Marcos V S Sales, Reginaldo C da Silva Filho, Marina M Silva, Jeanynne L Rocha, Ricardo O Freire, Eloiza Lopes de L Tanabe, Elaine C O Silva, Eduardo Jorge S Fonseca, Isis M Figueiredo, Ueslen Rocha, Josué Carinhanha C Santos, Ana Catarina R Leite
BACKGROUND: Thimerosal (TM) is an organic mercury compound used as a preservative in many pharmacological inputs. Mercury toxicity is related to structural and functional changes in macromolecules such as hemoglobin (Hb) in erythrocytes (Ery). METHOD: Human Hb and Ery were used to evaluate O2 uptake based on the TM concentration, incubation time, and temperature. The influence of TM on the sulfhydryl content, production of reactive oxygen species (ROS), and membrane fragility was also evaluated...
January 10, 2022: Journal of Trace Elements in Medicine and Biology