surgery at 4-year follow-up and to compare the post-study surgery rate in carpal tunnel syndrome CTS. METHODS: This randomized controlled trial was conducted in a tertiary public hospital and included 120 women with CTS who were randomly allocated to manual therapy or surgery...
August 6, 2020: Physical Therapy
Sureshkumar Kamalakannan, Stuti Chakraborty
Occupations refer to the everyday activities that people do as individuals, in families and with communities to occupy time and bring meaning and purpose to life. It is not always limited to just paid employment. Occupations of the global population have been adversely affected in one way or the other because of this COVID-19 pandemic. Four different key sects of occupations were majorly affected. These are the occupations of those who are or were COVID-positive, occupations of healthy individuals affected by COVID-19/lockdown, occupations of the population highly susceptible and vulnerable of contracting COVID-19 and occupations having a direct impact on global market, supply chain or economy...
2020: Wellcome Open Research
Paulo E P Teixeira, Laila Alawdah, Hassan Adam A Alhassan, Matteo Guidetti, Alberto Priori, Stefania Papatheodorou, Felipe Fregni
BACKGROUND: The analgesic effects of transcranial Direct Current Stimulation (tDCS) combined with physical therapy remain unclear. OBJECTIVE: To systematically review available evidence comparing tDCS with any physical therapy modality (PTM) to PTM alone or PTM with sham tDCS on pain relief on common musculoskeletal (MSK) conditions, namely knee osteoarthritis (KOA), chronic low back pain (CLBP), myofascial pain syndrome (MPS) and fibromyalgia. METHODS: EMBASE and MEDLINE were searched from inception to April 2019 for randomized controlled trials...
January 2020: Princ Pract Clin Res
Hirut Bekele, Adisu Asefa, Bekalu Getachew, Abebe Muche Belete
Background: Diabetes mellitus is a major chronic illness in Africa that requires lifelong lifestyle interventions and pharmacological therapy. Lifestyle change is the most important aspect of diabetes care and includes diabetes self-management education and support, medical nutrition therapy, physical activity, smoking cessation counseling, and psychosocial care. Purpose: The purpose of this project was to review published articles that investigate lifestyle and dietary pattern interventions for diabetes prevention and management in Africa...
2020: Journal of Diabetes Research
Weibo Zhang, Shruti Saxena, Amir Fakhrzadeh, Sara Rudolph, Joachim Kohn, Pamela C Yelick
The ability to effectively repair craniomaxillofacial (CMF) bone defects in a fully functional and aesthetically pleasing manner is essential to maintain physical and psychological health. Current challenges for CMF repair therapies include the facts that craniofacial bones exhibit highly distinct properties as compared to axial and appendicular bones, including their unique sizes, shapes and contours, and mechanical properties that enable the ability to support teeth and withstand the strong forces of mastication...
2020: Frontiers in Bioengineering and Biotechnology
Zachary Boychuck, John Andersen, André Bussières, Darcy Fehlings, Adam Kirton, Patricia Li, Maryam Oskoui, Charo Rodriguez, Michael Shevell, Laurie Snider, Annette Majnemer
Objectives: To develop expert-informed content regarding the early motor attributes of cerebral palsy (CP) that should prompt physician referral for diagnostic assessment of CP, as well as concurrent referral recommendations. This content will be used in the creation of knowledge translation (KT) tools for primary care practitioners and parents. Methods: Two nominal group processes were conducted with relevant stakeholders, representing Canadian ' content experts ' and ' knowledge-users' , using an integrated KT approach...
August 2020: Paediatrics & Child Health
Jane Fitzpatrick, Christen Richardson, Ianiv Klaber, Martin D Richardson
Background/Hypothesis: Adhesive capsulitis of the shoulder results in pain and restricted movement of the glenohumeral joint. Hypothesis: There would be a difference in active range of movement in the affected shoulder of patients with adhesive capsulitis after receiving a series of injections of collagenase Clostridium histolyticum (CCH) compared to placebo. Methods: This study reports the results from a single site that was part of a 321-participant, multicenter, double-blind, prospective parallel-group, randomized controlled clinical trial...
