Philip F Halloran, Katelynn Madill-Thomsen, Martina Mackova, Arezu Z Aliabadi-Zuckermann, Martin Cadeiras, Marisa G Crespo-Leiro, Eugene C Depasquale, Mario Deng, Johannes Gökler, Shelley A Hall, Daniel H Kim, Jon Kobashigawa, Peter Macdonald, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann, Jeff Reeve
PURPOSE: We explored the changes in gene expression correlating with dysfunction and graft failure in endomyocardial biopsies (EMBs). METHODS: Genome-wide microarrays (19462 genes) were used to define mRNA changes correlating with dysfunction (LVEF≤55) and risk of graft loss within 3 years post biopsy. LVEF data was available for 1013 biopsies, and survival data for 779 patients (74 losses). Molecular classifiers were built for predicting dysfunction (LVEF≤55) and post-biopsy 3-year survival...
November 30, 2023: Journal of Heart and Lung Transplantation