2020: Drug Design, Development and Therapy
Elena Tantillo, Antonella Colistra, Laura Baroncelli, Mario Costa, Matteo Caleo, Eleonora Vannini
Currently, high-grade gliomas are the most difficult brain cancers to treat and all the approved experimental treatments do not offer long-term benefits regarding symptom improvement. Epidemiological studies indicate that exercise decreases the risk of brain cancer mortality, but a direct relationship between physical exercise and glioma progression has not been established so far. Here, we exploited a mouse model of high-grade glioma to directly test the impact of voluntary physical exercise on the tumor proliferation and motor capabilities of affected animals...
August 5, 2020: International Journal of Environmental Research and Public Health
Keisuke Ono, Mitsumasa Kishimoto, Teppei Shimasaki, Hiroko Uchida, Daisuke Kurai, Gautam A Deshpande, Yoshinori Komagata, Shinya Kaname
Reactive arthritis (ReA) is typically preceded by sexually transmitted disease or gastrointestinal infection. An association has also been reported with bacterial and viral respiratory infections. Herein, we report the first case of ReA after the he severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This male patient is in his 50s who was admitted with COVID-19 pneumonia. On the second day of admission, SARS-CoV-2 PCR was positive from nasopharyngeal swab specimen. Despite starting standard dose of favipiravir, his respiratory condition deteriorated during hospitalisation...
August 2020: RMD Open
Xinli Ouyang, Jing Yang, Zexin Hong, Yide Wu, Yongfang Xie, Guohui Wang
The risk of blue light exposure to human health has attracted increased research attention. Blue light, with relatively high energy, can cause irreversible photochemical damage to eye tissue. Excessive exposure of the eye to blue light tends to cause a series of alterations, such as oxidative stress, mitochondrial apoptosis, inflammatory apoptosis, mitochondrial apoptosis and DNA damage, resulting in the development of dry eye disease, glaucoma, and keratitis. Accordingly, physical protection, chemical and pharmaceutical protective measures, gene therapy, and other methods are widely used in the clinical treatment of blue light hazard...
August 4, 2020: Biomedicine & Pharmacotherapy
David Kovacevic, Robert J Suriani, Brian M Grawe, Edward H Yian, Mohit N Gilotra, S Ashfaq Hasan, Umasuthan Srikumaran, Samer S Hasan, Frances Cuomo, Robert T Burks, Andrew G Green, Wesley M Nottage, Sai Theja, Hafiz F Kassam, Maarouf A Saad, Miguel A Ramirez, Rodney J Stanley, Matthew D Williams, Vidushan Nadarajah, Alexis C Konja, Jason L Koh, Andrew S Rokito, Charles M Jobin, William N Levine, Christopher C Schmidt
BACKGROUND: There is no consensus on treatment of irreparable massive rotator cuff tears (MRCT). The goal of this systematic review and meta-analysis was to (1) compare patient-reported outcome (PRO) scores, (2) define failure and reoperation rates, and (3) quantify magnitude of patient response across treatment strategies. METHODS: MEDLINE, Embase, CENTRAL, and Scopus databases were searched for studies including physical therapy and operative treatment of MRCT...
August 4, 2020: Journal of Shoulder and Elbow Surgery
Louise B Murphy, Miriam G Cisternas, Kristina A Theis, Teresa J Brady, Michele K Bohm, Dana Guglielmo, Jennifer M Hootman, Kamil E Barbour, Michael A Boring, Charles G Helmick
INTRODUCTION: Limited estimates of prescribed opioid use among adults with arthritis exist. All-cause (i.e., for any condition) prescribed opioid dispensed (referred to as opioid prescription in the remainder of this abstract) in the past 12 months among U.S. adults aged ≥18 years (n=35,427) were studied, focusing on adults with arthritis (n=12,875). METHODS: In 2018-2019, estimates were generated using Medical Expenditure Panel Survey data: (1) 2015 prevalence of 1 or more opioid prescriptions to U...
July 9, 2020: American Journal of Preventive Medicine
Virginia R Aldrich, Barbara B Hernandez-Rovira, Ankit Chandwani, Midhat H Abdulreda
The nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D) was discovered by coincidence in the 1980s and has since been widely used in the investigation of T1D and diabetic complications. The current in vivo study was originally designed to prospectively assess whether hyperglycemia onset is associated with physical destruction or functional impairment of beta cells under inflammatory insult during T1D progression in diabetes-prone female NOD mice. Prediabetic 16- to 20-wk-old NOD mice were transplanted with green fluorescent protein (GFP)-expressing reporter islets in the anterior chamber of the eye (ACE) that were monitored longitudinally, in addition to glycemia, with and without immune modulation using anti-CD3 monoclonal antibody therapy...
January 2020: Cell Transplantation
Shoshi Keisari, Rinat Feniger-Schaal, Yuval Palgi, Yulia Golland, Anat Gesser-Edelsburg, Boaz Ben-David
OBJECTIVE: Studies have shown that synchronized motion between people positively affects a range of emotional and social functions. The mirror-game is a synchrony-based paradigm, common to theater, performance arts, and therapy, which includes dyadic synchronized motion, playfulness, and spontaneity. The goal of the current study is to examine the effects of the mirror-game on subjective and cognitive indices in late life. METHOD: Thirty-four older adults (aged 71-98) participated in a within-group study design...
August 6, 2020: Clinical Gerontologist
Somayeh Asadi, Leonardo Bianchi, Martina De Landro, Sanzhar Korganbayev, Emiliano Schena, Paola Saccomandi
Gold nanoparticles (GNPs)-based photothermal therapy (PTT) is a promising minimally invasive thermal therapy for the treatment of focal malignancies. Although GNPs-based PTT has been known for over two decades and GNPs possess unique properties as therapeutic agents, the delivery of a safe and effective therapy is still an open question. This review aims at providing relevant and recent information on the usage of GNPs in combination with the laser to treat cancers, pointing out the practical aspects that bear on the therapy outcome...
August 6, 2020: Journal of Biophotonics
Salma Ayoub, Daniel P Howsmon, Chung-Hao Lee, Michael S Sacks
Ischemic mitral regurgitation (IMR), a frequent complication of myocardial infarction, is characterized by regurgitation of blood from the left ventricle back into the left atrium. Physical interventions via surgery or less-invasive techniques are the only available therapies for IMR, with valve repair via undersized ring annuloplasty (URA) generally preferred over valve replacement. However, recurrence of IMR after URA occurs frequently and is attributed to continued remodeling of the MV and infarct region of the left ventricle...
August 6, 2020: Biomechanics and Modeling in Mechanobiology
Turgay Altınbilek, Sadiye Murat
Objectives: This study aims to evaluate the effects of physical therapy modalities five days a week versus twice a week with a three-day interval on pain, depression, and functional disability in patients with chronic mechanical low back pain. Patients and methods: Between June 2018 and November 2018, a total of 60 patients (39 females, 21 males; mean age 41.0±6.8 years; range, 25 to 55 years) with chronic mechanical low back pain were included. The patients were divided into two groups: Group 1 (n=30) received physical therapy five days a week for a total of 15 sessions, while Group 2 (n=30) received physical therapy twice a week with a three-day interval for a total of six sessions...
June 2020: Turkish journal of physical medicine and rehabilitation
Hülya Kurt Saruhan, Murat Toprak
Objectives: This study aims to evaluate pain-diminishing and quality of life-related outcomes of Kinesio taping in patients on non-steroidal anti-inflammatory drug (NSAID) therapy for post-thoracotomy pain syndrome (PTPS). Patients and methods: Between February 2016 and May 2017, a total 60 patients (39 males, 21 females; median age 43.5 years; range, 18 to 76 years) with PTPS were included in this single-center, prospective, randomized study. The patients were randomized into two groups based on five-day pain management protocol including NSAIDs per se (NSAID group; n=30) and NSAIDs plus Kinesio taping (NSAID-KT group; n=30) groups...
June 2020: Turkish journal of physical medicine and rehabilitation
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